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Pharmaceuticals publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Therapeutic Potential of Silver Nanoparticles (AgNPs), 2nd Edition

edited by

Goreti Pereira

submission deadline 31 Jul 2025 | Viewed by 139 | Submission Open

Keywords: metallic nanostructures; plasmonic nanomaterials; photothermal therapy; photodynamic therapy; antimicrobial; antioxidant; anticancer

(This special issue belongs to the Section Medicinal Chemistry)

Advancing Cardio-Oncology: Mechanisms of Cardiotoxicity and Therapeutic Options for Old and New Anticancer Drugs

edited by

Vera Marisa Costa

submission deadline 31 Jul 2025 | Viewed by 124 | Submission Open

Keywords: cardio-oncology; anticancer therapies; cardiac dysfunction; hypertension; heart failure; intercellular communication; treatment; prevention; diagnosis; cardiac remodeling

(This special issue belongs to the Section Pharmacology)

Recent Advances in Natural Product-Based Nanostructured Systems: 2nd Edition

edited by

Luís Alexandre Muehlmann

and

João Paulo Longo

submission deadline 31 Jul 2025 | Viewed by 104 | Submission Open

Keywords: natural product; nanostructured systems; nanotechnology; nanostructures; nanocarriers; bioactive compounds

(This special issue belongs to the Section Natural Products)

Next-Generation Antinfective Agents

edited by

Fiorella Meneghetti

and

Daniela Barlocco

submission deadline 31 Jul 2025 | Viewed by 103 | Submission Open

Keywords: small molecules; peptides; peptidomimetics; bacterial infections; fungi; virus; parasites; drug design; computational tools; biology assays; resistance mechanisms

(This special issue belongs to the Section Medicinal Chemistry)

Identification and Extraction of Bioactive Compounds from Marine Life

edited by

Monde Mc Millan Ntwasa

and Wilfred T. Mabusela

submission deadline 31 Jul 2025 | Viewed by 102 | Submission Open

Keywords: natural products; marine life; bioactive compounds; cancer; antimicrobials

(This special issue belongs to the Section Natural Products)

Emerging Therapeutics for the Prevention of Chemotherapy-Induced Cardiotoxicity: Advances and Future Perspectives

edited by

Luigi Spadafora

Marco Bernardi

, Sarto Sarto and

Vincenzo Quagliariello

submission deadline 31 Jul 2025 | Viewed by 100 | Submission Open

Keywords: cardio-oncology; chemotherapy-induced cardiotoxicity; cardioprotective agents; biomarkers; heart failure prevention; precision medicine; pharmacological innovation; molecular targets; cancer survivorship; multidisciplinary care

(This special issue belongs to the Section Pharmacology)

Scientific Evidence-Based Applications of Polyamines in Pharmaceuticals Science

edited by Kuniyasu Soda

submission deadline 5 Aug 2025 | Viewed by 138 | Submission Open

Keywords: polyamine; spermine; spermidine; health; senescence; age-related; disease

(This special issue belongs to the Section Pharmacology)

The Role of Phytochemicals in Aging and Aging-Related Diseases

edited by

Giovanni Scapagnini

Sergio Davinelli

and

Alessandro Medoro

submission deadline 15 Aug 2025 | 6 articles | Viewed by 11485 | Submission Open

Keywords: phytochemicals; plant-based diet; dietary supplementation; pharma-nutrition; aging; aging-related diseases; prevention

(This special issue belongs to the Section Natural Products)

Innovative Tools for Drug Analysis and Therapeutic Drug Monitoring (TDM)

edited by

Juraj Piestansky

and

Andrej Kovac

submission deadline 15 Aug 2025 | 5 articles | Viewed by 7726 | Submission Open

Keywords: therapeutic drug monitoring; analysis of drugs; separation analytical methods; mass spectrometry; bioanalysis; quality control; dosage forms; green analytical chemistry

(This special issue belongs to the Section Pharmacology)

Natural Products in Internal Diseases: From Preclinical Research to Clinical Translation

edited by Roberto Pontarolo,

Luana Mota Ferreira

and

Raul Edison Luna Lazo

submission deadline 15 Aug 2025 | 1 articles | Viewed by 333 | Submission Open

Keywords: natural products; internal diseases; cardiovascular diseases; diabetes; autoimmune disorders; gastrointestinal conditions; respiratory illnesses

Potential Therapeutic Targets for the Management of Diabetes Mellitus, Obesity and Cancer

edited by Marisa Jádna Silva Frederico and

Fátima Regina Mena Barreto Silva

submission deadline 15 Aug 2025 | Viewed by 161 | Submission Open

Keywords: diabetes; obesity; cancer; pharmacological targets

(This special issue belongs to the Section Pharmacology)

Enzyme Inhibitors: Potential Therapeutic Approaches, 2nd Edition

edited by

Phaedra Eleftheriou

submission deadline 15 Aug 2025 | Viewed by 127 | Submission Open

Keywords: enzymes; inhibitors; competitive; uncompetitive; non-competitive; drug target; pharmaceutical approach; disease treatment

(This special issue belongs to the Section Medicinal Chemistry)

Glial Cells as Drug Targets for Schizophrenia

edited by

Kumlesh Kumar Dev

and Paraskevi Papakyriakopoulou

submission deadline 15 Aug 2025 | Viewed by 99 | Submission Open

Keywords: schizophrenia; astrocytes; oligodendrocytes; microglia

(This special issue belongs to the Section Pharmacology)

Interdisciplinary Approaches to Preventing and Treating Inflammatory and Oxidative Diseases with Medicinal Plants and Bioactive Compounds

edited by

Lucas Fornari Laurindo

and

Sandra Barbalho

submission deadline 15 Aug 2025 | Viewed by 93 | Submission Open

Keywords: interdisciplinary studies; inflammation; inflammatory diseases; oxidative stress; oxidative diseases; pro-inflammatory; pro-oxidative; neurodegenerative diseases; cardiovascular diseases; cancer; medicine; rheumatological diseases; endocrinological diseases; gastroenterological diseases; dermatological diseases; pulmonary diseases; dentistry; nutrition; dietetics; therapy; medicinal plants; bioactive compounds; phytochemicals; phytochemistry

(This special issue belongs to the Section Natural Products)

Design, Synthesis and Development of Novel Antiviral Agents

edited by

Antonio Lupia

submission deadline 20 Aug 2025 | 2 articles | Viewed by 3375 | Submission Open

Keywords: viruses; emerging viral diseases; infectious diseases; antiviral agents; small molecules; structure− activity relationship (SAR) studies; drug design (DD) and synthesis; computer-aided drug discovery (CADD); medicinal chemistry

(This special issue belongs to the Section Medicinal Chemistry)

Integrating Machine Learning (ML) into Medicinal Chemistry and Cheminformatics

edited by

Vartika Tomar

submission deadline 20 Aug 2025 | 3 articles | Viewed by 2649 | Submission Open

Keywords: small molecules; molecular descriptors; molecular similarity; structure-based and ligand-based screening; homology modeling; molecular docking; drug– receptor docking; biological activity

(This special issue belongs to the Section Medicinal Chemistry)

Small-Molecule Inhibitors for Novel Therapeutics

edited by

Gustavo Provensi

and Simone Giovannuzzi

submission deadline 20 Aug 2025 | 2 articles | Viewed by 2597 | Submission Open

Keywords: small molecules; enzyme inhibition/activation; protein modulation; novel therapeutics; high-throughput screening; target proteins; drug delivery

Computational (In Silico) Approaches for Drug Target Discovery and Disposition

edited by

Frederico Severino Martins

and

Leonardo Luiz Borges

submission deadline 20 Aug 2025 | 1 articles | Viewed by 621 | Submission Open

Keywords: computational drug discovery; in silico modeling; drug target identification; pharmacokinetics (pk); physiologically based pharmacokinetics (PBPK); physiologically based biokinetics (PBBK); physiologically based biopharmaceutics (PBBM); ADME/Tox; machine learning in drug development; systems pharmacology

Pharmaceutical Process Engineering: Experimental and Computational Innovation

edited by Marcial Gonzalez and Francesco Destro

submission deadline 22 Aug 2025 | Viewed by 96 | Submission Open

Keywords: pharmaceutical process engineering; process development; process analytical technology (PAT); process analytical chemistry (PAC); quality by design (QbD); sustainable manufacturing; drug product quality; biopharmaceuticals

(This special issue belongs to the Section Pharmaceutical Technology)

New Approaches to Fighting Infectious Diseases: Overcoming the Antimicrobial Resistance in Current Treatments

edited by

Antonia Efstathiou

and

Dimitra K. Toubanaki

submission deadline 25 Aug 2025 | 11 articles | Viewed by 22366 | Submission Open

Keywords: infectious diseases; antimicrobial resistance; parasites; viruses; bacteria; treatment approaches; therapeutics; chemotherapy; targeted drug design; natural products

(This special issue belongs to the Section Medicinal Chemistry)

Natural Products in Health Promotion and Disease Prevention 2025

edited by

Marco G. Alves

and

Ariane Zamoner

submission deadline 25 Aug 2025 | 6 articles | Viewed by 10383 | Submission Open

Keywords: natural products; nutraceuticals; bioactive compounds; traditional medicine; drug discovery

(This special issue belongs to the Section Natural Products)

Psychiatric Drug Treatment and Drug Addiction

edited by

Javier Navarro-Zaragoza

submission deadline 25 Aug 2025 | 2 articles | Viewed by 7617 | Submission Open

Keywords: drug addiction; drug abuse; psychiatric disorder; drug dependence

(This special issue belongs to the Section Pharmacology)

Tumor Immunopharmacology

edited by

Marco A. Velasco-Velázquez

submission deadline 25 Aug 2025 | 4 articles | Viewed by 7537 | Submission Open

Keywords: immunotherapy; immunomodulation; drug development; cytokine receptor antagonist; T-cell based therapies; therapeutic antibodies; drug delivery; cancer vaccine

(This special issue belongs to the Section Pharmacology)

Progress of Hydrogel Applications in Novel Drug Delivery Platforms

edited by

Anna Drabczyk

and

Katarzyna Bialik-Wąs

submission deadline 25 Aug 2025 | 4 articles | Viewed by 5984 | Submission Open

Keywords: hydrogels; targeted drug delivery; drug release; drug delivery; smart hydrogels; stimuli-responsive hydrogels; controlled release; hydrogel-based drug delivery; drug carriers

(This special issue belongs to the Section Pharmaceutical Technology)

Drug Candidates for the Treatment of Obesity, 2nd Edition

edited by

Maria Isabel Cardoso Alonso-Vale

and

Monica Marques Telles

submission deadline 25 Aug 2025 | 3 articles | Viewed by 5524 | Submission Open

Keywords: obesity; appetite supressors; nutraceuticals; plant extracts; lipid metabolism; high-fat diet; adipogenesis

(This special issue belongs to the Section Medicinal Chemistry)

The 20th Anniversary of Pharmaceuticals—New Insights in Medicinal Chemistry of Nitrogen-Containing Compounds

edited by

María del Carmen Terán Moldes

and Pedro Besada Pereira

submission deadline 25 Aug 2025 | 2 articles | Viewed by 4591 | Submission Open

Keywords: drug design; synthesis; nitrogen heterocycles; nitrogen functional groups; biological activity; structure-activity relationship; molecular modeling

(This special issue belongs to the Section Medicinal Chemistry)

Small Molecule Drug Discovery: Driven by In-Silico Techniques

edited by

Roberta Rocca

submission deadline 25 Aug 2025 | 1 articles | Viewed by 2325 | Submission Open

Keywords: drug discovery; nutraceuticals; virtual screening; docking; molecular dynamics; pharmacophore; lead compound

(This special issue belongs to the Section Medicinal Chemistry)

Recent Advancements in Radiochemistry and PET Radiotracer Development: 2nd Edition

edited by Kenneth Dahl and

Sangram Nag

submission deadline 25 Aug 2025 | 1 articles | Viewed by 1078 | Submission Open

Keywords: radiochemistry; labeling; automation; GMP; PET; radiotracer; radioligand; radiopharmaceutical; drug discovery

(This special issue belongs to the Section Radiopharmaceutical Sciences)

Flavonoids in Medicinal Chemistry: Trends and Future Directions

edited by

Honorina Cidade

submission deadline 25 Aug 2025 | Viewed by 433 | Submission Open

Keywords: flavonoids; synthesis; natural products; medicinal chemistry; biological activity

(This special issue belongs to the Section Medicinal Chemistry)

Natural Pharmaceutical Component Analysis

edited by

Tingting Zhou

submission deadline 25 Aug 2025 | 1 articles | Viewed by 315 | Submission Open

Keywords: natural pharmaceutical component analysis; data acquisition technologies; pretreatment methods; data processing; online activity analysis

(This special issue belongs to the Section Natural Products)

Pharmacological Approaches of Chronic Obstructive Pulmonary Disease (COPD) and Lung Cancer

edited by

Karolina H. Czarnecka-Chrebelska

and

Jinxiang Xi

submission deadline 25 Aug 2025 | Viewed by 265 | Submission Open

Keywords: chronic obstructive pulmonary disease (COPD); inflammasomes; lung cancer (LC); chronic bronchitis; cancer prevention and treatment; therapeutic approaches

(This special issue belongs to the Section Pharmacology)

Pharmacology and Mechanism of Action of Peptides in the Brain

edited by

Jana Tchekalarova

submission deadline 25 Aug 2025 | Viewed by 223 | Submission Open

Keywords: peptide derivatives; neuropeptides; receptors; brain; pain; epilepsy; depression; anxiety

(This special issue belongs to the Section Pharmacology)

Neuropsychiatric Disorders: Pharmacological Aspects

edited by

Ioana-Miruna Balmus

submission deadline 25 Aug 2025 | Viewed by 207 | Submission Open

Keywords: neuropsychiatric disorders; DSM-V; pharmacodynamics; innovative therapies; animal models; neuropsychiatric patients; trauma and stress; neurodegeneration; affective disorders; neurodevelopmental disorders; schizophrenia; sleep disorders; comorbidities; cardiovascular; coagulopathies; gastrointestinal; microbiome– gut– brain axis

(This special issue belongs to the Section Pharmacology)

Application of Neuroimaging Biomarkers in the Diagnosis and Treatment of Mental Diseases, 2nd Edition

edited by Deborah A. Yurgelun-Todd, Douglas Kondo, Nicolas A Nunez, Perry Franklin Renshaw and Dost Öngür

submission deadline 25 Aug 2025 | Viewed by 142 | Submission Open

Keywords: neuroimaging; biomarkers; 1H-MRS; 31P-MRS; brain spectroscopy; mood disorders

(This special issue belongs to the Section Pharmaceutical Technology)

Network Pharmacology of Natural Products, 2nd Edition

edited by

Alexander George Panossian

and

Karl Wah-Keung Tsim

submission deadline 25 Aug 2025 | Viewed by 113 | Submission Open

Keywords: natural compounds; plant extracts; structure-activity relationship; network pharmacology; multitarget effects; synergy of complex preparations; pleiotropic activity

(This special issue belongs to the Section Natural Products)

Treatment and Molecular Mechanisms of Depression

edited by Zuleide Maria Ignácio and Ricieri Mocelin

submission deadline 25 Aug 2025 | Viewed by 103 | Submission Open

Keywords: major depressive disorder; molecular mechanisms; neurotransmitters; epigenetic; genetic polymorphisms; inflammation; neuroinflammation; pharmacological strategies; drugs; intracellular signaling

(This special issue belongs to the Section Medicinal Chemistry)

Application of MRI in Drug Metabolism and Pharmacokinetics

edited by

Do-Wan Lee

and

Donghoon Lee

submission deadline 25 Aug 2025 | Viewed by 100 | Submission Open

Keywords: MRI; drug metabolism; pharmacokinetics; chemical exchange saturation transfer (CEST); magnetic resonance spectroscopy (MRS); advanced imaging techniques; molecular imaging; preclinical imaging; quantitative imaging biomarkers; ADME (absorption; distribution; metabolism; excretion)

(This special issue belongs to the Section Pharmacology)

Advances in Smooth Muscle Pharmacology

edited by

Beata Modzelewska

, Tomasz Kleszczewski and

Jacek Kapała

submission deadline 25 Aug 2025 | Viewed by 70 | Submission Open

Keywords: smooth muscle regulation; pharmacological interventions; ion channel modulation; receptor– ligand dynamics; therapeutic drug development; vascular tone regulation; smooth muscle disorders; translational pharmacology; cellular signaling pathways; pathophysiology

(This special issue belongs to the Section Pharmacology)

Lithium in Psychiatric Therapy: Celebrating 75th Anniversary

edited by

Janusz K. Rybakowski

and Ewa Ferensztajn-Rochowiak

submission deadline 28 Aug 2025 | 5 articles | Viewed by 7501 | Submission Open

Keywords: lithium; bipolar disorder; mania; depression; the prevention of recurrences; suicide; dementia; immunomodulation; genetics; kidney function

(This special issue belongs to the Section Pharmacology)

Unveiling Nature's Pharmacy: Exploring Drug Discovery Through Medicinal Plants

edited by

Guglielmina Froldi

submission deadline 29 Aug 2025 | 2 articles | Viewed by 3130 | Submission Open

Keywords: plant-derived drugs; secondary metabolites; advanced glycation end-products (AGEs); reactive oxygen species (ROS); molecular targets; pharmacokinetics; ADMET; bioavailability

(This special issue belongs to the Section Natural Products)

Natural Products for Therapeutic Potential

edited by

Xavier Siwe Noundou

submission deadline 29 Aug 2025 | 2 articles | Viewed by 2473 | Submission Open

Keywords: natural products chemistry; therapeutic potential; medicinal plants; marine organisms; microorganisms; bioactive compounds; natural products inspired compounds; biological activities; computational chemistry

(This special issue belongs to the Section Natural Products)

Advanced Nanosystems and Emerging Therapies: Innovations in Tuberculosis Treatment and Drug Resistance

edited by

Fernando Rogério Pavan

submission deadline 29 Aug 2025 | Viewed by 287 | Submission Open

Keywords: nanosystems; tuberculosis therapy; drug delivery; multidrug-resistant Mycobacterium tuberculosis (MDR-TB); nanotechnology-based therapeutics

(This special issue belongs to the Section Pharmaceutical Technology)

P2X Receptors and Their Pharmacology

edited by

Robson Xavier Faria

submission deadline 31 Aug 2025 | Viewed by 437 | Submission Open

Keywords: compounds; substances; synthetic; natural product; inhibitor; purinergic receptor; ATP; antagonista

(This special issue belongs to the Section Pharmacology)

Advances in Cancer Treatment and Toxicity

edited by

Dinender K. Singla

submission deadline 31 Aug 2025 | Viewed by 294 | Submission Open

Keywords: oxidative stress; cell signaling; cell death; tissue remodeling; inflammation; molecular mechanisms; heart; muscle; antioxidants; cell therapy; exosomes

(This special issue belongs to the Section Pharmacology)

Synthesis and Biological Activity of Metal Complexes

edited by

Francois Dufrasne

submission deadline 31 Aug 2025 | Viewed by 190 | Submission Open

Keywords: metal complexes; biological activity; synthesis; pharmacology; cancer; pathogens; medicine; chemistry; stability; target

(This special issue belongs to the Section Medicinal Chemistry)

Antibiotic Resistance and Misuse

edited by

Bogdan Vintila

Claudiu Morgovan

and

Anca-Maria Arseniu

submission deadline 31 Aug 2025 | Viewed by 185 | Submission Open

Keywords: antibiotic resistance; antibiotic misuse; antimicrobial stewardship; infection control; resistance mechanisms; diagnostic innovations; therapeutic strategies; policy reforms; clinical outcomes

(This special issue belongs to the Section Pharmacology)

A Commemorative Special Issue in Honor of Professor Eliezer J. Barreiro: Early Drug Discovery: From Target Identification and Validation to Lead Optimization

edited by

Luzineide Tinoco

and

Lídia Lima

submission deadline 31 Aug 2025 | Viewed by 124 | Submission Open

Keywords: target validation; LBDD; FBDD; SBDD; QSAR; artificial intelligence; organic synthesis; natural product; drug discovery; medicinal chemistry

(This special issue belongs to the Section Medicinal Chemistry)

Advances in Antiparasitic Drug Research

edited by