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Pharmaceuticals publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Advances in Pediatric Drug Formulations

edited by

Sonia M. Iurian

Ioan Tomuta

and

Catalina Bogdan

submission deadline 25 Sep 2025 | 3 articles | Viewed by 5633 | Submission Open

Keywords: pediatric dosage forms; child-friendly dosage forms; age-appropriate dosage forms; acceptability; administration devices; taste-masking; compounded pediatric formulations

(This special issue belongs to the Section Pharmaceutical Technology)

Drug Safety and Risk Management in Clinical Practice

edited by Andreea Maria Farcas

submission deadline 25 Sep 2025 | 3 articles | Viewed by 4187 | Submission Open

Keywords: drug safety; adverse drug reactions; risk minimization measures; effectiveness of risk minimization measures; drug utilization studies

(This special issue belongs to the Section Pharmacology)

Current Advances in Therapeutic Potential of Sigma Receptor Ligands

edited by Maria Dichiara and

Emanuele Amata

submission deadline 25 Sep 2025 | 3 articles | Viewed by 3686 | Submission Open

Keywords: sigma-1 receptor; sigma-2 receptor; TMEM97; cancer; neurodegeneration; neuroprotection; pain; CNS disorders; SAR

(This special issue belongs to the Section Medicinal Chemistry)

Heterocyclic Compounds in Medicinal Chemistry, 2nd Edition

edited by

Valentina Noemi Madia

and

Davide Ialongo

submission deadline 25 Sep 2025 | 2 articles | Viewed by 3670 | Submission Open

Keywords: heterocycles; drug design; drug discovery; bioactive compounds; structure-based drug design; structure– activity relationship; in silico studies; ADMET properties; multicomponent reactions; phytochemicals

(This special issue belongs to the Section Medicinal Chemistry)

Drug Treatment of Cancers

edited by

Abdullah Esmail

submission deadline 25 Sep 2025 | 1 articles | Viewed by 3466 | Submission Open

Keywords: cancer; oncology; chemotherapy; immunotherapy; targeted therapy; precision medicine; liquid biopsy; circulating tumor DNA (ctDNA); imaging

(This special issue belongs to the Section Pharmacology)

Pharmacotherapy of Dyslipidemias, 2nd Edition

edited by

Daniel Dias Rufino Arcanjo

and

Maria do Carmo de Carvalho e Martins

submission deadline 25 Sep 2025 | 1 articles | Viewed by 2647 | Submission Open

Keywords: atherosclerosis; dyslipidemia; endothelial dysfunction; fatty acids; high-fat diet; hyperlipidemia; hypertriglyceridemia; polyunsaturated fatty acids; PUFA; statins

(This special issue belongs to the Section Medicinal Chemistry)

Psychedelics: A New Drug Candidate for Treating Mental Illness

edited by

Raphaël Serreau

and

Sabine Berteina-Raboin

submission deadline 25 Sep 2025 | 2 articles | Viewed by 1703 | Submission Open

Keywords: psychedelics drugs; psilocybin; psilocin; pharmacokinetic; pharmacodynamic; new drug candidate; mental diseases

(This special issue belongs to the Section Pharmacology)

Challenges in the Development of PET and SPECT Radiotracers: Innovative Ideas with Negative Outcomes

edited by Magali Toussaint and Barbara Wenzel

submission deadline 25 Sep 2025 | 2 articles | Viewed by 1661 | Submission Open

Keywords: radiotracer development; positron emission tomography (PET); single-photon emission computed tomography (SPECT); negative results; diagnostic radiotracers; therapeutic radiopharmaceuticals; radiolabeling; automated synthesis and GMP; pre-clinical studies; medicinal chemistry

(This special issue belongs to the Section Radiopharmaceutical Sciences)

Peptide Biomaterials for Pharmaceutical Applications

edited by

Miguel Mendez-Rojas

, Sergio Alberto Bernal Chavez and

Sergio Alcalá Alcalá

submission deadline 25 Sep 2025 | 1 articles | Viewed by 1650 | Submission Open

Keywords: peptides; pharmaceutical applications; nanomedicine; peptide materials; peptide conjugates; drug delivery systems; nanocarriers; biologics

(This special issue belongs to the Section Pharmaceutical Technology)

Medicinal Potential of Cannabidiol and New Structural Analogs

edited by

Patricia Fernandes

submission deadline 25 Sep 2025 | 1 articles | Viewed by 1624 | Submission Open

Keywords: cancer; inflammation; pain; analgesia; cannabidiol; parkinson disease; huntington disease; alzheimer disease

(This special issue belongs to the Section Medicinal Chemistry)

Immunogenomics for Drug Discovery in Leukemia

edited by

Silvia Jiménez-Morales

and Adolfo Martínez-Tovar

submission deadline 25 Sep 2025 | Viewed by 1557 | Submission Open

Keywords: leukemia; hematological diseases; immunogenomics; omics studies; experimental models; therapeutic approaches

(This special issue belongs to the Section Medicinal Chemistry)

Therapeutic Applications of Micro-RNA in Cancer Management

edited by

Alma D. Campos-Parra

submission deadline 25 Sep 2025 | 1 articles | Viewed by 1178 | Submission Open

Keywords: cancer; miRNAs; therapeutic applications; miRNA treatments

(This special issue belongs to the Section Biopharmaceuticals)

Advances in Hybrid Anticancer Drugs: Innovations and Therapeutic Potential

edited by

Dmytro Khylyuk

submission deadline 25 Sep 2025 | 1 articles | Viewed by 993 | Submission Open

Keywords: drug design; molecular hybrids; anticancer agents; privileged scaffold; multiple mechanisms of action

(This special issue belongs to the Section Medicinal Chemistry)

Novel Drug Compositions for Ischemic Stroke: Mechanisms and Clinical Applications

edited by

Jasenka Mrsic-Pelcic

and

Anja Harej Hrkać

submission deadline 25 Sep 2025 | 1 articles | Viewed by 984 | Submission Open

Keywords: ischemic stroke; novel delivery systems; nanomedicine; nanotechnology; neuroregenerative therapy; neurorepair; new and emerging treatments; pharmacotherapy; tissue engineering

(This special issue belongs to the Section Pharmacology)

Next-Generation Antibiotic Strategies Against Drug-Resistant Bacteria

edited by

Jan Naseer Kaur

, Nicholas Smith and Parikshit Padhi

submission deadline 25 Sep 2025 | 1 articles | Viewed by 727 | Submission Open

Keywords: persisters and AMR; combination pharmacotherapy; drug repurposing; antibiotic adjuvants; next-generation beta lactamase inhibitors; small molecule inhibitors; bacteriophage therapy; peptides and CRISPR-based antimicrobials; novel therapeutics; heteroresistance

(This special issue belongs to the Section Pharmacology)

Advances in the Treatment of Leukemia and Lymphomas

edited by

Adriano de Paula Sabino

, Karina Braga Gomes and Maria Das Graças Carvalho

submission deadline 25 Sep 2025 | 1 articles | Viewed by 701 | Submission Open

Keywords: leukemias; lymphomas; chemotherapy; target therapy; immunotherapy; kinase inhibitors; hematologic oncology; therapy; treatment

(This special issue belongs to the Section Medicinal Chemistry)

Expanding the Cancer Drug Discovery Toolbox: A Focus on Protein Degradation, Allosteric Modulation, and Covalent Inhibition

edited by Rita Maria Concetta Di Martino and

Antonella Messore

submission deadline 25 Sep 2025 | 1 articles | Viewed by 641 | Submission Open

Keywords: protein degradation; proteolysis targeting chimeras; hydrophobic tags; molecular glues; allosteric modulators; covalent inhibitors

(This special issue belongs to the Section Medicinal Chemistry)

Combating Drug Resistance in Cancer

edited by

Nina Rembiałkowska

and

Wojciech Szlasa

submission deadline 25 Sep 2025 | 1 articles | Viewed by 434 | Submission Open

Keywords: multidrug resistance; cancer cells; cancer drug resistance; overcoming chemoresistance; targeted cancer therapies; novel anti-cancer strategies; tumor resistance mechanisms; innovative cancer treatments; reversing drug resistance

(This special issue belongs to the Section Medicinal Chemistry)

Computer-Aided Drug Design and Drug Discovery, 2nd Edition

edited by

Dragos Mihai

and

George Mihai Nitulescu

submission deadline 25 Sep 2025 | Viewed by 242 | Submission Open

Keywords: chemoinformatics; bioinformatics; molecular modeling; virtual screening; molecular docking; quantitative structure– activity relationship (QSAR); pharmacophore modeling; target identification; repurposing; ADME-T prediction

(This special issue belongs to the Section Medicinal Chemistry)

Application of Supercritical Fluids in Pharmaceutical Science

edited by

Cecília I. A. V. Santos

submission deadline 25 Sep 2025 | Viewed by 220 | Submission Open

Keywords: supercritical fluids; scCO2; drug formulation; bioavailability; green chemistry; drug delivery systems; nanoparticle encapsulation; bioactive compound extraction; pharmaceutical purification; controlled release; sustainable pharmaceutical processes

(This special issue belongs to the Section Pharmaceutical Technology)

Recent Research in Therapeutic Potentials of Venoms

edited by Samuel Teixeira, Daiana Silva Lopes and

Sarah Natalie Cirilo Gimenes

submission deadline 25 Sep 2025 | Viewed by 163 | Submission Open

Keywords: bioprospecting; biotechnological tools; snake venom toxins; drug discovery; natural products; pharmacological applications; molecular targets of venom toxins; toxicology; peptide therapeutics; venom-based drug delivery

(This special issue belongs to the Section Natural Products)

Advances in Drug Analysis and Drug Development, 2nd Edition

edited by

Daniela Amidžić Klarić

and Ana Mornar

submission deadline 25 Sep 2025 | Viewed by 111 | Submission Open

Keywords: analytical methodology; chromatographic techniques; spectrometric techniques; thermal analysis techniques; sample preparation; drug stability; compatibility study; bioavailability studies; therapeutic drug monitoring; quality by design in pharmaceutical analysis

(This special issue belongs to the Section Pharmaceutical Technology)

Design, Synthesis and Evaluation of Novel 18F Radiotracers

edited by

Junfeng Li

and John E. Shively

submission deadline 25 Sep 2025 | Viewed by 95 | Submission Open

Keywords: positron emission tomography (PET); fluorine-18 (F-18); radiotracer development; molecular imaging; non-invasive diagnostic technique; synthetic methodologies; preclinical evaluation

(This special issue belongs to the Section Radiopharmaceutical Sciences)

Innovative Drug Strategies in Chronic Disease Management: Addressing Non-Adherence and Improving Therapeutic Outcomes

edited by

Eduardo Gutiérrez-Abejón

and

F. Javier Alvarez

submission deadline 26 Sep 2025 | 1 articles | Viewed by 819 | Submission Open

Keywords: adherence; persistence; chronic diseases; therapeutic strategies; individualized therapy; personalized medicine; clinical pharmacology; clinical trials; observational studies; real-world data studies

(This special issue belongs to the Section Pharmacology)

Innovative Drug Delivery Systems for Enhanced Dissolution and Bioavailability

edited by Marival Bermejo,

Paloma Marina De la Torre-Iglesias

and Covadonga Álvarez-Álvarez

submission deadline 26 Sep 2025 | Viewed by 173 | Submission Open

Keywords: drug dissolution enhancement; oral bioavailability improvement; poorly soluble drugs; solid dispersions; nanoparticle drug delivery; amorphous formulations; 3D printing in pharmaceuticals; advanced drug-polymer systems; advanced excipients for solubility enhancement; controlled drug release

(This special issue belongs to the Section Pharmaceutical Technology)

Computational Predictions of Molecules with Potential Therapeutic Effects

edited by

Whelton Miller

submission deadline 30 Sep 2025 | 6 articles | Viewed by 9359 | Submission Open

Keywords: biophysics; medicinal chemistry; drug discovery; molecular docking; molecular dynamics; structure-activity relationships; computer-aided drug design (CADD)

(This special issue belongs to the Section Medicinal Chemistry)

Recent Advances in Drug Metabolism, Transport, and Pharmacokinetics

edited by Agnieszka Bienert and

Joanna Bartkowiak-Wieczorek

submission deadline 30 Sep 2025 | 2 articles | Viewed by 5109 | Submission Open

Keywords: pharmacokinetic analysis; analytical methods suitable for pharmacokinetics studies; pharmacogenetics in drug pharmacokinetics; clinical pharmacokinetics; drug concentrations in plasma and tissue; population PK modeling; drug metabolic pathways; drug transport across barriers

(This special issue belongs to the Section Pharmacology)

Advances in Ophthalmic Drug Discovery and Delivery: From Targets to Treatments

edited by

Hongli Wu

submission deadline 30 Sep 2025 | 3 articles | Viewed by 1943 | Submission Open

Keywords: retinal degeneration; glaucoma; cataract; diabetic retinopathy; drug target; drug delivery; drug candidate; gene therapy; stem cells; natural products; Artificial Intelligence

(This special issue belongs to the Section Pharmacology)

Advances in Pharmacotherapy for Nasal Disorders in Rhinology

edited by

Elena Cantone

submission deadline 30 Sep 2025 | 1 articles | Viewed by 1595 | Submission Open

Keywords: rhinology; CRS; asthma; nasal polyps; biologics; airflow; children; QoL; artificial intelligence; olfaction; chemical senses

(This special issue belongs to the Section Pharmacology)

Innovative Analytical Techniques and Nanotechnology in Natural Products Analysis and Drug Development

edited by Jinchao Wei and

Di Chen

submission deadline 30 Sep 2025 | Viewed by 370 | Submission Open

Keywords: natural product; Chinese medicine; drug development; analytical technique; nanotechnology; spectrometry; chromatography; sensors; formulation

(This special issue belongs to the Section Natural Products)

Effects of Drug Abuse and Its Consequences on Health

edited by

Diana Dias Da Silva

and

Marcelo Dutra Arbo

submission deadline 30 Sep 2025 | Viewed by 223 | Submission Open

Keywords: psychoactive substances; drug abuse; toxicological effects; neurotoxicity; substance use disorder; biomarkers of toxicity; public health impact; addiction mechanisms; harm reduction strategies; novel psychoactive substance (NPS)

(This special issue belongs to the Section Medicinal Chemistry)

Advancements and Possibilities for the Treatment of Idiopathic Inflammatory Myopathies

edited by

Jucier Gonçalves Júnior

and Samuel Katsuyuki Shinjo

submission deadline 30 Sep 2025 | Viewed by 158 | Submission Open

Keywords: anti-synthetase syndrome; dermatomyositis; polymyositis; inflammatory myopathy; myositis; treatment

(This special issue belongs to the Section Pharmacology)

Advances in Small-Molecule Therapeutics Targeting Signaling Pathways

edited by

Arianna Gelain

submission deadline 30 Sep 2025 | Viewed by 137 | Submission Open

Keywords: small molecules; natural compounds; synthetic compounds; signaling pathways; drug design; drug development; HTS; computational tools; biological evaluations; QSAR; bioavailability; pharmacokinetics

(This special issue belongs to the Section Medicinal Chemistry)

Advancements in Cardiometabolic Pharmacology Research

edited by

Gustavo Rodrigues Pedrino

submission deadline 30 Sep 2025 | Viewed by 64 | Submission Open

Keywords: cardiometabolic diseases; pharmacological interventions; drug discovery and development; preclinical models in cardiometabolic research; molecular mechanisms of cardioprotection; bioactive natural compounds; gut microbiome and metabolism; inflammation and oxidative stress in cardiometabolic disease; translational pharmacology

(This special issue belongs to the Section Pharmacology)

Pharmacotherapy for Alzheimer’s Disease

edited by

Gabriela Dumitrița Stanciu

submission deadline 5 Oct 2025 | 5 articles | Viewed by 5672 | Submission Open

Keywords: Alzheimer’ s disease; pharmacotherapy; therapeutic editing tools; repurposing existing therapeutics; multi-target-directed ligands; preclinical studies; neurodegeneration; drug development; neuroprotection; cannabinoid-based pharmaceuticals; single-molecule drugs or whole-plant extracts of Cannabis sativa L.

(This special issue belongs to the Section Pharmacology)

Melatonin Applications in Pharmaceutical Science

edited by

Javier Menéndez-Menéndez

submission deadline 5 Oct 2025 | Viewed by 121 | Submission Open

Keywords: melatonin; pineal gland; epigenetics; pharmacology; physiology; immunology; pharmaceutics; novel therapies; cancer

(This special issue belongs to the Section Pharmacology)

The Discovery and Development of Drug Ingredients from Food Sources

edited by

Justyna Żwawiak

and Dorota Olender

submission deadline 10 Oct 2025 | 2 articles | Viewed by 1280 | Submission Open

Keywords: natural compounds; food; antioxidants; biological activity of natural substances; the influence of food on health

(This special issue belongs to the Section Natural Products)

Affective Disorders Psychopharmacology

edited by Danilo Arnone

submission deadline 15 Oct 2025 | 2 articles | Viewed by 7452 | Submission Open

Keywords: psychopharmacology; affective disorders; mood disorders; major depressive disorders; bipolar affective disorders

(This special issue belongs to the Section Pharmacology)

Pharmacological Activity and Application of Polyphenolic Compounds

edited by

Luís Silva

submission deadline 15 Oct 2025 | Viewed by 866 | Submission Open

Keywords: phenolic compounds; biological potential; pharmacological activity; phenolic applications; health promoters; chronic diseases

(This special issue belongs to the Section Natural Products)

Recent Advances in Overcoming Therapy Resistance in Cancer

edited by

Manoj K. Pandey

submission deadline 15 Oct 2025 | Viewed by 116 | Submission Open

Keywords: cancer therapy resistance; hematological malignancies; solid tumors; targeted therapies; tumor microenvironment; drug resistance mechanisms; epigenetic factors; translational oncology; novel therapeutic strategies; biomarkers of resistance

The Modes of Action of Herbal Medicines and Natural Products, 2nd Edition

edited by Hongnan Cao

submission deadline 15 Oct 2025 | Viewed by 110 | Submission Open

Keywords: herbal compounds; natural products; pharmacokinetics and pharmacodynamics of natural products; herbal medicines; herbal therapies

(This special issue belongs to the Section Natural Products)

Applications of Beehive Products for Wound Repair and Skin Care

edited by Simona Martinotti

submission deadline 20 Oct 2025 | 3 articles | Viewed by 7450 | Submission Open

Keywords: anti-aging; antibacterial properties; healing properties; honey; propolis; bee venom; wound repair; skin care

(This special issue belongs to the Section Natural Products)

Sirtuins as Novel Biological Targets for Pharmacological Intervention in Physiology and Pathology—2nd Edition

edited by

Michele Aventaggiato

and

Marco Tafani

submission deadline 20 Oct 2025 | 1 articles | Viewed by 376 | Submission Open

Keywords: sirtuins; metabolism; cancer; hypoxia; damage recovery; cell death

(This special issue belongs to the Section Pharmacology)

Adjuvant Therapies for Cancer Treatment: 2nd Edition

edited by

Fuyi Wang

submission deadline 22 Oct 2025 | 4 articles | Viewed by 2857 | Submission Open

Keywords: drug repurposing; combined therapies; new compounds; drug resistance; chemosensitization; antitumoral strategies

(This special issue belongs to the Section Pharmacology)

Structural Insights into Protein Kinases-Targeted Therapies: Overcoming Resistance and Advancing Precision Oncology

edited by David Hecht

submission deadline 22 Oct 2025 | Viewed by 210 | Submission Open

Keywords: protein kinases inhibitor resistance; structural biology of of protein kinases; computational modeling; drug design; preclinical and clinical studies; precision oncology; ALK resistance for personalized medicine

(This special issue belongs to the Section Medicinal Chemistry)

Pharmaceutical Modeling and Real-World Data: Advancing Prescribing and Monitoring

edited by

Andreas Daniel Meid

submission deadline 22 Oct 2025 | Viewed by 148 | Submission Open

Keywords: adverse drug reaction; generalizability and transportability; machine learning; pharmacodynamics; pharmaceutical monitoring; pharmacokinetics; quantitative systems in pharmacology; real-world data; real-world evidence; therapeutic drug monitoring

(This special issue belongs to the Section Pharmacology)

Use of Encapsulating Polymers of Active Compounds in the Pharmaceutical Industry

edited by Alba Adriana Vallejo-Cardona, Inocencio Higuera-Ciapara and

Janna Douda

submission deadline 24 Oct 2025 | 1 articles | Viewed by 1407 | Submission Open

Keywords: polymer; drug delivery; active compounds; encapsulation; pharmaceutical industry; natural polymers; synthetic polymers

(This special issue belongs to the Section Pharmaceutical Technology)

New and Emerging Treatment Strategies for Gastrointestinal Diseases

edited by

Daniele Maria-Ferreira

submission deadline 25 Oct 2025 | 7 articles | Viewed by 23696 | Submission Open

Keywords: gastrointestinal diseases; gastrointestinal homeostasis; gastrointestinal injuries; gastrointestinal disturbances; dysbiosis; bile acid; inflammatory bowel diseases; diarrhea

(This special issue belongs to the Section Pharmacology)

Pharmacological Therapies for Stress-Related Disorders and Autism Spectrum Disorder

edited by

Anita Kovács

and

Attila Tóth

submission deadline 25 Oct 2025 | 4 articles | Viewed by 18275 | Submission Open

Keywords: new targets and therapies for stress-related disorders; molecular mechanism of drugs; ASD; PTSD; MDD; antidepressant; depression; animal model for depression; ASD; microbiome; gut-brain axis; brain electrophysiology; neuron activity in ASD

(This special issue belongs to the Section Pharmacology)

Pharmacotherapy of Thromboembolism

edited by

Matej Samoš

Tomáš Bolek

and

Marián Mokáň

submission deadline 25 Oct 2025 | 5 articles | Viewed by 13619 | Submission Open

Keywords: activated factor XI inhibitors; platelet glycoprotein VI antagonists; PAR4 antagonists; PI3K inhibitorslong-term anticoagulation; antiplatelet therapy; novel antithrombotic drugs; anticoagulation-related bleeding; post-vascular procedure-related thrombosis

(This special issue belongs to the Section Pharmacology)

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