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Pharmaceuticals publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Silver and Selenium Nanoparticles from Medicinal Plant Extracts: Synthesis and Biological Applications

edited by

Alan Kelbis Oliveira Lima

and

Luis Alexandre Muehlmann

submission deadline 27 Nov 2026 | Viewed by 154 | Submission Open

Keywords: selenium nanoparticles; silver nanoparticles; green synthesis; biological applications; sustainability; nanotechnology; nanomaterials; nanoscience; biotechnology; green chemistry

(This special issue belongs to the Section Pharmaceutical Technology)

The Application of Pharmacogenetics in Toxicity Prevention and Drug Effect Improvement—2nd Edition

edited by Pura Ballester

submission deadline 27 Nov 2026 | Viewed by 131 | Submission Open

Keywords: pharmacogenetics; drug toxicity prevention; efficacy enhancement; pharmaceutical research; precision medicine; therapeutic optimization

(This special issue belongs to the Section Pharmacology)

Computer-Aided Drug Design and Drug Discovery, 2nd Edition

edited by

Dragos Mihai

and

George Mihai Nitulescu

submission deadline 30 Nov 2026 | 12 articles | Viewed by 21187 | Submission Open

Keywords: chemoinformatics; bioinformatics; molecular modeling; virtual screening; molecular docking; quantitative structure–activity relationship (QSAR); pharmacophore modeling; target identification; repurposing; ADME-T prediction

(This special issue belongs to the Section Medicinal Chemistry)

Comprehensive Strategies in Cancer Immunotherapy

edited by Yee Peng Phoon

submission deadline 30 Nov 2026 | 9 articles | Viewed by 20379 | Submission Open

Keywords: immunotherapy; CAR-T; TIL therapy; predictive biomarker; neoadjuvant; cytokine therapy; bispecific antibodies; personalized treatment; combination therapies; tumor microenvironment; immune modulation, interaction and mechanism

(This special issue belongs to the Section Pharmacology)

The Therapeutic Potential of Cannabidiol

edited by

Karolina Walczyńska-Dragon

and

Anna Kurek-Górecka

submission deadline 30 Nov 2026 | 7 articles | Viewed by 14427 | Submission Open

Keywords: cannabidiol; endocannabinoid system; pain; anti-inflammatory agents; muscle spasticity; pain management; chronic pain

(This special issue belongs to the Section Natural Products)

Exosome and Biotherapeutic Strategies for Dermatological and Oncological Skin Complications

edited by

Lidia Majewska

and Jacek M. Kijowski

submission deadline 30 Nov 2026 | 1 articles | Viewed by 11784 | Submission Open

Keywords: exosomes; skin cancer; dermatological therapy; extracellular vesicles; biotherapeutics; regenerative medicine; nanomedicine; wound healing; cancer-related skin manifestations; dermatological drug delivery; wound healing therapeutics; cutaneous oncology; exosome-based therapy

(This special issue belongs to the Section Biopharmaceuticals)

Heterocyclic Chemistry in Modern Drug Development

edited by

Anna Kasprzycka

and

Magdalena Skonieczna

submission deadline 30 Nov 2026 | 3 articles | Viewed by 11536 | Submission Open

Keywords: heterocycles; drug design; drug development; green synthesis; organic synthesis; synthetic biology; enzyme inhibitors; medicinal chemistry; cell biology; in vitro assay

(This special issue belongs to the Section Medicinal Chemistry)

Advances in the Treatment of Leukemia, Lymphomas and Plasma Cell Disorders

edited by

Adriano de Paula Sabino

, Karina Braga Gomes and Maria Das Graças Carvalho

submission deadline 30 Nov 2026 | 4 articles | Viewed by 7344 | Submission Open

Keywords: leukemias; lymphomas; chemotherapy; target therapy; immunotherapy; kinase inhibitors; hematologic oncology; therapy; treatment

(This special issue belongs to the Section Medicinal Chemistry)

Advances in Solid-Phase Peptide and Oligonucleotide Synthesis: Methods, Mechanisms, and Therapeutic Applications

edited by

Danah AlShaer

and

Rakesh Tiwari

submission deadline 30 Nov 2026 | 1 articles | Viewed by 6803 | Submission Open

Keywords: solid-phase peptide synthesis (SPPS); oligonucleotide synthesis; hybrid chemical–enzymatic methods; peptide therapeutics; drug design and discovery; sustainable synthesis; automation and process optimization; resin and linker chemistry; post-synthetic modification; structure–activity relationships

(This special issue belongs to the Section Biopharmaceuticals)

Monitoring, Mitigation, and Risk Assessment of Pharmaceuticals in the Environment

edited by

Goreti Pereira

and

Vania Calisto

submission deadline 30 Nov 2026 | 4 articles | Viewed by 5600 | Submission Open

Keywords: pharmaceuticals; environmental impact; novel analytical techniques; remediation strategies; risk assessment; ecological effects

(This special issue belongs to the Section Pharmaceutical Technology)

Natural Product-Derived Treatments of Neurological and Neuropsychiatric Disorders

edited by

Cristiane S. F. Maia

Enéas A. Fontes-Júnior

Mozaniel Santana de Oliveira

and Jofre J. S. Freitas

submission deadline 30 Nov 2026 | 3 articles | Viewed by 4207 | Submission Open

Keywords: natural products; bioactive compounds; neurological conditions; psychiatric disorders; phytomedicine

Antidiabetic Agents: New Drug Discovery Insights and Prospects

edited by Rosanna Maccari

submission deadline 30 Nov 2026 | 3 articles | Viewed by 4119 | Submission Open

Keywords: diabetes mellitus; drug design; drug discovery; drug development; drug synthesis; computational-aided drug design; molecular targets; biological activity; structure–activity relationships

(This special issue belongs to the Section Medicinal Chemistry)

Design and Synthesis of Compounds with Potential Anti-Inflammatory Activity

edited by

Aleksandra Redzicka

Beata Tylińska

and Anna Wójcicka

submission deadline 30 Nov 2026 | 3 articles | Viewed by 3272 | Submission Open

Keywords: drug design; synthesis; anti-inflammatory activity; cyclooxygenases; lipoxygenases; cytokines; anticancer activity; Alzheimer's disease; neuroinflammation; molecular mechanisms

(This special issue belongs to the Section Medicinal Chemistry)

Antimicrobial and Anticancer Scaffolds in Medicinal Chemistry

edited by

Monika Pitucha

submission deadline 30 Nov 2026 | 2 articles | Viewed by 2149 | Submission Open

Keywords: antimicrobial; anticancer; synthesis; complex; organic compounds; heterocyclic compounds; SAR

(This special issue belongs to the Section Medicinal Chemistry)

Advances in Ocular Drug Delivery: Emerging Technologies for the Anterior Segment

edited by Raquel Gil-Cazorla and Affiong Iyire

submission deadline 30 Nov 2026 | 2 articles | Viewed by 1331 | Submission Open

Keywords: ocular drug delivery; anterior segment; sustained-release systems; nanotechnology; novel delivery platforms

(This special issue belongs to the Section Pharmaceutical Technology)

Natural Products for the Treatment of Anxiety and Depressive Disorders

edited by

Liz Girardi Muller

submission deadline 30 Nov 2026 | 1 articles | Viewed by 1261 | Submission Open

Keywords: natural products; anxiety; depression disorder; synaptic plasticity; mechanistic studies

(This special issue belongs to the Section Natural Products)

Pharmaceutical Targeting of Lipids in Metabolic and Neurological Disorders

edited by

Senka Blažetić

and

Barbara Viljetić

submission deadline 30 Nov 2026 | 1 articles | Viewed by 1231 | Submission Open

Keywords: lipid metabolism; pharmacological targets; metabolic disorders; neurodegenerative diseases; lipid signaling

(This special issue belongs to the Section Pharmacology)

Natural and Synthetic Bioactive Products for Treatment of Immune-Mediated Diseases

edited by

Fernando Calzada

Miguel Valdes

and

Jesica Ramírez-Santos

submission deadline 30 Nov 2026 | 1 articles | Viewed by 1096 | Submission Open

Keywords: diabetes; cancer; diarrhea; viral infections; bacterial infections; fungical infections; drug development; medicinal chemistry; phytochemistry; pharmacognosy; synthesis

(This special issue belongs to the Section Natural Products)

Emerging Computational Approaches in Drug Discovery and Design

edited by

Cleber C. Melo-Filho

submission deadline 30 Nov 2026 | 2 articles | Viewed by 1079 | Submission Open

Keywords: computer-aided drug design (CADD); quantitative structure-activity/property relationship (QSAR/QSPR); cheminformatics; virtual screening; data curation; in silico; molecular docking; machine learning; deep learning

(This special issue belongs to the Section Medicinal Chemistry)

Integrated Molecular Imaging and Targeted Radionuclide Therapy for the Precision Management of Breast and Pancreatic Cancers

edited by

Emmanuel Moreau

submission deadline 30 Nov 2026 | 1 articles | Viewed by 895 | Submission Open

Keywords: molecular imaging; radiotheranostics; targeted radionuclide therapy; radiopharmaceuticals; breast cancer; pancreatic cancer; precision oncology; PET/SPECT imaging; theranostic biomarkers

(This special issue belongs to the Section Radiopharmaceutical Sciences)

Drug Development and Emerging Pharmacotherapies in Stroke Management

edited by Federica Ferrari and

Pengyu Zong

submission deadline 30 Nov 2026 | Viewed by 710 | Submission Open

Keywords: brain ischemic stroke; cerebral hemorrhage; drug discovery; neuroprotection; immunomodulation; blood–brain barrier; drug delivery; biomarkers; neurorepair; post-stroke depression/dementia/spasticity

(This special issue belongs to the Section Pharmacology)

Applications of In Silico Technologies in Drug Design

edited by Xiaojun Yao and

Weiwei Xue

submission deadline 30 Nov 2026 | Viewed by 322 | Submission Open

Keywords: in silico technologies; drug design; molecular docking; molecular dynamics simulation; artificial intelligence; molecular generation; lead optimization; drug repurposing; protein–protein interactions; protein–ligand interactions

(This special issue belongs to the Section Medicinal Chemistry)

Pharmacological Therapy for Epilepsy

edited by Panagiota-Eleni Tsalouchidou and Susanne Knake

submission deadline 30 Nov 2026 | Viewed by 302 | Submission Open

Keywords: epilepsy; pharmacotherapy; antiseizure medications; drug-resistant epilepsy; pharmacokinetics; pharmacodynamics; pharmacogenomics; drug–drug interactions

(This special issue belongs to the Section Pharmacology)

Biosimilars in Oncology: Applications in Pharmaceutics and Pharmaceuticals

edited by Jacopo Giuliani

submission deadline 30 Nov 2026 | Viewed by 301 | Submission Open

Keywords: biosimilars; oncology; randomized controlled trials; pharmacokinetics; pharmacodynamics

(This special issue belongs to the Section Biopharmaceuticals)

Emerging Therapeutic Strategies and Resistance Mechanisms in Brain Tumors

edited by

Chia-Hung Chien

, Kwang-Yu Chang and

Wen-Bin Yang

submission deadline 30 Nov 2026 | Viewed by 261 | Submission Open

Keywords: brain tumors; glioblastoma; therapy resistance; reactive oxygen species; mitochondria; autophagy; tumor-initiating cells; microenvironment; immune therapy; targeted therapy

(This special issue belongs to the Section Pharmacology)

Bioprospecting, Drug Repositioning and Novel Therapeutic Strategies Against Protozoan Infections: From Mechanisms to Translational Applications

edited by

Samuel Teixeira

and Bellisa Freitas Barbosa

submission deadline 30 Nov 2026 | Viewed by 222 | Submission Open

Keywords: bioprospecting; drug repositioning; protozoan infections; mechanism; translational perspectives; congenital and neglected parasitic diseases

(This special issue belongs to the Section Natural Products)

Bioactive Natural Products as Antitumoral Agents: Recent Advantages, Technology, Therapy, Applications and Future Perspectives

edited by

Francisco Rivas García

, Javier Valverde-Pozo and Meriem Chayah

submission deadline 30 Nov 2026 | Viewed by 203 | Submission Open

Keywords: antitumoral compound synthesis; bioinorganic chemistry; physicochemical evaluation; innovative synthesis technologies; natural antitumoral analogues

(This special issue belongs to the Section Natural Products)

Synthetic Construction of Novel Templates and Chemotypes for the Solving of Problems in Drug Discovery and Development

edited by Stephen P. Wren

submission deadline 30 Nov 2026 | Viewed by 182 | Submission Open

Keywords: small molecule drug discovery; structure-guided drug design; molecularly imprinted polymers (MIPs); biosensors and biomarker detection; bioisosteres and squaric acid derivatives; structure–activity relationship (SAR); computational chemistry and in silico modeling; lead optimization and pharmacokinetics.

(This special issue belongs to the Section Medicinal Chemistry)

Pharmacology of Rare Diseases: Therapeutic Access for Orphan Medicines

edited by

Andrej Belančić

submission deadline 1 Dec 2026 | Viewed by 152 | Submission Open

Keywords: rare diseases; orphan medicines; clinical and translational pharmacology; advanced therapy medicinal products; adaptive clinical trials; regulatory science; real-world evidence; post-marketing surveillance; therapeutic access

(This special issue belongs to the Section Pharmacology)

The Modes of Action of Herbal Medicines and Natural Products, 2nd Edition

edited by Hongnan Cao

submission deadline 10 Dec 2026 | 8 articles | Viewed by 14277 | Submission Open

Keywords: herbal compounds; natural products; pharmacokinetics and pharmacodynamics of natural products; herbal medicines; herbal therapies

(This special issue belongs to the Section Natural Products)

Anticancer Compounds in Medicinal Plants—4th Edition

edited by

Paulo Santos

and

Lillian Barros

submission deadline 15 Dec 2026 | 5 articles | Viewed by 5852 | Submission Open

Keywords: natural products; phytochemicals; cancer; secondary metabolites; medicinal plants

(This special issue belongs to the Section Natural Products)

Metal-Based Nanoparticles’ Biological Activity and Pharmaceutical Applications, 2nd Edition

edited by

Elitsa L. Pavlova

and

Debbie C. C. Crans

submission deadline 20 Dec 2026 | 2 articles | Viewed by 2596 | Submission Open

Keywords: metal nanoparticles; redox reactions; biological activity; pharmaceuticals; cytotoxicity; antibacterial effect; oxidative stress; disease; safety; in vivo applications

(This special issue belongs to the Section Medicinal Chemistry)

Druggability of Mitochondrial Proteases: Emerging Targets and Therapeutic Opportunities in Cancer and Neurodegeneration

edited by

Morena Miciaccia

and

Maria Grazia Perrone

submission deadline 20 Dec 2026 | Viewed by 362 | Submission Open

Keywords: mitochondrial proteostasis; druggability; mitochondrial proteases; UPRmt signaling; small-molecule modulators; medicinal chemistry; cancer therapy; neurodegenerative diseases

(This special issue belongs to the Section Medicinal Chemistry)

Development of Small Molecules as Immunomodulators and Adjuvants for Cancer Immunotherapy

edited by Laura Fioretto,

Carmela Gallo

and Mario Dell'Isola

submission deadline 20 Dec 2026 | Viewed by 215 | Submission Open

Keywords: cancer immunotherapy; organic synthesis; small molecules; cancer therapy; immunomodulators; adjuvants; immunology

(This special issue belongs to the Section Pharmacology)

Challenges in Discovering Innovations Related to Biofilms: Virulence, Spread, Control Strategies and Treatment

edited by

Tsvetelina Paunova-Krasteva

submission deadline 25 Dec 2026 | 9 articles | Viewed by 18400 | Submission Open

Keywords: biofilm; structure; pathogenesis; virulence; tolerance; biofilm infections; dispersion; control strategies; quorum sensing

(This special issue belongs to the Section Pharmacology)

Pharmacological Activities of Flavonoids and Their Analogues, Third Edition

edited by

Fernando Calzada

and

Miguel Valdes

submission deadline 25 Dec 2026 | 8 articles | Viewed by 11909 | Submission Open

Keywords: natural products; polyphenols; flavonoids; medicinal chemistry; traditional medicine; flavonoids isolation; flavonoids identification; flavonoids pharmacology; flavonoids as prodrugs; in vivo, in vitro, and in silico studies; molecular modeling studies

(This special issue belongs to the Section Natural Products)

Plant-Derived Products in the Treatment of Internal Diseases: 2nd Edition

edited by

Dorin Dragoş

and

Adelina Vlad

submission deadline 25 Dec 2026 | 6 articles | Viewed by 11184 | Submission Open

Keywords: medicinal plants; phytotherapy; herbal treatment; natural products; herbalism; traditional medicine; cardiovascular disease; lung disease; liver disease; gastrointestinal disease; kidney disease; obesity; diabetes; rheumatological disease

(This special issue belongs to the Section Natural Products)

Novel Drug Compositions for Ischemic Stroke: Mechanisms and Clinical Applications

edited by

Jasenka Mrsic-Pelcic

and

Anja Harej Hrkać

submission deadline 25 Dec 2026 | 3 articles | Viewed by 6884 | Submission Open

Keywords: ischemic stroke; novel delivery systems; nanomedicine; nanotechnology; neuroregenerative therapy; neurorepair; new and emerging treatments; pharmacotherapy; tissue engineering

(This special issue belongs to the Section Pharmacology)

Recent Advances in Psychopharmacology: 2nd Edition

edited by Roos Van Westrhenen and Allan H. Young

submission deadline 25 Dec 2026 | 2 articles | Viewed by 4189 | Submission Open

Keywords: psychopharmaca; pharmacogenomics; pharmacogenetics; psychedelics; dementia drugs

(This special issue belongs to the Section Pharmacology)

Drug Target Exploration and Drug Design & Development Based on Small Molecule: 2nd Edition

edited by

Marco Tutone

and

Giulia Culletta

submission deadline 25 Dec 2026 | 2 articles | Viewed by 2777 | Submission Open

Keywords: small molecules; drug design and development; target exploration; anticancer drugs; anti-inflammatory drugs; neuromodulation; natural compounds; nutraceuticals; virtual screenings

(This special issue belongs to the Section Pharmacology)

Natural Products in Diabetes Mellitus: 3rd Edition

edited by

Ana Angélica Feregrino-Pérez

submission deadline 25 Dec 2026 | 2 articles | Viewed by 2302 | Submission Open

Keywords: natural products; hypoglycemia; phenolic compounds; diabetes mellitus; therapeutic; ROS

(This special issue belongs to the Section Natural Products)

Therapeutic Drug Monitoring and Adverse Drug Reactions: 3rd Edition

edited by Engi Abd El Hady Algharably and

Ursula Gundert-Remy

submission deadline 25 Dec 2026 | 4 articles | Viewed by 1949 | Submission Open

Keywords: therapeutic drug monitoring; adverse drug reactions; pharmacokinetics; personalized medicine; medication safety; pharmacogenomics; medication review; pharmacokinetic modeling

(This special issue belongs to the Section Pharmacology)

Pharmacogenomics and Ethnic Diversity: Optimizing Drug Response Across Populations

edited by

Fernanda Rodrigues-Soares

and Gisely Cardoso De Melo

submission deadline 25 Dec 2026 | 1 articles | Viewed by 1648 | Submission Open

Keywords: pharmacogenomics; pharmacogenetics; ethnic groups; population genetics; ancestry; drug response

(This special issue belongs to the Section Pharmacology)

Plant-Mediated Synthesis of Nanostructures for Biomedical Applications

edited by Irina Macovei and

Andreia Corciova

submission deadline 25 Dec 2026 | 1 articles | Viewed by 723 | Submission Open

Keywords: green synthesis; plant-mediated nenotechnology; biogenic nanostructures; biomedical applications; phytochemical capping agents; targeted drug delivery; biocompatibility; antimicrobial; antioxidant; cytotoxicity

(This special issue belongs to the Section Pharmaceutical Technology)

Pharmacotherapy of Prostate Cancer

edited by

Benyi Li

submission deadline 25 Dec 2026 | Viewed by 532 | Submission Open

Keywords: prostate cancer; clinical; treatment; prostate cancer imaging; targeted therapy; immunotherapy

(This special issue belongs to the Section Pharmacology)

Natural Products in Skin Inflammation and Oxidative Stress

edited by

Jihye Hwang

submission deadline 25 Dec 2026 | 1 articles | Viewed by 358 | Submission Open

Keywords: natural products; skin inflammation; oxidative stress; herbal medicine; phytochemicals; skin barrier; immune modulation; dermatologic therapeutics

(This special issue belongs to the Section Natural Products)

Micro and Nanocarrier-Based Delivery Systems for Active Compounds

edited by

Douglas Dourado

Éverton do Nascimento Alencar

and

Fabio Rocha Formiga

submission deadline 25 Dec 2026 | Viewed by 238 | Submission Open

Keywords: drug delivery systems; lipid nanoparticles; polymeric nanoparticles; liposomes; micro/nanoemulsions; micro/nanogels; microparticles; microcapsules; bioavailability; pharmaceutical formulations

(This special issue belongs to the Section Pharmaceutical Technology)

Recent Advances in Animal Models of Neuropsychiatric Diseases

edited by

Ioana-Miruna Balmus

submission deadline 25 Dec 2026 | Viewed by 150 | Submission Open

Keywords: neuropsychiatric diseases; DSM-5; ageing; neurodegeneration; affective disorders; neurodevelopmental disorders; schizophrenia; trauma and stress; sleep disorders; animal models; in vivo models; in vitro models; pharmacodynamics; innovative therapies

(This special issue belongs to the Section Pharmacology)

Therapeutic Applications of Micro-RNA in Cancer Management—2nd Edition

edited by