Pharmaceutical Targeting of Lipids in Metabolic and Neurological Disorders

A special issue of Pharmaceuticals (ISSN 1424-8247). This special issue belongs to the section "Pharmacology".

Deadline for manuscript submissions: 30 November 2026 | Viewed by 1231

Editors


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Guest Editor
Department of Biology, Josip Juraj Strossmayer University of Osijek, 31000 Osijek, Croatia
Interests: metabolic disorders; lipid metabolism; neuroregeneration

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Guest Editor
Faculty of Medicine, Josip Juraj Strossmayer University of Osijek, 31000 Osijek, Croatia
Interests: neuroscience; molecular biology; biochemistry

Special Issue Information

Dear Colleagues,

Lipids play a pivotal role in maintaining cellular structure, signaling, and energy metabolism, and their dysregulation is increasingly recognized as a central factor in the pathogenesis of numerous metabolic and neurological disorders. Growing evidence links disturbances in lipid metabolism with conditions such as type 2 diabetes, obesity, Alzheimer’s and Parkinson’s disease, and multiple sclerosis. This Special Issue aims to gather research elucidating the molecular mechanisms underlying lipid imbalance and its pharmacological modulation. We welcome studies exploring novel therapeutic strategies, lipid signaling pathways, drug development targeting lipid-related enzymes and receptors, as well as translational approaches that bridge metabolic and neurological dysfunctions. The goal is to foster interdisciplinary collaboration among lipid biochemistry, pharmacology, neuroscience, and clinical medicine to advance lipid-based therapeutic innovations.Lipids play a pivotal role in maintaining cellular structure, signaling, and energy metabolism, and their dysregulation is increasingly recognized as a central factor in the pathogenesis of numerous metabolic and neurological disorders. Growing evidence links disturbances in lipid metabolism with conditions such as type 2 diabetes, obesity, Alzheimer’s and Parkinson’s disease, and multiple sclerosis. This Special Issue aims to gather research elucidating the molecular mechanisms underlying lipid imbalance and its pharmacological modulation. We welcome studies exploring novel therapeutic strategies, lipid signaling pathways, drug development targeting lipid-related enzymes and receptors, as well as translational approaches that bridge metabolic and neurological dysfunctions. The goal is to foster interdisciplinary collaboration among lipid biochemistry, pharmacology, neuroscience, and clinical medicine to advance lipid-based therapeutic innovations.

Dr. Senka Blažetić
Dr. Barbara Viljetić
Guest Editors

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Keywords

  • lipid metabolism
  • pharmacological targets
  • metabolic disorders
  • neurodegenerative diseases
  • lipid signaling

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Published Papers (1 paper)

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Research

12 pages, 744 KB  
Article
PCSK9 Inhibitor Use and the Risk of Age-Related Macular Degeneration in Patients with Atherosclerotic Cardiovascular Disease
by Hou-Ren Tsai, Ji-Ze Hsu, Ching-Hui Loh and Huei-Kai Huang
Pharmaceuticals 2026, 19(5), 750; https://doi.org/10.3390/ph19050750 - 11 May 2026
Viewed by 823
Abstract
Background/Objectives: Emerging evidence suggests that alterations in lipid metabolism may play a contributing role in the pathogenesis of age-related macular degeneration (AMD). Proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors, a novel class of lipid-lowering agents, offer anti-inflammatory and antioxidant benefits, which may [...] Read more.
Background/Objectives: Emerging evidence suggests that alterations in lipid metabolism may play a contributing role in the pathogenesis of age-related macular degeneration (AMD). Proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors, a novel class of lipid-lowering agents, offer anti-inflammatory and antioxidant benefits, which may provide protective effects against AMD. We aimed to evaluate the risk of developing AMD among patients with atherosclerotic cardiovascular disease (ASCVD) who were newly treated with PCSK9 inhibitors compared with those receiving statins. Methods: This retrospective cohort study utilized data from the Global Collaborative Network within the TriNetX Research Network. Patients with ASCVD who were newly initiated on PCSK9 inhibitors or statins were identified and matched for age, sex, race, laboratory data, comorbidities, and concomitant medications. The primary outcomes were the hazard ratios (HRs) for developing AMD, dry AMD, and wet AMD. Propensity score matching (PSM) was used to adjust for baseline demographics and comorbidities. Results: After PSM, 50,102 patients were included in each group (PCSK9 inhibitor users vs. statin users). Compared to statin users, PCSK9 inhibitor users had significantly lower risks of AMD (HR, 0.81; 95% confidence interval [CI], 0.72–0.92) and dry AMD (HR, 0.78; 95% CI, 0.65–0.94), but not wet AMD (HR, 0.90; 95% CI, 0.70–1.16). Stratified and subgroup analyses showed reduced AMD risk among patients aged ≥65 years, White patients, female patients, and evolocumab users. Conclusions: In patients with ASCVD, compared with use of statins, use of PCSK9 inhibitors is associated with reduced risks of AMD and dry AMD, suggesting a potential novel strategy for managing a condition with limited therapeutic options. Full article
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