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Pharmaceuticals
Special Issues
Electrospinning for Biomedical Applications
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Electrospinning for Biomedical Applications

A Special Issue of Pharmaceuticals (ISSN 1424-8247) belonging to the section "Pharmaceutical Technology".

Deadline for manuscript submissions: 31 January 2027 | Viewed by 1271

Editors

Dr. Elisa Capuana

E-Mail Website
Guest Editor
Department of Engineering, University of Palermo, 90128 Palermo, Italy
Interests: tissue engineering; bioreactor; research; biomedical engineering; bioengineering
Dr. Vincenzo La Carrubba

E-Mail Website
Guest Editor
Department of Engineering, University of Palermo, 90128 Palermo, Italy
Interests: tissue engineering; bioreactor; research; biomedical engineering; bioengineering
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Electrospinning offers an exceptional level of control over fiber morphology, composition, and surface functionality, making it a powerful tool for engineering materials that mimic the structural intricacy of biological tissues. Its historical progression from a laboratory curiosity to a cornerstone of biomedical material science reflects both its adaptability and its capacity to address unmet needs in pharmaceutical technology. Today, electrospun constructs are increasingly considered for applications requiring precision, biocompatibility, and the ability to modulate molecular transport.

This Special Issue investigates the rapidly expanding landscape of electrospinning for biomedical applications, with a focus on how fiber-based architectures can be tailored to influence biological responses at multiple scales. Contributions in this volume explore strategies for optimizing polymer selection, incorporating bioactive cues, engineering multi-layer or composite systems, and integrating electrospinning with emerging fabrication approaches. Together, these studies demonstrate how this technology can contribute to controlled drug delivery, guided tissue regeneration, advanced wound care, biosensing, and implantable therapeutic platforms.

At the forefront of current research are dynamic and stimuli-responsive systems, fiber networks designed to regulate cell fate, and electrospun materials that bridge the gap between in vitro modelling and clinical translation. These developments illustrate the move toward more predictive and functional biomedical devices.

The Special Issue seeks submissions that provide rigorous experimental evidence, thoughtful mechanistic interpretation, and clear advancement beyond existing methodologies. Work that connects material design with therapeutic performance, safety, and manufacturability is particularly encouraged.

Dr. Elisa Capuana
Dr. Vincenzo La Carrubba
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-anonymized peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceuticals is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • electrospinning
  • nanofibers
  • drug delivery systems
  • tissue engineering scaffolds
  • biomedical materials
  • controlled release
  • polymer-based platforms
  • regenerative medicine

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Published Papers (1 paper)

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Review

31 pages, 7705 KB  
Review
Hybrid SES–MEW Scaffold Strategies: A Narrative Review of Multi-Scale Fiber Architectures for Soft and Hard Tissue Engineering
by Elisa Capuana, Valerio Brucato and Vincenzo La Carrubba
Pharmaceuticals 2026, 19(5), 683; https://doi.org/10.3390/ph19050683 - 27 Apr 2026
Viewed by 852
Abstract
Solution electrospinning (SES) and melt electrowriting (MEW) are complementary fiber-based fabrication platforms extensively investigated in tissue engineering. SES generates fibers typically ranging from the nanometer to the low-micrometer scale, producing fibrous networks that mimic the native extracellular matrix (ECM) and support key cellular [...] Read more.
Solution electrospinning (SES) and melt electrowriting (MEW) are complementary fiber-based fabrication platforms extensively investigated in tissue engineering. SES generates fibers typically ranging from the nanometer to the low-micrometer scale, producing fibrous networks that mimic the native extracellular matrix (ECM) and support key cellular functions. MEW, by contrast, operates solvent-free and enables precise, layer-by-layer deposition of microfibers with well-controlled geometry, conferring the mechanical integrity and open-pore architecture that SES constructs inherently lack. Despite growing interest, the body of peer-reviewed literature reporting original hybrid SES–MEW fabrication and biological outcome data remains limited, with no comprehensive cross-tissue synthesis available to date. This narrative review examines the current state of SES–MEW hybrid strategies across five tissue engineering targets selected for their clinical relevance: skin, vascular grafts, bone, cartilage, cardiac valves, and skeletal muscle. For each application, the architectural rationale, the fabrication approach, and the in vitro and in vivo biological outcomes are discussed in an integrated manner, with attention to how the spatial organization of nano- and microfibers translates into tissue-specific functional responses. A comparative analysis across tissue types highlights both the versatility of hybrid constructs and their persistent limitations, including suture retention values that remain below clinically accepted thresholds in vascular applications, incomplete cellular infiltration through dense nanofibrous layers, and the absence of validated, reproducible scale-up protocols compatible with clinical-grade manufacturing. The review concludes by identifying the most critical open questions in the field, encompassing process standardization, regulatory classification, and the emerging role of machine learning in closed-loop MEW process optimization. This work aims to provide an evidence-based perspective on the current state of hybrid SES–MEW scaffold engineering and the key translational gaps limiting clinical application. Full article
(This article belongs to the Special Issue Electrospinning for Biomedical Applications)
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