Special Issues

Pharmaceuticals publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Development of Antibacterial Drugs to Combat Drug-Resistant Bacteria: 2nd Edition
edited by and Iryna Voronkina
submission deadline 25 Jul 2026 | 2 articles | Viewed by 2499 | Submission Open
Keywords: development of antibacterial drugs; drug-resistant bacteria; antimicrobial resistance; new therapeutic solutions; improvement of existing therapies; nosocomial infections
(This special issue belongs to the Section Pharmacology)
Network Pharmacology of Natural Products, 3rd Edition submission deadline 25 Jul 2026 | 2 articles | Viewed by 1960 | Submission Open
Keywords: natural compounds; plant extracts; structure-activity relationship; network pharmacology; multitarget effects; synergy of complex preparations; pleiotropic activity
(This special issue belongs to the Section Natural Products)
Research Progress and Drug Intervention Strategies for Oral Health-Related Diseases
edited by and Mariana Pacurar
submission deadline 25 Jul 2026 | 1 articles | Viewed by 1706 | Submission Open
Keywords: oral health; dental caries; periodontal diseases; drug intervention; biomaterials; biomarkers; microbiome; pharmacogenomics; targeted therapy; oral drug delivery; oral disease prevention
(This special issue belongs to the Section Pharmacology)
Pharmacotherapy of Inflammatory Bowel Disease, 2nd Edition
edited by
submission deadline 25 Jul 2026 | 1 articles | Viewed by 1245 | Submission Open
Keywords: treatment of Crohn's Disease; treatment of ulcerative colitis; mesalamine for ulcerative colitis; mesalamine for Crohn's Disease; antibody strategies in IBD; small molecules for IBD; conservative management of Crohn's fistula; therapy for extraintestinal manifestations; new endpoints for treatment
(This special issue belongs to the Section Pharmacology)
Drug Target Exploration and Drug Design & Development Based on Small Molecule: 2nd Edition submission deadline 25 Jul 2026 | 1 articles | Viewed by 1173 | Submission Open
Keywords: small molecules; drug design and development; target exploration; anticancer drugs; anti-inflammatory drugs; neuromodulation; natural compounds; nutraceuticals; virtual screenings
(This special issue belongs to the Section Pharmacology)
Design, Synthesis and Evaluation of Novel 18F Radiotracers
edited by and John E. Shively
submission deadline 25 Jul 2026 | Viewed by 368 | Submission Open
Keywords: positron emission tomography (PET); fluorine-18 (F-18); radiotracer development; molecular imaging; non-invasive diagnostic technique; synthetic methodologies; preclinical evaluation
(This special issue belongs to the Section Radiopharmaceutical Sciences)
Therapeutic Drug Monitoring and Adverse Drug Reactions: 3rd Edition
edited by Engi Abd El Hady Algharably and
submission deadline 25 Jul 2026 | Viewed by 290 | Submission Open
Keywords: therapeutic drug monitoring; adverse drug reactions; pharmacokinetics; personalized medicine; medication safety; pharmacogenomics; medication review; pharmacokinetic modeling
(This special issue belongs to the Section Pharmacology)
Therapeutic Strategies for Co-Occurring Psychiatric and Substance Use Disorders
edited by Clara Cavallotto and
submission deadline 25 Jul 2026 | Viewed by 263 | Submission Open
Keywords: dual diagnosis; substance use disorder; schizophrenia spectrum disorder; antipsychotic; pharmacological treatment
(This special issue belongs to the Section Pharmacology)
Therapeutic Potential of Cannabinoids and Their Receptors: 2nd Edition
edited by Kruk-Słomka Marta
submission deadline 25 Jul 2026 | Viewed by 221 | Submission Open
Keywords: endocannabinoid system; cannabinoid receptor ligands; medical marihuana; cannabinoid-based therapies
(This special issue belongs to the Section Pharmacology)
Development of Biomaterials for Targeted and Localized Cancer Drug Release
edited by Precious O. Etinosa and
submission deadline 25 Jul 2026 | Viewed by 214 | Submission Open
Keywords: targeted delivery; localized drug release; controlled release kinetics; cancer biomaterials; injectable hydrogels; implantable depots; nanoparticles/microparticles; tumor microenvironment
(This special issue belongs to the Section Pharmaceutical Technology)
Pharmaceutical Applications of Metal Nanoparticles
edited by Andrew Knight
submission deadline 25 Jul 2026 | Viewed by 195 | Submission Open
Keywords: metal nanoparticles; nanomedicine; target drug delivery; theranostics; biocompatability and toxicity
(This special issue belongs to the Section Pharmaceutical Technology)
Novel Drug Targets and Drug Candidates for Neglected Tropical Diseases
edited by Juliana Mesquita and
submission deadline 27 Jul 2026 | 5 articles | Viewed by 6572 | Submission Open
Keywords: neglected tropical diseases; leishmaniasis; chagas disease
(This special issue belongs to the Section Medicinal Chemistry)
Advances in Drug Analysis and Drug Development, 2nd Edition
edited by and Ana Mornar
submission deadline 27 Jul 2026 | 5 articles | Viewed by 6557 | Submission Open
Keywords: analytical methodology; chromatographic techniques; spectrometric techniques; thermal analysis techniques; sample preparation; drug stability; compatibility study; bioavailability studies; therapeutic drug monitoring; quality by design in pharmaceutical analysis
(This special issue belongs to the Section Pharmaceutical Technology)
Animal-Derived Venom Compounds for Cancer Prevention and Intervention submission deadline 27 Jul 2026 | 1 articles | Viewed by 1547 | Submission Open
Keywords: animal-derived venom anticancer agents; cancer prevention and intervention; functional venom products in oncology; natural product oncology; toxin-derived drugs; bioactive peptides in cancer; venom-based therapeutics
(This special issue belongs to the Section Natural Products)
Aging-Related Musculoskeletal Disorders: Therapeutic Targets and Pharmacological Strategies
edited by , Sunny S.K. Chan and Cindy Thomas-Charles
submission deadline 27 Jul 2026 | Viewed by 223 | Submission Open
Keywords: aging; musculoskeletal disorders; sarcopenia; osteoporosis; osteoarthritis; inflammation; oxidative stress; therapeutic targets; pharmacological interventions
(This special issue belongs to the Section Pharmacology)
Plant Extracts with Biological Activity and Potential Antioxidant Action
edited by Claudia-Crina Toma, , , and Cerasela Elena Gîrd
submission deadline 30 Jul 2026 | 6 articles | Viewed by 5380 | Submission Open
Keywords: phenolic compounds; flavonoids; vegetal growth factors; oxidative stress; plant primary metabolites; plant secondary metabolites; nutraceuticals
(This special issue belongs to the Section Natural Products)
Pharmacological Activities and Therapeutic Potential of Novel Drug Derivatives submission deadline 31 Jul 2026 | 2 articles | Viewed by 12095 | Submission Open
Keywords: novel drug derivatives; synthesis; drug design; therapeutic potential; biological activity; pharmacological activity
(This special issue belongs to the Section Pharmacology)
Pharmacology and Toxicology of Opioids, 2nd Edition
edited by , Joana Barbosa and
submission deadline 31 Jul 2026 | 6 articles | Viewed by 9834 | Submission Open
Keywords: opioid toxicity; opioid pharmacodynamics; opioid pharmacokinetics; opioid pharmacogenetics; prescription opioids; toxicity assays; in vivo; in vitro; abuse; dependence
(This special issue belongs to the Section Pharmacology)
Hybrid and Chimeric Heterocycles: A Promising Approach to Synthesizing Biologically Active Compounds
edited by
submission deadline 31 Jul 2026 | 6 articles | Viewed by 8860 | Submission Open
Keywords: hybrid heterocyclic compounds; chimeric heterocyclic compounds; multifactorial diseases; multiple targeting drugs; biological activity: antimicrobials; antiviral; anthelmintic; anti-HIV; anticancer; antiallergic; diuretics; cardiotonic; antihypertensive; antiplatelet; analgesic; anxiolytics; antidepressant; hypnotic sedative; antineurodegenerative; anti-Alzheimer’ s etc.
(This special issue belongs to the Section Medicinal Chemistry)
Therapeutic Drug Monitoring: Techniques and Applications in Pharmaceutical Analysis
edited by Ivana Cizmarova and
submission deadline 31 Jul 2026 | 7 articles | Viewed by 6472 | Submission Open
Keywords: Therapeutic Drug Monitoring (TDM); bioanalytical method development; LC-MS/MS; sample preparation; method validation; pharmacokinetics; pharmacodynamics; individualized dosing; precision medicine; clinical applications
Application of Computer Simulation in Drug Design submission deadline 31 Jul 2026 | 4 articles | Viewed by 5876 | Submission Open
Keywords: in silico; drug design; drug discovery; molecular docking; molecular dynamics simulations; structure-based; ligand-based; virtual screening; drug repurposing
(This special issue belongs to the Section Medicinal Chemistry)
The Regulatory Roles of the Gut Microbiota in Multisystem Diseases submission deadline 31 Jul 2026 | 3 articles | Viewed by 5322 | Submission Open
Keywords: microbiota; multisystem diseases; bacteriophage therapy; metabolic disorders; precision medicine
(This special issue belongs to the Section Pharmacology)
Advances in Hydrazone Compounds with Anticancer Activity submission deadline 31 Jul 2026 | 2 articles | Viewed by 4373 | Submission Open
Keywords: hydrazones; lipophilicity; logP; anticancer activity; selectivity
(This special issue belongs to the Section Medicinal Chemistry)
Recent Advances in Medicinal Plants and Plant-Derived Compounds: Neuroprotective, Anti-Inflammatory, Antioxidant, Anticancer, and Antimicrobial Applications
edited by Isabel Martínez Solís, and
submission deadline 31 Jul 2026 | 1 articles | Viewed by 4047 | Submission Open
Keywords: medicinal plants; bioactive compounds; neuroprotection; antioxidant activity; anti-inflammatory effects; anti-tumour properties; antimicrobial agents; phytotherapy; natural product-based therapeutics
(This special issue belongs to the Section Natural Products)
Heterocyclic Compounds in Targeted Cancer Therapy: Advances in Medicinal Chemistry and Drug Development submission deadline 31 Jul 2026 | 2 articles | Viewed by 3604 | Submission Open
Keywords: heterocyclic compounds; targeted cancer therapy; medicinal chemistry; structure– activity relationship (SAR); computational drug design; small-molecule therapeutics; synthetic methodologies; bioactive heterocycles; green chemistry in drug discovery; in silico screening
(This special issue belongs to the Section Medicinal Chemistry)
New Advances and Treatment in Thrombosis and Endothelial Injury Syndromes submission deadline 31 Jul 2026 | 2 articles | Viewed by 2087 | Submission Open
Keywords: antiphospholipid syndrome; autoimmune rheumatic diseases; cardiovascular disease; endothelial dysfunction; hematopoietic cell transplantation; thromboinflammation; thrombosis; thrombotic microangiopathies; venous thromboembolism
(This special issue belongs to the Section Pharmacology)
The Nuclear Factor Kappa-B (NF-κB) Pathway as a Target for Drug Discovery
edited by Guozhou Xu
submission deadline 31 Jul 2026 | 1 articles | Viewed by 1633 | Submission Open
Keywords: NF-kappaB; TNFR; TLR; IL1R; receptor adaptor proteins; IRAK; c-IAP; AKT IKK; ubiquitin– proteasome system; inflammatory response
(This special issue belongs to the Section Medicinal Chemistry)
Advances in Targeted Therapy for Gastrointestinal Cancers submission deadline 31 Jul 2026 | 2 articles | Viewed by 1459 | Submission Open
Keywords: targeted therapy; gastrointestinal cancers; molecular targets; drug resistance; biomarkers; immunotherapy; precision medicine; translational research; clinical trials; tumor microenvironment
(This special issue belongs to the Section Pharmacology)
Advanced Nanocarriers for Intranasal Drug Delivery to the Central Nervous System
edited by
submission deadline 31 Jul 2026 | 1 articles | Viewed by 1233 | Submission Open
Keywords: intranasal drug delivery; nano-formulations; brain targeting; central nervous system disorders; neurological diseases; nanomedicine
(This special issue belongs to the Section Pharmaceutical Technology)
Immunomodulatory Drugs for Autoimmune Diseases: Mechanisms, Development and Clinical Translation
edited by Patricia Fanlo-Mateo
submission deadline 31 Jul 2026 | 1 articles | Viewed by 1126 | Submission Open
Keywords: autoimmune diseases; immunomodulatory drugs; biologic therapies; immunosupressants; immunotherapy; drug repurposing
(This special issue belongs to the Section Medicinal Chemistry)
Pharmaceutical Blood Products
edited by , Masaki Otagiri and
submission deadline 31 Jul 2026 | 1 articles | Viewed by 839 | Submission Open
Keywords: pharmaceutical blood products; plasma-derived therapeutics; recombinant blood factors; cellular therapies; immunoglobulins; fractionation technologies; viral inactivation; hemophilia treatments; gene-editing approaches; clinical efficacy
(This special issue belongs to the Section Biopharmaceuticals)
Peptide Synthesis and Drug Development: Exploring Progress and Potential, 2nd Edition
edited by and Vera D'Aloisio
submission deadline 31 Jul 2026 | 1 articles | Viewed by 576 | Submission Open
Keywords: peptides; enzymatic degradation; drug discovery; formulation; druggability
(This special issue belongs to the Section Biopharmaceuticals)
Supersaturated Formulations in Drug Development: From Solubility Investigations to the Advancement of In Vitro–In Vivo Predictability
edited by Réka Angi, , Anna Vincze, and
submission deadline 31 Jul 2026 | Viewed by 316 | Submission Open
Keywords: supersaturation; solubility assessment; dissolution mechanisms; advanced formulations; amorphous solid dispersion; nanoprecipitation; in vitro– in vivo prediction; absorption modelling; phase transitions
(This special issue belongs to the Section Pharmaceutical Technology)
Treating Cognitive Deficits in Neuropsychiatric and Neurodegenerative Disorders: Mechanisms, Targets, and Translational Advances
edited by Kinga Sałaciak and Klaudia Lustyk
submission deadline 31 Jul 2026 | Viewed by 313 | Submission Open
Keywords: cognitive enhancement; cognitive impairment; molecular targets; neuropharmacology; neural plasticity; translational research; memory; executive function
(This special issue belongs to the Section Pharmacology)
Advanced Three-Dimensional In Vitro Models for Disease Biology and Pharmaceutical Development submission deadline 31 Jul 2026 | Viewed by 260 | Submission Open
Keywords: 3D in vitro culture systems; extracellular matrix modeling; tumor microenvironment; cell– cell and cell– matrix interactions; invasiveness assays; biophysical characterization of cells; plant-based therapeutic agents
(This special issue belongs to the Section Medicinal Chemistry)
Discovery and Evaluation of Essential Oils with Pharmaceutical Potentials submission deadline 31 Jul 2026 | Viewed by 234 | Submission Open
Keywords: natural products; spectroscopic methods; spectrometric methods; bioprospection; structural characterization; secondary metabolism; volatile compounds
(This special issue belongs to the Section Natural Products)
Advances in GPCR Drug Discovery
edited by
submission deadline 31 Jul 2026 | Viewed by 218 | Submission Open
Keywords: GPCR; agonists; antagonists; biased ligands; allosteric sites; drug discovery; pharmacological tools; diagnostic tools; theranostics; biodistribution
(This special issue belongs to the Section Biopharmaceuticals)
Computational and Experimental Strategies for Antiparasitic Drug Discovery submission deadline 31 Jul 2026 | Viewed by 201 | Submission Open
Keywords: molecular modeling; virtual screening; machine learning; AlphaFold; 3D culture; chemogenomics; high-throughput screening; drug repurposing
(This special issue belongs to the Section Medicinal Chemistry)
Interdisciplinary Approaches to Preventing and Treating Inflammatory and Oxidative Diseases with Medicinal Plants and Bioactive Compounds submission deadline 10 Aug 2026 | 4 articles | Viewed by 10884 | Submission Open
Keywords: interdisciplinary studies; inflammation; inflammatory diseases; oxidative stress; oxidative diseases; pro-inflammatory; pro-oxidative; neurodegenerative diseases; cardiovascular diseases; cancer; medicine; rheumatological diseases; endocrinological diseases; gastroenterological diseases; dermatological diseases; pulmonary diseases; dentistry; nutrition; dietetics; therapy; medicinal plants; bioactive compounds; phytochemicals; phytochemistry
(This special issue belongs to the Section Natural Products)
Population Pharmacokinetics and Pharmacogenetics, 2nd Edition
edited by
submission deadline 10 Aug 2026 | Viewed by 252 | Submission Open
Keywords: pharmacokinetics; pharmacogenetics; precision medicine; population pharmacometrics model; mathematical modeling; dosage regimen; inter-subject variability
(This special issue belongs to the Section Pharmacology)
Recent Strategies for Delivery of Plant-Based Active Ingredients submission deadline 14 Aug 2026 | 2 articles | Viewed by 3936 | Submission Open
Keywords: drug delivery; polymeric nanoparticles; lipid nanosystems; inclusion complexes; polymeric cyclodextrins; protein carriers; inorganic delivery systems; nanostructured carriers; chemical– physical characterization; in vitro/ex vivo/in vivo evaluation
(This special issue belongs to the Section Pharmaceutical Technology)
Nanoparticle-Enabled Combination Therapy in Preclinical Development submission deadline 14 Aug 2026 | Viewed by 232 | Submission Open
Keywords: drug delivery systems; nanoparticles; nanomedicine; drug combinations; drug co-delivery; preclinical; translational drug development
(This special issue belongs to the Section Pharmaceutical Technology)
Application of Zebrafish Model in Pharmacology and Toxicology submission deadline 15 Aug 2026 | 5 articles | Viewed by 6540 | Submission Open
Keywords: chemical safety assessment; translational research; drug screening; human exposome; environmental contaminants
(This special issue belongs to the Section Pharmacology)
Enzyme Inhibitors: Potential Therapeutic Approaches, 2nd Edition submission deadline 15 Aug 2026 | 1 articles | Viewed by 1608 | Submission Open
Keywords: enzymes; inhibitors; competitive; uncompetitive; non-competitive; drug target; pharmaceutical approach; disease treatment
(This special issue belongs to the Section Medicinal Chemistry)
Advances in the Mechanism of Action and the Therapeutic Role of Phytopharmaceuticals
edited by Maria-Eleni Grafakou and
submission deadline 20 Aug 2026 | 5 articles | Viewed by 19958 | Submission Open
Keywords: medicinal plants; natural products; phytochemistry; biological activities; mechanism of action; biotransformation; microbiome
(This special issue belongs to the Section Natural Products)
Resveratrol: Pharmacological Mechanisms and Therapeutic Potential as a Natural Product submission deadline 20 Aug 2026 | 1 articles | Viewed by 2216 | Submission Open
Keywords: resveratrol; natural compound pharmacology; therapeutic potential; drug development; biomedical research
(This special issue belongs to the Section Natural Products)
Therapeutic Applications of Histone Deacetylase (HDAC) Inhibitors
edited by Chao-Wu Yu and Liqiang Chen
submission deadline 20 Aug 2026 | Viewed by 454 | Submission Open
Keywords: HDAC inhibitors; organ fibrosis; rare disease; neurodegenerative disease; antibiotics; anti-cancer
(This special issue belongs to the Section Medicinal Chemistry)
Challenges in the Development of PET and SPECT Radiotracers: Innovative Ideas with Negative Outcomes
edited by Magali Toussaint and Barbara Wenzel
submission deadline 25 Aug 2026 | 8 articles | Viewed by 12278 | Submission Open
Keywords: radiotracer development; positron emission tomography (PET); single-photon emission computed tomography (SPECT); negative results; diagnostic radiotracers; therapeutic radiopharmaceuticals; radiolabeling; automated synthesis and GMP; pre-clinical studies; medicinal chemistry
(This special issue belongs to the Section Radiopharmaceutical Sciences)
Chemotherapeutic and Targeted Drugs in Antitumor Therapy submission deadline 25 Aug 2026 | 2 articles | Viewed by 4013 | Submission Open
Keywords: cancer; drug discovery; small-molecule drugs; targeted therapy; combination therapy; synergism; selectivity; immunotherapy; precision medicine
(This special issue belongs to the Section Pharmacology)
Innovative Approaches to GABAergic Drug Discovery: From Molecular Mechanisms to Advanced Therapeutics submission deadline 25 Aug 2026 | 2 articles | Viewed by 3068 | Submission Open
Keywords: GABAergic signaling; GABA receptors; drug discovery; neurological and psychiatric disorders; ligand design; computational drug development; artificial intelligence in pharmacology; high-throughput screening; targeted drug delivery; controlled release systems
(This special issue belongs to the Section Pharmacology)
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