Advances in Smooth Muscle Pharmacology

A special issue of Pharmaceuticals (ISSN 1424-8247). This special issue belongs to the section "Pharmacology".

Deadline for manuscript submissions: 31 December 2025 | Viewed by 661

Special Issue Editors


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Guest Editor
Department of Biophysics, Medical University of Bialystok, 15-089 Bialystok, Poland
Interests: smooth muscles; gastric motility; uterine contractions; potassium channels; nitric oxide; polyphenols; quercetin; resveratrol; beta-adrenoceptor

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Guest Editor
Department of Biophysics, Medical University of Bialystok, 15-089 Bialystok, Poland
Interests: smooth muscles; gastric motility; uterine contractions; potassium channels; polyphenols

E-Mail Website
Guest Editor
Department of Biophysics, Medical University of Bialystok, 15-089 Bialystok, Poland
Interests: smooth muscles; bisphenols; air pollution; environmental monitoring; soil radioactivity

Special Issue Information

Dear Colleagues,

Smooth muscle tissue is essential for regulating a wide range of physiological processes, including vascular tone regulation, gastrointestinal motility, airway constriction, and urogenital functions. Dysfunctions in smooth muscle contribute to significant clinical conditions such as hypertension, aneurysms, coronary artery spasms, asthma, irritable bowel syndrome, gastroparesis, urinary incontinence, erectile dysfunction, dysmenorrhea, or infertility.

This Special Issue entitled "Advances in Smooth Muscle Pharmacology" aims to highlight cutting-edge research in smooth muscle pharmacology, focusing on novel signaling pathways, receptor–ligand interactions, ion channel regulation, and the development of new therapeutic agents. Emphasis is also placed on translational approaches that bridge basic research with clinical applications, providing insights into how innovative pharmacological strategies can address unmet medical needs.

The Special Issue explores the recent breakthroughs in studying smooth muscle function, regulation, and therapeutic targeting. By bringing together interdisciplinary contributions from molecular biology, biophysics, and pharmacology, this Special Issue seeks to advance our understanding of smooth muscle pathophysiology and stimulate the development of targeted therapies.

Dr. Beata Modzelewska
Dr. Tomasz Kleszczewski
Dr. Jacek Kapała
Guest Editors

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Keywords

  • smooth muscle regulation
  • pharmacological interventions
  • ion channel modulation
  • receptor–ligand dynamics
  • therapeutic drug development
  • vascular tone regulation
  • smooth muscle disorders
  • translational pharmacology
  • cellular signaling pathways
  • pathophysiology

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Published Papers (1 paper)

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Review

30 pages, 2981 KB  
Review
Polyphenols as Modulators of Gastrointestinal Motility: Mechanistic Insights from Multi-Model Studies
by Andrzej Chomentowski, Krzysztof Drygalski, Tomasz Kleszczewski, Marta Berczyńska, Marzena Tylicka, Jacek Kapała, Agnieszka Raciborska, Przemysław Zubrzycki, Hady Razak Hady and Beata Modzelewska
Pharmaceuticals 2025, 18(10), 1564; https://doi.org/10.3390/ph18101564 - 16 Oct 2025
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Abstract
Dietary polyphenols are recognized as crucial modulators of gastrointestinal motility, holding therapeutic promise for conditions like irritable bowel syndrome, postoperative ileus, and functional dyspepsia. However, their reported effects are heterogeneous, ranging from spasmolytic to prokinetic. This review aims to clarify these inconsistencies by [...] Read more.
Dietary polyphenols are recognized as crucial modulators of gastrointestinal motility, holding therapeutic promise for conditions like irritable bowel syndrome, postoperative ileus, and functional dyspepsia. However, their reported effects are heterogeneous, ranging from spasmolytic to prokinetic. This review aims to clarify these inconsistencies by synthesizing experimental evidence on structure–activity relationships and underlying mechanisms. Relevant publications were identified in PubMed and Google Scholar using terms related to polyphenols and gastrointestinal motility. References were selected for relevance, and the narrative review integrates findings from in vitro, ex vivo, in vivo, and clinical studies. Across various experimental models, polyphenols function as multi-target modulators of gastrointestinal smooth muscle. The primary mechanisms identified involve the blockade of voltage-dependent L-type Ca2+ channels, activation of K+ channels (BK, KATP), and modulation of the NO/cGMP and cAMP/PKA pathways. Flavones and multiple flavonols consistently demonstrate spasmolytic activity via Ca2+ channel antagonism. In contrast, flavanones engage BK and KATP channels to induce membrane hyperpolarization. Complex extracts from plants like ginger and turmeric exhibit mixed pro- or antimotility effects, reflecting the diverse profiles of their constituent compounds. While robust ex vivo pharmacology and some in vivo and human data exist, a high degree of dataset heterogeneity and inconsistent reporting impedes direct translational efforts. Polyphenols are promising multi-mechanistic modulators of gastrointestinal motility with clear structure–activity patterns. To advance their clinical application, future research must focus on establishing standardized in vivo pharmacokinetics, conducting targeted structure–activity studies, employing bioassay-guided fractionation, and designing rigorous clinical trials. Full article
(This article belongs to the Special Issue Advances in Smooth Muscle Pharmacology)
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