Role of Neuroinflammation in Neurological Disorders

Dear Colleagues,

Neuroinflammation plays a critical role in the development and progression of many neurological disorders. It is a process through which the brain’s innate immune system is activated, resulting in an inflammatory challenge posed by the influence of exogenous and endogenous factors such as trauma, stroke, chronic infections, disease-related proteins, etc. This in turn triggers certain biochemical and cellular activities, which have several physiological, biochemical, and behavioral outcomes. Certain key factors of brain inflammation are the activation of glial cells and stimulation of complement-mediated pathways, production of inflammatory mediators, and leukocyte recruitment. The activation of microglia initiates various signal transduction pathways comprising PI3K/AKT, MAPK, and mTOR pathways, also leading to the synthesis of various cytokines, such as TNF-α, IL-1β, IL-6, IL-18, and others. Though the research and the information on the inflammatory processes in the brain have increased tremendously in recent years, more studies need to be conducted to understand how this immune response contributes to the development of neurologic disorders, including schizophrenia, Alzheimer’s, Parkinson’s, migraines, multiple sclerosis (MS), encephalitis, stroke, and other neurodevelopmental diseases. Composite and distinctive changes in the body’s immune response cause approximately all primary pediatric, adult, and neuropsychiatric disorders. This Special Issue focuses on, but is not limited to, highlighting new advances in the field of inflammation and neurological disorders. To evolve the knowledge in this area, we invite authors to contribute original research articles, reviews, case reports, and brief communications from a range of studies, including pharmacological and therapeutic advances in both human and animal models.

Dr. Rekha Jagadapillai
Guest Editor

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• neuroinflammation
• neurological disorders
• schizophrenia
• PI3K/AKT pathways
• MAPK pathways
• mTOR pathways
• cytokines
• Alzheimer’s
• Parkinson’s
• migraines
• multiple sclerosis
• neurodevelopmental disorders