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Pharmaceuticals publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Research on Guanidine-Based Drugs: Synthesis, Antiparasitic, Antifungal, Antiviral, and Anticancer Activities

edited by

Eduardo René Pérez González

Eduardo Henrique Zampieri

, Francisco Jaime Bezerra Mendonça-Junior,

Eduardo Maffud Cilli

and

Ana Marisa Fusco Almeida

submission deadline 31 Jan 2026 | Viewed by 342 | Submission Open

Keywords: guanidine derivatives; medicinal chemistry; SAR analysis; neglected diseases; antiparasitic; antifungal; antiviral; anticancer; drug development

(This special issue belongs to the Section Medicinal Chemistry)

Heterocyclic Compounds in Targeted Cancer Therapy: Advances in Medicinal Chemistry and Drug Development

edited by

Gabriele La Monica

and

Annamaria Martorana

submission deadline 31 Jan 2026 | Viewed by 326 | Submission Open

Keywords: heterocyclic compounds; targeted cancer therapy; medicinal chemistry; structure– activity relationship (SAR); computational drug design; small-molecule therapeutics; synthetic methodologies; bioactive heterocycles; green chemistry in drug discovery; in silico screening

(This special issue belongs to the Section Medicinal Chemistry)

Novel Drug Candidates for the Treatment of Cardiac and Renal Diseases

edited by

Ana Karina Aranda-Rivera

José Pedraza Chaverri

and Diana Barrera-Oviedo

submission deadline 31 Jan 2026 | Viewed by 323 | Submission Open

Keywords: kidney diseases; cardiac diseases; cardiorenal syndrome; treatments; chronic kidney diseases; drugs; dyslipidemia; oxidative stress

(This special issue belongs to the Section Pharmacology)

Advances in Targeting Mitochondrial Sirtuins for Treatment of Metabolic Diseases Such as Type 2 Diabetes and Obesity

edited by Linh Ho and

Tibebe Woldemariam

submission deadline 31 Jan 2026 | Viewed by 218 | Submission Open

Keywords: mitochondrial sirtuins; Sirt3; Sirt5; metabolic disorders; type 2 diabetes; drug targets; insulin resistance; reactive oxygen species (ROS)

(This special issue belongs to the Section Pharmacology)

Promising Natural Products with Anti-Inflammatory and Antioxidant Bioactivities: Extraction, Identification, and Biological Evaluation

edited by Sara Vieira and

Lillian Barros

submission deadline 31 Jan 2026 | Viewed by 218 | Submission Open

Keywords: bioactive compounds; extraction techniques; anti-inflammatory activity; antioxidant activity; inflammation; inflammatory molecules; signaling pathways

(This special issue belongs to the Section Natural Products)

Dopamine Receptor: Novel Opportunities for Drug Developments

edited by Pegi Pavletić and

Fabio Del Bello

submission deadline 31 Jan 2026 | Viewed by 196 | Submission Open

Keywords: dopamine receptors (DRs); GPCR; drug discovery; in silico drug design; drug optimization; molecular modelling; targeted protein degradation; DMPK; neurological disorders; cancer

(This special issue belongs to the Section Medicinal Chemistry)

Design, Synthesis and Biological Evaluation of Small Molecules for the Treatment of Solid Tumors

edited by

Aleksandra Sochacka-Ćwikła

Małgorzata Strzelecka

and

Żaneta Czyżnikowska

submission deadline 31 Jan 2026 | Viewed by 176 | Submission Open

Keywords: anticancer drugs; small-molecule agents; targeted therapy; solid cancers; drug delivery systems; drug resistance; approval characteristic; FDA; EMA

(This special issue belongs to the Section Medicinal Chemistry)

Development of Antibacterial Drugs to Combat Drug-Resistant Bacteria: 2nd Edition

edited by

Adriána Liptáková

and Iryna Voronkina

submission deadline 31 Jan 2026 | Viewed by 173 | Submission Open

Keywords: development of antibacterial drugs; drug-resistant bacteria; antimicrobial resistance; new therapeutic solutions; improvement of existing therapies; nosocomial infections

(This special issue belongs to the Section Pharmacology)

Advances in Targeted Therapy for Gastrointestinal Cancers

edited by

Juraj Prejac

and

Marin Golčić

submission deadline 31 Jan 2026 | Viewed by 146 | Submission Open

Keywords: targeted therapy; gastrointestinal cancers; molecular targets; drug resistance; biomarkers; immunotherapy; precision medicine; translational research; clinical trials; tumor microenvironment

(This special issue belongs to the Section Pharmacology)

Pharmaceutical Blood Products

edited by

Victor Tuan Giam Chuang

, Masaki Otagiri and

Kazuaki Taguchi

submission deadline 31 Jan 2026 | Viewed by 93 | Submission Open

Keywords: pharmaceutical blood products; plasma-derived therapeutics; recombinant blood factors; cellular therapies; immunoglobulins; fractionation technologies; viral inactivation; hemophilia treatments; gene-editing approaches; clinical efficacy

(This special issue belongs to the Section Biopharmaceuticals)

Classical and Novel Technology in the Extraction and Analysis of Active Ingredients from Natural Products for Effective Pre-Clinical Use

edited by

Pierre Dramou

and

Raphael Nammahime Alolga

submission deadline 5 Feb 2026 | 1 articles | Viewed by 1079 | Submission Open

Keywords: classical extraction; nanotechnology; active ingredients; nanozymes; nanocomposites; molecularly imprinted polymer; magnetic nanoparticles; MOFs; natural products; pre-clinical studies

(This special issue belongs to the Section Natural Products)

Advances in Topical and Mucosal Drug Delivery Systems

edited by

Michelle Franz-Montan

submission deadline 15 Feb 2026 | 2 articles | Viewed by 3965 | Submission Open

Keywords: topical drug delivery; mucosal drug delivery; transdermal drug delivery; controlled release; bioavailability enhancement; formulation development

(This special issue belongs to the Section Pharmaceutical Technology)

Chemotherapeutic and Targeted Drugs in Antitumor Therapy

edited by

Angéla Takács

and

László Kőhidai

submission deadline 15 Feb 2026 | 1 articles | Viewed by 1563 | Submission Open

Keywords: cancer; drug discovery; small-molecule drugs; targeted therapy; combination therapy; synergism; selectivity; immunotherapy; precision medicine

(This special issue belongs to the Section Pharmacology)

Application of Zebrafish Model in Pharmacology and Toxicology

edited by

Geonildo Rodrigo Disner

and

Mônica Lopes-Ferreira

submission deadline 15 Feb 2026 | 1 articles | Viewed by 354 | Submission Open

Keywords: chemical safety assessment; translational research; drug screening; human exposome; environmental contaminants

(This special issue belongs to the Section Pharmacology)

Click Chemistry-Aided Drug Discovery

edited by

Damien Bosc

submission deadline 15 Feb 2026 | Viewed by 88 | Submission Open

Keywords: click chemistry; drug discovery; structure– activity relationship; hit-to-lead; chemical probes; bio-orthogonal reactions; protein-templated reactions; bioisosteres; cycloaddition; 1; 2; 3-triazole

(This special issue belongs to the Section Medicinal Chemistry)

Heterocyclic Compounds in Medicinal Chemistry, 2nd Edition

edited by

Valentina Noemi Madia

and

Davide Ialongo

submission deadline 20 Feb 2026 | 2 articles | Viewed by 6765 | Submission Open

Keywords: heterocycles; drug design; drug discovery; bioactive compounds; structure-based drug design; structure– activity relationship; in silico studies; ADMET properties; multicomponent reactions; phytochemicals

(This special issue belongs to the Section Medicinal Chemistry)

Recent Advances in Ocular Pharmacology

edited by

Lampros Lamprogiannis

and

Ioannis Tsinopoulos

submission deadline 20 Feb 2026 | 3 articles | Viewed by 6403 | Submission Open

Keywords: ophthalmology; ocular diseases; drug delivery; drug targeting; controlled drug release; eye drops; biopolymers; nanomedicine; clinical applications; clinical trials

(This special issue belongs to the Section Pharmacology)

Discovering Novel Drugs from Plants

edited by

Yung-Chia Chen

submission deadline 20 Feb 2026 | 1 articles | Viewed by 1634 | Submission Open

Keywords: natural products; drug discovery; bioactive compound; extraction; ethnopharmacology; preclinical test

(This special issue belongs to the Section Natural Products)

Pharmacotherapy of Macular Diseases

edited by

Yoichi Sakurada

submission deadline 20 Feb 2026 | Viewed by 85 | Submission Open

Keywords: VEGF inhibitors; macular disorders; neovascular age-related macular degeneration; diabetic macular edema; macular edema associated with retinal vein occlusion

(This special issue belongs to the Section Pharmacology)

Medicinal Chemistry of Thiazine and Oxazine Derivatives: Trends and Future Directions as Therapeutic Drugs

edited by

Berenika M. Szczȩśniak-Siȩga

and

Żaneta Czyżnikowska

submission deadline 22 Feb 2026 | 1 articles | Viewed by 1022 | Submission Open

Keywords: thiazine; oxazine; morpholine; thiomorpholine; benzothiazine; phenothiazine; synthesis; drug; anti-inflammatory; anticancer

(This special issue belongs to the Section Medicinal Chemistry)

Biological Properties of Nanostructures Incorporated in Polymeric Matrices

edited by

Isabella Macário Ferro Cavalcanti

submission deadline 22 Feb 2026 | Viewed by 182 | Submission Open

Keywords: antimicrobial resistance; cancer; diseases; nanotechnology; polimer

(This special issue belongs to the Section Pharmaceutical Technology)

Medicinal Plants: A Natural Approach to Inflammatory Diseases and Conditions Related to Oxidative Stress

edited by

Sandra Barbalho

and

Adriano Araujo

submission deadline 25 Feb 2026 | 6 articles | Viewed by 18691 | Submission Open

Keywords: medicinal plants; phytocompounds; natural products; inflammatory diseases; oxidative stress

(This special issue belongs to the Section Natural Products)

Exploring Biomarkers and Pharmacotherapies for Substance Use Disorders

edited by

Ani Gasparyan

Daniela Navarro

and

Jorge Manzanares

submission deadline 25 Feb 2026 | 4 articles | Viewed by 18396 | Submission Open

(This special issue belongs to the Section Pharmacology)

Development of Novel Radiopharmaceuticals for SPECT and PET Imaging

edited by

Bianca Gutfilen

submission deadline 25 Feb 2026 | 8 articles | Viewed by 11391 | Submission Open

Keywords: oncology; theranostics; inflammation/infection diagnosis; autoimmune diseases; neurodegenerative diseases; cardiovascular diseases

(This special issue belongs to the Section Radiopharmaceutical Sciences)

Therapeutic Potential of Silver Nanoparticles (AgNPs), 2nd Edition

edited by

Goreti Pereira

submission deadline 25 Feb 2026 | 7 articles | Viewed by 8959 | Submission Open

Keywords: metallic nanostructures; plasmonic nanomaterials; photothermal therapy; photodynamic therapy; antimicrobial; antioxidant; anticancer

(This special issue belongs to the Section Medicinal Chemistry)

Advances in Biotechnological Formulations for Skin Disorders: Delivery Strategies and Biocompatibility

edited by Marcel Henrique Marcondes Sari,

Raul Edison Luna Lazo

and

Luana Mota Ferreira

submission deadline 25 Feb 2026 | 1 articles | Viewed by 5855 | Submission Open

Keywords: skin disorders; biotechnological formulations; nanocarriers; probiotic-based formulations; natural products; polysaccharides; skin delivery systems; bioactive compounds; antioxidant and anti-inflammatory effects; wound healing; safety and efficacy in skin therapies

(This special issue belongs to the Section Pharmaceutical Technology)

Self-Assembling Nanostructures for Cancer Therapy

edited by

André Moreni Lopes

submission deadline 25 Feb 2026 | 4 articles | Viewed by 5397 | Submission Open

Keywords: drug delivery systems; polymeric micelles; polymeric vesicles (polymersomes); surfactants; amphiphilic copolymers; stimuli-responsive polymers; cancer therapy; drugs; biopharmaceuticals; dual delivery

(This special issue belongs to the Section Pharmaceutical Technology)

Neuropsychiatric Disorders: Pharmacological Aspects

edited by

Ioana-Miruna Balmus

submission deadline 25 Feb 2026 | 2 articles | Viewed by 3662 | Submission Open

Keywords: neuropsychiatric disorders; DSM-V; pharmacodynamics; innovative therapies; animal models; neuropsychiatric patients; trauma and stress; neurodegeneration; affective disorders; neurodevelopmental disorders; schizophrenia; sleep disorders; comorbidities; cardiovascular; coagulopathies; gastrointestinal; microbiome– gut– brain axis

(This special issue belongs to the Section Pharmacology)

Treatment and Molecular Mechanisms of Depression

edited by Zuleide Maria Ignácio and Ricieri Mocelin

submission deadline 25 Feb 2026 | 1 articles | Viewed by 2524 | Submission Open

Keywords: major depressive disorder; molecular mechanisms; neurotransmitters; epigenetic; genetic polymorphisms; inflammation; neuroinflammation; pharmacological strategies; drugs; intracellular signaling

(This special issue belongs to the Section Medicinal Chemistry)

Drug Treatment for Epilepsy

edited by Clarissa Fantin Cavarsan

submission deadline 25 Feb 2026 | 1 articles | Viewed by 931 | Submission Open

Keywords: epilepsy; anticonvulsant; epileptic syndrome; seizure; epileptogenic; small molecule drugs

(This special issue belongs to the Section Pharmacology)

Innovative Approaches to GABAergic Drug Discovery: From Molecular Mechanisms to Advanced Therapeutics

edited by

Wojciech Kołodziejczyk

and

Donato Colangelo

submission deadline 25 Feb 2026 | 1 articles | Viewed by 624 | Submission Open

Keywords: GABAergic signaling; GABA receptors; drug discovery; neurological and psychiatric disorders; ligand design; computational drug development; artificial intelligence in pharmacology; high-throughput screening; targeted drug delivery; controlled release systems

(This special issue belongs to the Section Pharmacology)

Innovations in Solid Dispersions for Drug Delivery

edited by Qun Zhou

submission deadline 25 Feb 2026 | Viewed by 483 | Submission Open

Keywords: solid dispersions; chemistry; properties; crystal; delivery systems

(This special issue belongs to the Section Pharmaceutical Technology)

Pharmacological Approaches of Chronic Obstructive Pulmonary Disease (COPD) and Lung Cancer

edited by

Karolina H. Czarnecka-Chrebelska

and

Jinxiang Xi

submission deadline 25 Feb 2026 | Viewed by 423 | Submission Open

Keywords: chronic obstructive pulmonary disease (COPD); inflammasomes; lung cancer (LC); chronic bronchitis; cancer prevention and treatment; therapeutic approaches

(This special issue belongs to the Section Pharmacology)

Challenges and Emerging Trends in Photopharmacology

edited by Oleksandra Tiapko and Bernadett Bacsa

submission deadline 25 Feb 2026 | Viewed by 400 | Submission Open

Keywords: photopharmacology; ion channels; receptors; protein– ligand interactions; precision medicine; optogenetics

(This special issue belongs to the Section Pharmacology)

Scientific Evidence-Based Applications of Polyamines in Pharmaceuticals Science

edited by Kuniyasu Soda

submission deadline 25 Feb 2026 | Viewed by 310 | Submission Open

Keywords: polyamine; spermine; spermidine; health; senescence; age-related; disease

(This special issue belongs to the Section Pharmacology)

Targeting Epigenetic Regulation for Cancer Therapy

edited by

Bence Raposa

and

John M. Macharia

submission deadline 25 Feb 2026 | Viewed by 183 | Submission Open

Keywords: epigenetics; chromatin remodeling; histone modifications; non-coding RNAs; gene regulation; cancer therapy; epigenetic biomarkers; therapeutic targets

(This special issue belongs to the Section Pharmacology)

Innovative Applications and Performance Optimization of Biodegradable Polymers in Drug Delivery

edited by

Nikolaos D. Bikiaris

submission deadline 25 Feb 2026 | Viewed by 150 | Submission Open

Keywords: biodegradable polymers; drug delivery systems; controlled release; polymeric nanoparticles; targeted drug delivery; in vivo drug delivery; sustained release formulations

(This special issue belongs to the Section Pharmaceutical Technology)

Advances in Perinatal Pharmacology

edited by

Khaled Abduljalil

and

Raj Badhan

submission deadline 25 Feb 2026 | Viewed by 128 | Submission Open

Keywords: maternal; perinatal; neonatal; pharmacology; placenta; pregnancy

(This special issue belongs to the Section Pharmacology)

Antiparasitic Essential Oils: Mechanisms of Action, Technological Approaches, and Metabolism

edited by

Damião Pergentino de Sousa

submission deadline 25 Feb 2026 | Viewed by 116 | Submission Open

Keywords: volatile; essential oils; aromatic plants; aromas; protozoa; helminths; Trypanosoma; Leishmania

(This special issue belongs to the Section Natural Products)

Protein Silencing in Pharmaceutical Applications

edited by

Hamidreza Montazeri Aliabadi

submission deadline 25 Feb 2026 | Viewed by 54 | Submission Open

Keywords: siRNA; CRISPR/Cas9; protein silencing; cancer; in vivo; clinical applications

(This special issue belongs to the Section Biopharmaceuticals)

Pharmaceutical Application of Essential Oils and Their Compounds

edited by

Paweł Kwiatkowski

submission deadline 26 Feb 2026 | 1 articles | Viewed by 6276 | Submission Open

Keywords: essential oils; bacteria; fungi; alternative therapy; antimicrobial resistance; mechanism of action

(This special issue belongs to the Section Natural Products)

Adjuvant Therapies for Cancer Treatment: 2nd Edition

edited by

Fuyi Wang

submission deadline 27 Feb 2026 | 7 articles | Viewed by 20166 | Submission Open

Keywords: drug repurposing; combined therapies; new compounds; drug resistance; chemosensitization; antitumoral strategies

(This special issue belongs to the Section Pharmacology)

Challenges in the Development of PET and SPECT Radiotracers: Innovative Ideas with Negative Outcomes

edited by Magali Toussaint and Barbara Wenzel

submission deadline 27 Feb 2026 | 4 articles | Viewed by 4525 | Submission Open

Keywords: radiotracer development; positron emission tomography (PET); single-photon emission computed tomography (SPECT); negative results; diagnostic radiotracers; therapeutic radiopharmaceuticals; radiolabeling; automated synthesis and GMP; pre-clinical studies; medicinal chemistry

(This special issue belongs to the Section Radiopharmaceutical Sciences)

Advances in the Mechanism of Action and the Therapeutic Role of Phytopharmaceuticals

edited by Maria-Eleni Grafakou and

Jörg Heilmann

submission deadline 28 Feb 2026 | 1 articles | Viewed by 8008 | Submission Open

Keywords: medicinal plants; natural products; phytochemistry; biological activities; mechanism of action; biotransformation; microbiome

(This special issue belongs to the Section Natural Products)

Vitamin D and Its Derivatives in Pharmacology: Mechanisms and Therapeutic Applications

edited by

Agnieszka Sliwinska

submission deadline 28 Feb 2026 | 2 articles | Viewed by 1247 | Submission Open

Keywords: vitamin D; synthesis and metabolism; vitamin D derivatives; vitamin D deficiency related diseases; clinical trials on vitamin D and/or its derivatives

(This special issue belongs to the Section Pharmacology)

New Horizons in Drug Development Targeting Depression

edited by

Michał Górski

, Joanna Fojcik, Agnieszka Koźmin-Burzyńska and Marek Krzystanek

submission deadline 28 Feb 2026 | 1 articles | Viewed by 1072 | Submission Open

Keywords: treatment-resistant depression; novel antidepressants; glutamatergic system; personalized medicine; psychoactive therapies

(This special issue belongs to the Section Pharmacology)

Advances in Natural Products: Basic, Therapeutic, and Computational Approaches in Chronic and Infectious Diseases

edited by

Maira Huerta-Reyes

Gil Alfonso Magos-Guerrero

Oscar Barrera-Vázquez

and

Michael Danilenko

submission deadline 28 Feb 2026 | 2 articles | Viewed by 1056 | Submission Open

Keywords: natural products; chronic diseases; infectious diseases; computational; in silico

(This special issue belongs to the Section Natural Products)

Integrating Machine Learning (ML) into Medicinal Chemistry and Cheminformatics, 2nd Edition

edited by

Vartika Tomar

submission deadline 28 Feb 2026 | 1 articles | Viewed by 544 | Submission Open

Keywords: small molecules; molecular descriptors; molecular similarity; structure-based and ligand-based screening; homology modeling; molecular docking; drug– receptor docking; biological activity

(This special issue belongs to the Section Medicinal Chemistry)

Advances in Radionuclide Production and Their Applications in Therapeutic Radiopharmaceuticals

edited by Svetlana Selivanova

submission deadline 28 Feb 2026 | Viewed by 281 | Submission Open

Keywords: radiopharmaceutical sciences; radiochemistry; radiopharmacology; radionuclide production; molecular imaging

(This special issue belongs to the Section Radiopharmaceutical Sciences)

Discovery of Natural Products to Promote the Wound Healing

edited by