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Pharmaceuticals publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Population Pharmacokinetics and Pharmacogenetics, 2nd Edition

edited by

Seung-Hyun Jeong

submission deadline 10 Aug 2026 | Viewed by 244 | Submission Open

Keywords: pharmacokinetics; pharmacogenetics; precision medicine; population pharmacometrics model; mathematical modeling; dosage regimen; inter-subject variability

(This special issue belongs to the Section Pharmacology)

Recent Strategies for Delivery of Plant-Based Active Ingredients

edited by

Federica De Gaetano

and

Cinzia Anna Ventura

submission deadline 14 Aug 2026 | 2 articles | Viewed by 3895 | Submission Open

Keywords: drug delivery; polymeric nanoparticles; lipid nanosystems; inclusion complexes; polymeric cyclodextrins; protein carriers; inorganic delivery systems; nanostructured carriers; chemical– physical characterization; in vitro/ex vivo/in vivo evaluation

(This special issue belongs to the Section Pharmaceutical Technology)

Nanoparticle-Enabled Combination Therapy in Preclinical Development

edited by Tamiles Caroline Fernandes Pedrosa,

Eduardo Burgarelli Lages

Fernanda Karoline Vieira da Silva Torchelsen

and

Raquel Silva Araújo

submission deadline 14 Aug 2026 | Viewed by 230 | Submission Open

Keywords: drug delivery systems; nanoparticles; nanomedicine; drug combinations; drug co-delivery; preclinical; translational drug development

(This special issue belongs to the Section Pharmaceutical Technology)

Application of Zebrafish Model in Pharmacology and Toxicology

edited by

Geonildo Rodrigo Disner

and

Mônica Lopes-Ferreira

submission deadline 15 Aug 2026 | 4 articles | Viewed by 6307 | Submission Open

Keywords: chemical safety assessment; translational research; drug screening; human exposome; environmental contaminants

(This special issue belongs to the Section Pharmacology)

Enzyme Inhibitors: Potential Therapeutic Approaches, 2nd Edition

edited by

Phaedra Eleftheriou

submission deadline 15 Aug 2026 | 1 articles | Viewed by 1571 | Submission Open

Keywords: enzymes; inhibitors; competitive; uncompetitive; non-competitive; drug target; pharmaceutical approach; disease treatment

(This special issue belongs to the Section Medicinal Chemistry)

Advances in the Mechanism of Action and the Therapeutic Role of Phytopharmaceuticals

edited by Maria-Eleni Grafakou and

Jörg Heilmann

submission deadline 20 Aug 2026 | 5 articles | Viewed by 19793 | Submission Open

Keywords: medicinal plants; natural products; phytochemistry; biological activities; mechanism of action; biotransformation; microbiome

(This special issue belongs to the Section Natural Products)

Resveratrol: Pharmacological Mechanisms and Therapeutic Potential as a Natural Product

edited by

Dumitriţa Rugină

and

Roxana Pop

submission deadline 20 Aug 2026 | 1 articles | Viewed by 2208 | Submission Open

Keywords: resveratrol; natural compound pharmacology; therapeutic potential; drug development; biomedical research

(This special issue belongs to the Section Natural Products)

Therapeutic Applications of Histone Deacetylase (HDAC) Inhibitors

edited by Chao-Wu Yu and Liqiang Chen

submission deadline 20 Aug 2026 | Viewed by 449 | Submission Open

Keywords: HDAC inhibitors; organ fibrosis; rare disease; neurodegenerative disease; antibiotics; anti-cancer

(This special issue belongs to the Section Medicinal Chemistry)

Challenges in the Development of PET and SPECT Radiotracers: Innovative Ideas with Negative Outcomes

edited by Magali Toussaint and Barbara Wenzel

submission deadline 25 Aug 2026 | 8 articles | Viewed by 12172 | Submission Open

Keywords: radiotracer development; positron emission tomography (PET); single-photon emission computed tomography (SPECT); negative results; diagnostic radiotracers; therapeutic radiopharmaceuticals; radiolabeling; automated synthesis and GMP; pre-clinical studies; medicinal chemistry

(This special issue belongs to the Section Radiopharmaceutical Sciences)

Chemotherapeutic and Targeted Drugs in Antitumor Therapy

edited by

Angéla Takács

and

László Kőhidai

submission deadline 25 Aug 2026 | 2 articles | Viewed by 3997 | Submission Open

Keywords: cancer; drug discovery; small-molecule drugs; targeted therapy; combination therapy; synergism; selectivity; immunotherapy; precision medicine

(This special issue belongs to the Section Pharmacology)

Innovative Approaches to GABAergic Drug Discovery: From Molecular Mechanisms to Advanced Therapeutics

edited by

Wojciech Kołodziejczyk

and

Donato Colangelo

submission deadline 25 Aug 2026 | 2 articles | Viewed by 3040 | Submission Open

Keywords: GABAergic signaling; GABA receptors; drug discovery; neurological and psychiatric disorders; ligand design; computational drug development; artificial intelligence in pharmacology; high-throughput screening; targeted drug delivery; controlled release systems

(This special issue belongs to the Section Pharmacology)

Drug Treatment for Epilepsy

edited by Clarissa Fantin Cavarsan

submission deadline 25 Aug 2026 | 1 articles | Viewed by 2547 | Submission Open

Keywords: epilepsy; anticonvulsant; epileptic syndrome; seizure; epileptogenic; small molecule drugs

(This special issue belongs to the Section Pharmacology)

Crystal Engineering in the Pharmaceutical Sciences

edited by

Stephen Robert Byrn

submission deadline 25 Aug 2026 | 2 articles | Viewed by 1202 | Submission Open

Keywords: intermolecular interactions; cocrystals; salts; disproportionation; crystal structure prediction; space manufacturing

(This special issue belongs to the Section Medicinal Chemistry)

Innovative Applications and Performance Optimization of Biodegradable Polymers in Drug Delivery

edited by

Nikolaos D. Bikiaris

submission deadline 25 Aug 2026 | 1 articles | Viewed by 1003 | Submission Open

Keywords: biodegradable polymers; drug delivery systems; controlled release; polymeric nanoparticles; targeted drug delivery; in vivo drug delivery; sustained release formulations

(This special issue belongs to the Section Pharmaceutical Technology)

Drug Safety and Real-World Evidence: From Databases to Artificial Intelligence

edited by

Maria Antonietta Barbieri

submission deadline 25 Aug 2026 | 1 articles | Viewed by 928 | Submission Open

Keywords: drug safety; real-world evidence; patient’ s clinical outcomes; pharmacovigilance; pharmacoepidemiology; artificial intelligence; adverse drug reactions; inappropriate prescribing

(This special issue belongs to the Section AI in Drug Development)

Network and Systems Pharmacology of Natural Products for Multi-Target Intervention in Cancer and Metabolic Disease

edited by Aleksandra Golonko

submission deadline 25 Aug 2026 | Viewed by 309 | Submission Open

Keywords: pleiotropy; multi-target; obesity; cancer; diabetes; adverse effect; metabolism; drug synthesis; drug discovery

(This special issue belongs to the Section Natural Products)

Antiparasitic Essential Oils: Mechanisms of Action, Technological Approaches, and Metabolism

edited by

Damião Pergentino de Sousa

submission deadline 25 Aug 2026 | Viewed by 295 | Submission Open

Keywords: volatile; essential oils; aromatic plants; aromas; protozoa; helminths; Trypanosoma; Leishmania

(This special issue belongs to the Section Natural Products)

Innovative Tools for Drug Analysis and Therapeutic Drug Monitoring (TDM): 2nd Edition

edited by

Juraj Piestansky

and

Andrej Kovac

submission deadline 25 Aug 2026 | Viewed by 232 | Submission Open

Keywords: therapeutic drug monitoring; biologics; separation analytical methods; bioanalysis; quality control; dosage forms; green analytical chemistry; personalized medicine; clinical bioanalysis; bioanalytical methods

(This special issue belongs to the Section Pharmacology)

Perioperative Precision in Modern Anesthesia: Efficacy and Safety of Pharmacotherapy with Risk Modulation

edited by

Michał Jan Stasiowski

submission deadline 25 Aug 2026 | Viewed by 192 | Submission Open

Keywords: perioperative precision anesthesia; anesthesia pharmacotherapy; perioperative drug management; anesthesia efficacy; anesthesia safety; risk modulation; adverse event prevention

(This special issue belongs to the Section Pharmacology)

Immunotherapy as a Promising Therapeutic Paradigm for Cancers

edited by

Gheorghița Isvoranu

and

Marioara Chiritoiu-Butnaru

submission deadline 25 Aug 2026 | Viewed by 181 | Submission Open

Keywords: cancer immunotherapy; cell-based therapy in cancer; immune checkpoint and co-stimulator modulators; bispecific antibodies; neoantigen-based vaccines; signal transduction inhibitors; small molecules of cancer drugs; tumor microenvironment; mechanisms of resistance

(This special issue belongs to the Section Pharmacology)

AI-Driven Multi-Omics and Pharmacomicrobiomics: Personalizing Cardiovascular Therapeutics

edited by

Tim Dong

and Gianni Angelini

submission deadline 25 Aug 2026 | Viewed by 156 | Submission Open

Keywords: pharmacomicrobiomics; multi-omics data integration; artificial intelligence in drug discovery; atrial fibrillation & anticoagulant metabolism; interindividual variability in drug response (IVDR); gut– heart axis; precision cardiovascular medicine

(This special issue belongs to the Section AI in Drug Development)

Vitamin D and Its Derivatives in Pharmacology: Mechanisms and Therapeutic Applications

edited by

Agnieszka Sliwinska

submission deadline 27 Aug 2026 | 3 articles | Viewed by 7643 | Submission Open

Keywords: vitamin D; synthesis and metabolism; vitamin D derivatives; vitamin D deficiency related diseases; clinical trials on vitamin D and/or its derivatives

(This special issue belongs to the Section Pharmacology)

Innovative Drug Strategies in Chronic Disease Management: Addressing Non-Adherence and Improving Therapeutic Outcomes

edited by

Eduardo Gutiérrez-Abejón

and

F. Javier Alvarez

submission deadline 27 Aug 2026 | 3 articles | Viewed by 5221 | Submission Open

Keywords: adherence; persistence; chronic diseases; therapeutic strategies; individualized therapy; personalized medicine; clinical pharmacology; clinical trials; observational studies; real-world data studies

(This special issue belongs to the Section Pharmacology)

Drug Candidates for the Treatment of Oral Cancer and Oral Cancer Pain, 2nd Edition

edited by

Cara B. Gonzales

submission deadline 27 Aug 2026 | Viewed by 393 | Submission Open

Keywords: oral cancer; oral cancer pain; drug discovery; natural compounds; immunotherapy; small molecule inhibitors; biomarkers

(This special issue belongs to the Section Pharmacology)

A Commemorative Special Issue in Honor of Professor Carlos Alberto Manssour Fraga: Medicinal Chemistry’s Efforts to Discover Novel Bioactive Molecules for Complex Diseases

edited by

Luzineide Tinoco

and

Pedro De Sena Murteira Pinheiro

submission deadline 28 Aug 2026 | 7 articles | Viewed by 22834 | Submission Open

Keywords: medicinal chemistry; bioactive molecules; complex diseases; cardiovascular diseases; diabetes; cancer; neurodegenerative disorders; drug discovery; synthetic chemistry; target identification; structure– activity relationship; preclinical evaluation

(This special issue belongs to the Section Medicinal Chemistry)

Multitargeted Compounds: A Promising Approach in Medicinal Chemistry—2nd Edition

edited by Abdallah Hamze

submission deadline 28 Aug 2026 | Viewed by 285 | Submission Open

Keywords: multitargeted compounds; medicinal chemistry; rational design; drug discovery; synergistic effects; emerging technologies; therapeutic applications; dual compounds

(This special issue belongs to the Section Medicinal Chemistry)

Natural Compounds and Extracts Loaded into Advanced Delivery Platforms

edited by Judyta Cielecka-Piontek,

Anna Stasiłowicz-Krzemień

and

Nunzio Denora

submission deadline 30 Aug 2026 | Viewed by 292 | Submission Open

Keywords: bioavailability enhancement; biopolymer-based carriers; controlled delivery; nanoencapsulation; nanocarriers; natural bioactive compounds; phytochemical delivery systems; plant extract formulations; sustainable delivery systems; targeted delivery

(This special issue belongs to the Section Natural Products)

Plant-Based Extracts and the Therapeutic Potential of Bioactive Compounds, 2nd Edition

edited by

Grażyna Zgórka

submission deadline 31 Aug 2026 | 8 articles | Viewed by 17275 | Submission Open

Keywords: plant extracts; herbal medicinal products; standardization; phytochemical profiling; bioactive plant compounds; therapeutic effects

(This special issue belongs to the Section Natural Products)

Bioactive Compounds from Plants and Foods: From Traditional Medicine to Modern Applications in Nutrition and Health

edited by

Sendar Nery-Flores

Filiberto Gutierrez-Gutierrez

, Walter Trujillo-Rangel and

Raúl Rodríguez-Herrera

submission deadline 31 Aug 2026 | 4 articles | Viewed by 4857 | Submission Open

Keywords: herbal extracts; natural compounds; nutraceuticals; bioactive compounds; in vitro and in vivo studies; biological activities; phytochemistry; natural product drug discovery; computational screening of natural products; nanomaterials for natural product extraction

(This special issue belongs to the Section Natural Products)

Metabolism, Inflammation and Neurodegeneration: Natural Compounds as Therapeutic Agents

edited by Pedro Cisternas

submission deadline 31 Aug 2026 | 3 articles | Viewed by 3548 | Submission Open

Keywords: neurodegenerative diseases; natural compounds; metabolic dysfunction; neuroinflammation; therapeutic strategies

(This special issue belongs to the Section Natural Products)

Applications of Pharmacogenomics in Precision Medicine

edited by

Kariofyllis Karamperis

, Branka Zukic and

Fernanda Rodrigues-Soares

submission deadline 31 Aug 2026 | 2 articles | Viewed by 3065 | Submission Open

Keywords: personalized medicine; pharmacogenomics; drug– gene interactions; adverse drug reactions; pharmacogenomic biomarkers; multi-omics; population pharmacogenomics; precision therapeutics

(This special issue belongs to the Section Pharmacology)

Pyrazole and Its Derivatives: Drug Design, Synthesis, and Biological Evaluation

edited by

Matteo Lusardi

and

Marco Ponassi

submission deadline 31 Aug 2026 | 1 articles | Viewed by 2074 | Submission Open

Keywords: medicinal chemistry; drug design; drug discovery; pyrazole-based compounds; innovative synthesis; structure– activity relationships; biological activities; drug-like properties

(This special issue belongs to the Section Medicinal Chemistry)

Novel Vasoactive and Anti-Inflammatory Agents: From Mechanisms to Therapeutic Applications

edited by

Thyago Moreira De Queiroz

and Alice Valença Araújo

submission deadline 31 Aug 2026 | 3 articles | Viewed by 2063 | Submission Open

Keywords: vasorelaxation; inflammation; oxidative stress; nitric oxide; natural and synthetic products; blood pressure

(This special issue belongs to the Section Pharmacology)

Research on Guanidine-Based Drugs: Synthesis, Antiparasitic, Antifungal, Antiviral, and Anticancer Activities

edited by

Eduardo René Pérez González

Eduardo Henrique Zampieri

, Francisco Jaime Bezerra Mendonça-Junior,

Eduardo Maffud Cilli

and

Ana Marisa Fusco Almeida

submission deadline 31 Aug 2026 | 2 articles | Viewed by 1942 | Submission Open

Keywords: guanidine derivatives; medicinal chemistry; SAR analysis; neglected diseases; antiparasitic; antifungal; antiviral; anticancer; drug development

(This special issue belongs to the Section Medicinal Chemistry)

New Perspective of Antiviral Drugs

edited by

Grigoris Zoidis

submission deadline 31 Aug 2026 | 1 articles | Viewed by 1747 | Submission Open

Keywords: antiviral drugs; antiviral agents; small organic molecules; metal complexes; natural products

(This special issue belongs to the Section Medicinal Chemistry)

Current Advances, Applications and Future Development of Transition Metal Complexes, 2nd Edition

edited by

Domenico Iacopetta

submission deadline 31 Aug 2026 | 1 articles | Viewed by 1546 | Submission Open

Keywords: transition metal complexes; synthesis; catalysis; ligands; biological activity; applications; enzyme inhibition

(This special issue belongs to the Section Medicinal Chemistry)

Molecular Systems for the Delivery of Drugs and Contrast Agents, 2nd Edition

edited by

Angelo Maspero

Luca Nardo

and

Marco Lamperti

submission deadline 31 Aug 2026 | 1 articles | Viewed by 1319 | Submission Open

Keywords: biomarker-targeted drugs; contrast media for diagnostic imaging; drug delivery systems; photoactivated drugs and photoswitches; theranostics; liposomes; biomaterials-based drugs and drug shuttles (e.g.; DNA origami); biomimetic materials; nanoparticle applications to diagnostics and therapy; in silico drug design

(This special issue belongs to the Section Medicinal Chemistry)

Application of Natural Products in Retinal Disorders Therapy

edited by

Francesca Corsi

and

Maria Claudia Gargini

submission deadline 31 Aug 2026 | 1 articles | Viewed by 990 | Submission Open

Keywords: natural products; retinal disorders; neuroprotection; oxidative stress; retinal inflammation; retinal neurodegeneration; nutraceuticals; in vitro and in vivo retinal models

(This special issue belongs to the Section Natural Products)

Natural Products Drug Discovery and Their Pharmacological Applications

edited by Rosana Crespo

submission deadline 31 Aug 2026 | 1 articles | Viewed by 856 | Submission Open

Keywords: natural product; pharmaceutical applications; neurodegenerative disorders

(This special issue belongs to the Section Natural Products)

Cancer Therapeutics: Drug Repurposing and Computational Strategies

edited by

Minh Tuan Nguyen

submission deadline 31 Aug 2026 | 1 articles | Viewed by 747 | Submission Open

Keywords: cancer therapeutics; drug repurposing; computer-aided drug design (CADD); molecular dynamics simulation; virtual screening; targeted therapy; structure-based drug design; molecular docking; pharmacophore modeling

(This special issue belongs to the Section AI in Drug Development)

Discovery of Natural Products to Promote the Wound Healing

edited by

Ying Li

submission deadline 31 Aug 2026 | Viewed by 571 | Submission Open

Keywords: natural ingredients; natural biomedical polymers; drug delivery; nanomedicine; hydrogels; wound healing

Advances in Neuropharmacology and Brain Injury Therapeutics

edited by

Bruce X.W. Wong

and

Kaelyn Tan

submission deadline 31 Aug 2026 | Viewed by 427 | Submission Open

Keywords: neurodegenerative diseases; brain injuries; nanomedicine and targeted delivery; stem cell and regenerative therapies; precision medicine and diagnostic biomarkers

(This special issue belongs to the Section Pharmacology)

Contemporary Challenges and Solutions in Antimicrobial Use

edited by

Anca-Maria Arseniu

Alina Bereanu

and

Bogdan Vintila

submission deadline 31 Aug 2026 | Viewed by 422 | Submission Open

Keywords: antimicrobial use; novel drug delivery systems; biological barriers

(This special issue belongs to the Section Pharmacology)

From Prion Molecular Mechanisms to Targeted Therapeutics: Informing the Broader Proteinopathy Paradigm

edited by Patricia Aguilar-Calvo

submission deadline 31 Aug 2026 | Viewed by 326 | Submission Open

Keywords: prion diseases; prion-like; protein aggregation; proteinopathies; neurodegeneration; neurotoxicity; diagnostics; therapeutic strategies

(This special issue belongs to the Section Pharmacology)

Hybrid Molecules in Medicinal Chemistry: Design, Synthesis and Biological Evaluation

edited by

Tao Zhang

and John J. Walsh

submission deadline 31 Aug 2026 | Viewed by 281 | Submission Open

Keywords: hybrid molecules; medicinal chemistry; drug discovery; drug development; structure– activity relationships (SAR); multitarget-directed ligands; natural products; synthetic chemistry; biological evaluation; therapeutic innovation

(This special issue belongs to the Section Medicinal Chemistry)

Innovations in Integrin-Targeted Drug Delivery: From Peptide Conjugates to Dual-Action Therapeutics

edited by

Kelly Bugatti

Lucia Battistini

and

Andrea Sartori

submission deadline 31 Aug 2026 | Viewed by 253 | Submission Open

Keywords: integrins; peptide-drug conjugates (PDCs); drug delivery; peptide synthesis; dual conjugates

(This special issue belongs to the Section Biopharmaceuticals)

Protein Silencing in Pharmaceutical Applications

edited by

Hamidreza Montazeri Aliabadi

submission deadline 31 Aug 2026 | Viewed by 245 | Submission Open

Keywords: siRNA; CRISPR/Cas9; protein silencing; cancer; in vivo; clinical applications

(This special issue belongs to the Section Biopharmaceuticals)

Active Molecule Design Based on Conformational Pharmacology: Synthesis, NMR Spectroscopy, and Computational Modeling

edited by

Nikitas Georgiou

and

Demeter Tzeli

submission deadline 31 Aug 2026 | Viewed by 239 | Submission Open

Keywords: DFT; molecular docking; NMR; molecular dynamics

(This special issue belongs to the Section Pharmacology)

Bio-Based Materials from Food Sources: Advanced Platforms for Drug Delivery and Regenerative Therapeutics

edited by

Chengliang Li

, Min Wu and

Ruoyang Zhao

submission deadline 31 Aug 2026 | Viewed by 237 | Submission Open

Keywords: food biomacromolecules; natural proteins and peptides; formulation science; controlled release; targeted delivery; bone regeneration; wound healing; drug delivery

(This special issue belongs to the Section Pharmaceutical Technology)

Antioxidant Therapeutics: From Discovery to Clinical Practice

edited by

Alain R. Rodríguez-Orozco

and