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Pharmaceuticals publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Pyrazole and Its Derivatives: Drug Design, Synthesis, and Biological Evaluation

edited by

Matteo Lusardi

and

Marco Ponassi

submission deadline 28 Feb 2026 | Viewed by 230 | Submission Open

Keywords: medicinal chemistry; drug design; drug discovery; pyrazole-based compounds; innovative synthesis; structure– activity relationships; biological activities; drug-like properties

(This special issue belongs to the Section Medicinal Chemistry)

Applications of Pharmacogenomics in Precision Medicine

edited by

Kariofyllis Karamperis

, Branka Zukic and

Fernanda Rodrigues-Soares

submission deadline 28 Feb 2026 | Viewed by 217 | Submission Open

Keywords: personalized medicine; pharmacogenomics; drug– gene interactions; adverse drug reactions; pharmacogenomic biomarkers; multi-omics; population pharmacogenomics; precision therapeutics

(This special issue belongs to the Section Pharmacology)

Therapeutic Applications of Histone Deacetylase (HDAC) Inhibitors

edited by Chao-Wu Yu and Liqiang Chen

submission deadline 28 Feb 2026 | Viewed by 143 | Submission Open

Keywords: HDAC inhibitors; organ fibrosis; rare disease; neurodegenerative disease; antibiotics; anti-cancer

(This special issue belongs to the Section Medicinal Chemistry)

New Perspective of Antiviral Drugs

edited by

Grigoris Zoidis

submission deadline 28 Feb 2026 | Viewed by 137 | Submission Open

Keywords: antiviral drugs; antiviral agents; small organic molecules; metal complexes; natural products

(This special issue belongs to the Section Medicinal Chemistry)

Molecular Insights and Clinical Implications in Geriatric Medicine and Drug Development

edited by

Katarzyna Mądra-Gackowska

Marcin Gackowski

, Kornelia Kędziora-Kornatowska and

Iga Hołyńska-Iwan

submission deadline 28 Feb 2026 | Viewed by 128 | Submission Open

Keywords: older adults; age-related diseases; biomarkers; drug development; molecular modeling; computer-aided drug design; geriatrics in laboratory medicine; laboratory tests in older patients; malnutrition diagnostics; test results versus a clinical image of an older patient

(This special issue belongs to the Section Pharmacology)

Innovations in Integrin-Targeted Drug Delivery: From Peptide Conjugates to Dual-Action Therapeutics

edited by

Kelly Bugatti

Lucia Battistini

and

Andrea Sartori

submission deadline 28 Feb 2026 | Viewed by 99 | Submission Open

Keywords: integrins; peptide-drug conjugates (PDCs); drug delivery; peptide synthesis; dual conjugates

(This special issue belongs to the Section Biopharmaceuticals)

The Emerging Field of Critical Care Psychiatry: Pharmacologic Treatment from ICU to Post-ICU Recovery

edited by Shixie Jiang,

Matthew Gunther

and Jose R. Maldonado

submission deadline 28 Feb 2026 | Viewed by 73 | Submission Open

Keywords: critical care psychiatry; ICU psychiatry; delirium; encephalopathy; cognitive impairment; neurocognitive disorders; dementia; post-intensive care syndrome; depression; anxiety; trauma; insomnia; sleep disturbances; mental health; behavioral health

(This special issue belongs to the Section Pharmacology)

Bioactive Substances and Skin Health: The Role of Pharmacy and Nutrition—Properties and Technology

edited by

Francisco Rivas

, Margarita López-Viota and Rafael Jesús Giménez Martínez

submission deadline 1 Mar 2026 | 4 articles | Viewed by 26720 | Submission Open

Keywords: supplements; bioactive substances; skin health

(This special issue belongs to the Section Pharmaceutical Technology)

Medications: Interactions with Diet, Herbs, Dietary Supplements and Probiotics

edited by

Francisco Rivas

, María Isabel Valverde Merino and Maria José Zarzuelo Romero

submission deadline 1 Mar 2026 | 3 articles | Viewed by 15709 | Submission Open

Keywords: food– drug interactions; dietary supplements; probiotics; herb– drug interaction

(This special issue belongs to the Section Pharmacology)

Innovations in Chemotherapy: From Synthetic to Natural Agents and Combined Therapies

edited by

Stefano Ruga

submission deadline 1 Mar 2026 | Viewed by 218 | Submission Open

Keywords: chemotherapy; immunotherapy; innovative drugs; natural compounds; combination therapy; targeted therapy; customized administration; drug stability; drug storage

(This special issue belongs to the Section Pharmacology)

Advances in Cancer Treatment and Toxicity

edited by

Dinender K. Singla

submission deadline 10 Mar 2026 | 2 articles | Viewed by 1750 | Submission Open

Keywords: oxidative stress; cell signaling; cell death; tissue remodeling; inflammation; molecular mechanisms; heart; muscle; antioxidants; cell therapy; exosomes

(This special issue belongs to the Section Pharmacology)

Pharmacogenomics and Pediatric Pharmacotherapy

edited by

Chakradhara Rao Satyanarayana Uppugunduri

submission deadline 10 Mar 2026 | Viewed by 91 | Submission Open

Keywords: pharmacokinetics; pediatric formulations; pharmacodynamics; drug metabolism; pharmacogenetics; drug transport; ontogeny developmental pattern; modeling; drug safety; simulation; off-label drug use

(This special issue belongs to the Section Pharmacology)

Pharmacokinetics and Pharmacometrics Driving Innovation

edited by

Michel L Campos

Marcelo Gomes Davanço

and

Mariana Millan Fachi

submission deadline 12 Mar 2026 | Viewed by 94 | Submission Open

Keywords: pharmacokinetics; drug development; ADME; bioanalytical methods; bioequivalence; bioavailability; IVIVC; PBBM; PBBK; biopharmacy

(This special issue belongs to the Section Pharmacology)

Innovative Analytical Techniques and Nanotechnology in Natural Products Analysis and Drug Development

edited by Jinchao Wei and

Di Chen

submission deadline 15 Mar 2026 | 1 articles | Viewed by 2735 | Submission Open

Keywords: natural product; Chinese medicine; drug development; analytical technique; nanotechnology; spectrometry; chromatography; sensors; formulation

(This special issue belongs to the Section Natural Products)

Triazole and Derivatives in Medicinal Chemistry, 2nd Edition

edited by Saeed Bahadorikhalili

submission deadline 15 Mar 2026 | Viewed by 367 | Submission Open

Keywords: triazole; heterocycles; medicinal chemistry; pharmaceutical chemistry; organic synthesis; catalytic organic synthesis; bioactivity; organocatalysis

(This special issue belongs to the Section Medicinal Chemistry)

Pharmaceutical Formulation Characterization Design, 2nd Edition

edited by

Katalin Kristó

and

Tamás Sovány

submission deadline 15 Mar 2026 | Viewed by 101 | Submission Open

Keywords: Quality by Design; factorial design; design space; solid dosage forms; risk assessment; critical process parameters; quality target product profile

(This special issue belongs to the Section Pharmaceutical Technology)

Natural Products for Therapeutic Potential

edited by

Xavier Siwe Noundou

submission deadline 20 Mar 2026 | 6 articles | Viewed by 20305 | Submission Open

Keywords: natural products chemistry; therapeutic potential; medicinal plants; marine organisms; microorganisms; bioactive compounds; natural products inspired compounds; biological activities; computational chemistry

(This special issue belongs to the Section Natural Products)

Natural Pharmacons: Biologically Active Plant-Based Pharmaceuticals—4th Edition

edited by

Dejan Stojković

and

Marina Soković

submission deadline 20 Mar 2026 | 7 articles | Viewed by 7888 | Submission Open

Keywords: chemical characterization of natural preparations; therapeutic potential of natural matrices in cardiovascular diseases; diabetes; cancer; and neurodegenerative diseases; antimicrobial activity; antioxidant activity; anti-enzymatic activity; anti-inflammatory activity; mechanism of pharmacological actions; structure– activity relationship studies

(This special issue belongs to the Section Natural Products)

Potential Pharmacotherapeutic Targets in Neurodegenerative Diseases

edited by

Cláudio Viegas-Junior

submission deadline 20 Mar 2026 | 2 articles | Viewed by 4355 | Submission Open

Keywords: neurodegenerative diseases; neuroinflammation; neuroprotection; molecular targets; therapeutic drugs

(This special issue belongs to the Section Pharmacology)

Natural Antioxidants from Medicinal Plants: Extraction and Bioactivity

edited by

Julio Escalona-Arranz

and

Jesús García-Díaz

submission deadline 20 Mar 2026 | Viewed by 144 | Submission Open

Keywords: natural antioxidants; medicinal plants; extraction methods; bioactivity; phenolic compounds; free radical scavenging; pharmacological potential; in silico and in vitro correlation; molecular modeling

(This special issue belongs to the Section Natural Products)

Novel Therapeutic Targets in the Cardiovascular Treatment Landscape

edited by Weida Wu and

Nikolaos Kadoglou

submission deadline 22 Mar 2026 | Viewed by 128 | Submission Open

Keywords: cardiovascular disease; novel therapeutic targets; lipid metabolism; cardiac fibrosis and remodeling; inflammation and immune modulation; Lp(a); heart failure; RNA therapeutics; precision cardiology; cardiomyopathy

(This special issue belongs to the Section Pharmacology)

Medicinal Plants: Exploring Plant-Based Bioactive Compounds for Cancer and Metabolic Diseases Prevention and Intervention

edited by

Lucas Fornari Laurindo

and

Sandra Barbalho

submission deadline 25 Mar 2026 | 4 articles | Viewed by 10780 | Submission Open

Keywords: cancer; metastasis; tumor growth; tumor spread; bioactive compounds; phytochemicals; medicinal plants; phytochemistry; cancer prevention; cancer intervention; metabolic diseases; metabolism; diabetes; MAFLD; dyslipidemia

(This special issue belongs to the Section Natural Products)

Drug Treatment of Thyroid Cancer

edited by

Cristina Alina Silaghi

Carmen Emanuela Georgescu

Horaţiu Silaghi

and

Cristina Pop

submission deadline 25 Mar 2026 | 3 articles | Viewed by 7192 | Submission Open

Keywords: differentiated thyroid cancer; medullary thyroid cancer; anaplastic thyroid carcinoma; advanced/metastatic thyroid cancer; refractory thyroid cancer; targeted therapy in thyroid cancer; tyrosine kinase inhibitors; immune checkpoint inhibitors; redifferentiation treatment; drug resistance

Innovative Approaches to Radiopharmaceuticals: Advances in Design, Labeling, and Applications

edited by Shvan J. Raheem and

Justin J. Bailey

submission deadline 25 Mar 2026 | 3 articles | Viewed by 5362 | Submission Open

Keywords: radiochemistry; radiopharmaceutical; radiotracers

(This special issue belongs to the Section Radiopharmaceutical Sciences)

Advances in Prostate Cancer Therapeutics

edited by

David Danielpour

submission deadline 25 Mar 2026 | 4 articles | Viewed by 4780 | Submission Open

Keywords: prostate cancer; androgen deprivation therapy (ADT); castration-resistant prostate cancer (CRPC); androgen receptor signaling inhibitors; PARP inhibitors; ionizing radiation therapy; radiopharmaceuticals; immunotherapy; biomarkers; personalized medicine; therapeutic resistance; targeted therapy; combination therapy; hormone-sensitive prostate cancer (HSPC); next-generation therapeutics; translational oncology

(This special issue belongs to the Section Pharmacology)

Pharmacological Activities of Flavonoids and Their Analogues, Third Edition

edited by

Fernando Calzada

and

Miguel Valdes

submission deadline 25 Mar 2026 | 3 articles | Viewed by 3453 | Submission Open

Keywords: natural products; polyphenols; flavonoids; medicinal chemistry; traditional medicine; flavonoids isolation; flavonoids identification; flavonoids pharmacology; flavonoids as prodrugs; in vivo; in vitro; and in silico studies; molecular modeling studies

(This special issue belongs to the Section Natural Products)

Challenges in Discovering Innovations Related to Biofilms: Virulence, Spread, Control Strategies and Treatment

edited by

Tsvetelina Paunova-Krasteva

submission deadline 25 Mar 2026 | 4 articles | Viewed by 2793 | Submission Open

Keywords: biofilm; structure; pathogenesis; virulence; tolerance; biofilm infections; dispersion; control strategies; quorum sensing

(This special issue belongs to the Section Pharmacology)

Immunogenomics for Drug Discovery in Leukemia

edited by

Silvia Jiménez-Morales

and Adolfo Martínez-Tovar

submission deadline 25 Mar 2026 | 1 articles | Viewed by 2613 | Submission Open

Keywords: leukemia; hematological diseases; immunogenomics; omics studies; experimental models; therapeutic approaches

(This special issue belongs to the Section Medicinal Chemistry)

Cholinergic Modulation, Anticholinergic Burden, and Neuroprotection: Mechanisms to Therapeutics

edited by

Ion Brinza

and

Lucian Hritcu

submission deadline 25 Mar 2026 | 2 articles | Viewed by 2270 | Submission Open

Keywords: scopolamine; anticholinergic burden; cholinergic modulation; cognitive impairment; neuroinflammation; oxidative stress; BBB/drug delivery; PK/PD; biomarkers; network pharmacology; flavonoids/polyphenols; zebrafish models; translational neuroscience; deprescribing

(This special issue belongs to the Section Pharmacology)

Expanding the Cancer Drug Discovery Toolbox: A Focus on Protein Degradation, Allosteric Modulation, and Covalent Inhibition

edited by Rita Maria Concetta Di Martino and

Antonella Messore

submission deadline 25 Mar 2026 | 1 articles | Viewed by 1341 | Submission Open

Keywords: protein degradation; proteolysis targeting chimeras; hydrophobic tags; molecular glues; allosteric modulators; covalent inhibitors

(This special issue belongs to the Section Medicinal Chemistry)

Advances in the Medicinal Synthesis of Bioactive Compounds

edited by

Iliyan Ivanov

and

Stanimir Manolov

submission deadline 25 Mar 2026 | 1 articles | Viewed by 1298 | Submission Open

Keywords: medicinal chemistry; bioactive compounds; synthetic methodologies; structure– activity relationship (SAR); drug discovery; pharmacokinetics; therapeutic agents; green chemistry; computational modeling; interdisciplinary research

(This special issue belongs to the Section Medicinal Chemistry)

Metabolism, Inflammation and Neurodegeneration: Natural Compounds as Therapeutic Agents

edited by Pedro Cisternas

submission deadline 25 Mar 2026 | 1 articles | Viewed by 664 | Submission Open

Keywords: neurodegenerative diseases; natural compounds; metabolic dysfunction; neuroinflammation; therapeutic strategies

(This special issue belongs to the Section Natural Products)

Organochalcogen Derivatives in Medicinal Chemistry

edited by Agata Pacuła-Miszewska and

Jacek Ścianowski

submission deadline 25 Mar 2026 | 1 articles | Viewed by 318 | Submission Open

Keywords: organochalcogens; modern organic synthesis; medicinal chemistry; biological activity

(This special issue belongs to the Section Medicinal Chemistry)

Application of Supercritical Fluids in Pharmaceutical Science

edited by

Cecília I. A. V. Santos

submission deadline 25 Mar 2026 | Viewed by 311 | Submission Open

Keywords: supercritical fluids; scCO2; drug formulation; bioavailability; green chemistry; drug delivery systems; nanoparticle encapsulation; bioactive compound extraction; pharmaceutical purification; controlled release; sustainable pharmaceutical processes

(This special issue belongs to the Section Pharmaceutical Technology)

Melatonin Applications in Pharmaceutical Science

edited by

Javier Menéndez-Menéndez

submission deadline 25 Mar 2026 | Viewed by 249 | Submission Open

Keywords: melatonin; pineal gland; epigenetics; pharmacology; physiology; immunology; pharmaceutics; novel therapies; cancer

(This special issue belongs to the Section Pharmacology)

Applications and Perspectives of Metal Chelators and Metal Complexes in Drug Development

edited by Joanna Izabela Lachowicz

submission deadline 25 Mar 2026 | Viewed by 204 | Submission Open

Keywords: metal chelators; metal complexes; drug development; cancer treatment; neurodegenerative disorder therapy; targeted drug delivery; metal-based nanomedicine; coordination chemistry in medicine; bioinorganic chemistry

(This special issue belongs to the Section Medicinal Chemistry)

Essential Oil-Based Nanoemulsions

edited by Pinho Fernandes Fernandes

submission deadline 25 Mar 2026 | Viewed by 198 | Submission Open

Keywords: volatile oil; monoterpene; sesquiterpene; phenylpropanoid; dynamic light scattering

(This special issue belongs to the Section Pharmaceutical Technology)

Exploring Natural Products with Antioxidant and Anticancer Properties, 2nd Edition

edited by

Sikiru Olaitan Balogun

and

Edson Lucas Dos Santos

submission deadline 25 Mar 2026 | Viewed by 184 | Submission Open

Keywords: antioxidant; anticancer; neoplasms; natural products; cytotoxicity

(This special issue belongs to the Section Natural Products)

Metal-Based Nanoparticles’ Biological Activity and Pharmaceutical Applications, 2nd Edition

edited by

Elitsa L. Pavlova

and

Debbie C. Crans

submission deadline 25 Mar 2026 | Viewed by 155 | Submission Open

Keywords: metal nanoparticles; redox reactions; biological activity; pharmaceuticals; cytotoxicity; antibacterial effect; oxidative stress; disease; safety; in vivo applications

(This special issue belongs to the Section Medicinal Chemistry)

Novel Anti-Obesity Pharmacotherapies

edited by

Khanyisani Ziqubu

and

Zibele Ndlovu

submission deadline 25 Mar 2026 | Viewed by 145 | Submission Open

Keywords: obesity; anti-obesity pharmacotherapy; weight management; combination therapy; incretin-based polyagonists; amylin analogs; melanocortin receptor modulators; fibroblast growth factor mimetics; mitochondrial uncoupler; clinical efficacy; obesity-induced diseases

(This special issue belongs to the Section Pharmacology)

Crystal Engineering in the Pharmaceutical Sciences

edited by

Stephen Robert Byrn

submission deadline 25 Mar 2026 | Viewed by 124 | Submission Open

Keywords: intermolecular interactions; cocrystals; salts; disproportionation; crystal structure prediction; space manufacturing

(This special issue belongs to the Section Medicinal Chemistry)

Novel Vasoactive and Anti-Inflammatory Agents: From Mechanisms to Therapeutic Applications

edited by

Thyago Moreira De Queiroz

and Alice Valença Araújo

submission deadline 25 Mar 2026 | Viewed by 92 | Submission Open

Keywords: vasorelaxation; inflammation; oxidative stress; nitric oxide; natural and synthetic products; blood pressure

(This special issue belongs to the Section Pharmacology)

Kynurenine Pathway: A Novel Therapeutic Opportunity—2nd Edition

edited by

Verónica Pérez de la Cruz

Tonali Blanco-Ayala

and

Daniela Ramírez-Ortega

submission deadline 25 Mar 2026 | Viewed by 87 | Submission Open

Keywords: tryptophan catabolism; redox modulation; kynurenines; immunoregulation

(This special issue belongs to the Section Pharmacology)

Pharmacotherapy and Molecular Biomarkers of Metabolic Diseases

edited by Kathleen F. Saavedra Peña and

Nicolás R. Saavedra Cuevas

submission deadline 25 Mar 2026 | Viewed by 86 | Submission Open

Keywords: molecular biomarkers; cardiovascular diseases; metabolic diseases; precision medicine; pharmacogenomics; translational research; omics technologies; drug response variability; personalized medicine

(This special issue belongs to the Section Pharmacology)

Advancements in Cardiovascular and Antidiabetic Drug Therapy, 2nd Edition

edited by

Alfredo Caturano

submission deadline 27 Mar 2026 | 13 articles | Viewed by 17216 | Submission Open

Keywords: cardiovascular diseases; antidiabetic drugs; pharmacological interventions; sodium– glucose cotransporter 2 inhibitors; PCSK9 inhibitors; obeticholic acid; lipid-lowering agents; heart failure treatment; diabetes management; drug therapy innovations

(This special issue belongs to the Section Pharmacology)

Therapeutic Applications of Micro-RNA in Cancer Management

edited by

Alma D. Campos-Parra

submission deadline 27 Mar 2026 | 2 articles | Viewed by 2768 | Submission Open

Keywords: cancer; miRNAs; therapeutic applications; miRNA treatments

(This special issue belongs to the Section Biopharmaceuticals)

Structural Insights into Protein Kinases-Targeted Therapies: Overcoming Resistance and Advancing Precision Oncology

edited by David Hecht

submission deadline 27 Mar 2026 | 2 articles | Viewed by 507 | Submission Open

Keywords: protein kinases inhibitor resistance; structural biology of of protein kinases; computational modeling; drug design; preclinical and clinical studies; precision oncology; ALK resistance for personalized medicine

(This special issue belongs to the Section Medicinal Chemistry)

Innovative Drug Delivery Systems for Enhanced Dissolution and Bioavailability

edited by Marival Bermejo,

Paloma Marina De la Torre-Iglesias

and Covadonga Álvarez-Álvarez

submission deadline 27 Mar 2026 | Viewed by 315 | Submission Open

Keywords: drug dissolution enhancement; oral bioavailability improvement; poorly soluble drugs; solid dispersions; nanoparticle drug delivery; amorphous formulations; 3D printing in pharmaceuticals; advanced drug-polymer systems; advanced excipients for solubility enhancement; controlled drug release

(This special issue belongs to the Section Pharmaceutical Technology)

Discovery and Validation of Novel Antimicrobial Molecules for the Treatment of Multidrug-Resistant Bacterial Infections

edited by