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Recent Advances in the Research of Drug Delivery System: Materials,...
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Recent Advances in the Research of Drug Delivery System: Materials, Preparation Methods, and Mechanisms

A special issue of Pharmaceuticals (ISSN 1424-8247). This special issue belongs to the section "Pharmaceutical Technology".

Deadline for manuscript submissions: 30 December 2026 | Viewed by 6677

Editor

Prof. Dr. Haixia Chen

E-Mail Website
Guest Editor
Tianjin Key Laboratory for Modern Drug Delivery & High-Efficiency, School of Pharmaceutical Science and Technology, Tianjin University, Tianjin 300072, China
Interests: natural product; isolation; structure identification; physicochemical properties; bioactivity; structure-activity relationship; mechanism
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Drug delivery systems are designed to transport medications to the appropriate position in the body, reducing the severity of side effects and enhancing their efficacy. Therefore, they have been extensively implemented in the field of medicine. With the development of science and technology, a growing number of medications have emerged, and the traditional drug delivery systems are inadequate in meeting the demands of health care. The development of new drug delivery systems has become a research hotspot.

This Special Issue covers the progress in all areas of drug delivery systems or reviews, including their materials, preparation methods, mechanisms, and their novel applications in the prevention of osteoporosis and other diseases.

Prof. Dr. Haixia Chen
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-anonymized peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceuticals is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • drug delivery system
  • preparation
  • material
  • mechanism
  • application
  • bioactivities
  • targeted delivery

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Published Papers (3 papers)

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Research

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22 pages, 3989 KB  
Article
Precipitation-Based Encapsulation of Fibrinogen in Calcium Carbonate for Non-Compressible Hemorrhage Control
by Henry T. Peng, Tristan Bonnici, Catherine Tenn, Christian J. Kastrup and Andrew Beckett
Pharmaceuticals 2026, 19(6), 923; https://doi.org/10.3390/ph19060923 - 11 Jun 2026
Viewed by 503
Abstract
Background: Uncontrolled hemorrhage, especially at non-compressible sites, remains a major cause of preventable trauma deaths. This study reports the development of fibrinogen-loaded calcium carbonate (CaCO3) microparticles that combine hemostatic activity with self-propelling capability for targeted delivery against blood flow, with [...] Read more.
Background: Uncontrolled hemorrhage, especially at non-compressible sites, remains a major cause of preventable trauma deaths. This study reports the development of fibrinogen-loaded calcium carbonate (CaCO3) microparticles that combine hemostatic activity with self-propelling capability for targeted delivery against blood flow, with a focus on understanding formulation-dependent trade-offs among particle yield, protein loading, clotting performance, and transport behavior. Methods: Microparticles were synthesized via a precipitation method using different carbonate sources and characterized for yield, morphology, size, and fibrinogen encapsulation. Hemostatic function was assessed using rotational thromboelastometry (ROTEM) in fibrinogen-deficient plasma. Propulsion behavior was evaluated following exposure to protonated tranexamic acid (TXA+), which triggers CO2 generation. Particle size and encapsulation were examined by microscopy and fluorescence imaging. Results: The precipitation method produced spherical micrometer-sized particles, with fibrinogen inclusion reducing yield and particle size relative to unload controls. Fluorescence microscopy confirmed successful encapsulation. Encapsulation efficiency varied with formulation, with sodium carbonate-based particles showing higher relative fibrinogen loading. ROTEM analysis demonstrated that fibrinogen-loaded particles significantly improved clot formation, increasing maximum clot firmness compared to fibrinogen-free particles, although performance remained formulation-dependent. TXA+-triggered propulsion achieved maximum speeds up to 4.221 cm/s. Fibrinogen-loaded particles exhibited longer activation lag times than unloaded particles, indicating a trade-off between hemostatic functionality and propulsion kinetics. Conclusions: Fibrinogen-loaded CaCO3 microparticles exhibit both hemostatic activity and chemically triggered motion in vitro. The study identifies key formulation-dependent trade-offs between particle yield, fibrinogen loading, clotting performance, and propulsion behavior. While these findings support the feasibility of combining localization and clot stabilization mechanisms, further studies under physiologically relevant flow conditions and in vivo models are required to evaluate their potential for active delivery in non-compressible hemorrhage. Full article
(This article belongs to the Special Issue Recent Advances in the Research of Drug Delivery System: Materials, Preparation Methods, and Mechanisms)
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17 pages, 1412 KB  
Article
Effect of Acoustic Pressure on Temozolomide-Loaded Oleic Acid-Based Liposomes and Its Safety to Brain Tissue
by Vasilisa D. Dalinina, Vera S. Shashkovskaya, Iman M. Khaskhanova, Daria Yu. Travnikova, Nelly S. Chmelyuk, Dmitry A. Korzhenevskiy, Vsevolod V. Belousov and Tatiana O. Abakumova
Pharmaceuticals 2025, 18(6), 910; https://doi.org/10.3390/ph18060910 - 18 Jun 2025
Cited by 6 | Viewed by 1951
Abstract
Background: Glioblastoma (GBM) is a highly aggressive primary brain tumor with limited therapeutic options, particularly due to the limited blood–brain barrier (BBB) permeability. Nanoparticle-based drug delivery systems, such as liposomes, can prolong drugs’ circulation time and enhance their accumulation within brain tumors, thereby [...] Read more.
Background: Glioblastoma (GBM) is a highly aggressive primary brain tumor with limited therapeutic options, particularly due to the limited blood–brain barrier (BBB) permeability. Nanoparticle-based drug delivery systems, such as liposomes, can prolong drugs’ circulation time and enhance their accumulation within brain tumors, thereby improving therapeutic outcomes. Controlled drug release further contributes to high local drug concentrations while minimizing systemic toxicity. Oleic acid (OA), a monounsaturated fatty acid, is commonly used to enhance drug loading and increase lipid membrane fluidity. In this study, we developed liposomal formulations with optimized temozolomide (TMZ)’s loading and analyze its response to focused ultrasound (FUS). Methods: We synthetized OA-based liposomes with different lipid composition, performed physicochemical characterization (DLS, TEM) and analyzed the TMZ loading efficiency. Different FUS parameters were tested for effective OA-based liposomes destruction. Safety of selected parameters was evaluated in vivo by MRI, histological staining and RT-PCR of pro-inflammatory cytokines. Results: All the formulations exhibited comparable hydrodynamic diameters; however, OA-containing liposomes demonstrated a significantly higher TMZ encapsulation efficiency and enhanced cytotoxicity in U87 glioma cells. Moreover, it was shown that OA-liposomes were disrupted at lower acoustic pressures (5 MPa), while conventional liposomes required higher thresholds (>8 MPa). A safety analysis of FUS parameters indicated that pressures exceeding 11 MPa induced brain edema, necrotic lesions and elevated cytokine levels within 72 h post-treatment. Conclusions: These results suggest that OA-based liposomes possess favorable characteristics, with an increased sonosensitivity for the site-specific delivery of TMZ, offering a promising strategy for glioma treatment. Full article
(This article belongs to the Special Issue Recent Advances in the Research of Drug Delivery System: Materials, Preparation Methods, and Mechanisms)
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33 pages, 1271 KB  
Systematic Review
Updated Advances on Drugs and Bone-Targeting Nanoparticles for Osteoporosis Therapy: Carrier Materials, Modification, Function Mechanism, and Applications—A Systematic Review
by Yehao Lin, Yidong Xu, Siyue Zhou, Junyu Liu, Min Zhang, Baoxin Zhang and Haixia Chen
Pharmaceuticals 2025, 18(12), 1809; https://doi.org/10.3390/ph18121809 - 27 Nov 2025
Cited by 5 | Viewed by 3522
Abstract
Background: Osteoporosis is one of the most common bone metabolic diseases that affects mainly the health of elderly people. It is a kind of prevalent chronic disease, and the conventional treatment methods have some limitations or side effects. Targeting nanoparticles represent a novel [...] Read more.
Background: Osteoporosis is one of the most common bone metabolic diseases that affects mainly the health of elderly people. It is a kind of prevalent chronic disease, and the conventional treatment methods have some limitations or side effects. Targeting nanoparticles represent a novel technology that has garnered extensive attention in recent years. They can selectively enhance the drug concentration at the targeted site, offering a novel treatment method. Methods: The review is carried out according to the Preferred Reporting Items for Systematic Reviews (PRISMA 2020) guidelines. Results: This article comprehensively summarizes recent research progress on the status of existing anti-osteoporosis drugs and bone-targeting nanoparticles for the treatment of osteoporosis, including their carrier materials, modification techniques, preparation methods, and function mechanisms. It also discusses their applications in RNA interference (RNAi) therapy and other related areas. Furthermore, given the limitations of bone-targeting nanoparticles, solutions and viewpoints have been proposed. This review summarizes that bone-targeting nanoparticles are useful for osteoporosis therapy and provide a novel perspective for new drug discovery. Conclusions: Bone-targeting nanoparticles overcome the limitations of traditional treatment methods and enhance therapeutic efficacy. However, the clinical translation of bone-targeted nanoparticles remains challenging and requires further investigation. Full article
(This article belongs to the Special Issue Recent Advances in the Research of Drug Delivery System: Materials, Preparation Methods, and Mechanisms)
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