Advances in Regulatory Mechanisms and Therapeutic Potential of Non-Coding RNAs in Neurodegenerative Diseases
A special issue of Pharmaceuticals (ISSN 1424-8247). This special issue belongs to the section "Biopharmaceuticals".
Deadline for manuscript submissions: 31 December 2025 | Viewed by 39
Special Issue Editors
Interests: amyotrophic lateral sclerosis; non-coding RNA; computational biology
Special Issue Information
Dear Colleagues,
Neurodegenerative diseases—such as amyotrophic lateral sclerosis (ALS), Alzheimer’s disease (AD), and Parkinson’s disease (PD) —are complex and multifactorial disorders characterized by progressive neuronal dysfunction and loss. Accumulating evidence underscores the critical roles of non-coding RNAs (ncRNAs), including microRNAs, long non-coding RNAs, and circular RNAs, in modulating gene expression, synaptic plasticity, mitochondrial function, and neuroinflammatory pathways implicated in disease pathogenesis.
This Special Issue will spotlight recent advances in elucidating the molecular mechanisms through which ncRNAs contribute to neurodegeneration. It will also highlight their translational potential as biomarkers for early diagnosis and disease progression and their promise as therapeutic targets in precision medicine. We welcome original research articles and reviews focusing on the mechanistic insights into ncRNA biology, novel regulatory networks, and the preclinical or clinical applications of ncRNA-based strategies.
Additionally, this collection aims to foster a comprehensive understanding of ncRNA functions in the central nervous system and catalyze the development of innovative diagnostic and therapeutic approaches for these devastating diseases by integrating findings from experimental and clinical research.
Dr. Paola Ruffo
Dr. Maurizio Grassano
Guest Editors
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Keywords
- non-coding RNAs
- microRNAs
- long non-coding RNAs
- circular RNAs
- neurodegeneration
- Alzheimer's disease
- Parkinson's disease
- amyotrophic lateral sclerosis
- gene regulation
- biomarkers
- RNA therapeutics
- neuroinflammation
- synaptic dysfunction
- translational neuroscience
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