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Pharmaceuticals publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Novel Therapeutic Approaches for Chronic Urticaria: Advances and Challenges

edited by Luis Felipe Ensina

submission deadline 28 Jul 2025 | Viewed by 222 | Submission Open

Keywords: chronic urticaria; current management; biosimilar pharmaceuticals; biologic drugs; monoclonal antibodies; tyrosine kinase inhibitors

(This special issue belongs to the Section Pharmacology)

Natural Pharmacons: Biologically Active Plant-Based Pharmaceuticals—4th Edition

edited by

Dejan Stojković

and

Marina Soković

submission deadline 29 Jul 2025 | 4 articles | Viewed by 2588 | Submission Open

Keywords: chemical characterization of natural preparations; therapeutic potential of natural matrices in cardiovascular diseases; diabetes; cancer; and neurodegenerative diseases; antimicrobial activity; antioxidant activity; anti-enzymatic activity; anti-inflammatory activity; mechanism of pharmacological actions; structure– activity relationship studies

(This special issue belongs to the Section Natural Products)

Recent Advances in Cancer Diagnosis and Therapy

edited by

Adriana Grigoraș

and

Hsin-Sheng Yang

submission deadline 30 Jul 2025 | 3 articles | Viewed by 4138 | Submission Open

Keywords: early diagnosis; advanced therapy; biomarkers; immunohistochemistry; molecular diagnosis; metastasis; prognosis; targeted therapies; combination therapies; cancer pharmacology

(This special issue belongs to the Section Pharmacology)

Drug Discovery, Development, and Synthesis for Glioblastoma

edited by

Shizue Mito

, Sue Anne Chew and

Mitsuhiro Arisawa

submission deadline 30 Jul 2025 | 1 articles | Viewed by 1448 | Submission Open

Keywords: glioblastoma; drug design; drug synthesis; anticancer; natural products; biomolecules; combination therapy; pharmaceuticals

(This special issue belongs to the Section Pharmacology)

Green Synthesis and Biological Evaluation of Quinazolinone-Based Compounds

edited by Mario Komar,

Marija Paurević

and

Maja Molnar

submission deadline 30 Jul 2025 | Viewed by 376 | Submission Open

Keywords: synthesis in deep eutectic solvents; microwave-assisted synthesis; ultrasound-assisted synthesis; mechanochemical synthesis; quinazolinones; biological activity; computational methods

(This special issue belongs to the Section Medicinal Chemistry)

Pharmacological Advances for Treatment in Hypertension 2.0

edited by

Arquimedes Gasparotto Junior

submission deadline 31 Jul 2025 | 2 articles | Viewed by 4086 | Submission Open

Keywords: antihypertensive; cardioprotective; herbal medicine; hypertension; medicinal plants

(This special issue belongs to the Section Pharmacology)

Advancements in Cardiovascular and Antidiabetic Drug Therapy, 2nd Edition

edited by

Alfredo Caturano

submission deadline 31 Jul 2025 | 5 articles | Viewed by 3711 | Submission Open

Keywords: cardiovascular diseases; antidiabetic drugs; pharmacological interventions; sodium– glucose cotransporter 2 inhibitors; PCSK9 inhibitors; obeticholic acid; lipid-lowering agents; heart failure treatment; diabetes management; drug therapy innovations

(This special issue belongs to the Section Pharmacology)

Recent Advances in Ocular Pharmacology

edited by

Lampros Lamprogiannis

and

Ioannis Tsinopoulos

submission deadline 31 Jul 2025 | 2 articles | Viewed by 3461 | Submission Open

Keywords: ophthalmology; ocular diseases; drug delivery; drug targeting; controlled drug release; eye drops; biopolymers; nanomedicine; clinical applications; clinical trials

(This special issue belongs to the Section Pharmacology)

Antibiotic Resistance in Gram-Negative Bacteria: The Threat from the Pink Corner, 2nd Edition

edited by

Bruno Silvester Lopes

and

Alfizah Hanafiah

submission deadline 31 Jul 2025 | 1 articles | Viewed by 2285 | Submission Open

Keywords: gram-negative; pseudomonas; acinetobacter; campylobacter; helicobacter; klebsiella; enterobacteriaceae; arcobacter; phages; complementary alternative medicine; antimicrobial peptides; food security; hospital acquired infections; microbiome; gram negative pathogens; antibiotic resistance; virulence and other molecular mechanisms

(This special issue belongs to the Section Medicinal Chemistry)

Therapeutic Potential of Silver Nanoparticles (AgNPs), 2nd Edition

edited by

Goreti Pereira

submission deadline 31 Jul 2025 | 4 articles | Viewed by 2110 | Submission Open

Keywords: metallic nanostructures; plasmonic nanomaterials; photothermal therapy; photodynamic therapy; antimicrobial; antioxidant; anticancer

(This special issue belongs to the Section Medicinal Chemistry)

The Application of Pharmacogenetics in Toxicity Prevention and Drug Effect Improvement

edited by Pura Ballester

submission deadline 31 Jul 2025 | 2 articles | Viewed by 1868 | Submission Open

Keywords: pharmacogenetics; drug toxicity prevention; efficacy enhancement; pharmaceutical research; precision medicine; therapeutic optimization

(This special issue belongs to the Section Pharmacology)

Medicinal Plants: Exploring Plant-Based Bioactive Compounds for Cancer and Metabolic Diseases Prevention and Intervention

edited by

Lucas Fornari Laurindo

and

Sandra Barbalho

submission deadline 31 Jul 2025 | 2 articles | Viewed by 1597 | Submission Open

Keywords: cancer; metastasis; tumor growth; tumor spread; bioactive compounds; phytochemicals; medicinal plants; phytochemistry; cancer prevention; cancer intervention; metabolic diseases; metabolism; diabetes; MAFLD; dyslipidemia

(This special issue belongs to the Section Natural Products)

Recent Advances in Natural Product-Based Nanostructured Systems: 2nd Edition

edited by

Luís Alexandre Muehlmann

and

João Paulo Longo

submission deadline 31 Jul 2025 | 1 articles | Viewed by 1085 | Submission Open

Keywords: natural product; nanostructured systems; nanotechnology; nanostructures; nanocarriers; bioactive compounds

(This special issue belongs to the Section Natural Products)

Advances and Future Trends in Development of Novel Antifungals and Antifungal Therapy

edited by

Radu Tamaian

submission deadline 31 Jul 2025 | Viewed by 872 | Submission Open

Keywords: antifungals; antifungal drug discovery; antifungal resistance; repositioning of non-antifungal drugs to antifungals; unconventional antifungal drug targets and signaling pathways

(This special issue belongs to the Section Medicinal Chemistry)

Advancing Cardio-Oncology: Mechanisms of Cardiotoxicity and Therapeutic Options for Old and New Anticancer Drugs

edited by

Vera Marisa Costa

submission deadline 31 Jul 2025 | 1 articles | Viewed by 445 | Submission Open

Keywords: cardio-oncology; anticancer therapies; cardiac dysfunction; hypertension; heart failure; intercellular communication; treatment; prevention; diagnosis; cardiac remodeling

(This special issue belongs to the Section Pharmacology)

Scientific Evidence-Based Applications of Polyamines in Pharmaceuticals Science

edited by Kuniyasu Soda

submission deadline 5 Aug 2025 | Viewed by 197 | Submission Open

Keywords: polyamine; spermine; spermidine; health; senescence; age-related; disease

(This special issue belongs to the Section Pharmacology)

The Role of Phytochemicals in Aging and Aging-Related Diseases

edited by

Giovanni Scapagnini

Sergio Davinelli

and

Alessandro Medoro

submission deadline 15 Aug 2025 | 7 articles | Viewed by 14883 | Submission Open

Keywords: phytochemicals; plant-based diet; dietary supplementation; pharma-nutrition; aging; aging-related diseases; prevention

(This special issue belongs to the Section Natural Products)

Innovative Tools for Drug Analysis and Therapeutic Drug Monitoring (TDM)

edited by

Juraj Piestansky

and

Andrej Kovac

submission deadline 15 Aug 2025 | 8 articles | Viewed by 10853 | Submission Open

Keywords: therapeutic drug monitoring; analysis of drugs; separation analytical methods; mass spectrometry; bioanalysis; quality control; dosage forms; green analytical chemistry

(This special issue belongs to the Section Pharmacology)

Interdisciplinary Approaches to Preventing and Treating Inflammatory and Oxidative Diseases with Medicinal Plants and Bioactive Compounds

edited by

Lucas Fornari Laurindo

and

Sandra Barbalho

submission deadline 15 Aug 2025 | 1 articles | Viewed by 1731 | Submission Open

Keywords: interdisciplinary studies; inflammation; inflammatory diseases; oxidative stress; oxidative diseases; pro-inflammatory; pro-oxidative; neurodegenerative diseases; cardiovascular diseases; cancer; medicine; rheumatological diseases; endocrinological diseases; gastroenterological diseases; dermatological diseases; pulmonary diseases; dentistry; nutrition; dietetics; therapy; medicinal plants; bioactive compounds; phytochemicals; phytochemistry

(This special issue belongs to the Section Natural Products)

Natural Products in Internal Diseases: From Preclinical Research to Clinical Translation

edited by Roberto Pontarolo,

Luana Mota Ferreira

and

Raul Edison Luna Lazo

submission deadline 15 Aug 2025 | 1 articles | Viewed by 1019 | Submission Open

Keywords: natural products; internal diseases; cardiovascular diseases; diabetes; autoimmune disorders; gastrointestinal conditions; respiratory illnesses

Potential Therapeutic Targets for the Management of Diabetes Mellitus, Obesity and Cancer

edited by Marisa Jádna Silva Frederico and

Fátima Regina Mena Barreto Silva

submission deadline 15 Aug 2025 | Viewed by 250 | Submission Open

Keywords: diabetes; obesity; cancer; pharmacological targets

(This special issue belongs to the Section Pharmacology)

Enzyme Inhibitors: Potential Therapeutic Approaches, 2nd Edition

edited by

Phaedra Eleftheriou

submission deadline 15 Aug 2025 | Viewed by 215 | Submission Open

Keywords: enzymes; inhibitors; competitive; uncompetitive; non-competitive; drug target; pharmaceutical approach; disease treatment

(This special issue belongs to the Section Medicinal Chemistry)

Glial Cells as Drug Targets for Schizophrenia

edited by

Kumlesh Kumar Dev

and Paraskevi Papakyriakopoulou

submission deadline 15 Aug 2025 | Viewed by 163 | Submission Open

Keywords: schizophrenia; astrocytes; oligodendrocytes; microglia

(This special issue belongs to the Section Pharmacology)

Small-Molecule Inhibitors for Novel Therapeutics

edited by

Gustavo Provensi

and Simone Giovannuzzi

submission deadline 20 Aug 2025 | 4 articles | Viewed by 8687 | Submission Open

Keywords: small molecules; enzyme inhibition/activation; protein modulation; novel therapeutics; high-throughput screening; target proteins; drug delivery

Integrating Machine Learning (ML) into Medicinal Chemistry and Cheminformatics

edited by

Vartika Tomar

submission deadline 20 Aug 2025 | 5 articles | Viewed by 5564 | Submission Open

Keywords: small molecules; molecular descriptors; molecular similarity; structure-based and ligand-based screening; homology modeling; molecular docking; drug– receptor docking; biological activity

(This special issue belongs to the Section Medicinal Chemistry)

Design, Synthesis and Development of Novel Antiviral Agents

edited by

Antonio Lupia

submission deadline 20 Aug 2025 | 3 articles | Viewed by 4604 | Submission Open

Keywords: viruses; emerging viral diseases; infectious diseases; antiviral agents; small molecules; structure− activity relationship (SAR) studies; drug design (DD) and synthesis; computer-aided drug discovery (CADD); medicinal chemistry

(This special issue belongs to the Section Medicinal Chemistry)

Computational (In Silico) Approaches for Drug Target Discovery and Disposition

edited by

Frederico Severino Martins

and

Leonardo Luiz Borges

submission deadline 20 Aug 2025 | 1 articles | Viewed by 1415 | Submission Open

Keywords: computational drug discovery; in silico modeling; drug target identification; pharmacokinetics (pk); physiologically based pharmacokinetics (PBPK); physiologically based biokinetics (PBBK); physiologically based biopharmaceutics (PBBM); ADME/Tox; machine learning in drug development; systems pharmacology

Pharmaceutical Process Engineering: Experimental and Computational Innovation

edited by Marcial Gonzalez and Francesco Destro

submission deadline 22 Aug 2025 | Viewed by 140 | Submission Open

Keywords: pharmaceutical process engineering; process development; process analytical technology (PAT); process analytical chemistry (PAC); quality by design (QbD); sustainable manufacturing; drug product quality; biopharmaceuticals

(This special issue belongs to the Section Pharmaceutical Technology)

New Approaches to Fighting Infectious Diseases: Overcoming the Antimicrobial Resistance in Current Treatments

edited by

Antonia Efstathiou

and

Dimitra K. Toubanaki

submission deadline 25 Aug 2025 | 12 articles | Viewed by 36458 | Submission Open

Keywords: infectious diseases; antimicrobial resistance; parasites; viruses; bacteria; treatment approaches; therapeutics; chemotherapy; targeted drug design; natural products

(This special issue belongs to the Section Medicinal Chemistry)

Natural Products in Health Promotion and Disease Prevention 2025

edited by

Marco Alves

and

Ariane Zamoner

submission deadline 25 Aug 2025 | 9 articles | Viewed by 15627 | Submission Open

Keywords: natural products; nutraceuticals; bioactive compounds; traditional medicine; drug discovery

(This special issue belongs to the Section Natural Products)

Tumor Immunopharmacology

edited by

Marco A. Velasco-Velázquez

submission deadline 25 Aug 2025 | 4 articles | Viewed by 13137 | Submission Open

Keywords: immunotherapy; immunomodulation; drug development; cytokine receptor antagonist; T-cell based therapies; therapeutic antibodies; drug delivery; cancer vaccine

(This special issue belongs to the Section Pharmacology)

Therapeutic Drug Monitoring and Adverse Drug Reactions: 2nd Edition

edited by Engi Abd El Hady Algharably and

Ursula Gundert-Remy

submission deadline 25 Aug 2025 | 10 articles | Viewed by 10332 | Submission Open

Keywords: therapeutic drug monitoring; adverse drug reactions; pharmacokinetics; personalized medicine; medication safety; pharmacogenomics; medication review; pharmacokinetic modelling

(This special issue belongs to the Section Pharmacology)

Progress of Hydrogel Applications in Novel Drug Delivery Platforms

edited by

Anna Drabczyk

and

Katarzyna Bialik-Wąs

submission deadline 25 Aug 2025 | 4 articles | Viewed by 9341 | Submission Open

Keywords: hydrogels; targeted drug delivery; drug release; drug delivery; smart hydrogels; stimuli-responsive hydrogels; controlled release; hydrogel-based drug delivery; drug carriers

(This special issue belongs to the Section Pharmaceutical Technology)

Psychiatric Drug Treatment and Drug Addiction

edited by

Javier Navarro-Zaragoza

submission deadline 25 Aug 2025 | 2 articles | Viewed by 8447 | Submission Open

Keywords: drug addiction; drug abuse; psychiatric disorder; drug dependence

(This special issue belongs to the Section Pharmacology)

Drug Candidates for the Treatment of Obesity, 2nd Edition

edited by

Maria Isabel Cardoso Alonso-Vale

and

Monica Marques Telles

submission deadline 25 Aug 2025 | 3 articles | Viewed by 6434 | Submission Open

Keywords: obesity; appetite supressors; nutraceuticals; plant extracts; lipid metabolism; high-fat diet; adipogenesis

(This special issue belongs to the Section Medicinal Chemistry)

The 20th Anniversary of Pharmaceuticals—New Insights in Medicinal Chemistry of Nitrogen-Containing Compounds

edited by

María del Carmen Terán Moldes

and Pedro Besada Pereira

submission deadline 25 Aug 2025 | 2 articles | Viewed by 6072 | Submission Open

Keywords: drug design; synthesis; nitrogen heterocycles; nitrogen functional groups; biological activity; structure-activity relationship; molecular modeling

(This special issue belongs to the Section Medicinal Chemistry)

Small Molecule Drug Discovery: Driven by In-Silico Techniques

edited by

Roberta Rocca

submission deadline 25 Aug 2025 | 1 articles | Viewed by 2783 | Submission Open

Keywords: drug discovery; nutraceuticals; virtual screening; docking; molecular dynamics; pharmacophore; lead compound

(This special issue belongs to the Section Medicinal Chemistry)

Drug Treatment of Thyroid Cancer

edited by

Cristina Alina Silaghi

Carmen Emanuela Georgescu

Horaţiu Silaghi

and

Cristina Pop

submission deadline 25 Aug 2025 | 2 articles | Viewed by 2302 | Submission Open

Keywords: differentiated thyroid cancer; medullary thyroid cancer; anaplastic thyroid carcinoma; advanced/metastatic thyroid cancer; refractory thyroid cancer; targeted therapy in thyroid cancer; tyrosine kinase inhibitors; immune checkpoint inhibitors; redifferentiation treatment; drug resistance

Antimalarial Drug Candidates

edited by Djane Baia-da-Silva and Anna Caroline Campos Aguiar

submission deadline 25 Aug 2025 | 1 articles | Viewed by 1900 | Submission Open

Keywords: malaria; antimalarial drug candidates; efficacy; safety; pharmacokinetics; clinical; preclinical and translational; resistance

(This special issue belongs to the Section Medicinal Chemistry)

Recent Advancements in Radiochemistry and PET Radiotracer Development: 2nd Edition

edited by Kenneth Dahl and

Sangram Nag

submission deadline 25 Aug 2025 | 1 articles | Viewed by 1340 | Submission Open

Keywords: radiochemistry; labeling; automation; GMP; PET; radiotracer; radioligand; radiopharmaceutical; drug discovery

(This special issue belongs to the Section Radiopharmaceutical Sciences)

Natural Pharmaceutical Component Analysis

edited by

Tingting Zhou

submission deadline 25 Aug 2025 | 1 articles | Viewed by 923 | Submission Open

Keywords: natural pharmaceutical component analysis; data acquisition technologies; pretreatment methods; data processing; online activity analysis

(This special issue belongs to the Section Natural Products)

Network Pharmacology of Natural Products, 2nd Edition

edited by

Alexander George Panossian

and

Karl Wah-Keung Tsim

submission deadline 25 Aug 2025 | 2 articles | Viewed by 840 | Submission Open

Keywords: natural compounds; plant extracts; structure-activity relationship; network pharmacology; multitarget effects; synergy of complex preparations; pleiotropic activity

(This special issue belongs to the Section Natural Products)

Pharmacology and Mechanism of Action of Peptides in the Brain

edited by

Jana Tchekalarova

submission deadline 25 Aug 2025 | 1 articles | Viewed by 713 | Submission Open

Keywords: peptide derivatives; neuropeptides; receptors; brain; pain; epilepsy; depression; anxiety

(This special issue belongs to the Section Pharmacology)

Flavonoids in Medicinal Chemistry: Trends and Future Directions

edited by

Honorina Cidade

submission deadline 25 Aug 2025 | Viewed by 537 | Submission Open

Keywords: flavonoids; synthesis; natural products; medicinal chemistry; biological activity

(This special issue belongs to the Section Medicinal Chemistry)

Pharmacological Approaches of Chronic Obstructive Pulmonary Disease (COPD) and Lung Cancer

edited by

Karolina H. Czarnecka-Chrebelska

and

Jinxiang Xi

submission deadline 25 Aug 2025 | Viewed by 335 | Submission Open

Keywords: chronic obstructive pulmonary disease (COPD); inflammasomes; lung cancer (LC); chronic bronchitis; cancer prevention and treatment; therapeutic approaches

(This special issue belongs to the Section Pharmacology)

Challenges and Emerging Trends in Photopharmacology

edited by Oleksandra Tiapko and Bernadett Bacsa

submission deadline 25 Aug 2025 | Viewed by 297 | Submission Open

Keywords: photopharmacology; ion channels; receptors; protein– ligand interactions; precision medicine; optogenetics

(This special issue belongs to the Section Pharmacology)

Neuropsychiatric Disorders: Pharmacological Aspects

edited by

Ioana-Miruna Balmus

submission deadline 25 Aug 2025 | Viewed by 296 | Submission Open

Keywords: neuropsychiatric disorders; DSM-V; pharmacodynamics; innovative therapies; animal models; neuropsychiatric patients; trauma and stress; neurodegeneration; affective disorders; neurodevelopmental disorders; schizophrenia; sleep disorders; comorbidities; cardiovascular; coagulopathies; gastrointestinal; microbiome– gut– brain axis

(This special issue belongs to the Section Pharmacology)

Application of Biosensors in Pharmaceutical Research

edited by

Vasileios Tsekouras

and

Sofia Mavrikou

submission deadline 25 Aug 2025 | Viewed by 285 | Submission Open

Keywords: biosensors; diagnostics; high-throughput screening of pharmaceuticals; pharmaceutical analysis; point-of-care systems; drug discovery; drug analysis

(This special issue belongs to the Section Pharmaceutical Technology)

Application of Neuroimaging Biomarkers in the Diagnosis and Treatment of Mental Diseases, 2nd Edition

edited by Deborah A. Yurgelun-Todd, Douglas Kondo, Nicolas A Nunez, Perry Franklin Renshaw and Dost Öngür

submission deadline 25 Aug 2025 | Viewed by 181 | Submission Open

Keywords: neuroimaging; biomarkers; 1H-MRS; 31P-MRS; brain spectroscopy; mood disorders

(This special issue belongs to the Section Pharmaceutical Technology)

Application of MRI in Drug Metabolism and Pharmacokinetics

edited by

Do-Wan Lee

and

Donghoon Lee

submission deadline 25 Aug 2025 | Viewed by 177 | Submission Open

Keywords: MRI; drug metabolism; pharmacokinetics; chemical exchange saturation transfer (CEST); magnetic resonance spectroscopy (MRS); advanced imaging techniques; molecular imaging; preclinical imaging; quantitative imaging biomarkers; ADME (absorption; distribution; metabolism; excretion)

(This special issue belongs to the Section Pharmacology)

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