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Pharmaceuticals publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Plant-Derived Natural Compounds as Bioactive Molecules with Beneficial Effects on Human Health, 2nd Edition

edited by

Diego Morales

submission deadline 25 Oct 2025 | Viewed by 115 | Submission Open

Keywords: plant bioactives; bioactive compounds; gut microbiome; immune-modulatory; antioxidant; hypocholesterolemic; antihypertensive; clinical trials

(This special issue belongs to the Section Natural Products)

Therapeutic Potential of Cannabinoid Receptors Type 1 and 2—Novel Insights for Enhancing the Chance of Clinical Success, 2nd Edition

edited by

Uwe M. Grether

submission deadline 25 Oct 2025 | Viewed by 90 | Submission Open

Keywords: endocannabinoid system (ECS); cannabinoid receptor type 1 (CB1R); cannabinoid receptor type 2 (CB2R); cannabinoids; ligand

(This special issue belongs to the Section Pharmacology)

Organochalcogen Derivatives in Medicinal Chemistry

edited by Agata Pacuła-Miszewska and

Jacek Ścianowski

submission deadline 25 Oct 2025 | Viewed by 68 | Submission Open

Keywords: organochalcogens; modern organic synthesis; medicinal chemistry; biological activity

(This special issue belongs to the Section Medicinal Chemistry)

Natural Products and Their Modifications as Agents Used in the Fight Against Pathogens, 2nd Edition

edited by

Anna Duda-Madej

submission deadline 27 Oct 2025 | 1 articles | Viewed by 432 | Submission Open

Keywords: plant extract; natural compounds; multidrug-resistant strains; intestinal microbiota; chemical modyfication; biotransformation

(This special issue belongs to the Section Natural Products)

Development of Copper-Based Drugs: Synthesis, Characterisation and Biological Activity

edited by

Anita Kornicka

and

Łukasz Balewski

submission deadline 28 Oct 2025 | 1 articles | Viewed by 2183 | Submission Open

Keywords: copper; copper coordination compounds; biologically active agents; radiopharmaceuticals; drug development; drug design

(This special issue belongs to the Section Medicinal Chemistry)

Advances in Prostate Cancer Therapeutics

edited by

David Danielpour

submission deadline 30 Oct 2025 | 2 articles | Viewed by 1463 | Submission Open

Keywords: prostate cancer; androgen deprivation therapy (ADT); castration-resistant prostate cancer (CRPC); androgen receptor signaling inhibitors; PARP inhibitors; ionizing radiation therapy; radiopharmaceuticals; immunotherapy; biomarkers; personalized medicine; therapeutic resistance; targeted therapy; combination therapy; hormone-sensitive prostate cancer (HSPC); next-generation therapeutics; translational oncology

(This special issue belongs to the Section Pharmacology)

Precision Oncology: Targeting Molecular Subtypes in Cancer Therapy

edited by

Shuhei Suzuki

and Jiro Ogura

submission deadline 30 Oct 2025 | 1 articles | Viewed by 619 | Submission Open

Keywords: cancer chemotherapy; cancer genomic profiling test; next-generation sequencing; genetic variants; molecular targeted therapy; molecular tumor board; liquid biopsy

(This special issue belongs to the Section Pharmacology)

Advancements and Challenges of Intrapleural and Peritoneal Drug Delivery

edited by

Veria Khosrawipour

Agata Mikolajczyk-Martinez

and

Tanja Khosrawipour

submission deadline 31 Oct 2025 | 2 articles | Viewed by 5475 | Submission Open

Keywords: peritoneal and pleural malignancies; intraperitoneal and pleural drug delivery; peritoneal dialyses; peritonitis; pleuritis; hyperthermic intraperitoneal chemotherapy (HIPEC); surface applications; colorectal cancer; ovarian cancer

(This special issue belongs to the Section Pharmaceutical Technology)

Drug Discovery and Development for Parasitic Diseases

edited by

Francois Dufrasne

submission deadline 31 Oct 2025 | 5 articles | Viewed by 5262 | Submission Open

Keywords: parasitic diseases; biological activity; synthesis; pharmacology; medicine; chemistry; target

(This special issue belongs to the Section Medicinal Chemistry)

Purinergic Signaling in Cancer Therapy: From Mechanisms to Targeting Strategies

edited by

Margarete Dulce Bagatini

submission deadline 31 Oct 2025 | 1 articles | Viewed by 1626 | Submission Open

Keywords: purinergic signaling; cancer; ATP; adenosine; purinergic receptors; immune modulation; tumor progression; therapeutic potential

(This special issue belongs to the Section Pharmacology)

Pharmaceuticals for Inflammatory Bowel Disease (IBD)

edited by

Phurpa Wangchuk

submission deadline 31 Oct 2025 | 1 articles | Viewed by 1584 | Submission Open

Keywords: inflammatory bowel disease; IBD symptoms; IBD pathogenesis; IBD treatments

(This special issue belongs to the Section Pharmacology)

Classical and Novel Technology in the Extraction and Analysis of Active Ingredients from Natural Products for Effective Pre-Clinical Use

edited by

Pierre Dramou

and

Raphael Nammahime Alolga

submission deadline 31 Oct 2025 | 1 articles | Viewed by 657 | Submission Open

Keywords: classical extraction; nanotechnology; active ingredients; nanozymes; nanocomposites; molecularly imprinted polymer; magnetic nanoparticles; MOFs; natural products; pre-clinical studies

(This special issue belongs to the Section Natural Products)

Advances in Medicinal Chemistry: 2nd Edition

edited by

Mary J. Meegan

submission deadline 31 Oct 2025 | 1 articles | Viewed by 618 | Submission Open

Keywords: drug discovery; novel drug targets; drug discovery; drug design and development; synthetic methods for drugs; analytical methodologies; in silico screening; structure and ligand-based drug design; structure– activity relationships (SAR); drug metabolism

(This special issue belongs to the Section Medicinal Chemistry)

Production, Development and Theranostic Applications of Radiopharmaceuticals for Nuclear Medicine

edited by Vlad Ghizdovat, Cipriana Stefanescu and Cécile Philippe

submission deadline 31 Oct 2025 | Viewed by 528 | Submission Open

Keywords: theranostic; radiopharmaceuticals; nuclear medicine; alpha-emitting radioisotopes; beta-emitting radioisotopes; gamma-emitting radioisotopes

(This special issue belongs to the Section Radiopharmaceutical Sciences)

Identification and Extraction of Bioactive Compounds from Marine Life

edited by

Monde Mc Millan Ntwasa

and Wilfred T. Mabusela

submission deadline 31 Oct 2025 | Viewed by 172 | Submission Open

Keywords: natural products; marine life; bioactive compounds; cancer; antimicrobials

(This special issue belongs to the Section Natural Products)

Essential Oil-Based Nanoemulsions

edited by Pinho Fernandes Fernandes

submission deadline 31 Oct 2025 | Viewed by 89 | Submission Open

Keywords: volatile oil; monoterpene; sesquiterpene; phenylpropanoid; dynamic light scattering

(This special issue belongs to the Section Pharmaceutical Technology)

Drug-Induced and Herbal Hepatotoxicity and Methods of Its Prevention: 2nd Edition

edited by

Anna Merwid-Ląd

and

Malgorzata Trocha

submission deadline 31 Oct 2025 | Viewed by 86 | Submission Open

Keywords: drug-induced hepatotoxicity; herbal hepatotoxicity; hepatotoxic interactions; acute and chronic liver damage; pathomechanisms of liver injury; oxidative stress; inflammation; apoptosis and necrosis; fibrosis

(This special issue belongs to the Section Pharmacology)

Advances in the Chemical-Biological Knowledge of Essential Oils

edited by

Andrea Maxia

and Emma Cocco

submission deadline 10 Nov 2025 | 3 articles | Viewed by 4667 | Submission Open

Keywords: essential oils (EOs); volatile compounds; chemical composition; biological activity; traditional botanical knowledge

(This special issue belongs to the Section Natural Products)

Therapeutic Potential of Chalcone Derivatives

edited by

Hélcio Silva Dos Santos

submission deadline 10 Nov 2025 | 2 articles | Viewed by 3501 | Submission Open

Keywords: chalcones; pharmacological potential; structural characterization; bioactivity; in silico study; cytotoxicity; quantum chemical calculations; ecapsulation

(This special issue belongs to the Section Pharmacology)

The 20th Anniversary of Pharmaceuticals—Ethnopharmacology in Latin America

edited by

Angel Josabad Alonso-Castro

submission deadline 15 Nov 2025 | 6 articles | Viewed by 11115 | Submission Open

Keywords: Latin America; preclinical; clinical; ethnobotany; pharmacology; chemical standardization; herbal products

(This special issue belongs to the Section Natural Products)

Recent Advances in Stomach and Intestinal Drug Delivery Systems

edited by

Agustin Rascon-Chu

submission deadline 15 Nov 2025 | Viewed by 434 | Submission Open

Keywords: stomach delivery; intestinal delivery; meso– nanostructured carriers; micro– nanoparticles/capsules; permeability enhancement; stability; absorption enhancement; gut delivery

(This special issue belongs to the Section Pharmaceutical Technology)

Pharmacotherapy of Prostate Cancer

edited by

Benyi Li

submission deadline 15 Nov 2025 | Viewed by 71 | Submission Open

Keywords: prostate cancer; clinical; treatment; prostate cancer imaging; targeted therapy; immunotherapy

(This special issue belongs to the Section Pharmacology)

Optimized or Precise Pharmacological Treatment of Bipolar Disorder

edited by

Shaohua Hu

submission deadline 20 Nov 2025 | 5 articles | Viewed by 24770 | Submission Open

(This special issue belongs to the Section Pharmacology)

Protein and Peptide-Based Drug Delivery

edited by Hoda M. Eltaher

submission deadline 20 Nov 2025 | 2 articles | Viewed by 3373 | Submission Open

Keywords: proteolytic degradation; chemical stability; immunogenicity; oral bioavailability; scalability; off- target; effects; bioconjugation; peptide engineering; biodegradable polymers; regulatory and clinical considerations

(This special issue belongs to the Section Biopharmaceuticals)

Pharmacotherapy of Diseases Affecting Urinary Tract

edited by

Priscila de Souza

submission deadline 20 Nov 2025 | 2 articles | Viewed by 1988 | Submission Open

Keywords: natural products; plant extracts and isolated compounds; synthesized compounds; modified compounds; drug repositioning; kidney stone; urolithiasis; diuresis; urinary tract; urinary tract infection; cystitis; urethritis; nephritis; renal hypertension; diabetic nephropathy; nephrotoxicity; renal failure; urinary incontinence; overactive bladder; prostatitis; prostatic hyperplasia

(This special issue belongs to the Section Pharmacology)

Antiplatelet Therapy in Inflammatory Diseases

edited by

Patricia Pia Wadowski

submission deadline 20 Nov 2025 | Viewed by 213 | Submission Open

Keywords: atherosclerotic diseases; inflammatory diseases; antiplatelet therapy; platelet inhibition

(This special issue belongs to the Section Biopharmaceuticals)

Discovery of Novel Antidepressants and Anxiolytics

edited by James Oluwagbamigbe Fajemiroye and Gunnar P. H. Dietz

submission deadline 25 Nov 2025 | 6 articles | Viewed by 11835 | Submission Open

Keywords: biomarkers; depression; anxiety; anxiolytics; antidepressants; preclinical or clinical overview; experimental data; adverse effects; pharmacotherapy options; novel drugs

(This special issue belongs to the Section Pharmacology)

Multitargeted Compounds: A Promising Approach in Medicinal Chemistry

edited by Abdallah Hamze

submission deadline 25 Nov 2025 | 4 articles | Viewed by 10765 | Submission Open

Keywords: multitargeted compounds; medicinal chemistry; rational design; drug discovery; synergistic effects; emerging technologies; therapeutic applications; dual compounds

(This special issue belongs to the Section Medicinal Chemistry)

Peptide Synthesis and Drug Development: Exploring Progress and Potential

edited by

Othman Al Musaimi

, Da’san M.M. Jaradat and Vera D'Aloisio

submission deadline 25 Nov 2025 | 3 articles | Viewed by 5897 | Submission Open

Keywords: peptides; enzymatic degradation; drug discovery; formulation; draggability

(This special issue belongs to the Section Biopharmaceuticals)

Pediatric Drug Therapy: Safety, Efficacy, and Personalized Medicine

edited by

Catherine M. T. Sherwin

submission deadline 25 Nov 2025 | 4 articles | Viewed by 5342 | Submission Open

Keywords: pediatric pharmacotherapy; drug safety in children; pediatric drug efficacy; personalized medicine in pediatrics; pediatric pharmacokinetics; pediatric pharmacodynamics; pharmacogenomics in children; pediatric clinical trials; pediatric dosing strategies; pediatric drug formulations

(This special issue belongs to the Section Pharmacology)

Molecular Mechanisms and Treatment of Brain Cancer: Recent Advances and Future Trends

edited by

Terezia Kiskova

submission deadline 25 Nov 2025 | 3 articles | Viewed by 4587 | Submission Open

Keywords: brain cancer; molecular mechanism; treatment; diagnosis; in vitro; in vivo; models

(This special issue belongs to the Section Pharmacology)

Biosimilars Development Strategies

edited by

Sarfaraz K. Niazi

and Sesselja S. Ómarsdóttir

submission deadline 25 Nov 2025 | 3 articles | Viewed by 3319 | Submission Open

Keywords: biosimilars; generic medicines; drug development; biosimilar development

(This special issue belongs to the Section Medicinal Chemistry)

Novel Therapeutic Strategies for Alzheimer’s Disease Treatment

edited by

Melvin Hayden

submission deadline 25 Nov 2025 | 1 articles | Viewed by 3305 | Submission Open

Keywords: Sporadic; late-onset Alzheimer’ s disease (LOAD); neurodegenerative diseases

(This special issue belongs to the Section Pharmacology)

Nanotechnology in Biomedical Applications

edited by

Luciano Paulino Silva

submission deadline 25 Nov 2025 | 5 articles | Viewed by 3122 | Submission Open

Keywords: nanotechnology; nanobiotechnology; biomedical applications; drug delivery; nanobiosensors; targeted therapy; diagnostics; nanomaterials; therapeutics; theranostics

(This special issue belongs to the Section Pharmaceutical Technology)

New Development in Pharmacotherapy of Kidney Diseases

edited by Chihchao Yang

submission deadline 25 Nov 2025 | 3 articles | Viewed by 1789 | Submission Open

Keywords: chronic kidney disease (CKD); acute kidney injury (AKI); pharmacotherapy; cardiovascular protection; kidney protection; bone health; endocrine function; gut health; metabolism; neuromuscular function; nutrition; symptom management; sodium-glucose cotransporter-2 (SGLT-2) inhibitors; glucagon-like peptide-1 (GLP-1) receptor agonists; non-steroidal mineralocorticoid receptor antagonists (MRA); endothelin receptor antagonists; anemia management; electrolyte abnormalities; dialysis; nephrotoxicity; drug interactions; uremic toxin; clinical trials; innovative therapies; protein-energy wasting; chronic kidney disease and bone mineral disease; inflammation; oxidation; diabetes; hypertension; obesity; hyperlipidemia; pruritus; osteoporosis; fracture; sarcopenia; protein-energy wasting

(This special issue belongs to the Section Pharmacology)

Medicinal Chemistry of Metal Complexes: Design, Synthesis and Evaluation

edited by

Bojana B. Zmejkovski

Goran Kaluđerović

and

Nebojša Pantelić

submission deadline 25 Nov 2025 | 1 articles | Viewed by 1673 | Submission Open

Keywords: metal complexes; medicinal chemistry; bioinorganic chemistry; coordination chemistry; organometallics; metal-based drugs; biological activity; toxicology; biomedical application; drug delivery

(This special issue belongs to the Section Medicinal Chemistry)

Recent Advances in the Discovery and Development of Drugs for Civilization Diseases, 2nd Edition

edited by

Marcin Gackowski

Karolina Szewczyk-Golec

and

Renata Studzińska

submission deadline 25 Nov 2025 | 3 articles | Viewed by 1171 | Submission Open

Keywords: anticancer drugs; anticancer treatment; anticoagulants; atherosclerosis; cardiovascular disease; civilization diseases; diabetes mellitus; drug development; in silico research; medication form/drug dosage form; molecular descriptors; molecular docking; molecular dynamics; molecular modeling; neoplastic disease; obesity; QSAR; radiopharmaceuticals; synthesis of bioactive compounds; type 2 diabetes

(This special issue belongs to the Section Medicinal Chemistry)

The Therapeutic Potential of Cannabidiol

edited by

Karolina Walczyńska-Dragon

and

Anna Kurek-Górecka

submission deadline 25 Nov 2025 | 1 articles | Viewed by 1001 | Submission Open

Keywords: cannabidiol; endocannabinoid system; pain; anti-inflammatory agents; muscle spasticity; pain management; chronic pain

(This special issue belongs to the Section Natural Products)

Innovations in Therapeutic Strategies for Retinal and Neurodegenerative Diseases

edited by

Tonking Bastola

and Won-Kyu Ju

submission deadline 25 Nov 2025 | 1 articles | Viewed by 932 | Submission Open

Keywords: glaucoma; Alzheimer's diseases; retinal disease; neuroprotection; neuroinflammation

(This special issue belongs to the Section Pharmacology)

Pharmaceutical Approaches to Orofacial Pain and Chronic Pain Conditions

edited by

Takahiko Nagamine

submission deadline 25 Nov 2025 | 1 articles | Viewed by 829 | Submission Open

Keywords: chronic orofacial pain; pharmaceutical approach; myofascial orofacial pain; temporomandibular joint pain; neurovascular orofacial pain; idiopathic orofacial pain; burning mouth syndrome; persistent idiopathic facial pain; persistent idiopathic dentoalveolar pain; tricyclic antidepressants; serotonin reuptake inhibitors; anticonvulsants

(This special issue belongs to the Section Pharmacology)

Antimicrobial Therapies Affect the Microbial Ecosystems Within Our Body: The Urinary Microbiome and Urolithiasis

edited by

Loredana Sabina Cornelia Manolescu

submission deadline 25 Nov 2025 | 1 articles | Viewed by 604 | Submission Open

Keywords: antibiotics; antimicrobials; resistance; microbiome; urolithiasis; biofilms; infections; pathogens; pharmacotherapy; inflammation

(This special issue belongs to the Section Pharmacology)

Pharmacology and Toxicology of Opioids, 2nd Edition

edited by

Juliana Faria

, Joana Barbosa and

Ricardo Dinis-Oliveira

submission deadline 25 Nov 2025 | Viewed by 588 | Submission Open

Keywords: opioid toxicity; opioid pharmacodynamics; opioid pharmacokinetics; opioid pharmacogenetics; prescription opioids; toxicity assays; in vivo; in vitro; abuse; dependence

(This special issue belongs to the Section Pharmacology)

Cutting-Edge Biotechnologies and Applications of Natural Products in Drug R&D and Disease Treatment

edited by

Sujay Paul

submission deadline 25 Nov 2025 | 1 articles | Viewed by 515 | Submission Open

Keywords: natural products; bioactive compounds; natural product drug discovery and drug design; natural drug formulation; metabolic engineering for bioactive compounds; natural therapeutic agents; nanoformulations of natural compounds; synthetic biology for natural product biosynthesis; genome editing and creation of novel bioactive compounds

(This special issue belongs to the Section Natural Products)

New Findings in Pharmacogenomics of Neuropsychiatric Disorders

edited by

Alireza Tafazoli

and

Mandana Hasanzad

submission deadline 25 Nov 2025 | Viewed by 414 | Submission Open

Keywords: pharmacogenomics; genome informatics; advanced DNA-sequencing technologies; bioinformatics of pharmacogenomics; diagnostic approaches in the pharmacogenomics of neuropsychiatric disorders

(This special issue belongs to the Section Pharmacology)

Research on Diagnosis, Treatment and Related Microbiota in Gastrointestinal Diseases

edited by

Edoardo V. Savarino

and Brigida Barberio

submission deadline 25 Nov 2025 | Viewed by 272 | Submission Open

Keywords: gut microbiota; inflammatory bowel disease; eosinophilic esophagitis; primary sclerosing cholangitis; metabolic-associated steatotic liver disease; immune checkpoint inhibitor colitis; dysbiosis; prebiotics; probiotics

(This special issue belongs to the Section Medicinal Chemistry)

The Development and Application of Broad-Spectrum Antiviral Drugs

edited by Chieh-Wen Lo

submission deadline 25 Nov 2025 | Viewed by 243 | Submission Open

Keywords: broad-spectrum antiviral; direct-acting antiviral; host-targeted antiviral; emerging viruses; pandemic preparedness

(This special issue belongs to the Section Medicinal Chemistry)

Anticancer Compounds in Medicinal Plants—4th Edition

edited by

Paulo Santos

and

Lillian Barros

submission deadline 25 Nov 2025 | Viewed by 214 | Submission Open

Keywords: natural products; phytochemicals; cancer; secondary metabolites; medicinal plants

(This special issue belongs to the Section Natural Products)

Application of Nanotechnology in Drug Delivery

edited by Camila Batista Da Silva and

Michelle Franz-Montan

submission deadline 25 Nov 2025 | Viewed by 170 | Submission Open

Keywords: drug discovery; drug combinations; nanotechnology; drug liberation

(This special issue belongs to the Section Pharmaceutical Technology)

Advances in Hydrazone Compounds with Anticancer Activity

edited by

Boryana Nikolova-Mladenova

and

Mariyana Atanasova

submission deadline 25 Nov 2025 | Viewed by 141 | Submission Open

Keywords: hydrazones; lipophilicity; logP; anticancer activity; selectivity

(This special issue belongs to the Section Medicinal Chemistry)

Pharmacological Activities of Flavonoids and Their Analogues, Third Edition

edited by

Fernando Calzada

and

Miguel Valdes

submission deadline 25 Nov 2025 | Viewed by 137 | Submission Open

Keywords: natural products; polyphenols; flavonoids; medicinal chemistry; traditional medicine; flavonoids isolation; flavonoids identification; flavonoids pharmacology; flavonoids as prodrugs; in vivo; in vitro; and in silico studies; molecular modeling studies

(This special issue belongs to the Section Natural Products)

Displaying special issue 151-200 on page 4 of 7.

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