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Pharmaceuticals publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Medicinal Chemistry of Metal Complexes: Design, Synthesis and Evaluation

edited by

Bojana B. Zmejkovski

Goran Kaluđerović

and

Nebojša Pantelić

submission deadline 25 Nov 2025 | 1 articles | Viewed by 1669 | Submission Open

Keywords: metal complexes; medicinal chemistry; bioinorganic chemistry; coordination chemistry; organometallics; metal-based drugs; biological activity; toxicology; biomedical application; drug delivery

(This special issue belongs to the Section Medicinal Chemistry)

Recent Advances in the Discovery and Development of Drugs for Civilization Diseases, 2nd Edition

edited by

Marcin Gackowski

Karolina Szewczyk-Golec

and

Renata Studzińska

submission deadline 25 Nov 2025 | 3 articles | Viewed by 1094 | Submission Open

Keywords: anticancer drugs; anticancer treatment; anticoagulants; atherosclerosis; cardiovascular disease; civilization diseases; diabetes mellitus; drug development; in silico research; medication form/drug dosage form; molecular descriptors; molecular docking; molecular dynamics; molecular modeling; neoplastic disease; obesity; QSAR; radiopharmaceuticals; synthesis of bioactive compounds; type 2 diabetes

(This special issue belongs to the Section Medicinal Chemistry)

The Therapeutic Potential of Cannabidiol

edited by

Karolina Walczyńska-Dragon

and

Anna Kurek-Górecka

submission deadline 25 Nov 2025 | 1 articles | Viewed by 988 | Submission Open

Keywords: cannabidiol; endocannabinoid system; pain; anti-inflammatory agents; muscle spasticity; pain management; chronic pain

(This special issue belongs to the Section Natural Products)

Innovations in Therapeutic Strategies for Retinal and Neurodegenerative Diseases

edited by

Tonking Bastola

and Won-Kyu Ju

submission deadline 25 Nov 2025 | 1 articles | Viewed by 918 | Submission Open

Keywords: glaucoma; Alzheimer's diseases; retinal disease; neuroprotection; neuroinflammation

(This special issue belongs to the Section Pharmacology)

Pharmaceutical Approaches to Orofacial Pain and Chronic Pain Conditions

edited by

Takahiko Nagamine

submission deadline 25 Nov 2025 | 1 articles | Viewed by 823 | Submission Open

Keywords: chronic orofacial pain; pharmaceutical approach; myofascial orofacial pain; temporomandibular joint pain; neurovascular orofacial pain; idiopathic orofacial pain; burning mouth syndrome; persistent idiopathic facial pain; persistent idiopathic dentoalveolar pain; tricyclic antidepressants; serotonin reuptake inhibitors; anticonvulsants

(This special issue belongs to the Section Pharmacology)

Pharmacology and Toxicology of Opioids, 2nd Edition

edited by

Juliana Faria

, Joana Barbosa and

Ricardo Dinis-Oliveira

submission deadline 25 Nov 2025 | Viewed by 587 | Submission Open

Keywords: opioid toxicity; opioid pharmacodynamics; opioid pharmacokinetics; opioid pharmacogenetics; prescription opioids; toxicity assays; in vivo; in vitro; abuse; dependence

(This special issue belongs to the Section Pharmacology)

Antimicrobial Therapies Affect the Microbial Ecosystems Within Our Body: The Urinary Microbiome and Urolithiasis

edited by

Loredana Sabina Cornelia Manolescu

submission deadline 25 Nov 2025 | 1 articles | Viewed by 584 | Submission Open

Keywords: antibiotics; antimicrobials; resistance; microbiome; urolithiasis; biofilms; infections; pathogens; pharmacotherapy; inflammation

(This special issue belongs to the Section Pharmacology)

Cutting-Edge Biotechnologies and Applications of Natural Products in Drug R&D and Disease Treatment

edited by

Sujay Paul

submission deadline 25 Nov 2025 | 1 articles | Viewed by 508 | Submission Open

Keywords: natural products; bioactive compounds; natural product drug discovery and drug design; natural drug formulation; metabolic engineering for bioactive compounds; natural therapeutic agents; nanoformulations of natural compounds; synthetic biology for natural product biosynthesis; genome editing and creation of novel bioactive compounds

(This special issue belongs to the Section Natural Products)

New Findings in Pharmacogenomics of Neuropsychiatric Disorders

edited by

Alireza Tafazoli

and

Mandana Hasanzad

submission deadline 25 Nov 2025 | Viewed by 414 | Submission Open

Keywords: pharmacogenomics; genome informatics; advanced DNA-sequencing technologies; bioinformatics of pharmacogenomics; diagnostic approaches in the pharmacogenomics of neuropsychiatric disorders

(This special issue belongs to the Section Pharmacology)

Research on Diagnosis, Treatment and Related Microbiota in Gastrointestinal Diseases

edited by

Edoardo V. Savarino

and Brigida Barberio

submission deadline 25 Nov 2025 | Viewed by 272 | Submission Open

Keywords: gut microbiota; inflammatory bowel disease; eosinophilic esophagitis; primary sclerosing cholangitis; metabolic-associated steatotic liver disease; immune checkpoint inhibitor colitis; dysbiosis; prebiotics; probiotics

(This special issue belongs to the Section Medicinal Chemistry)

The Development and Application of Broad-Spectrum Antiviral Drugs

edited by Chieh-Wen Lo

submission deadline 25 Nov 2025 | Viewed by 236 | Submission Open

Keywords: broad-spectrum antiviral; direct-acting antiviral; host-targeted antiviral; emerging viruses; pandemic preparedness

(This special issue belongs to the Section Medicinal Chemistry)

Anticancer Compounds in Medicinal Plants—4th Edition

edited by

Paulo Santos

and

Lillian Barros

submission deadline 25 Nov 2025 | Viewed by 214 | Submission Open

Keywords: natural products; phytochemicals; cancer; secondary metabolites; medicinal plants

(This special issue belongs to the Section Natural Products)

Application of Nanotechnology in Drug Delivery

edited by Camila Batista Da Silva and

Michelle Franz-Montan

submission deadline 25 Nov 2025 | Viewed by 170 | Submission Open

Keywords: drug discovery; drug combinations; nanotechnology; drug liberation

(This special issue belongs to the Section Pharmaceutical Technology)

Advances in Hydrazone Compounds with Anticancer Activity

edited by

Boryana Nikolova-Mladenova

and

Mariyana Atanasova

submission deadline 25 Nov 2025 | Viewed by 140 | Submission Open

Keywords: hydrazones; lipophilicity; logP; anticancer activity; selectivity

(This special issue belongs to the Section Medicinal Chemistry)

Pharmacological Activities of Flavonoids and Their Analogues, Third Edition

edited by

Fernando Calzada

and

Miguel Valdes

submission deadline 25 Nov 2025 | Viewed by 133 | Submission Open

Keywords: natural products; polyphenols; flavonoids; medicinal chemistry; traditional medicine; flavonoids isolation; flavonoids identification; flavonoids pharmacology; flavonoids as prodrugs; in vivo; in vitro; and in silico studies; molecular modeling studies

(This special issue belongs to the Section Natural Products)

Pharmacovigilance Insights: Addressing Drug Misuse and Enhancing Drug Safety

edited by

Cristina Sofia De Jesus Monteiro

and

Samuel Martins Silvestre

submission deadline 25 Nov 2025 | Viewed by 110 | Submission Open

Keywords: adverse drug reaction; pharmacovigilance; drug safety; signal detection; risk management

(This special issue belongs to the Section Pharmacology)

Epithelial Plasticity and Therapy Resistance in Cancer

edited by Naisana Seyedasli

submission deadline 25 Nov 2025 | Viewed by 98 | Submission Open

Keywords: cancer stem cells; epithelial– mesenchymal transition; epithelial reprogramming; resistance; drug targets; resistance mechanisms; biomarker discovery

(This special issue belongs to the Section Pharmacology)

Dental Medication

edited by

Michelle Franz-Montan

and Camila Batista Da Silva

submission deadline 25 Nov 2025 | Viewed by 92 | Submission Open

Keywords: dental medication; local anesthetics; controlled drug delivery; nanotechnology in dentistry; therapeutic biomaterials; smart drug delivery systems; digital health in dental pharmacology; dental materials

(This special issue belongs to the Section Pharmaceutical Technology)

Metal Complexes in Medicinal Chemistry: From Coordination Chemistry to Pharmaceutical Applications

edited by

Laura Rodriguez-Silva

and Cristina Núñez González

submission deadline 25 Nov 2025 | Viewed by 71 | Submission Open

Keywords: medicinal inorganic chemistry; metallodrugs; coordination compounds; bioinorganic chemistry; anticancer agents; antimicrobial agents; therapeutic applications; diagnostic applications; bioactive metal complexes; drug development

(This special issue belongs to the Section Medicinal Chemistry)

Small Molecules to Fight Cancer and Neurodegenerative Diseases

edited by

Daniela Catarzi

Vittoria Colotta

and

Flavia Varano

submission deadline 25 Nov 2025 | Viewed by 60 | Submission Open

Keywords: small molecules; cancer; neurodegenerative diseases; receptor ligands; enzyme modulators; targeted drugs; multitarget agents; PROTACs; immunomodulators; natural products; drug design

(This special issue belongs to the Section Medicinal Chemistry)

Synthesis, In Silico Prediction and Antitumor Activity of Nitrogen Heterocycle-Based Drug Development

edited by Jamerson F. De Oliveira and Paulo André Teixeira de Moraes Gomes

submission deadline 25 Nov 2025 | Viewed by 59 | Submission Open

Keywords: privileged structures; nitrogen heterocycles; ADMET prediction; cancer biological target; molecular dynamic; computational studies; antitumor activity; in vitro and in vivo studies; SAR of lead compounds; molecular hybridization

(This special issue belongs to the Section Medicinal Chemistry)

Targeting Bacterial Metabolism with Natural and Synthetic Inhibitors

edited by

Mihaela Ileana Ionescu

Cristina Nastasă

and

Ovidiu Oniga

submission deadline 25 Nov 2025 | Viewed by 50 | Submission Open

Keywords: bacterial metabolism; protein kinases; therapeutic strategy; clinical studies; natural inhibitors; enzymatic activity; drug design; structural studies

(This special issue belongs to the Section Medicinal Chemistry)

Boron-Containing Compounds: Identification, Synthesis, Biological Actions and Pharmacology

edited by

Marvin Antonio Soriano-Ursúa

and

Andrei Biță

submission deadline 28 Nov 2025 | 2 articles | Viewed by 3678 | Submission Open

Keywords: boron; drug development; drug discovery; bioactive boron compounds; bioinorganic chemistry; inorganic biological chemistry; synthesis; natural boron compounds; chemical characterization

(This special issue belongs to the Section Medicinal Chemistry)

Medicinal Plants: Current Insights into Their Biological Activities and Integration with Micro- or Nanotechnologies

edited by

Jorge L. Mejía Méndez

Gildardo Sanchez-Ante

and

Edgar R. López-Mena

submission deadline 28 Nov 2025 | 2 articles | Viewed by 3173 | Submission Open

Keywords: medicinal plants; plant extracts; bioactive nanomaterials; inorganic materials; organic materials; drug delivery systems

Next-Generation Targeted Therapy: vNARs as Drug Carriers and Intracellular Neutralizing Agents

edited by

Tanya Camacho-Villegas

and

Mirna Burciaga-Flores

submission deadline 28 Nov 2025 | Viewed by 85 | Submission Open

Keywords: vNAR; drug delivery; intrabodies; payload; nanotechnology; immunotoxins; phage display; biopanning; single-domain antibody

(This special issue belongs to the Section Pharmacology)

New Insights of Sodium-Glucose Cotransporter 2 (SGLT2) Inhibitors in Biomedical Applications

edited by

Afif Nakhleh

, Bshara Mansour and Naim Shehadeh

submission deadline 30 Nov 2025 | 3 articles | Viewed by 5338 | Submission Open

Keywords: SGLT2 Inhibitors; cardiovascular protection; renal health; metabolic benefits

(This special issue belongs to the Section Pharmacology)

Medicinal Plants: Exploring Plant-Based Bioactive Compounds for Metabolic Diseases Prevention and Intervention

edited by

Nceba Gqaleni

and

Suresh Babu Naidu Krishna

submission deadline 30 Nov 2025 | Viewed by 634 | Submission Open

Keywords: metabolic diseases; diabetes; medicinal plants; bioactives; metabolic disorders

(This special issue belongs to the Section Natural Products)

Comprehensive Strategies in Cancer Immunotherapy

edited by Yee Peng Phoon

submission deadline 30 Nov 2025 | Viewed by 176 | Submission Open

Keywords: immunotherapy; CAR-T; TIL therapy; predictive biomarker; neoadjuvant; cytokine therapy; bispecific antibodies; personalized treatment; combination therapies; tumor microenvironment; immune modulation; interaction and mechanism

(This special issue belongs to the Section Pharmacology)

Emerging Computational Approaches in Drug Discovery and Design

edited by

Cleber C. Melo-Filho

submission deadline 30 Nov 2025 | Viewed by 169 | Submission Open

Keywords: computer-aided drug design (CADD); quantitative structure-activity/property relationship (QSAR/QSPR); cheminformatics; virtual screening; data curation; in silico; molecular docking; machine learning; deep learning

(This special issue belongs to the Section Medicinal Chemistry)

Advancements in Radiopharmaceutical Theranostics

edited by

Aiko Yamaguchi

, Shilpa Sharma and

Ryan Patrick Coll

submission deadline 30 Nov 2025 | Viewed by 163 | Submission Open

Keywords: radiopharmaceuticals; radiotheranostics; emerging radionuclides; radiometals; image-guided dosimetry; alpha-emitters; PET; SPECT; radioligand therapy; targeted radionuclide therapy

(This special issue belongs to the Section Radiopharmaceutical Sciences)

Therapeutic Potential of Natural Extracts in Cancer Prevention and Treatment

edited by

Zlatina Gospodinova

and

Michael Danilenko

submission deadline 30 Nov 2025 | Viewed by 140 | Submission Open

Keywords: natural products; anticancer therapeutic potential; cancer chemoprevention; mechanism of action and molecular targets; preclinical and clinical studies

(This special issue belongs to the Section Natural Products)

Advances in Antibody–Drug Conjugates

edited by

Aiko Yamaguchi

submission deadline 30 Nov 2025 | Viewed by 117 | Submission Open

Keywords: antibody– drug conjugates; linker technology; bispecific antibodies; conditionally activated antibodies; degrader– antibody conjugates; antibody– immunotoxin conjugates; antibody– radionuclide conjugates; oncology; autoimmune disease; infectious disease

(This special issue belongs to the Section Pharmacology)

Green Synthesis and Biological Applications of Metal Nanoparticles Influenced by Different Seasonal Periods

edited by Paulo Sérgio Taube and

Gerson Nakazato

submission deadline 30 Nov 2025 | Viewed by 117 | Submission Open

Keywords: nanobiotechnology; metal nanoparticles; green chemistry; biodiversity; seasonality

(This special issue belongs to the Section Pharmacology)

Pharmacological Strategies to Modulate Symptoms in Autism Spectrum Disorders (ASD)

edited by

Jaime Mella Raipan

submission deadline 30 Nov 2025 | Viewed by 106 | Submission Open

Keywords: pharmacological treatment of ASD; neurodevelopmental disorders; molecular modeling and ASD; drug discovery for autism; repurposing drugs for ASD; 5-HT receptors; GABAergic system; TRPC6; mGluR5

(This special issue belongs to the Section Pharmacology)

Population Pharmacokinetics and Pharmacogenetics

edited by

Seung-Hyun Jeong

submission deadline 10 Dec 2025 | 5 articles | Viewed by 4352 | Submission Open

Keywords: pharmacokinetics; pharmacogenetics; precision medicine; population pharmacometrics model; mathematical modeling; dosage regimen; inter-subject variability

(This special issue belongs to the Section Pharmacology)

New Platforms for Cancer Treatment—Emerging Advances

edited by Fernanda Karoline Vieira da Silva Torchelsen, Maria Alice de Oliveira, Renata Tupinambá Branquinho and

Vanessa Carla Furtado Mosqueira

submission deadline 10 Dec 2025 | 1 articles | Viewed by 1113 | Submission Open

Keywords: cancer treatment; emerging advances; nanotechnology; nanotheranostics; novel drugs; nanostructures; pre-clinical studies

(This special issue belongs to the Section Pharmaceutical Technology)

Natural Products for Anticancer, Anti-Inflammatory and Antimicrobial Therapies

edited by Heriberto Torres-Moreno,

Julio César López-Romero

Elena Y. Enioutina

and

Max Vidal Gutiérrez

submission deadline 10 Dec 2025 | Viewed by 230 | Submission Open

Keywords: natural products; anticancer; anti-inflammatory; antimicrobial; pharmacy; pharmacology

(This special issue belongs to the Section Natural Products)

Metal–Organic Frameworks (MOFs) in Drug Delivery

edited by

Vânia André

submission deadline 12 Dec 2025 | Viewed by 66 | Submission Open

Keywords: MOFs; drug delivery; drugs; drug delivery systems

(This special issue belongs to the Section Pharmaceutical Technology)

QSAR and Chemoinformatics in Drug Design and Discovery

edited by

Elena Cichero

and

Naomi Scarano

submission deadline 15 Dec 2025 | 1 articles | Viewed by 301 | Submission Open

Keywords: QSAR modeling; machine learning; ligand-based virtual screening and design; computer-aided drug repurposing; computational methods; molecular modeling; molecular dynamics; drug design

(This special issue belongs to the Section Medicinal Chemistry)

Antifungal Therapy Strategies: A Focus on Novel Compounds and Inhibitors

edited by

Lucimar Ferreira Kneipp

and

André Luis Souza dos Santos

submission deadline 15 Dec 2025 | Viewed by 69 | Submission Open

Keywords: medicinal chemistry; combined therapy; antivirulence action; anti-resistance strategies; drug repositioning; drug delivery; multi-omics technologies

(This special issue belongs to the Section Medicinal Chemistry)

Structural and Computationally Driven Molecule Design in Drug Discovery: 2nd Edition

edited by

Halil İbrahim Ciftci

Belgin Sever

and

Hasan Demirci

submission deadline 20 Dec 2025 | 12 articles | Viewed by 18013 | Submission Open

Keywords: structural dynamics studies; computer-aided drug design; molecular dynamics simulations; molecular docking; virtual screening; QSAR; in silico ADMET; artificial intelligence (AI) techniques

(This special issue belongs to the Section Medicinal Chemistry)

Management of Pain in Oral Mucositis

edited by

Carlos Roldan

and Thomas Chai

submission deadline 20 Dec 2025 | 1 articles | Viewed by 1231 | Submission Open

Keywords: oral mucositis; oral pain; pain management; cancer; cancer therapy

(This special issue belongs to the Section Pharmacology)

Pharmaceutical Applications and Therapeutic Mechanisms of Substances from Plant Origin

edited by Iliya Zhelev Slavov,

Stanislava Ivanova

Nadezhda Hvarchanova

and

Nadezhda Ivanova

submission deadline 20 Dec 2025 | 1 articles | Viewed by 484 | Submission Open

Keywords: natural substances; phytotherapy; phytochemistry; chromatography; pharmacokinetics; pharmacodynamics; drug delivery

(This special issue belongs to the Section Natural Products)

Pharmacologically Active Compounds from Plants

edited by Duc Dat Le and

Cao Van Anh

submission deadline 25 Dec 2025 | 4 articles | Viewed by 9903 | Submission Open

Keywords: herbal medicines; bioactive compounds; NMR; phytochemistry; analytical method

(This special issue belongs to the Section Natural Products)

Inhibition and Treatment in Adhesion, Migration, Invasion, and Metastasis of Cancer Cells

edited by

Magdalena Izdebska

Marta Hałas-Wiśniewska

and Wioletta Arendt

submission deadline 25 Dec 2025 | 3 articles | Viewed by 6391 | Submission Open

Keywords: migration; metastasis; invasion; tumor progression; cell adhesion; cancer; epithelial– mesenchymal transition; cancer therapy

(This special issue belongs to the Section Medicinal Chemistry)

Common Medications Used in Anesthesia

edited by Michał Jan Stasiowski

submission deadline 25 Dec 2025 | 1 articles | Viewed by 1752 | Submission Open

Keywords: anesthesia; medications; pharmacology; perioperative care; drug interactions; patient safety; clinical practice; anesthesia management; drug development; patient outcomes

(This special issue belongs to the Section Medicinal Chemistry)

Photodynamic Therapy: 3rd Edition

edited by

Céline Frochot

submission deadline 25 Dec 2025 | 2 articles | Viewed by 1636 | Submission Open

Keywords: photodynamic therapy; photosensitizers; nanoparticles; photo-diagnosis; targeting; antimicrobial; X-rays excitation; two photon and upconversion; immunomodulation; dosimetry; hypoxia

(This special issue belongs to the Section Pharmaceutical Technology)

Mathematical Modeling in Drug Metabolism and Pharmacokinetics

edited by

Ziran Li

and

Dongsheng Yang

submission deadline 25 Dec 2025 | 2 articles | Viewed by 1252 | Submission Open

Keywords: pharmacokinetics; mathematical modeling; physiologically based pharmacokinetic (PBPK); pharmacokinetic/pharmacodynamic (PK/PD); quantitative systems pharmacology (QSP); machine learning; model-informed drug development; translational modeling; artificial intelligence (AI); personalized medicine

(This special issue belongs to the Section Medicinal Chemistry)

Exosome and Biotherapeutic Strategies for Dermatological and Oncological Skin Complications

edited by

Lidia Majewska

and Jacek M. Kijowski

submission deadline 25 Dec 2025 | 1 articles | Viewed by 310 | Submission Open

Keywords: exosomes; skin cancer; dermatological therapy; extracellular vesicles; biotherapeutics; regenerative medicine; nanomedicine; wound healing; cancer-related skin manifestations; dermatological drug delivery; wound healing therapeutics; cutaneous oncology; exosome-based therapy

(This special issue belongs to the Section Biopharmaceuticals)

Cancer Pain—from Novel Mechanisms to Clinical Management

edited by Xuejun Song and Xiaodong Liu

submission deadline 25 Dec 2025 | Viewed by 250 | Submission Open

Keywords: cancer pain; novel analgesics; mechanism-driven therapeies; pain management; palliative care

(This special issue belongs to the Section Pharmacology)

Displaying special issue 201-250 on page 5 of 7.

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