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Pharmaceuticals publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Combating Drug Resistance in Cancer

edited by

Nina Rembiałkowska

and

Wojciech Szlasa

submission deadline 25 Sep 2025 | 1 articles | Viewed by 477 | Submission Open

Keywords: multidrug resistance; cancer cells; cancer drug resistance; overcoming chemoresistance; targeted cancer therapies; novel anti-cancer strategies; tumor resistance mechanisms; innovative cancer treatments; reversing drug resistance

(This special issue belongs to the Section Medicinal Chemistry)

Computer-Aided Drug Design and Drug Discovery, 2nd Edition

edited by

Dragos Mihai

and

George Mihai Nitulescu

submission deadline 25 Sep 2025 | Viewed by 245 | Submission Open

Keywords: chemoinformatics; bioinformatics; molecular modeling; virtual screening; molecular docking; quantitative structure– activity relationship (QSAR); pharmacophore modeling; target identification; repurposing; ADME-T prediction

(This special issue belongs to the Section Medicinal Chemistry)

Application of Supercritical Fluids in Pharmaceutical Science

edited by

Cecília I. A. V. Santos

submission deadline 25 Sep 2025 | Viewed by 221 | Submission Open

Keywords: supercritical fluids; scCO2; drug formulation; bioavailability; green chemistry; drug delivery systems; nanoparticle encapsulation; bioactive compound extraction; pharmaceutical purification; controlled release; sustainable pharmaceutical processes

(This special issue belongs to the Section Pharmaceutical Technology)

Recent Research in Therapeutic Potentials of Venoms

edited by Samuel Teixeira, Daiana Silva Lopes and

Sarah Natalie Cirilo Gimenes

submission deadline 25 Sep 2025 | Viewed by 174 | Submission Open

Keywords: bioprospecting; biotechnological tools; snake venom toxins; drug discovery; natural products; pharmacological applications; molecular targets of venom toxins; toxicology; peptide therapeutics; venom-based drug delivery

(This special issue belongs to the Section Natural Products)

Advances in Drug Analysis and Drug Development, 2nd Edition

edited by

Daniela Amidžić Klarić

and Ana Mornar

submission deadline 25 Sep 2025 | Viewed by 118 | Submission Open

Keywords: analytical methodology; chromatographic techniques; spectrometric techniques; thermal analysis techniques; sample preparation; drug stability; compatibility study; bioavailability studies; therapeutic drug monitoring; quality by design in pharmaceutical analysis

(This special issue belongs to the Section Pharmaceutical Technology)

Design, Synthesis and Evaluation of Novel 18F Radiotracers

edited by

Junfeng Li

and John E. Shively

submission deadline 25 Sep 2025 | Viewed by 99 | Submission Open

Keywords: positron emission tomography (PET); fluorine-18 (F-18); radiotracer development; molecular imaging; non-invasive diagnostic technique; synthetic methodologies; preclinical evaluation

(This special issue belongs to the Section Radiopharmaceutical Sciences)

Innovative Drug Strategies in Chronic Disease Management: Addressing Non-Adherence and Improving Therapeutic Outcomes

edited by

Eduardo Gutiérrez-Abejón

and

F. Javier Alvarez

submission deadline 26 Sep 2025 | 1 articles | Viewed by 826 | Submission Open

Keywords: adherence; persistence; chronic diseases; therapeutic strategies; individualized therapy; personalized medicine; clinical pharmacology; clinical trials; observational studies; real-world data studies

(This special issue belongs to the Section Pharmacology)

Innovative Drug Delivery Systems for Enhanced Dissolution and Bioavailability

edited by Marival Bermejo,

Paloma Marina De la Torre-Iglesias

and Covadonga Álvarez-Álvarez

submission deadline 26 Sep 2025 | Viewed by 184 | Submission Open

Keywords: drug dissolution enhancement; oral bioavailability improvement; poorly soluble drugs; solid dispersions; nanoparticle drug delivery; amorphous formulations; 3D printing in pharmaceuticals; advanced drug-polymer systems; advanced excipients for solubility enhancement; controlled drug release

(This special issue belongs to the Section Pharmaceutical Technology)

Computational Predictions of Molecules with Potential Therapeutic Effects

edited by

Whelton Miller

submission deadline 30 Sep 2025 | 6 articles | Viewed by 9415 | Submission Open

Keywords: biophysics; medicinal chemistry; drug discovery; molecular docking; molecular dynamics; structure-activity relationships; computer-aided drug design (CADD)

(This special issue belongs to the Section Medicinal Chemistry)

Recent Advances in Drug Metabolism, Transport, and Pharmacokinetics

edited by Agnieszka Bienert and

Joanna Bartkowiak-Wieczorek

submission deadline 30 Sep 2025 | 2 articles | Viewed by 5140 | Submission Open

Keywords: pharmacokinetic analysis; analytical methods suitable for pharmacokinetics studies; pharmacogenetics in drug pharmacokinetics; clinical pharmacokinetics; drug concentrations in plasma and tissue; population PK modeling; drug metabolic pathways; drug transport across barriers

(This special issue belongs to the Section Pharmacology)

Advances in Ophthalmic Drug Discovery and Delivery: From Targets to Treatments

edited by

Hongli Wu

submission deadline 30 Sep 2025 | 3 articles | Viewed by 1982 | Submission Open

Keywords: retinal degeneration; glaucoma; cataract; diabetic retinopathy; drug target; drug delivery; drug candidate; gene therapy; stem cells; natural products; Artificial Intelligence

(This special issue belongs to the Section Pharmacology)

Advances in Pharmacotherapy for Nasal Disorders in Rhinology

edited by

Elena Cantone

submission deadline 30 Sep 2025 | 1 articles | Viewed by 1607 | Submission Open

Keywords: rhinology; CRS; asthma; nasal polyps; biologics; airflow; children; QoL; artificial intelligence; olfaction; chemical senses

(This special issue belongs to the Section Pharmacology)

Innovative Analytical Techniques and Nanotechnology in Natural Products Analysis and Drug Development

edited by Jinchao Wei and

Di Chen

submission deadline 30 Sep 2025 | Viewed by 374 | Submission Open

Keywords: natural product; Chinese medicine; drug development; analytical technique; nanotechnology; spectrometry; chromatography; sensors; formulation

(This special issue belongs to the Section Natural Products)

Effects of Drug Abuse and Its Consequences on Health

edited by

Diana Dias Da Silva

and

Marcelo Dutra Arbo

submission deadline 30 Sep 2025 | Viewed by 227 | Submission Open

Keywords: psychoactive substances; drug abuse; toxicological effects; neurotoxicity; substance use disorder; biomarkers of toxicity; public health impact; addiction mechanisms; harm reduction strategies; novel psychoactive substance (NPS)

(This special issue belongs to the Section Medicinal Chemistry)

Advancements and Possibilities for the Treatment of Idiopathic Inflammatory Myopathies

edited by

Jucier Gonçalves Júnior

and Samuel Katsuyuki Shinjo

submission deadline 30 Sep 2025 | Viewed by 162 | Submission Open

Keywords: anti-synthetase syndrome; dermatomyositis; polymyositis; inflammatory myopathy; myositis; treatment

(This special issue belongs to the Section Pharmacology)

Advances in Small-Molecule Therapeutics Targeting Signaling Pathways

edited by

Arianna Gelain

submission deadline 30 Sep 2025 | Viewed by 137 | Submission Open

Keywords: small molecules; natural compounds; synthetic compounds; signaling pathways; drug design; drug development; HTS; computational tools; biological evaluations; QSAR; bioavailability; pharmacokinetics

(This special issue belongs to the Section Medicinal Chemistry)

Advancements in Cardiometabolic Pharmacology Research

edited by

Gustavo Rodrigues Pedrino

submission deadline 30 Sep 2025 | Viewed by 64 | Submission Open

Keywords: cardiometabolic diseases; pharmacological interventions; drug discovery and development; preclinical models in cardiometabolic research; molecular mechanisms of cardioprotection; bioactive natural compounds; gut microbiome and metabolism; inflammation and oxidative stress in cardiometabolic disease; translational pharmacology

(This special issue belongs to the Section Pharmacology)

Pharmacotherapy for Alzheimer’s Disease

edited by

Gabriela Dumitrița Stanciu

submission deadline 5 Oct 2025 | 5 articles | Viewed by 5708 | Submission Open

Keywords: Alzheimer’ s disease; pharmacotherapy; therapeutic editing tools; repurposing existing therapeutics; multi-target-directed ligands; preclinical studies; neurodegeneration; drug development; neuroprotection; cannabinoid-based pharmaceuticals; single-molecule drugs or whole-plant extracts of Cannabis sativa L.

(This special issue belongs to the Section Pharmacology)

Melatonin Applications in Pharmaceutical Science

edited by

Javier Menéndez-Menéndez

submission deadline 5 Oct 2025 | Viewed by 122 | Submission Open

Keywords: melatonin; pineal gland; epigenetics; pharmacology; physiology; immunology; pharmaceutics; novel therapies; cancer

(This special issue belongs to the Section Pharmacology)

The Discovery and Development of Drug Ingredients from Food Sources

edited by

Justyna Żwawiak

and Dorota Olender

submission deadline 10 Oct 2025 | 2 articles | Viewed by 1298 | Submission Open

Keywords: natural compounds; food; antioxidants; biological activity of natural substances; the influence of food on health

(This special issue belongs to the Section Natural Products)

Affective Disorders Psychopharmacology

edited by Danilo Arnone

submission deadline 15 Oct 2025 | 2 articles | Viewed by 7522 | Submission Open

Keywords: psychopharmacology; affective disorders; mood disorders; major depressive disorders; bipolar affective disorders

(This special issue belongs to the Section Pharmacology)

Pharmacological Activity and Application of Polyphenolic Compounds

edited by

Luís Silva

submission deadline 15 Oct 2025 | Viewed by 872 | Submission Open

Keywords: phenolic compounds; biological potential; pharmacological activity; phenolic applications; health promoters; chronic diseases

(This special issue belongs to the Section Natural Products)

Recent Advances in Overcoming Therapy Resistance in Cancer

edited by

Manoj K. Pandey

submission deadline 15 Oct 2025 | Viewed by 116 | Submission Open

Keywords: cancer therapy resistance; hematological malignancies; solid tumors; targeted therapies; tumor microenvironment; drug resistance mechanisms; epigenetic factors; translational oncology; novel therapeutic strategies; biomarkers of resistance

The Modes of Action of Herbal Medicines and Natural Products, 2nd Edition

edited by Hongnan Cao

submission deadline 15 Oct 2025 | Viewed by 112 | Submission Open

Keywords: herbal compounds; natural products; pharmacokinetics and pharmacodynamics of natural products; herbal medicines; herbal therapies

(This special issue belongs to the Section Natural Products)

Applications of Beehive Products for Wound Repair and Skin Care

edited by Simona Martinotti

submission deadline 20 Oct 2025 | 3 articles | Viewed by 7549 | Submission Open

Keywords: anti-aging; antibacterial properties; healing properties; honey; propolis; bee venom; wound repair; skin care

(This special issue belongs to the Section Natural Products)

Sirtuins as Novel Biological Targets for Pharmacological Intervention in Physiology and Pathology—2nd Edition

edited by

Michele Aventaggiato

and

Marco Tafani

submission deadline 20 Oct 2025 | 1 articles | Viewed by 447 | Submission Open

Keywords: sirtuins; metabolism; cancer; hypoxia; damage recovery; cell death

(This special issue belongs to the Section Pharmacology)

Adjuvant Therapies for Cancer Treatment: 2nd Edition

edited by

Fuyi Wang

submission deadline 22 Oct 2025 | 4 articles | Viewed by 2914 | Submission Open

Keywords: drug repurposing; combined therapies; new compounds; drug resistance; chemosensitization; antitumoral strategies

(This special issue belongs to the Section Pharmacology)

Structural Insights into Protein Kinases-Targeted Therapies: Overcoming Resistance and Advancing Precision Oncology

edited by David Hecht

submission deadline 22 Oct 2025 | Viewed by 210 | Submission Open

Keywords: protein kinases inhibitor resistance; structural biology of of protein kinases; computational modeling; drug design; preclinical and clinical studies; precision oncology; ALK resistance for personalized medicine

(This special issue belongs to the Section Medicinal Chemistry)

Pharmaceutical Modeling and Real-World Data: Advancing Prescribing and Monitoring

edited by

Andreas Daniel Meid

submission deadline 22 Oct 2025 | Viewed by 149 | Submission Open

Keywords: adverse drug reaction; generalizability and transportability; machine learning; pharmacodynamics; pharmaceutical monitoring; pharmacokinetics; quantitative systems in pharmacology; real-world data; real-world evidence; therapeutic drug monitoring

(This special issue belongs to the Section Pharmacology)

Use of Encapsulating Polymers of Active Compounds in the Pharmaceutical Industry

edited by Alba Adriana Vallejo-Cardona, Inocencio Higuera-Ciapara and

Janna Douda

submission deadline 24 Oct 2025 | 1 articles | Viewed by 1416 | Submission Open

Keywords: polymer; drug delivery; active compounds; encapsulation; pharmaceutical industry; natural polymers; synthetic polymers

(This special issue belongs to the Section Pharmaceutical Technology)

New and Emerging Treatment Strategies for Gastrointestinal Diseases

edited by

Daniele Maria-Ferreira

submission deadline 25 Oct 2025 | 7 articles | Viewed by 23963 | Submission Open

Keywords: gastrointestinal diseases; gastrointestinal homeostasis; gastrointestinal injuries; gastrointestinal disturbances; dysbiosis; bile acid; inflammatory bowel diseases; diarrhea

(This special issue belongs to the Section Pharmacology)

Pharmacological Therapies for Stress-Related Disorders and Autism Spectrum Disorder

edited by

Anita Kovács

and

Attila Tóth

submission deadline 25 Oct 2025 | 4 articles | Viewed by 18353 | Submission Open

Keywords: new targets and therapies for stress-related disorders; molecular mechanism of drugs; ASD; PTSD; MDD; antidepressant; depression; animal model for depression; ASD; microbiome; gut-brain axis; brain electrophysiology; neuron activity in ASD

(This special issue belongs to the Section Pharmacology)

Pharmacotherapy of Thromboembolism

edited by

Matej Samoš

Tomáš Bolek

and

Marián Mokáň

submission deadline 25 Oct 2025 | 5 articles | Viewed by 13678 | Submission Open

Keywords: activated factor XI inhibitors; platelet glycoprotein VI antagonists; PAR4 antagonists; PI3K inhibitorslong-term anticoagulation; antiplatelet therapy; novel antithrombotic drugs; anticoagulation-related bleeding; post-vascular procedure-related thrombosis

(This special issue belongs to the Section Pharmacology)

Tumor Therapy and Drug Delivery

edited by

Rositsa Mihaylova

submission deadline 25 Oct 2025 | 6 articles | Viewed by 10621 | Submission Open

Keywords: antitumor therapy; drug delivery systems; nanocarriers; immunoconjugates; nanotechnology; cancer selectivity

(This special issue belongs to the Section Pharmaceutical Technology)

Exploring the Anticancer and Immunomodulatory Mechanisms of Phytochemicals and Natural Bioactive Compounds

edited by Suyun Lyu

submission deadline 25 Oct 2025 | 7 articles | Viewed by 8457 | Submission Open

Keywords: natural products; phytochemicals; anticancer; immunomodulation; bioactive compounds

(This special issue belongs to the Section Pharmacology)

Pharmacology of Antidepressants: Recent Advances

edited by

Anna Wiktorowska-Owczarek

submission deadline 25 Oct 2025 | 3 articles | Viewed by 4375 | Submission Open

Keywords: new mechanisms of antidepressants action; new targets for antidepressant therapy; rapid-acting antidepressants; inflammation in depression; gut– microbiota– brain axis in depression; probiotic as an antidepressant; quo vadis pharmacology of antidepressants

(This special issue belongs to the Section Pharmacology)

Therapeutic Methods Against Acute and Chronic Diseases and Oxidative Stress

edited by

Yanka Karamalakova

submission deadline 25 Oct 2025 | 3 articles | Viewed by 4278 | Submission Open

Keywords: natural antioxidant; synthetic agents; acute diseases; chronic diseases; oxidative stress

(This special issue belongs to the Section Medicinal Chemistry)

Sulfur-Containing Scaffolds in Medicinal Chemistry

edited by

David Rodrigues da Rocha

and

Fernando de Carvalho da Silva

submission deadline 25 Oct 2025 | 2 articles | Viewed by 3593 | Submission Open

Keywords: sulfur; medicinal chemistry; organic synthesis; heterocycles; cancer; malaria; neglected diseases

(This special issue belongs to the Section Medicinal Chemistry)

Therapeutic Potential of Scopolamine and Its Adverse Effect

edited by

Ion Brinza

and

Lucian Hritcu

submission deadline 25 Oct 2025 | 1 articles | Viewed by 938 | Submission Open

Keywords: scopolamine; neuropharmacology; neurodegenerative diseases; drug delivery systems; neuromodulation and neurotransmitters; pharmacokinetics; therapeutic strategies; toxicology; neurodevelopmental disorders

(This special issue belongs to the Section Pharmacology)

Sustainable Approaches and Strategies for Bioactive Natural Compounds

edited by

Annalisa Santucci

, Alfonso Trezza and

Anna Visibelli

submission deadline 25 Oct 2025 | 2 articles | Viewed by 799 | Submission Open

Keywords: natural compounds; sustainability; biochemical approaches; computational biology; molecular docking; machine learning; systems biology; bioactive molecules

(This special issue belongs to the Section Natural Products)

Challenges in Discovering Innovations Related to Biofilms: Virulence, Spread, Control Strategies and Treatment

edited by

Tsvetelina Paunova-Krasteva

submission deadline 25 Oct 2025 | 1 articles | Viewed by 690 | Submission Open

Keywords: biofilm; structure; pathogenesis; virulence; tolerance; biofilm infections; dispersion; control strategies; quorum sensing

(This special issue belongs to the Section Pharmacology)

Novel Anticancer Drug Development and Toxicity Reduction Strategies

edited by

Monika Papież

submission deadline 25 Oct 2025 | 1 articles | Viewed by 615 | Submission Open

Keywords: cancer; targeted therapy; anticancer drug; structure-based computational technique; combination therapy; nanocarriers; hydrogels

(This special issue belongs to the Section Medicinal Chemistry)

Ion Channels as Pharmacological Targets in Cancer

edited by

Concetta Altamura

Ilaria Saltarella

and

Ester Pagano

submission deadline 25 Oct 2025 | Viewed by 479 | Submission Open

Keywords: ion channels; cancer; cancer pharmacology; target therapies; personalized therapy; chemoresistance; oncology; channelopathies

(This special issue belongs to the Section Pharmacology)

Endocrine Diseases and Pharmacogenomics

edited by

Leonidas A. Phylactou

Vassos Neocleous

and

Pavlos Fanis

submission deadline 25 Oct 2025 | Viewed by 303 | Submission Open

Keywords: inherited endocrine disorders; pharmacogenomics; pharmacogenetics; genome sequencing; clinical trials

(This special issue belongs to the Section Pharmacology)

Current Trends to Discover New Drugs Targeting Protease Inhibition

edited by

Ricardo Olímpio de Moura

João Augusto Oshiro Júnior

and

Igor José dos Santos Nascimento

submission deadline 25 Oct 2025 | Viewed by 250 | Submission Open

Keywords: protease inhibitors; target-based drug design (TBDD); computer-aided drug design (CADD); drug development; neglected diseases

(This special issue belongs to the Section Medicinal Chemistry)

Innovative Approaches to GABAergic Drug Discovery: From Molecular Mechanisms to Advanced Therapeutics

edited by

Wojciech Kołodziejczyk

and

Donato Colangelo

submission deadline 25 Oct 2025 | Viewed by 181 | Submission Open

Keywords: GABAergic signaling; GABA receptors; drug discovery; neurological and psychiatric disorders; ligand design; computational drug development; artificial intelligence in pharmacology; high-throughput screening; targeted drug delivery; controlled release systems

(This special issue belongs to the Section Pharmacology)

Pharmaceutical Excipients in Formulation Design and Drug Delivery: 2nd Edition

edited by

Beverley D. Glass

submission deadline 25 Oct 2025 | Viewed by 136 | Submission Open

Keywords: formulation; excipients labelling; adverse effects; inactive ingredients; stability; regulation and quality; safety

(This special issue belongs to the Section Pharmaceutical Technology)

Applications and Perspectives of Metal Chelators and Metal Complexes in Drug Development

edited by Joanna Izabela Lachowicz

submission deadline 25 Oct 2025 | Viewed by 128 | Submission Open

Keywords: metal chelators; metal complexes; drug development; cancer treatment; neurodegenerative disorder therapy; targeted drug delivery; metal-based nanomedicine; coordination chemistry in medicine; bioinorganic chemistry

(This special issue belongs to the Section Medicinal Chemistry)

Advances in the Medicinal Synthesis of Bioactive Compounds

edited by

Iliyan Ivanov

and

Stanimir Manolov

submission deadline 25 Oct 2025 | Viewed by 127 | Submission Open

Keywords: medicinal chemistry; bioactive compounds; synthetic methodologies; structure– activity relationship (SAR); drug discovery; pharmacokinetics; therapeutic agents; green chemistry; computational modeling; interdisciplinary research

(This special issue belongs to the Section Medicinal Chemistry)

Synthesis and Anticancer Activity of Biologically Active Heterocyclic Compounds

edited by

Birutė Grybaitė

and Rita Vaickelionienė

submission deadline 25 Oct 2025 | Viewed by 115 | Submission Open

Keywords: heterocyclic compounds; five- or six-membered heterocycles; oxygen- and nitrogen-based heterocycles; sulfur- and nitrogen-based heterocycles; azoles; small molecules; anticancer activity; cell lines; cytotoxicity

(This special issue belongs to the Section Medicinal Chemistry)

Displaying special issue 101-150 on page 3 of 7.

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