Pharmaceuticals for Inflammatory Bowel Disease (IBD)

A special issue of Pharmaceuticals (ISSN 1424-8247). This special issue belongs to the section "Pharmacology".

Deadline for manuscript submissions: 31 October 2025 | Viewed by 1202

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College of Public Health, Medical, and Veterinary Sciences (CPHMVS), Cairns Campus, James Cook University, Cairns, QLD 4878, Australia
Interests: pharmaceutical chemistry; drug discovery; medicinal plants; inflammatory bowel disease; cancer; diabetes
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Special Issue Information

Dear Colleagues,

Inflammatory bowel disease (IBD) is a chronic and debilitating inflammation of the gastrointestinal tract. It comprises Crohn’s and Ulcerative Colitis. IBD affects industrialized countries. The causes of IBD are not well established. However, its pathogenesis has been linked to genetics, microbiome, environment, and lifestyle. The clinical symptoms include loss of appetite, weight loss, severe abdominal cramps, constant diarrhea, and rectal bleeding. There is no cure for IBD, and the existing treatments, which are used for the induction and maintenance of IBD remission, are expensive and come with unwanted side effects. As a result, this comes with huge social, economic, and health burdens for people and countries. In their desperate searches for a cure, patients with IBD have been using herbal medicines, helminth therapy, and fecal microbiota transplant with limited success. There is a need for novel and effective treatments. Treatments can be developed from natural products or synthetically in laboratories. This Special Issue is dedicated to bringing in treatment perspectives from IBD clinicians, researchers, and patients.

Dr. Phurpa Wangchuk
Guest Editor

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Keywords

  • inflammatory bowel disease
  • IBD symptoms
  • IBD pathogenesis
  • IBD treatments

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Published Papers (1 paper)

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Research

18 pages, 6192 KiB  
Article
Mapping the Evolution of IBD Treatment: A Bibliometric Study on Biologics and Small Molecules
by Huibo Li, Jia Wang, Yang Hu, Wei Hu, Jun Li, Yang Liu, Rongsheng Zhao and Yi Zhun Zhu
Pharmaceuticals 2025, 18(3), 312; https://doi.org/10.3390/ph18030312 - 24 Feb 2025
Viewed by 908
Abstract
Objectives: This bibliometric analysis investigates recent research trends in biologics and small molecules for treating inflammatory bowel disease (IBD) based on literature from the past decade. Methods: This cross-sectional study involved analyzing data retrieved from the Web of Science Core Collection (WoSCC) [...] Read more.
Objectives: This bibliometric analysis investigates recent research trends in biologics and small molecules for treating inflammatory bowel disease (IBD) based on literature from the past decade. Methods: This cross-sectional study involved analyzing data retrieved from the Web of Science Core Collection (WoSCC) database to examine the evolution and thematic trends of biological agents and small-molecular drugs for IBD conducted between 1 January 2014, and 20 September 2024. VOSviewer software was utilized to assess co-authorship, co-occurrence, co-citation, and network visualization, followed by a further discussion on significant sub-themes. Results: From 2014 to 20 September 2024, the annual number of global publications increased by 23%, reflecting an acceleration in research activity. The journal “Inflammatory Bowel Diseases” published the highest number of manuscripts (579 publications) and garnered the most citations (13,632 citations), followed by the “Journal of Crohn’s & Colitis” (480 publications) and “Alimentary Pharmacology & Therapeutics” (250 publications). The United States led in productivity with 1943 publications and 66,320 citations, with UC San Diego (291) and authors Sandborn and Vermeire (180) topping the list. The co-occurrence cluster analysis of the top 100 keywords resulted in the formation of six distinct clusters: Disease Mechanisms, Drug Development, Surgical Interventions, Therapeutic Drug Monitoring (TDM), Immunological Targets, and Emerging Therapies. Burst terms (TNF-α inhibitors, JAK inhibitors, and trough-level optimization) highlight trends toward personalized biologics and small-molecule regimens. Conclusions: The bibliometric analysis indicates that IBD therapeutic research and clinical applications focus on biologics and small molecules, with research trends leaning toward precise therapy conversion or the combination in non-responders. Future work will assess monotherapy, the combination, and conversion therapies and investigate new drugs targeting inflammatory pathways. Full article
(This article belongs to the Special Issue Pharmaceuticals for Inflammatory Bowel Disease (IBD))
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