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Pharmaceuticals publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Progress of Hydrogel Applications in Novel Drug Delivery Platforms

edited by

Anna Drabczyk

and

Katarzyna Bialik-Wąs

submission deadline 25 Aug 2025 | 4 articles | Viewed by 9253 | Submission Open

Keywords: hydrogels; targeted drug delivery; drug release; drug delivery; smart hydrogels; stimuli-responsive hydrogels; controlled release; hydrogel-based drug delivery; drug carriers

(This special issue belongs to the Section Pharmaceutical Technology)

Psychiatric Drug Treatment and Drug Addiction

edited by

Javier Navarro-Zaragoza

submission deadline 25 Aug 2025 | 2 articles | Viewed by 8416 | Submission Open

Keywords: drug addiction; drug abuse; psychiatric disorder; drug dependence

(This special issue belongs to the Section Pharmacology)

Drug Candidates for the Treatment of Obesity, 2nd Edition

edited by

Maria Isabel Cardoso Alonso-Vale

and

Monica Marques Telles

submission deadline 25 Aug 2025 | 3 articles | Viewed by 6398 | Submission Open

Keywords: obesity; appetite supressors; nutraceuticals; plant extracts; lipid metabolism; high-fat diet; adipogenesis

(This special issue belongs to the Section Medicinal Chemistry)

The 20th Anniversary of Pharmaceuticals—New Insights in Medicinal Chemistry of Nitrogen-Containing Compounds

edited by

María del Carmen Terán Moldes

and Pedro Besada Pereira

submission deadline 25 Aug 2025 | 2 articles | Viewed by 5979 | Submission Open

Keywords: drug design; synthesis; nitrogen heterocycles; nitrogen functional groups; biological activity; structure-activity relationship; molecular modeling

(This special issue belongs to the Section Medicinal Chemistry)

Small Molecule Drug Discovery: Driven by In-Silico Techniques

edited by

Roberta Rocca

submission deadline 25 Aug 2025 | 1 articles | Viewed by 2766 | Submission Open

Keywords: drug discovery; nutraceuticals; virtual screening; docking; molecular dynamics; pharmacophore; lead compound

(This special issue belongs to the Section Medicinal Chemistry)

Drug Treatment of Thyroid Cancer

edited by

Cristina Alina Silaghi

Carmen Emanuela Georgescu

Horaţiu Silaghi

and

Cristina Pop

submission deadline 25 Aug 2025 | 2 articles | Viewed by 2222 | Submission Open

Keywords: differentiated thyroid cancer; medullary thyroid cancer; anaplastic thyroid carcinoma; advanced/metastatic thyroid cancer; refractory thyroid cancer; targeted therapy in thyroid cancer; tyrosine kinase inhibitors; immune checkpoint inhibitors; redifferentiation treatment; drug resistance

Antimalarial Drug Candidates

edited by Djane Baia-da-Silva and Anna Caroline Campos Aguiar

submission deadline 25 Aug 2025 | 1 articles | Viewed by 1875 | Submission Open

Keywords: malaria; antimalarial drug candidates; efficacy; safety; pharmacokinetics; clinical; preclinical and translational; resistance

(This special issue belongs to the Section Medicinal Chemistry)

Recent Advancements in Radiochemistry and PET Radiotracer Development: 2nd Edition

edited by Kenneth Dahl and

Sangram Nag

submission deadline 25 Aug 2025 | 1 articles | Viewed by 1331 | Submission Open

Keywords: radiochemistry; labeling; automation; GMP; PET; radiotracer; radioligand; radiopharmaceutical; drug discovery

(This special issue belongs to the Section Radiopharmaceutical Sciences)

Natural Pharmaceutical Component Analysis

edited by

Tingting Zhou

submission deadline 25 Aug 2025 | 1 articles | Viewed by 906 | Submission Open

Keywords: natural pharmaceutical component analysis; data acquisition technologies; pretreatment methods; data processing; online activity analysis

(This special issue belongs to the Section Natural Products)

Pharmacology and Mechanism of Action of Peptides in the Brain

edited by

Jana Tchekalarova

submission deadline 25 Aug 2025 | 1 articles | Viewed by 706 | Submission Open

Keywords: peptide derivatives; neuropeptides; receptors; brain; pain; epilepsy; depression; anxiety

(This special issue belongs to the Section Pharmacology)

Network Pharmacology of Natural Products, 2nd Edition

edited by

Alexander George Panossian

and

Karl Wah-Keung Tsim

submission deadline 25 Aug 2025 | 1 articles | Viewed by 547 | Submission Open

Keywords: natural compounds; plant extracts; structure-activity relationship; network pharmacology; multitarget effects; synergy of complex preparations; pleiotropic activity

(This special issue belongs to the Section Natural Products)

Flavonoids in Medicinal Chemistry: Trends and Future Directions

edited by

Honorina Cidade

submission deadline 25 Aug 2025 | Viewed by 535 | Submission Open

Keywords: flavonoids; synthesis; natural products; medicinal chemistry; biological activity

(This special issue belongs to the Section Medicinal Chemistry)

Pharmacological Approaches of Chronic Obstructive Pulmonary Disease (COPD) and Lung Cancer

edited by

Karolina H. Czarnecka-Chrebelska

and

Jinxiang Xi

submission deadline 25 Aug 2025 | Viewed by 333 | Submission Open

Keywords: chronic obstructive pulmonary disease (COPD); inflammasomes; lung cancer (LC); chronic bronchitis; cancer prevention and treatment; therapeutic approaches

(This special issue belongs to the Section Pharmacology)

Challenges and Emerging Trends in Photopharmacology

edited by Oleksandra Tiapko and Bernadett Bacsa

submission deadline 25 Aug 2025 | Viewed by 294 | Submission Open

Keywords: photopharmacology; ion channels; receptors; protein– ligand interactions; precision medicine; optogenetics

(This special issue belongs to the Section Pharmacology)

Neuropsychiatric Disorders: Pharmacological Aspects

edited by

Ioana-Miruna Balmus

submission deadline 25 Aug 2025 | Viewed by 292 | Submission Open

Keywords: neuropsychiatric disorders; DSM-V; pharmacodynamics; innovative therapies; animal models; neuropsychiatric patients; trauma and stress; neurodegeneration; affective disorders; neurodevelopmental disorders; schizophrenia; sleep disorders; comorbidities; cardiovascular; coagulopathies; gastrointestinal; microbiome– gut– brain axis

(This special issue belongs to the Section Pharmacology)

Application of Biosensors in Pharmaceutical Research

edited by

Vasileios Tsekouras

and

Sofia Mavrikou

submission deadline 25 Aug 2025 | Viewed by 281 | Submission Open

Keywords: biosensors; diagnostics; high-throughput screening of pharmaceuticals; pharmaceutical analysis; point-of-care systems; drug discovery; drug analysis

(This special issue belongs to the Section Pharmaceutical Technology)

Application of Neuroimaging Biomarkers in the Diagnosis and Treatment of Mental Diseases, 2nd Edition

edited by Deborah A. Yurgelun-Todd, Douglas Kondo, Nicolas A Nunez, Perry Franklin Renshaw and Dost Öngür

submission deadline 25 Aug 2025 | Viewed by 180 | Submission Open

Keywords: neuroimaging; biomarkers; 1H-MRS; 31P-MRS; brain spectroscopy; mood disorders

(This special issue belongs to the Section Pharmaceutical Technology)

Application of MRI in Drug Metabolism and Pharmacokinetics

edited by

Do-Wan Lee

and

Donghoon Lee

submission deadline 25 Aug 2025 | Viewed by 170 | Submission Open

Keywords: MRI; drug metabolism; pharmacokinetics; chemical exchange saturation transfer (CEST); magnetic resonance spectroscopy (MRS); advanced imaging techniques; molecular imaging; preclinical imaging; quantitative imaging biomarkers; ADME (absorption; distribution; metabolism; excretion)

(This special issue belongs to the Section Pharmacology)

Treatment and Molecular Mechanisms of Depression

edited by Zuleide Maria Ignácio and Ricieri Mocelin

submission deadline 25 Aug 2025 | Viewed by 141 | Submission Open

Keywords: major depressive disorder; molecular mechanisms; neurotransmitters; epigenetic; genetic polymorphisms; inflammation; neuroinflammation; pharmacological strategies; drugs; intracellular signaling

(This special issue belongs to the Section Medicinal Chemistry)

Advances in Smooth Muscle Pharmacology

edited by

Beata Modzelewska

, Tomasz Kleszczewski and

Jacek Kapała

submission deadline 25 Aug 2025 | Viewed by 125 | Submission Open

Keywords: smooth muscle regulation; pharmacological interventions; ion channel modulation; receptor– ligand dynamics; therapeutic drug development; vascular tone regulation; smooth muscle disorders; translational pharmacology; cellular signaling pathways; pathophysiology

(This special issue belongs to the Section Pharmacology)

Lithium in Psychiatric Therapy: Celebrating 75th Anniversary

edited by

Janusz K. Rybakowski

and Ewa Ferensztajn-Rochowiak

submission deadline 28 Aug 2025 | 5 articles | Viewed by 17910 | Submission Open

Keywords: lithium; bipolar disorder; mania; depression; the prevention of recurrences; suicide; dementia; immunomodulation; genetics; kidney function

(This special issue belongs to the Section Pharmacology)

Natural Products for Therapeutic Potential

edited by

Xavier Siwe Noundou

submission deadline 29 Aug 2025 | 4 articles | Viewed by 4688 | Submission Open

Keywords: natural products chemistry; therapeutic potential; medicinal plants; marine organisms; microorganisms; bioactive compounds; natural products inspired compounds; biological activities; computational chemistry

(This special issue belongs to the Section Natural Products)

Unveiling Nature's Pharmacy: Exploring Drug Discovery Through Medicinal Plants

edited by

Guglielmina Froldi

submission deadline 29 Aug 2025 | 2 articles | Viewed by 4657 | Submission Open

Keywords: plant-derived drugs; secondary metabolites; advanced glycation end-products (AGEs); reactive oxygen species (ROS); molecular targets; pharmacokinetics; ADMET; bioavailability

(This special issue belongs to the Section Natural Products)

Advanced Nanosystems and Emerging Therapies: Innovations in Tuberculosis Treatment and Drug Resistance

edited by

Fernando Rogério Pavan

submission deadline 29 Aug 2025 | 1 articles | Viewed by 1139 | Submission Open

Keywords: nanosystems; tuberculosis therapy; drug delivery; multidrug-resistant Mycobacterium tuberculosis (MDR-TB); nanotechnology-based therapeutics

(This special issue belongs to the Section Pharmaceutical Technology)

Antibiotic Resistance and Misuse

edited by

Bogdan Vintila

Claudiu Morgovan

and

Anca-Maria Arseniu

submission deadline 31 Aug 2025 | 2 articles | Viewed by 3634 | Submission Open

Keywords: antibiotic resistance; antibiotic misuse; antimicrobial stewardship; infection control; resistance mechanisms; diagnostic innovations; therapeutic strategies; policy reforms; clinical outcomes

(This special issue belongs to the Section Pharmacology)

A Commemorative Special Issue in Honor of Professor Eliezer J. Barreiro: Early Drug Discovery: From Target Identification and Validation to Lead Optimization

edited by

Luzineide Tinoco

and

Lídia Lima

submission deadline 31 Aug 2025 | 2 articles | Viewed by 2762 | Submission Open

Keywords: target validation; LBDD; FBDD; SBDD; QSAR; artificial intelligence; organic synthesis; natural product; drug discovery; medicinal chemistry

(This special issue belongs to the Section Medicinal Chemistry)

Advances in the Synthesis and Application of Heterocyclic Compounds

edited by

Monika Olesiejuk

and

Agnieszka Kudelko

submission deadline 31 Aug 2025 | 1 articles | Viewed by 2072 | Submission Open

Keywords: organic synthesis; heterocyclic compounds; biological activity; medicine; therapeutics

(This special issue belongs to the Section Medicinal Chemistry)

Advances in Antiparasitic Drug Research

edited by

Andre Aires

and

Maria Cristiano

submission deadline 31 Aug 2025 | 2 articles | Viewed by 1346 | Submission Open

Keywords: antiparasitic drug; novel drug targets; parasite resistance; drug efficacy; parasite genetics

(This special issue belongs to the Section Pharmacology)

P2X Receptors and Their Pharmacology

edited by

Robson Xavier Faria

submission deadline 31 Aug 2025 | 1 articles | Viewed by 1121 | Submission Open

Keywords: compounds; substances; synthetic; natural product; inhibitor; purinergic receptor; ATP; antagonista

(This special issue belongs to the Section Pharmacology)

Advances in Cancer Treatment and Toxicity

edited by

Dinender K. Singla

submission deadline 31 Aug 2025 | Viewed by 366 | Submission Open

Keywords: oxidative stress; cell signaling; cell death; tissue remodeling; inflammation; molecular mechanisms; heart; muscle; antioxidants; cell therapy; exosomes

(This special issue belongs to the Section Pharmacology)

Synthesis and Biological Activity of Metal Complexes

edited by

Francois Dufrasne

submission deadline 31 Aug 2025 | Viewed by 264 | Submission Open

Keywords: metal complexes; biological activity; synthesis; pharmacology; cancer; pathogens; medicine; chemistry; stability; target

(This special issue belongs to the Section Medicinal Chemistry)

Pharmacotherapeutics of Sarcoidosis

edited by

Lucrezia Mondini

Barbara Ruaro

and Giorgio Monteleone

submission deadline 31 Aug 2025 | Viewed by 163 | Submission Open

Keywords: sarcoidosis; drug combinations; interstitial lung disease; biological therapy; target therapy; biomarkers

(This special issue belongs to the Section Pharmacology)

Advances in Radionuclide Production and Their Applications in Therapeutic Radiopharmaceuticals

edited by Svetlana Selivanova

submission deadline 31 Aug 2025 | Viewed by 120 | Submission Open

Keywords: radiopharmaceutical sciences; radiochemistry; radiopharmacology; radionuclide production; molecular imaging

(This special issue belongs to the Section Radiopharmaceutical Sciences)

Stem Cells in Oncology: Emerging Targets for Therapy

edited by

Ling Li

and

Umesh P Yadav

submission deadline 31 Aug 2025 | Viewed by 90 | Submission Open

Keywords: cancer stem cells (CSCs); tumor microenvironment (TME); targeted therapy; treatment resistance; biomarkers

(This special issue belongs to the Section Biopharmaceuticals)

Design, Synthesis and Biological Assessment of Amphiphiles

edited by

Renata Odžak

and

Matilda Šprung

submission deadline 1 Sep 2025 | Viewed by 282 | Submission Open

Keywords: amphiphilic compounds; structure– activity relationship; biological potential

(This special issue belongs to the Section Medicinal Chemistry)

Bioactive Compounds Derived from Plants and Their Medicinal Potential, 2nd Edition

edited by

Maria de Lourdes Pereira

Veeranoot Nissapatorn

, Ana Paula Girol and

Sónia M. R. Oliveira

submission deadline 5 Sep 2025 | 2 articles | Viewed by 1631 | Submission Open

Keywords: phytopharmaceutical drugs; activity screening (antimicrobial; antioxidant; anticancer; and immunomodulatory activity); experimental models (in vitro; ex vivo; in vivo; etc.); microfluidic systems

(This special issue belongs to the Section Natural Products)

Emerging Freeze Drying and Spray Drying Techniques

edited by

Lauryna Pudžiuvelytė

and

Jurga Bernatoniene

submission deadline 10 Sep 2025 | 1 articles | Viewed by 4613 | Submission Open

Keywords: freeze drying; spray drying; microencapsulation; emulsions; herbal extracts; essential oil; natural ingredients; active ingredients; wall materials; polysaccharides; powders; physicochemical characteristics; microparticles; encapsulation efficiency; biological activity; pharmaceutical forms (tablets; capsules; solutions; gels; etc.); study of stability; study of release in vitro; active compound(s) and wall material interaction; morphology of microparticles

(This special issue belongs to the Section Pharmaceutical Technology)

New Targets and Experimental Therapeutic Approaches for Cancers

edited by

Saurabh Agarwal

and Rohit K. Srivastava

submission deadline 10 Sep 2025 | 2 articles | Viewed by 3128 | Submission Open

Keywords: cancer; pharmaceutical therapy; therapeutic targets; drug delivery; immunotherapy; precision medicine; emerging pharmaceutical technologies; combination therapy

(This special issue belongs to the Section Pharmacology)

Recent Advances in Nanocarriers for Drug Delivery

edited by

Liliana Mititelu-Tartau

submission deadline 15 Sep 2025 | 2 articles | Viewed by 2655 | Submission Open

Keywords: nanocarriers; drug delivery; targeted therapy; controlled release; biocompatibility; liposomal delivery; polymeric nanoparticles; gene therapy; smart drug systems; biomedical applications

(This special issue belongs to the Section Pharmaceutical Technology)

Novel Antimicrobials and the Antimicrobial Activity: New Advances

edited by

Davide Carcione

Luigi Principe

and

Cattaneo Dario

submission deadline 15 Sep 2025 | Viewed by 490 | Submission Open

Keywords: multi-drug resistance; infection; mechanism of action; resistance mechanisms; therapeutic medicine; diagnostic tools; antimicrobial stewardship; pharmacokinetics/pharmacodynamics

(This special issue belongs to the Section Pharmacology)

Triazole and Derivatives in Medicinal Chemistry, 2nd Edition

edited by Saeed Bahadorikhalili

submission deadline 15 Sep 2025 | Viewed by 275 | Submission Open

Keywords: triazole; heterocycles; medicinal chemistry; pharmaceutical chemistry; organic synthesis; catalytic organic synthesis; bioactivity; organocatalysis

(This special issue belongs to the Section Medicinal Chemistry)

Peptide Drug Conjugates and Their Applications

edited by

Stela Georgieva

and

Petar Todorov

submission deadline 20 Sep 2025 | 1 articles | Viewed by 2464 | Submission Open

Keywords: peptides; endogenous opioid peptides; peptidomimetics; neuropeptides; peptide– metal complexes; opioid receptors; chemical biology of peptides

(This special issue belongs to the Section Biopharmaceuticals)

Pharmaceutical Strategy for Mood Disorders

edited by Delfina Janiri and Alexia Koukopoulos

submission deadline 22 Sep 2025 | 1 articles | Viewed by 663 | Submission Open

Keywords: mood disorders; pharmacotherapy; pharmacological targets; gut– brain axis; microbiome-based interventions; biomarker-driven treatment optimize treatment response

(This special issue belongs to the Section Pharmacology)

Pharmacokinetic Modeling and Simulation in the Design of Long-Acting Drug Delivery Systems

edited by Mackenzie Cottrell and

Leah M. Johnson

submission deadline 22 Sep 2025 | Viewed by 112 | Submission Open

Keywords: long-acting drug delivery systems (LADDSs); pharmacokinetic modeling; pharmacokinetic simulation; physiologically based pharmacokinetic (PBPK) modeling; quantitative systems pharmacology (QSP); absorption; in vitro– in vivo correlation (IVIVC); model-informed drug development (MIDD); artificial intelligence (AI); machine learning (ML); drug disposition; controlled release

(This special issue belongs to the Section Pharmaceutical Technology)

Fighting Tropical Neglected Diseases with Natural Products: New Approaches Against Ancient Diseases

edited by

Igor Rodrigues

André Luis Souza dos Santos

, Dirlei Nico and Ana Claudia Fernandes Amaral

submission deadline 23 Sep 2025 | 2 articles | Viewed by 2049 | Submission Open

Keywords: plant extracts; natural compounds; neglected diseases; drug resistance; natural product-based formulations; antiparasitic drugs; enzyme inhibition

Recent Advances in Inhalation Therapy

edited by

Luca Casula

and

Francesco Lai

submission deadline 25 Sep 2025 | 5 articles | Viewed by 15956 | Submission Open

Keywords: inhalation therapy; pulmonary delivery; aerosols; dry powder inhalation; inhalable micro and nanoparticles; pulmonary deposition

(This special issue belongs to the Section Pharmaceutical Technology)

Pharmacotherapy of Liver Fibrosis and Hepatitis: Recent Advances

edited by

Ching-Lung Lai

submission deadline 25 Sep 2025 | 8 articles | Viewed by 13659 | Submission Open

Keywords: treatment of HBV; HCV; SLD; detection and prevention of liver fibrosis and HCC

(This special issue belongs to the Section Pharmacology)

Pharmacogenomics for Precision Medicine

edited by

Vacis Tatarūnas

submission deadline 25 Sep 2025 | 6 articles | Viewed by 9496 | Submission Open

Keywords: pharmacogenomics in precise therapy; tailored medicine; pharmacoeconomics; personalized medicine; education in pharmacogenomics and precise medicine; future directions in pharmacogenomics; pharmacogenomics and phenotype; genotype; epigenetic variation; and gene expression axis in pharmacogenomics

(This special issue belongs to the Section Pharmacology)

Recent Advancements in the Development of Antiprotozoal Agents

edited by Francesco Saccoliti and Alessandro Giraudo

submission deadline 25 Sep 2025 | 5 articles | Viewed by 9054 | Submission Open

Keywords: antiprotozoal; drug discovery; chemotherapy; parasite; protozoa; mechanism of action of antiprotozoal agents

(This special issue belongs to the Section Medicinal Chemistry)

Antiviral Agents, 2024

edited by

Luis Octavio Regasini

submission deadline 25 Sep 2025 | 5 articles | Viewed by 8738 | Submission Open

Keywords: antiviral; virus; arbovirus; drugs; protease; helicase; polymerase; reverse transcriptase

(This special issue belongs to the Section Medicinal Chemistry)

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