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Pharmaceuticals publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Antifungal Therapy Strategies: A Focus on Novel Compounds and Inhibitors

edited by

Lucimar Ferreira Kneipp

and

André Luis Souza dos Santos

submission deadline 15 Dec 2025 | Viewed by 182 | Submission Open

Keywords: medicinal chemistry; combined therapy; antivirulence action; anti-resistance strategies; drug repositioning; drug delivery; multi-omics technologies

(This special issue belongs to the Section Medicinal Chemistry)

Structural and Computationally Driven Molecule Design in Drug Discovery: 2nd Edition

edited by

Halil İbrahim Ciftci

Belgin Sever

and

Hasan Demirci

submission deadline 20 Dec 2025 | 13 articles | Viewed by 31919 | Submission Open

Keywords: structural dynamics studies; computer-aided drug design; molecular dynamics simulations; molecular docking; virtual screening; QSAR; in silico ADMET; artificial intelligence (AI) techniques

(This special issue belongs to the Section Medicinal Chemistry)

Natural Products as an Alternative for Treatment of Human Diseases

edited by Eduardo Lira,

Jackson Guedes

and Raimundo Gonçalves De Oliveira Junior

submission deadline 20 Dec 2025 | 7 articles | Viewed by 17368 | Submission Open

Keywords: medicinal plants; herbal remedies; natural products; traditional medicine

(This special issue belongs to the Section Natural Products)

Pharmaceutical Applications and Therapeutic Mechanisms of Substances from Plant Origin

edited by Iliya Zhelev Slavov,

Stanislava Ivanova

Nadezhda Hvarchanova

and

Nadezhda Ivanova

submission deadline 20 Dec 2025 | 5 articles | Viewed by 5770 | Submission Open

Keywords: natural substances; phytotherapy; phytochemistry; chromatography; pharmacokinetics; pharmacodynamics; drug delivery

(This special issue belongs to the Section Natural Products)

Management of Pain in Oral Mucositis

edited by

Carlos Roldan

and Thomas Chai

submission deadline 20 Dec 2025 | 1 articles | Viewed by 1662 | Submission Open

Keywords: oral mucositis; oral pain; pain management; cancer; cancer therapy

(This special issue belongs to the Section Pharmacology)

Pharmaceutical Process Engineering: Experimental and Computational Innovation

edited by Marcial Gonzalez and Francesco Destro

submission deadline 22 Dec 2025 | 1 articles | Viewed by 640 | Submission Open

Keywords: pharmaceutical process engineering; process development; process analytical technology (PAT); process analytical chemistry (PAC); quality by design (QbD); sustainable manufacturing; drug product quality; biopharmaceuticals

(This special issue belongs to the Section Pharmaceutical Technology)

The Discovery and Development of Drug Ingredients from Food Sources

edited by

Justyna Żwawiak

and Dorota Olender

submission deadline 23 Dec 2025 | 3 articles | Viewed by 4538 | Submission Open

Keywords: natural compounds; food; antioxidants; biological activity of natural substances; the influence of food on health

(This special issue belongs to the Section Natural Products)

Pharmacologically Active Compounds from Plants

edited by Duc Dat Le and

Cao Van Anh

submission deadline 25 Dec 2025 | 5 articles | Viewed by 15795 | Submission Open

Keywords: herbal medicines; bioactive compounds; NMR; phytochemistry; analytical method

(This special issue belongs to the Section Natural Products)

Network Pharmacology of Natural Products, 2nd Edition

edited by

Alexander George Panossian

and

Karl Wah-Keung Tsim

submission deadline 25 Dec 2025 | 8 articles | Viewed by 9910 | Submission Open

Keywords: natural compounds; plant extracts; structure-activity relationship; network pharmacology; multitarget effects; synergy of complex preparations; pleiotropic activity

(This special issue belongs to the Section Natural Products)

Inhibition and Treatment in Adhesion, Migration, Invasion, and Metastasis of Cancer Cells

edited by

Magdalena Izdebska

Marta Hałas-Wiśniewska

and Wioletta Arendt

submission deadline 25 Dec 2025 | 4 articles | Viewed by 9792 | Submission Open

Keywords: migration; metastasis; invasion; tumor progression; cell adhesion; cancer; epithelial– mesenchymal transition; cancer therapy

(This special issue belongs to the Section Medicinal Chemistry)

Recent Advances in Cancer Diagnosis and Therapy

edited by

Adriana Grigoraș

and

Hsin-Sheng Yang

submission deadline 25 Dec 2025 | 4 articles | Viewed by 9137 | Submission Open

Keywords: early diagnosis; advanced therapy; biomarkers; immunohistochemistry; molecular diagnosis; metastasis; prognosis; targeted therapies; combination therapies; cancer pharmacology

(This special issue belongs to the Section Pharmacology)

Exosome and Biotherapeutic Strategies for Dermatological and Oncological Skin Complications

edited by

Lidia Majewska

and Jacek M. Kijowski

submission deadline 25 Dec 2025 | 1 articles | Viewed by 6345 | Submission Open

Keywords: exosomes; skin cancer; dermatological therapy; extracellular vesicles; biotherapeutics; regenerative medicine; nanomedicine; wound healing; cancer-related skin manifestations; dermatological drug delivery; wound healing therapeutics; cutaneous oncology; exosome-based therapy

(This special issue belongs to the Section Biopharmaceuticals)

Plant-Based Extracts and the Therapeutic Potential of Bioactive Compounds, 2nd Edition

edited by

Grażyna Zgórka

submission deadline 25 Dec 2025 | 5 articles | Viewed by 5290 | Submission Open

Keywords: plant extracts; herbal medicinal products; standardization; phytochemical profiling; bioactive plant compounds; therapeutic effects

(This special issue belongs to the Section Natural Products)

Photodynamic Therapy: 3rd Edition

edited by

Céline Frochot

submission deadline 25 Dec 2025 | 3 articles | Viewed by 3512 | Submission Open

Keywords: photodynamic therapy; photosensitizers; nanoparticles; photo-diagnosis; targeting; antimicrobial; X-rays excitation; two photon and upconversion; immunomodulation; dosimetry; hypoxia

(This special issue belongs to the Section Pharmaceutical Technology)

Plant-Derived Products in the Treatment of Internal Diseases: 2nd Edition

edited by

Dorin Dragoş

and

Adelina Vlad

submission deadline 25 Dec 2025 | 3 articles | Viewed by 3107 | Submission Open

Keywords: medicinal plants; phytotherapy; herbal treatment; natural products; herbalism; traditional medicine; cardiovascular disease; lung disease; liver disease; gastrointestinal disease; kidney disease; obesity; diabetes; rheumatological disease

(This special issue belongs to the Section Natural Products)

Mathematical Modeling in Drug Metabolism and Pharmacokinetics

edited by

Ziran Li

and

Dongsheng Yang

submission deadline 25 Dec 2025 | 3 articles | Viewed by 2928 | Submission Open

Keywords: pharmacokinetics; mathematical modeling; physiologically based pharmacokinetic (PBPK); pharmacokinetic/pharmacodynamic (PK/PD); quantitative systems pharmacology (QSP); machine learning; model-informed drug development; translational modeling; artificial intelligence (AI); personalized medicine

(This special issue belongs to the Section Medicinal Chemistry)

Hybrid and Chimeric Heterocycles: A Promising Approach to Synthesizing Biologically Active Compounds

edited by

Ionel Mangalagiu

submission deadline 25 Dec 2025 | 3 articles | Viewed by 2742 | Submission Open

Keywords: hybrid heterocyclic compounds; chimeric heterocyclic compounds; multifactorial diseases; multiple targeting drugs; biological activity: antimicrobials; antiviral; anthelmintic; anti-HIV; anticancer; antiallergic; diuretics; cardiotonic; antihypertensive; antiplatelet; analgesic; anxiolytics; antidepressant; hypnotic sedative; antineurodegenerative; anti-Alzheimer’ s etc.

(This special issue belongs to the Section Medicinal Chemistry)

Common Medications Used in Anesthesia

edited by Michał Jan Stasiowski

submission deadline 25 Dec 2025 | 1 articles | Viewed by 2465 | Submission Open

Keywords: anesthesia; medications; pharmacology; perioperative care; drug interactions; patient safety; clinical practice; anesthesia management; drug development; patient outcomes

(This special issue belongs to the Section Medicinal Chemistry)

Drug Formulation: Solubilization and Controlled-Release Strategies

edited by

María Peña Fernández

submission deadline 25 Dec 2025 | 2 articles | Viewed by 1909 | Submission Open

Keywords: drug formulation; solubilization; controlled-release systems; solubility; poorly water-soluble drugs

(This special issue belongs to the Section Pharmaceutical Technology)

Natural Products Derived from Fungi and Their Biological Activities, 2nd Edition

edited by

Katarzyna J. Kała

submission deadline 25 Dec 2025 | 2 articles | Viewed by 1804 | Submission Open

Keywords: fungi; medicinal fungi; fruiting bodies; mycelial cultures; bioactive compounds; pro-health activity; mushroom products; natural therapy; natural medicines

(This special issue belongs to the Section Natural Products)

Advances in Non-Coding RNAs as Prognostic Biomarkers, Therapeutic Targets, and Regulatory Mechanisms in Cancer

edited by

Pablo Pérez-Moreno

and

Juan Pablo Muñoz

submission deadline 25 Dec 2025 | 1 articles | Viewed by 537 | Submission Open

Keywords: non-coding RNAs; non-coding RNAs as prognostic biomarkers in cancer; non-coding RNAs as treatment targets in cancer; non-coding RNAs as diagnostic targets in cancer; molecular mechanisms on non-coding RNAs in cancer

(This special issue belongs to the Section Biopharmaceuticals)

Plant Extracts with Biological Activity and Potential Antioxidant Action

edited by Claudia-Crina Toma,

Giancarlo Statti

Filomena Conforti

Mariangela Marrelli

and Cerasela Elena Gîrd

submission deadline 25 Dec 2025 | Viewed by 333 | Submission Open

Keywords: phenolic compounds; flavonoids; vegetal growth factors; oxidative stress; plant primary metabolites; plant secondary metabolites; nutraceuticals

(This special issue belongs to the Section Natural Products)

Cancer Pain—from Novel Mechanisms to Clinical Management

edited by Xuejun Song and Xiaodong Liu

submission deadline 25 Dec 2025 | Viewed by 309 | Submission Open

Keywords: cancer pain; novel analgesics; mechanism-driven therapeies; pain management; palliative care

(This special issue belongs to the Section Pharmacology)

The Nuclear Factor Kappa-B (NF-κB) Pathway as a Target for Drug Discovery

edited by Guozhou Xu

submission deadline 25 Dec 2025 | Viewed by 231 | Submission Open

Keywords: NF-kappaB; TNFR; TLR; IL1R; receptor adaptor proteins; IRAK; c-IAP; AKT IKK; ubiquitin– proteasome system; inflammatory response

(This special issue belongs to the Section Medicinal Chemistry)

HIV and Viral Hepatitis Prevention, Treatment and Coinfection, 2nd Edition

edited by

Daniel Sepúlveda-Crespo

and

Salvador Resino

submission deadline 25 Dec 2025 | Viewed by 218 | Submission Open

Keywords: coinfection; drug discovery; HBV; HCV; HDV; HIV; neutralizing antibodies; prevention; treatment; vaccine

(This special issue belongs to the Section Biopharmaceuticals)

Treatment for HPV-Associated Cervical Cancer: Novel Therapeutic Strategies

edited by

Berenice Illades-Aguiar

Yazmín Gómez-Gómez

, Marco Antonio Leyva-Vázquez,

Jorge Organista-Nava

and Olga Lilia Garibay-Cerdenares

submission deadline 25 Dec 2025 | Viewed by 187 | Submission Open

Keywords: cervical cancer; proteomic; transcriptomic; miRNA; lncRNA; drug repositioning; nano-transport; liposomes and immunoliposomes

(This special issue belongs to the Section Pharmacology)

Photodynamic Therapy for Cancer: Recent Advances

edited by

Cristina Pacheco-Soares

submission deadline 25 Dec 2025 | Viewed by 185 | Submission Open

Keywords: photodynamic therapy; cancer treatment; photosensitizers; targeted therapy; combination therapies; mechanisms of action; molecular biology

(This special issue belongs to the Section Pharmaceutical Technology)

Gene Delivery and Its Application in Pharmaceutical Science

edited by Xuanyu Chen and Wen Xiao

submission deadline 25 Dec 2025 | Viewed by 184 | Submission Open

Keywords: microRNAs; neuronal reprogramming; gene therapy; adeno-associated virus; neurodegenerative diseases; brain injury; spinal cord injury; tumor

(This special issue belongs to the Section Pharmaceutical Technology)

Bioactive Substances, Oxidative Stress, and Inflammation, 2nd Edition

edited by

Pilar Zafrilla

and

Begoña Cerdá

submission deadline 25 Dec 2025 | Viewed by 175 | Submission Open

Keywords: bioactive compounds; oxidative stress; chronic inflammation; chronic non-communicable diseases; polyphenol; vitamins; omega-3 fatty acids

(This special issue belongs to the Section Natural Products)

Secondary Metabolites as Drug Leads: Bridging Experimental Discovery and Computational Innovation

edited by

Alberto Jorge Oliveira Lopes

, Francisco das Chagas Alves Lima,

Antônio José Cantanhede Filho

, Luisa Di Paola and

Robert Vianello

submission deadline 25 Dec 2025 | Viewed by 173 | Submission Open

Keywords: medicinal chemistry; computer aided-drug design; new drugs agents; natural products

(This special issue belongs to the Section Medicinal Chemistry)

Novel Drug Targets and Drug Candidates for Neglected Tropical Diseases

edited by Juliana Mesquita and

Juliana Quero Reimão

submission deadline 26 Dec 2025 | 3 articles | Viewed by 2901 | Submission Open

Keywords: neglected tropical diseases; leishmaniasis; chagas disease

(This special issue belongs to the Section Medicinal Chemistry)

Bioactive Compounds from Plants and Their Therapeutic Applications in Lifestyle-Related Diseases, 2nd Edition

edited by

Syota Kagawa

submission deadline 26 Dec 2025 | Viewed by 237 | Submission Open

Keywords: natural compounds; lifestyle-related diseases; pharmacology; molecular mechanisms; clinical applications

(This special issue belongs to the Section Natural Products)

Animal-Derived Venom Compounds for Cancer Prevention and Intervention

edited by

Lucas Fornari Laurindo

and

Sandra Barbalho

submission deadline 26 Dec 2025 | Viewed by 219 | Submission Open

Keywords: animal-derived venom anticancer agents; cancer prevention and intervention; functional venom products in oncology; natural product oncology; toxin-derived drugs; bioactive peptides in cancer; venom-based therapeutics

(This special issue belongs to the Section Natural Products)

Chirality in Drugs

edited by

Li Li

submission deadline 26 Dec 2025 | Viewed by 123 | Submission Open

Keywords: chirality; chiral drugs; chiral resolution; asymmetric synthesis; chiral analysis; chiroptical spectroscopy

(This special issue belongs to the Section Medicinal Chemistry)

Selective Histone Deacetylase Isoforms as Potential Therapeutic Targets

edited by

Anna Artese

submission deadline 31 Dec 2025 | 7 articles | Viewed by 21995 | Submission Open

(This special issue belongs to the Section Medicinal Chemistry)

Pharmacotherapy of Endometriosis

edited by

Jang-Kyung Park

, Dong Il Kim and

Soo-Hyun Sung

submission deadline 31 Dec 2025 | 4 articles | Viewed by 17400 | Submission Open

Keywords: endometriosis; pharmacotherapy; integrative medicine; herbal medicine herbal formulations; plant-based compounds; herbal extracts; pharmacopuncture; pelvic pain; infertility

(This special issue belongs to the Section Pharmacology)

Natural Compounds as Potential Anticancer, Anti-inflammatory and Antioxidant Agents in Medicine

edited by

Justyna Stefanowicz-Hajduk

submission deadline 31 Dec 2025 | 6 articles | Viewed by 14836 | Submission Open

Keywords: phytochemistry of plant extracts; plant secondary metabolites; clinical applications; in vitro; in vivo; ex vivo studies; cell and tissue cultures

(This special issue belongs to the Section Natural Products)

Drug Target Exploration and Drug Design & Development Based on Small Molecule

edited by

Giulia Culletta

and

Marco Tutone

submission deadline 31 Dec 2025 | 7 articles | Viewed by 11755 | Submission Open

Keywords: small molecules; drug design and development; target exploration; anticancer drugs; anti-inflammatory drugs; neuromodulation; natural compounds; nutraceuticals; virtual screenings

(This special issue belongs to the Section Pharmacology)

Antibiotic Resistance and Misuse

edited by

Bogdan Vintila

Claudiu Morgovan

and

Anca-Maria Arseniu

submission deadline 31 Dec 2025 | 2 articles | Viewed by 9975 | Submission Open

Keywords: antibiotic resistance; antibiotic misuse; antimicrobial stewardship; infection control; resistance mechanisms; diagnostic innovations; therapeutic strategies; policy reforms; clinical outcomes

(This special issue belongs to the Section Pharmacology)

Advances in the Synthesis and Application of Heterocyclic Compounds

edited by

Monika Olesiejuk

and

Agnieszka Kudelko

submission deadline 31 Dec 2025 | 4 articles | Viewed by 9935 | Submission Open

Keywords: organic synthesis; heterocyclic compounds; biological activity; medicine; therapeutics

(This special issue belongs to the Section Medicinal Chemistry)

Pharmacology of Heart Failure

edited by

Wioletta Szczurek-Wasilewicz

and

Bożena Szyguła-Jurkiewicz

submission deadline 31 Dec 2025 | 3 articles | Viewed by 7928 | Submission Open

Keywords: heart failure; pharmacological treatment; drug interactions; side effect; comorbidities

(This special issue belongs to the Section Pharmacology)

Heterocyclic Chemistry in Modern Drug Development

edited by

Anna Kasprzycka

and

Magdalena Skonieczna

submission deadline 31 Dec 2025 | 3 articles | Viewed by 6383 | Submission Open

Keywords: heterocycles; drug design; drug development; green synthesis; organic synthesis; synthetic biology; enzyme inhibitors; medicinal chemistry; cell biology; in vitro assay

(This special issue belongs to the Section Medicinal Chemistry)

Novel Heterocyclic Compounds as Potential Anti-Inflammatory and/or Anticancer Agents

edited by Ester Colarusso and

Assunta Giordano

submission deadline 31 Dec 2025 | 1 articles | Viewed by 3745 | Submission Open

Keywords: drug discovery; medicinal chemistry; privileged scaffolds; heterocyclic compounds; anticancer activity; anti-inflammatory activity

(This special issue belongs to the Section Medicinal Chemistry)

Infectious Disease Epidemiology and Pharmaceutical Development in the Era of Antimicrobial Resistance (AMR)

edited by Victoria Birlutiu

submission deadline 31 Dec 2025 | 2 articles | Viewed by 2748 | Submission Open

Keywords: antimicrobial resistance (AMR); antibiotic stewardship; multidrug-resistant organisms (MDROs); infectious disease epidemiology; rapid diagnostics; antimicrobial surveillance; therapeutic development; resistance mechanisms

(This special issue belongs to the Section Pharmacology)

PET/CT for Diagnosis, Treatment Planning and Prognosis Prediction in Oncology and Inflammatory Diseases

edited by

Alessio Rizzo

and

Giorgio Treglia

submission deadline 31 Dec 2025 | 1 articles | Viewed by 2211 | Submission Open

Keywords: nuclear medicine; PET/CT; radiopharmaceuticals; theragnostics; oncology; inflammation; personalised medicine

(This special issue belongs to the Section Radiopharmaceutical Sciences)

Recent Strategies for Delivery of Plant-Based Active Ingredients

edited by

Federica De Gaetano

and

Cinzia Anna Ventura

submission deadline 31 Dec 2025 | 1 articles | Viewed by 2054 | Submission Open

Keywords: drug delivery; polymeric nanoparticles; lipid nanosystems; inclusion complexes; polymeric cyclodextrins; protein carriers; inorganic delivery systems; nanostructured carriers; chemical– physical characterization; in vitro/ex vivo/in vivo evaluation

(This special issue belongs to the Section Pharmaceutical Technology)

Next-Generation Antinfective Agents

edited by

Fiorella Meneghetti

and

Daniela Barlocco

submission deadline 31 Dec 2025 | 1 articles | Viewed by 1771 | Submission Open

Keywords: small molecules; peptides; peptidomimetics; bacterial infections; fungi; virus; parasites; drug design; computational tools; biology assays; resistance mechanisms

(This special issue belongs to the Section Medicinal Chemistry)

Recent Advances in the Research of Drug Delivery System: Materials, Preparation Methods, and Mechanisms

edited by

Haixia Chen

submission deadline 31 Dec 2025 | 1 articles | Viewed by 1411 | Submission Open

Keywords: drug delivery system; preparation; material; mechanism; application; bioactivities; targeted delivery

(This special issue belongs to the Section Pharmaceutical Technology)

Applications of Nerve Growth Factor in Pharmaceuticals

edited by

Lorenzo Di Sarno

and Antonio Chiaretti

submission deadline 31 Dec 2025 | 1 articles | Viewed by 1355 | Submission Open

Keywords: nerve growth factor; neurotrophins; neuroplasticity; brain injury; neuronal survival

(This special issue belongs to the Section Pharmacology)

New Perspective on Bioactive Peptides from Natural Sources: Current Applications and Future Directions

edited by

Daniel Dias Rufino Arcanjo

and

José Roberto de Souza de Almeida Leite

submission deadline 31 Dec 2025 | 1 articles | Viewed by 1296 | Submission Open

Keywords: bioactivity; bioassays; bioproducts; functional foods; immunogenicity; nutraceuticals; pharmacology; plant-derived peptides; skin secretion; toxicology; venom

Displaying special issue 51-100 on page 2 of 8.

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