Special Issues

Pharmaceuticals publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Pharmaceutical Targeting of Lipids in Metabolic and Neurological Disorders submission deadline 1 Jun 2026 | 1 articles | Viewed by 742
Keywords: lipid metabolism; pharmacological targets; metabolic disorders; neurodegenerative diseases; lipid signaling
(This special issue belongs to the Section Pharmacology)
The Modes of Action of Herbal Medicines and Natural Products, 2nd Edition
edited by Hongnan Cao
submission deadline 10 Jun 2026 | 5 articles | Viewed by 10466 | Submission Open
Keywords: herbal compounds; natural products; pharmacokinetics and pharmacodynamics of natural products; herbal medicines; herbal therapies
(This special issue belongs to the Section Natural Products)
Natural Origin Polyphenols and Oxidative Stress: Mechanisms and Therapeutic Applications submission deadline 15 Jun 2026 | Viewed by 276 | Submission Open
Keywords: polyphenols; oxidative stress; antioxidant mechanisms; therapeutic applications; chronic diseases; functional foods; bioavailability; cellular signaling; natural products
(This special issue belongs to the Section Natural Products)
Epigenetic Regulatory Mechanisms and Applications of Non-Coding RNAs in Chemoresistance and Metabolic Disorders
edited by , Francisca Villagrán-Silva and Pablo J. Letelier
submission deadline 15 Jun 2026 | Viewed by 241 | Submission Open
Keywords: non-coding RNAs; epigenetic regulation; chemoresistance; metabolic disorders; chemotherapy-related toxicities; DNA methylation; histone modification; chromatin remodeling; RNA-based therapeutics; biomarkers
(This special issue belongs to the Section Biopharmaceuticals)
Ethnopharmacology in Latin America, 2nd Edition submission deadline 20 Jun 2026 | 1 articles | Viewed by 531 | Submission Open
Keywords: Latin America; preclinical; clinical; ethnobotany; pharmacology; chemical standardization; herbal products
(This special issue belongs to the Section Natural Products)
Allosteric Modulators: Unlocking New Dimensions from Molecular Discovery to Therapeutic Potential
edited by , and Kwangho Kim
submission deadline 20 Jun 2026 | Viewed by 513 | Submission Open
Keywords: allosteric binding sites; protein– ligand interactions; mechanism of action; isoform selectivity; signal bias; structure-based design; pharmacological profiling; allosteric anchoring; GPCRs; ion channels; kinases; heterobifunctional ligand; allosteric synergy
(This special issue belongs to the Section Medicinal Chemistry)
Innovative Synthetic Strategies in Drug Discovery submission deadline 20 Jun 2026 | Viewed by 321 | Submission Open
Keywords: drug discovery; synthetic methodology; medicinal chemistry; organic synthesis; total synthesis; catalysis; biocatalysis; enzyme-mediated reaction; late-stage functionalization; computational synthesis; AI-guided synthesis; green chemistry
(This special issue belongs to the Section Medicinal Chemistry)
Tumor Therapy and Drug Delivery: 2nd Edition
edited by
submission deadline 20 Jun 2026 | Viewed by 191 | Submission Open
Keywords: antitumor therapy; drug-delivery systems; nanocarriers; immunoconjugates; nanotechnology; cancer selectivity
(This special issue belongs to the Section Pharmaceutical Technology)
Structural and Computationally Driven Molecule Design in Drug Discovery: 2nd Edition submission deadline 22 Jun 2026 | 14 articles | Viewed by 46684 | Submission Open
Keywords: structural dynamics studies; computer-aided drug design; molecular dynamics simulations; molecular docking; virtual screening; QSAR; in silico ADMET; artificial intelligence (AI) techniques
(This special issue belongs to the Section Medicinal Chemistry)
Electrospinning for Biomedical Applications submission deadline 22 Jun 2026 | 1 articles | Viewed by 678 | Submission Open
Keywords: electrospinning; nanofibers; drug delivery systems; tissue engineering scaffolds; biomedical materials; controlled release; polymer-based platforms; regenerative medicine
(This special issue belongs to the Section Pharmaceutical Technology)
Immune Modulation and Precision Targeting of the Tumor Microenvironment
edited by
submission deadline 22 Jun 2026 | Viewed by 224 | Submission Open
Keywords: tumor microenvironment (TME); immune modulation; targeted therapeutics; molecular engineering; macrophage reprogramming; immune checkpoint targeting; radiotheranostics; small-molecule modulators; nanomedicine
(This special issue belongs to the Section Pharmacology)
Integrated Molecular Imaging and Targeted Radionuclide Therapy for the Precision Management of Breast and Pancreatic Cancers
edited by
submission deadline 22 Jun 2026 | Viewed by 172 | Submission Open
Keywords: molecular imaging; radiotheranostics; targeted radionuclide therapy; radiopharmaceuticals; breast cancer; pancreatic cancer; precision oncology; PET/SPECT imaging; theranostic biomarkers
(This special issue belongs to the Section Radiopharmaceutical Sciences)
Natural Products as an Alternative for Treatment of Human Diseases
edited by Eduardo Lira, and Raimundo Gonçalves De Oliveira Junior
submission deadline 25 Jun 2026 | 11 articles | Viewed by 37231 | Submission Open
Keywords: medicinal plants; herbal remedies; natural products; traditional medicine
(This special issue belongs to the Section Natural Products)
Photodynamic Therapy: 3rd Edition
edited by
submission deadline 25 Jun 2026 | 7 articles | Viewed by 11713 | Submission Open
Keywords: photodynamic therapy; photosensitizers; nanoparticles; photo-diagnosis; targeting; antimicrobial; X-rays excitation; two photon and upconversion; immunomodulation; dosimetry; hypoxia
(This special issue belongs to the Section Pharmaceutical Technology)
Plant-Derived Products in the Treatment of Internal Diseases: 2nd Edition
edited by and
submission deadline 25 Jun 2026 | 6 articles | Viewed by 8490 | Submission Open
Keywords: medicinal plants; phytotherapy; herbal treatment; natural products; herbalism; traditional medicine; cardiovascular disease; lung disease; liver disease; gastrointestinal disease; kidney disease; obesity; diabetes; rheumatological disease
(This special issue belongs to the Section Natural Products)
Natural Products Derived from Fungi and Their Biological Activities, 2nd Edition
edited by
submission deadline 25 Jun 2026 | 4 articles | Viewed by 8000 | Submission Open
Keywords: fungi; medicinal fungi; fruiting bodies; mycelial cultures; bioactive compounds; pro-health activity; mushroom products; natural therapy; natural medicines
(This special issue belongs to the Section Natural Products)
Pharmaceutical Applications of Cannabinoids submission deadline 25 Jun 2026 | 1 articles | Viewed by 5054 | Submission Open
Keywords: cannabis; cannabinoids; therapeutic properties; medicinal plant; phytochemicals
Secondary Metabolites as Drug Leads: Bridging Experimental Discovery and Computational Innovation
edited by , Francisco das Chagas Alves Lima, , Luisa Di Paola and
submission deadline 25 Jun 2026 | 2 articles | Viewed by 2942 | Submission Open
Keywords: medicinal chemistry; computer aided-drug design; new drugs agents; natural products
(This special issue belongs to the Section Medicinal Chemistry)
Advances in Drug Hypersensitivity Research
edited by José Antonio Cornejo-García
submission deadline 25 Jun 2026 | 3 articles | Viewed by 2835 | Submission Open
Keywords: drug hypersensitivity/allergic reactions; IgE antibodies; T-cells; non-immunological reactions; antibiotics; NSAIDs; anaesthetics; chemotherapeutics; biologicals  
(This special issue belongs to the Section Pharmacology)
Green Synthesis and Biological Evaluation of Nitrogen-Containing Heterocycles
edited by Mario Komar, and
submission deadline 25 Jun 2026 | 2 articles | Viewed by 2598 | Submission Open
Keywords: N-containing heterocycles; microwave-assisted synthesis; ultrasound-assisted synthesis; mechanochemical synthesis; deep eutectic solvents; biomass-derived solvents; biological evaluation; computational methods
(This special issue belongs to the Section Medicinal Chemistry)
Bioactive Substances, Oxidative Stress, and Inflammation, 2nd Edition submission deadline 25 Jun 2026 | 2 articles | Viewed by 2187 | Submission Open
Keywords: bioactive compounds; oxidative stress; chronic inflammation; chronic non-communicable diseases; polyphenol; vitamins; omega-3 fatty acids
(This special issue belongs to the Section Natural Products)
Epidemiological Surveillance of Clinical Bacterial Infections and Antimicrobial Resistance Management submission deadline 25 Jun 2026 | 2 articles | Viewed by 1367 | Submission Open
Keywords: antimicrobial resistance (AMR); clinical bacterial infections; epidemiological surveillance; antimicrobial stewardship (AMS); drug-resistant pathogens; rapid diagnostic tools for AMR; pharmacokinetics/pharmacodynamics (PK/PD) of antimicrobials; infection control; multi-center surveillance data; public health policy for AMR
(This special issue belongs to the Section Pharmacology)
HIV and Viral Hepatitis Prevention, Treatment and Coinfection, 2nd Edition submission deadline 25 Jun 2026 | 1 articles | Viewed by 1227 | Submission Open
Keywords: coinfection; drug discovery; HBV; HCV; HDV; HIV; neutralizing antibodies; prevention; treatment; vaccine
(This special issue belongs to the Section Biopharmaceuticals)
Extracellular Vesicles and Bioinspired Nanovesicles as Next-Generation Drug-Delivery Systems
edited by
submission deadline 25 Jun 2026 | 1 articles | Viewed by 1156 | Submission Open
Keywords: extracellular vesicles; bioinspired nanovesicles; drug-delivery systems; therapeutics; exosomes; exosome-like nanoparticles; hybrid exosomes
(This special issue belongs to the Section Biopharmaceuticals)
Pharmacogenomics and Ethnic Diversity: Optimizing Drug Response Across Populations
edited by and Gisely Cardoso De Melo
submission deadline 25 Jun 2026 | 1 articles | Viewed by 1083 | Submission Open
Keywords: pharmacogenomics; pharmacogenetics; ethnic groups; population genetics; ancestry; drug response
(This special issue belongs to the Section Pharmacology)
New and Emerging Treatment Strategies for Gastrointestinal Diseases, 2nd Edition submission deadline 25 Jun 2026 | 1 articles | Viewed by 859 | Submission Open
Keywords: gastrointestinal diseases; gastrointestinal homeostasis; gastrointestinal injuries; gastrointestinal disturbances; dysbiosis; bile acid; inflammatory bowel diseases; diarrhea
(This special issue belongs to the Section Pharmacology)
Pharmacological Interventions for Opioid-Induced Respiratory Depression
edited by David Matthew Walentiny
submission deadline 25 Jun 2026 | 1 articles | Viewed by 763 | Submission Open
Keywords: opioid; respiratory depression; medication development; overdose; wooden chest syndrome; apnea; polysubstance; medicinal chemistry
(This special issue belongs to the Section Medicinal Chemistry)
Gut Microbiota and Metabolites: Novel Strategies for Intestinal Inflammation Therapy
edited by Alexander S. Dowdell
submission deadline 25 Jun 2026 | Viewed by 244 | Submission Open
(This special issue belongs to the Section Biopharmaceuticals)
Self-Assembling Materials for Next-Generation Biopharmaceuticals
edited by
submission deadline 25 Jun 2026 | Viewed by 229 | Submission Open
Keywords: peptide self-assembly; peptide drug design; drug-loaded nanostructures; biomaterials; AI-driven design
(This special issue belongs to the Section Biopharmaceuticals)
Treatment for HPV-Associated Cervical Cancer: Novel Therapeutic Strategies
edited by , , Marco Antonio Leyva-Vázquez, and Olga Lilia Garibay-Cerdenares
submission deadline 26 Jun 2026 | 1 articles | Viewed by 924 | Submission Open
Keywords: cervical cancer; proteomic; transcriptomic; miRNA; lncRNA; drug repositioning; nano-transport; liposomes and immunoliposomes
(This special issue belongs to the Section Pharmacology)
Chirality in Drugs
edited by
submission deadline 26 Jun 2026 | Viewed by 347 | Submission Open
Keywords: chirality; chiral drugs; chiral resolution; asymmetric synthesis; chiral analysis; chiroptical spectroscopy
(This special issue belongs to the Section Medicinal Chemistry)
Use of Anesthetic Agents: Management and New Strategy: 2nd Edition submission deadline 26 Jun 2026 | Viewed by 249 | Submission Open
Keywords: anesthetic agents; anesthetic drugs; anesthetic; general anesthetic agents; therapeutic tools
(This special issue belongs to the Section Pharmacology)
Selective Histone Deacetylase Isoforms as Potential Therapeutic Targets
edited by
submission deadline 30 Jun 2026 | 7 articles | Viewed by 29213 | Submission Open
(This special issue belongs to the Section Medicinal Chemistry)
Boron-Containing Compounds: Identification, Synthesis, Biological Actions and Pharmacology submission deadline 30 Jun 2026 | 11 articles | Viewed by 27560 | Submission Open
Keywords: boron; drug development; drug discovery; bioactive boron compounds; bioinorganic chemistry; inorganic biological chemistry; synthesis; natural boron compounds; chemical characterization
(This special issue belongs to the Section Medicinal Chemistry)
Nanotechnology in Biomedical Applications submission deadline 30 Jun 2026 | 8 articles | Viewed by 15912 | Submission Open
Keywords: nanotechnology; nanobiotechnology; biomedical applications; drug delivery; nanobiosensors; targeted therapy; diagnostics; nanomaterials; therapeutics; theranostics
(This special issue belongs to the Section Pharmaceutical Technology)
Pharmaceutical Applications and Therapeutic Mechanisms of Substances from Plant Origin submission deadline 30 Jun 2026 | 6 articles | Viewed by 13531 | Submission Open
Keywords: natural substances; phytotherapy; phytochemistry; chromatography; pharmacokinetics; pharmacodynamics; drug delivery
(This special issue belongs to the Section Natural Products)
Therapeutic Potential of Cannabinoid Receptors Type 1 and 2—Novel Insights for Enhancing the Chance of Clinical Success, 2nd Edition
edited by
submission deadline 30 Jun 2026 | 3 articles | Viewed by 12331 | Submission Open
Keywords: endocannabinoid system (ECS); cannabinoid receptor type 1 (CB1R); cannabinoid receptor type 2 (CB2R); cannabinoids; ligand
(This special issue belongs to the Section Pharmacology)
Novel Heterocyclic Compounds as Potential Anti-Inflammatory and/or Anticancer Agents
edited by Ester Colarusso and
submission deadline 30 Jun 2026 | 2 articles | Viewed by 6858 | Submission Open
Keywords: drug discovery; medicinal chemistry; privileged scaffolds; heterocyclic compounds; anticancer activity; anti-inflammatory activity
(This special issue belongs to the Section Medicinal Chemistry)
Advances in Smooth Muscle Pharmacology
edited by , Tomasz Kleszczewski and
submission deadline 30 Jun 2026 | 4 articles | Viewed by 5547 | Submission Open
Keywords: smooth muscle regulation; pharmacological interventions; ion channel modulation; receptor– ligand dynamics; therapeutic drug development; vascular tone regulation; smooth muscle disorders; translational pharmacology; cellular signaling pathways; pathophysiology
(This special issue belongs to the Section Pharmacology)
Recent Advances in the Research of Drug Delivery System: Materials, Preparation Methods, and Mechanisms
edited by
submission deadline 30 Jun 2026 | 2 articles | Viewed by 5294 | Submission Open
Keywords: drug delivery system; preparation; material; mechanism; application; bioactivities; targeted delivery
(This special issue belongs to the Section Pharmaceutical Technology)
Artificial Intelligence: New Molecules, Therapeutic Targets and Discovery of New Drugs
edited by , Maria José Zarzuelo Romero and Margarita López-Viota
submission deadline 30 Jun 2026 | 6 articles | Viewed by 5243 | Submission Open
Keywords: artificial intelligence; drug design; pharmaceutical technology; molecular dynamics simulation
(This special issue belongs to the Section AI in Drug Development)
Pharmaceuticals for Inflammatory Bowel Disease (IBD)
edited by
submission deadline 30 Jun 2026 | 1 articles | Viewed by 4685 | Submission Open
Keywords: inflammatory bowel disease; IBD symptoms; IBD pathogenesis; IBD treatments
(This special issue belongs to the Section Pharmacology)
Advances in Regulatory Mechanisms and Therapeutic Potential of Non-Coding RNAs in Neurodegenerative Diseases
edited by and Maurizio Grassano
submission deadline 30 Jun 2026 | 2 articles | Viewed by 4415 | Submission Open
Keywords: non-coding RNAs; microRNAs; long non-coding RNAs; circular RNAs; neurodegeneration; Alzheimer's disease; Parkinson's disease; amyotrophic lateral sclerosis; gene regulation; biomarkers; RNA therapeutics; neuroinflammation; synaptic dysfunction; translational neuroscience
(This special issue belongs to the Section Biopharmaceuticals)
Characterization and Quality Control of Biopharmaceuticals Using the Multi-Attribute Method (MAM): Advantages and Challenges
edited by Jingzhong Guo
submission deadline 30 Jun 2026 | 2 articles | Viewed by 3780 | Submission Open
Keywords: analytical characterization; critical quality attribute (CQA); the multi-attribute method (MAM); new peak detection (NPD); post-translational modifications (PTM); product quality attribute (PQA); peptide mapping (PM); quality by design (QbD); quality control (QC); structure– activity relationship (SAR)
(This special issue belongs to the Section Biopharmaceuticals)
Extracts and Essential Oils from Medicinal Plants: Biological Activities, Applications, and Perspectives submission deadline 30 Jun 2026 | 3 articles | Viewed by 3623 | Submission Open
Keywords: medicinal plants; spices and herbs; bioactive compounds; antimicrobial agents; plant extracts; essential oils; phytochemical analysis; microbiological analysis; natural medicines
(This special issue belongs to the Section Natural Products)
Next-Generation Antinfective Agents submission deadline 30 Jun 2026 | 2 articles | Viewed by 3263 | Submission Open
Keywords: small molecules; peptides; peptidomimetics; bacterial infections; fungi; virus; parasites; drug design; computational tools; biology assays; resistance mechanisms
(This special issue belongs to the Section Medicinal Chemistry)
Advances in Enzyme Inhibitors and Protein Degraders as Anticancer Agents
edited by and
submission deadline 30 Jun 2026 | 3 articles | Viewed by 3233 | Submission Open
Keywords: anticancer agents; mechanism of action; epigenetics; PROTAC; antibody– drug conjugates; enzymes
(This special issue belongs to the Section Medicinal Chemistry)
Monitoring, Mitigation, and Risk Assessment of Pharmaceuticals in the Environment submission deadline 30 Jun 2026 | 4 articles | Viewed by 2792 | Submission Open
Keywords: pharmaceuticals; environmental impact; novel analytical techniques; remediation strategies; risk assessment; ecological effects
(This special issue belongs to the Section Pharmaceutical Technology)
Platform Technologies and Emerging Modalities for Neglected Tropical Disease Therapeutics
edited by , Guillermo Labadie and Brian Suárez Mantilla
submission deadline 30 Jun 2026 | 2 articles | Viewed by 2425 | Submission Open
Keywords: neglected tropical diseases (NTDs); leishmaniasis; Chagas disease; human African trypanosomiasis; Dengue; Zika; chikungunya; mycetoma; platform technologies; cross-pathogen therapeutics; drug discovery; medicinal chemistry; molecular targets; target deconvolution; new chemical entities; covalent inhibitors; peptides/peptidomimetics; biologics; structure-based design; AI/ML-guided design; phenotypic screening; hit-to-lead; lead optimisation; ADME/PK; PK/PD; formulation and delivery; resistance
(This special issue belongs to the Section Medicinal Chemistry)
Advances in Non-Coding RNAs as Prognostic Biomarkers, Therapeutic Targets, and Regulatory Mechanisms in Cancer submission deadline 30 Jun 2026 | 1 articles | Viewed by 1868 | Submission Open
Keywords: non-coding RNAs; non-coding RNAs as prognostic biomarkers in cancer; non-coding RNAs as treatment targets in cancer; non-coding RNAs as diagnostic targets in cancer; molecular mechanisms on non-coding RNAs in cancer
(This special issue belongs to the Section Biopharmaceuticals)
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