Natural Origin Polyphenols and Oxidative Stress: Mechanisms and Therapeutic Applications
A special issue of Pharmaceuticals (ISSN 1424-8247). This special issue belongs to the section "Natural Products".
Deadline for manuscript submissions: 15 June 2026 | Viewed by 243
Special Issue Editors
Interests: antioxidants; antimicrobials; agro-food by-product valorization; analytical chemistry (HPLC-DAD-ESI/MS); bioactive compounds
Interests: antioxidant phytochemicals; polyphenol characterization (HPLC-DAD-ESI/MSn); agri-food by-product valorization; in vitro antioxidant assays (DPPH, RP, TBARS, OxHL-IA); bioactive extracts from Solanaceae & mushrooms; green extraction technologies (ultrasound, microwave); structure-activity relationships of antioxidants; plant secondary metabolites; sustainable nutraceutical development; oxidative stress mitigation; natural antioxidant discovery; foodomics approaches
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Special Issue Information
Dear Colleagues,
Natural origin polyphenols are among the most abundant and biologically relevant groups of plant-derived compounds in human health. These molecules, including flavonoids, phenolic acids, tannins, and stilbenes, among others, exhibit remarkable antioxidant properties and play a critical role in counteracting oxidative stress, one of the major contributors to chronic and degenerative diseases. Beyond their well-recognized free-radical scavenging activity, recent discoveries highlight complex mechanisms through which polyphenols modulate cellular signaling, gene expression, mitochondrial function, and host–microbiota interactions.
These advances open new perspectives for the development of polyphenol-based therapeutic strategies targeting conditions such as metabolic and cardiovascular disorders, neurodegeneration, inflammation, and cancer. Furthermore, growing interest in sustainable and health-promoting nutrition has driven exploration of natural food matrices, nutraceuticals, and functional foods as delivery systems for polyphenol-rich ingredients.
This Special Issue invites original research papers, systematic reviews, and communications that expand the mechanistic understanding and therapeutic relevance of dietary polyphenols related to oxidative stress-related disorders. Studies addressing bioaccessibility and bioavailability, innovative extraction and stabilization techniques, polyphenol-derived metabolites, safety evaluation, and clinical implications are particularly welcomed. Research on emerging natural sources and the valorization of food by-products is also encouraged.
We believe this collection will provide a comprehensive and up-to-date view of the growing opportunities to harness polyphenols in preventive and therapeutic applications.
We look forward to your valuable contributions.
Dr. Adriana Molina
Dr. Mikel Añibarro-Ortega
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceuticals is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- polyphenols
- oxidative stress
- antioxidant mechanisms
- therapeutic applications
- chronic diseases
- functional foods
- bioavailability
- cellular signaling
- natural products
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