Advances in Non-Coding RNAs as Prognostic Biomarkers, Therapeutic Targets, and Regulatory Mechanisms in Cancer

A special issue of Pharmaceuticals (ISSN 1424-8247). This special issue belongs to the section "Biopharmaceuticals".

Deadline for manuscript submissions: 30 June 2026 | Viewed by 800

Special Issue Editors


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Guest Editor
Programa de Comunicación Celular en Cáncer, Instituto de Ciencias e Innovación en Medicina (ICIM), Facultad de Medicina Clínica Alemana, Universidad del Desarrollo, Santiago, Chile
Interests: non-coding RNAs in cancer; long non-coding RNAs in cancer; prognostic biomarkers in cancer; treatment targets in cancer; molecular mechanisms of long non-coding RNAs in cancer; cancer stem cell phenotype

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Guest Editor
Biochemistry Laboratory, Department of Chemistry, Faculty of Sciences, University of Tarapacá, Arica, Chile
Interests: estrogen receptor; hormone-related cancer; ER-alpha; oncogenic pathways; non-coding RNAs in cancer

Special Issue Information

Dear Colleagues,

It is a great pleasure to welcome you to this Special Issue of Pharmaceuticals, titled "Advances in Non-Coding RNAs as Prognostic Biomarkers, Therapeutic Targets, and Regulatory Mechanisms in Cancer". This collection aims to highlight recent progress and emerging concepts in the rapidly expanding field of non-coding RNAs (ncRNAs), with a particular focus on their roles in cancer biology and their potential clinical applications.

In recent years, the scientific community has uncovered the vast complexity and functional significance of ncRNAs, including long non-coding RNAs (lncRNAs) and microRNAs (miRNAs). These molecules have been shown to influence critical processes such as tumor initiation, progression, metastasis, therapy resistance, and immune regulation. As a result, ncRNAs are gaining increasing attention as both biomarkers for early diagnosis and prognosis, and as promising therapeutic targets.

This Special Issue welcomes original research articles and reviews addressing the multifaceted roles of ncRNAs in cancer. Topics of interest include molecular mechanisms of action, functional characterization, clinical correlations, biomarker discovery, and ncRNA-based therapeutic strategies.

We hope this Special Issue will contribute to a better understanding of how ncRNAs participate in cancer behavior and how they can be harnessed in precision medicine. We look forward to receiving your contributions and to showcasing the latest advances in this dynamic and promising area of cancer research.

Dr. Pablo Pérez-Moreno
Dr. Juan Pablo Muñoz
Guest Editors

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Keywords

  • non-coding RNAs
  • non-coding RNAs as prognostic biomarkers in cancer
  • non-coding RNAs as treatment targets in cancer
  • non-coding RNAs as diagnostic targets in cancer
  • molecular mechanisms on non-coding RNAs in cancer

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Published Papers (1 paper)

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Research

25 pages, 5685 KB  
Article
From Single-Cell and Bulk Transcriptomic Integration to Functional Verification: Triaptosis-Associated lncRNA Signature Predicts Survival and Guides Therapy in Hepatocellular Carcinoma
by Xiaolong Liu, Ziyun Zhuang, Jiaxi Cheng, Yujie Li, Duguang Li, Zhaoqi Shi, Jing Yang, Xiaoxiao Fan and Hui Lin
Pharmaceuticals 2025, 18(11), 1691; https://doi.org/10.3390/ph18111691 - 7 Nov 2025
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Abstract
Background: Hepatocellular carcinoma (HCC) continues to be a major cause of cancer associated deaths worldwide, highlighting the need for new prognostic biomarkers and treatment strategies. Triaptosis, a recently characterized mode of regulated cell death, has shown potential as a therapeutic target in various [...] Read more.
Background: Hepatocellular carcinoma (HCC) continues to be a major cause of cancer associated deaths worldwide, highlighting the need for new prognostic biomarkers and treatment strategies. Triaptosis, a recently characterized mode of regulated cell death, has shown potential as a therapeutic target in various malignancies, including HCC. Nevertheless, how long non-coding RNAs (lncRNAs) regulate triaptosis, as well as their function in HCC, is still not well understood. Methods: This study integrates bioinformatics and functional validation to delineate the interplay between lncRNAs and triaptosis in HCC progression. Results: Firstly, we confirm that pharmacologically inducing triaptosis, a process centrally mediated by ROS accumulation, with menadione sodium bisulfite (MSB) can inhibit HCC growth both in vitro and in vivo. Furthermore, single-cell RNA sequencing identifies a specific elevation of the triaptosis-related gene MTM1 in malignant hepatocytes. Through systematic bioinformatics analysis of TCGA data, we develop a 5-lncRNA prognostic signature (LINC01134, HPN-AS1, DDX11-AS1, AC009283.1, AC009005.1) with superior predictive power over conventional clinical parameters. Strikingly, functional studies reveal that LINC01134 acts as a crucial oncogenic driver and its depletion suppresses proliferation, migration, and invasion while sensitizing cells to triaptosis via MTM1-mediated PI(3)P catabolism. Conclusions: Collectively, our study confirms that triaptosis is a therapeutically targetable signaling in HCC and proposes LINC01134 as a biomarker and therapeutic target, offering new insights into lncRNA-mediated regulation of cell death for precision oncology. Full article
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