Special Issues

Pharmaceuticals publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Emerging Therapies for Diabetes and Obesity
edited by Pedro Cisternas
submission deadline 15 Jan 2026 | 5 articles | Viewed by 8939 | Submission Open
Keywords: insulin resistance; adipose tissue dysfunction; antidiabetic agents; metabolic disease; metabolic inflammation; pharmacological interventions
(This special issue belongs to the Section Pharmacology)
The Pharmacology of Bisphosphonates: New Advances submission deadline 20 Jan 2026 | 6 articles | Viewed by 13319 | Submission Open
Keywords: bisphosphonates; bisphosphonic acids; pharmacology of bisphosphonates; pharmacokinetics; pharmacodynamics; hypocalcemia; osteonecrosis; gastrointestinal disturbances; delivery systems of bisphosphonates; bisphosphonate prodrugs; osteoporosis; breast cancer; prostate cancer; hypercalcemia; antiresorptive properties; antibacterial properties; anti-cancer properties; antiparasitic activity; antiprotozoal properties; antiviral properties; effects of drugs on the metabolism and biomechanical properties of bone tissue; properties and effects of bisphosphonates in in vitro and/or in vivo experimental models of bone disorders; different bisphosphonates in an in vitro experimental model of bone disease
(This special issue belongs to the Section Pharmacology)
Pharmacological Activities and Therapeutic Potential of Novel Drug Derivatives submission deadline 20 Jan 2026 | 2 articles | Viewed by 9305 | Submission Open
Keywords: novel drug derivatives; synthesis; drug design; therapeutic potential; biological activity; pharmacological activity
(This special issue belongs to the Section Pharmacology)
Interdisciplinary Approaches to Preventing and Treating Inflammatory and Oxidative Diseases with Medicinal Plants and Bioactive Compounds submission deadline 20 Jan 2026 | 2 articles | Viewed by 6899 | Submission Open
Keywords: interdisciplinary studies; inflammation; inflammatory diseases; oxidative stress; oxidative diseases; pro-inflammatory; pro-oxidative; neurodegenerative diseases; cardiovascular diseases; cancer; medicine; rheumatological diseases; endocrinological diseases; gastroenterological diseases; dermatological diseases; pulmonary diseases; dentistry; nutrition; dietetics; therapy; medicinal plants; bioactive compounds; phytochemicals; phytochemistry
(This special issue belongs to the Section Natural Products)
Biological and Pharmacological Research on Indole-3-Carbinol (I3C) and Its Derivatives submission deadline 20 Jan 2026 | 3 articles | Viewed by 6084 | Submission Open
Keywords: indole-3-carbinol; natural and synthetic derivatives of I3C; synthetic procedures; biosynthetic processes; in vitro; in vivo and clinical studies; mechanism of action; biological properties; pharmacological properties; potential therapeutic applications in health and disease
(This special issue belongs to the Section Pharmacology)
Resveratrol: Pharmacological Mechanisms and Therapeutic Potential as a Natural Product submission deadline 20 Jan 2026 | 1 articles | Viewed by 1379 | Submission Open
Keywords: resveratrol; natural compound pharmacology; therapeutic potential; drug development; biomedical research
(This special issue belongs to the Section Natural Products)
Pharmacotherapeutics of Sarcoidosis
edited by , and Giorgio Monteleone
submission deadline 20 Jan 2026 | 1 articles | Viewed by 1002 | Submission Open
Keywords: sarcoidosis; drug combinations; interstitial lung disease; biological therapy; target therapy; biomarkers
(This special issue belongs to the Section Pharmacology)
Pharmacoepidemiology and Pharmacovigilance in Drug Therapy: New Issues, Challenges, and Applications
edited by Loreta Kubilienė
submission deadline 25 Jan 2026 | 6 articles | Viewed by 19585 | Submission Open
Keywords: pharmacoepidemiology; pharmacovigilance; drug safety monitoring; regulatory practices; hospitalization; adverse drug events; drug safety; preventability
(This special issue belongs to the Section Pharmacology)
The Application of Pharmacogenetics in Toxicity Prevention and Drug Effect Improvement
edited by Pura Ballester
submission deadline 25 Jan 2026 | 5 articles | Viewed by 19330 | Submission Open
Keywords: pharmacogenetics; drug toxicity prevention; efficacy enhancement; pharmaceutical research; precision medicine; therapeutic optimization
(This special issue belongs to the Section Pharmacology)
2D and 3D Culture Systems: Current Trends and Biomedical Applications
edited by , Colus Ilce Mara and
submission deadline 25 Jan 2026 | 8 articles | Viewed by 13974 | Submission Open
Keywords: spheroids; organoids; 3D cultures; tissue engineering; disease modelling; regenerative medicine; cell-extracellular matrix interaction; drug screening
(This special issue belongs to the Section Biopharmaceuticals)
Recent Research in Therapeutic Potentials of Venoms
edited by Samuel Teixeira, Daiana Silva Lopes and
submission deadline 25 Jan 2026 | 2 articles | Viewed by 2644 | Submission Open
Keywords: bioprospecting; biotechnological tools; snake venom toxins; drug discovery; natural products; pharmacological applications; molecular targets of venom toxins; toxicology; peptide therapeutics; venom-based drug delivery
(This special issue belongs to the Section Natural Products)
Anti-Inflammatory and Antithrombotic Natural Bioactives for Drug Development: Current Status and Future Perspectives submission deadline 25 Jan 2026 | 1 articles | Viewed by 2200 | Submission Open
Keywords: chronic disorders; bioactives; natural sources; sustainable sources; pharmaceuticals; drug discovery; structure– activity relationship; synergism; health promotion; bio-functional; drugs; inflammation; thrombosis; platelets; cancer; CVD; neurodegenerative; neuroprotective; anti-inflammatory; cardio-protective; anti-cancer; anti-tumor; anti-thrombotic; antiplatelet; anticoagulant
(This special issue belongs to the Section Natural Products)
Therapeutic Drug Monitoring: Techniques and Applications in Pharmaceutical Analysis
edited by Ivana Cizmarova and
submission deadline 25 Jan 2026 | 2 articles | Viewed by 1002 | Submission Open
Keywords: Therapeutic Drug Monitoring (TDM); bioanalytical method development; LC-MS/MS; sample preparation; method validation; pharmacokinetics; pharmacodynamics; individualized dosing; precision medicine; clinical applications
Dysregulation of Cyclic AMP and Cyclic PIP Synthesis: Implications for Disease and Advances in Therapeutic Development
edited by
submission deadline 25 Jan 2026 | 1 articles | Viewed by 968 | Submission Open
Keywords: reversible protein phosphorylation; cyclic AMP; cyclic PIP; signal transduction; cyclic AMP antagonist
(This special issue belongs to the Section Medicinal Chemistry)
Current Advances, Applications and Future Development of Transition Metal Complexes, 2nd Edition
edited by
submission deadline 25 Jan 2026 | 1 articles | Viewed by 820 | Submission Open
Keywords: transition metal complexes; synthesis; catalysis; ligands; biological activity; applications; enzyme inhibition
(This special issue belongs to the Section Medicinal Chemistry)
Therapeutic Potential of Aldehyde Dehydrogenases submission deadline 25 Jan 2026 | Viewed by 653 | Submission Open
Keywords: ALDH; cancer; cancer stem cells; diabetes; Parkinson’ s disease; Alzheimer’ s disease; ALDH inhibitors; ALDH signaling; CSC-based therapeutics; therapeutic strategies
(This special issue belongs to the Section Medicinal Chemistry)
Advances in Drug Treatment for Pediatric Gastroenterology
edited by Roxana Elena Matran, Iulia Florentina Ţincu and
submission deadline 25 Jan 2026 | Viewed by 320 | Submission Open
Keywords: biologics; Crohn’ s disease; ulcerative colitis; eosinophilic esophagitis; autoimmune hepatitis; probiotics; inflammatory bowel disease
(This special issue belongs to the Section Pharmacology)
Gut Microbiota Modulation: Probiotics, Postbiotics and Other Bioactive Compounds—2nd Edition submission deadline 25 Jan 2026 | Viewed by 282 | Submission Open
Keywords: gut microbiota; bioactive compounds; immune system; nutrition respiratory health
Pharmacogenomics and Ethnic Diversity: Optimizing Drug Response Across Populations
edited by and Gisely Cardoso De Melo
submission deadline 25 Jan 2026 | Viewed by 262 | Submission Open
Keywords: pharmacogenomics; pharmacogenetics; ethnic groups; population genetics; ancestry; drug response
(This special issue belongs to the Section Pharmacology)
Design, Synthesis and Evaluation of Novel 18F Radiotracers
edited by and John E. Shively
submission deadline 25 Jan 2026 | Viewed by 256 | Submission Open
Keywords: positron emission tomography (PET); fluorine-18 (F-18); radiotracer development; molecular imaging; non-invasive diagnostic technique; synthetic methodologies; preclinical evaluation
(This special issue belongs to the Section Radiopharmaceutical Sciences)
Pharmacotherapy of Inflammatory Bowel Disease, 2nd Edition
edited by
submission deadline 25 Jan 2026 | 1 articles | Viewed by 204 | Submission Open
Keywords: treatment of Crohn's Disease; treatment of ulcerative colitis; mesalamine for ulcerative colitis; mesalamine for Crohn's Disease; antibody strategies in IBD; small molecules for IBD; conservative management of Crohn's fistula; therapy for extraintestinal manifestations; new endpoints for treatment
(This special issue belongs to the Section Pharmacology)
Osteosarcomas: Treatment Strategies, 2nd Edition
edited by
submission deadline 26 Jan 2026 | 4 articles | Viewed by 12166 | Submission Open
Keywords: osteosarcoma; anti-cancer; apoptosis; natural compounds; target; drug
(This special issue belongs to the Section Pharmacology)
Advances in Drug Analysis and Drug Development, 2nd Edition
edited by and Ana Mornar
submission deadline 26 Jan 2026 | 3 articles | Viewed by 3706 | Submission Open
Keywords: analytical methodology; chromatographic techniques; spectrometric techniques; thermal analysis techniques; sample preparation; drug stability; compatibility study; bioavailability studies; therapeutic drug monitoring; quality by design in pharmaceutical analysis
(This special issue belongs to the Section Pharmaceutical Technology)
Pharmacological Modulation of Inflammation in Autoimmune Diseases and Cancer submission deadline 27 Jan 2026 | 1 articles | Viewed by 3898 | Submission Open
Keywords: microenvironment; TRAP; NET; tumor niche; exosomes; neuromodulation of tumor growth; autoimmune diseases; pharmacology; biomarkers
(This special issue belongs to the Section Pharmacology)
Innovative Drug Strategies in Chronic Disease Management: Addressing Non-Adherence and Improving Therapeutic Outcomes submission deadline 27 Jan 2026 | 2 articles | Viewed by 3128 | Submission Open
Keywords: adherence; persistence; chronic diseases; therapeutic strategies; individualized therapy; personalized medicine; clinical pharmacology; clinical trials; observational studies; real-world data studies
(This special issue belongs to the Section Pharmacology)
Drug Candidates for the Treatment of Oral Cancer and Oral Cancer Pain, 2nd Edition
edited by
submission deadline 27 Jan 2026 | Viewed by 162 | Submission Open
Keywords: oral cancer; oral cancer pain; drug discovery; natural compounds; immunotherapy; small molecule inhibitors; biomarkers
(This special issue belongs to the Section Pharmacology)
Enzyme Inhibitors: Potential Therapeutic Approaches, 2nd Edition submission deadline 30 Jan 2026 | Viewed by 427 | Submission Open
Keywords: enzymes; inhibitors; competitive; uncompetitive; non-competitive; drug target; pharmaceutical approach; disease treatment
(This special issue belongs to the Section Medicinal Chemistry)
Ischemic Stroke: Current and Emerging Treatment Strategies
edited by Mikahela A. López-Morales and
submission deadline 30 Jan 2026 | Viewed by 306 | Submission Open
Keywords: ischemic stroke; cerebrovascular disease; neuroprotection; neurorepair; pharmacotherapy; therapeutic approaches
(This special issue belongs to the Section Pharmacology)
NeuroImmunoEndocrinology
edited by , , and Oscar Adelmo Bottasso
submission deadline 31 Jan 2026 | 11 articles | Viewed by 50214 | Submission Open
Keywords: cytokines; neurotransmitters; hormones; infections; antibiotics; antidepressants; antipsychotics; drugs; stress; depression; schizophrenia; immunomodulation
(This special issue belongs to the Section Pharmacology)
Natural Products for Skin Applications submission deadline 31 Jan 2026 | 3 articles | Viewed by 6126 | Submission Open
Keywords: bioactive compounds; plant extracts; topic preparations; skincare; cutaneous applications; skin cancer; medicinal plants; modern extraction techniques; optimized/standardized extracts; phytochemical analysis; health outcomes of plant extracts; bioaccessability of compounds from various vegetal matrices; drug– vegetal extract interactions at metabolic level
(This special issue belongs to the Section Natural Products)
Antibiotic Resistance in Gram-Negative Bacteria: The Threat from the Pink Corner, 2nd Edition
edited by and
submission deadline 31 Jan 2026 | 1 articles | Viewed by 3853 | Submission Open
Keywords: gram-negative; pseudomonas; acinetobacter; campylobacter; helicobacter; klebsiella; enterobacteriaceae; arcobacter; phages; complementary alternative medicine; antimicrobial peptides; food security; hospital acquired infections; microbiome; gram negative pathogens; antibiotic resistance; virulence and other molecular mechanisms
(This special issue belongs to the Section Medicinal Chemistry)
Application of Computer Simulation in Drug Design submission deadline 31 Jan 2026 | 3 articles | Viewed by 2825 | Submission Open
Keywords: in silico; drug design; drug discovery; molecular docking; molecular dynamics simulations; structure-based; ligand-based; virtual screening; drug repurposing
(This special issue belongs to the Section Medicinal Chemistry)
Radiopharmaceuticals in Cancer Disorders: Clinical and Pharmaceutical Perspectives
edited by
submission deadline 31 Jan 2026 | 1 articles | Viewed by 2109 | Submission Open
Keywords: radiopharmaceuticals; cancer theranostics; targeted radionuclide therapy; molecular imaging; pharmaceutical development
(This special issue belongs to the Section Radiopharmaceutical Sciences)
The Regulatory Roles of the Gut Microbiota in Multisystem Diseases submission deadline 31 Jan 2026 | 2 articles | Viewed by 1935 | Submission Open
Keywords: microbiota; multisystem diseases; bacteriophage therapy; metabolic disorders; precision medicine
(This special issue belongs to the Section Pharmacology)
Promising Natural Products with Anti-Inflammatory and Antioxidant Bioactivities: Extraction, Identification, and Biological Evaluation
edited by Sara Vieira and
submission deadline 31 Jan 2026 | 3 articles | Viewed by 1754 | Submission Open
Keywords: bioactive compounds; extraction techniques; anti-inflammatory activity; antioxidant activity; inflammation; inflammatory molecules; signaling pathways
(This special issue belongs to the Section Natural Products)
Heterocyclic Compounds in Targeted Cancer Therapy: Advances in Medicinal Chemistry and Drug Development submission deadline 31 Jan 2026 | 2 articles | Viewed by 1559 | Submission Open
Keywords: heterocyclic compounds; targeted cancer therapy; medicinal chemistry; structure– activity relationship (SAR); computational drug design; small-molecule therapeutics; synthetic methodologies; bioactive heterocycles; green chemistry in drug discovery; in silico screening
(This special issue belongs to the Section Medicinal Chemistry)
Drug Therapy for Rheumatological Diseases
edited by
submission deadline 31 Jan 2026 | 2 articles | Viewed by 1385 | Submission Open
Keywords: rheumatology; drug therapy; biologics; DMARDs; therapeutic drug monitoring; shared decision-making; autoimmune diseases; chronic disease management; safety vs. efficacy of rheumatic disease therapy
(This special issue belongs to the Section Pharmacology)
Research on Guanidine-Based Drugs: Synthesis, Antiparasitic, Antifungal, Antiviral, and Anticancer Activities submission deadline 31 Jan 2026 | 1 articles | Viewed by 997 | Submission Open
Keywords: guanidine derivatives; medicinal chemistry; SAR analysis; neglected diseases; antiparasitic; antifungal; antiviral; anticancer; drug development
(This special issue belongs to the Section Medicinal Chemistry)
Development of Antibacterial Drugs to Combat Drug-Resistant Bacteria: 2nd Edition
edited by and Iryna Voronkina
submission deadline 31 Jan 2026 | 1 articles | Viewed by 603 | Submission Open
Keywords: development of antibacterial drugs; drug-resistant bacteria; antimicrobial resistance; new therapeutic solutions; improvement of existing therapies; nosocomial infections
(This special issue belongs to the Section Pharmacology)
Novel Therapeutic Targets and Strategies for Drug Addiction and Medication-Induced Toxicity
edited by , Hecson Jesser Segat, Camila Simonetti Pase and Vinicia Garsella Metz
submission deadline 31 Jan 2026 | Viewed by 516 | Submission Open
Keywords: neuropsychopharmacology; toxicology; drug addiction; animal models; complementary and integrative medicines; abuse drugs; psychostimulants; anxiolytics; addictive substances; prescription drug misuse; pharmacological interventions; public health; illicit and legal substances
(This special issue belongs to the Section Pharmacology)
Advances in Targeting Mitochondrial Sirtuins for Treatment of Metabolic Diseases Such as Type 2 Diabetes and Obesity
edited by Linh Ho and
submission deadline 31 Jan 2026 | Viewed by 282 | Submission Open
Keywords: mitochondrial sirtuins; Sirt3; Sirt5; metabolic disorders; type 2 diabetes; drug targets; insulin resistance; reactive oxygen species (ROS)
(This special issue belongs to the Section Pharmacology)
Dopamine Receptor: Novel Opportunities for Drug Developments
edited by Pegi Pavletić and
submission deadline 31 Jan 2026 | Viewed by 247 | Submission Open
Keywords: dopamine receptors (DRs); GPCR; drug discovery; in silico drug design; drug optimization; molecular modelling; targeted protein degradation; DMPK; neurological disorders; cancer
(This special issue belongs to the Section Medicinal Chemistry)
Design, Synthesis and Biological Evaluation of Small Molecules for the Treatment of Solid Tumors submission deadline 31 Jan 2026 | Viewed by 229 | Submission Open
Keywords: anticancer drugs; small-molecule agents; targeted therapy; solid cancers; drug delivery systems; drug resistance; approval characteristic; FDA; EMA
(This special issue belongs to the Section Medicinal Chemistry)
Advances in Targeted Therapy for Gastrointestinal Cancers submission deadline 31 Jan 2026 | Viewed by 196 | Submission Open
Keywords: targeted therapy; gastrointestinal cancers; molecular targets; drug resistance; biomarkers; immunotherapy; precision medicine; translational research; clinical trials; tumor microenvironment
(This special issue belongs to the Section Pharmacology)
Pharmaceutical Blood Products
edited by , Masaki Otagiri and
submission deadline 31 Jan 2026 | Viewed by 135 | Submission Open
Keywords: pharmaceutical blood products; plasma-derived therapeutics; recombinant blood factors; cellular therapies; immunoglobulins; fractionation technologies; viral inactivation; hemophilia treatments; gene-editing approaches; clinical efficacy
(This special issue belongs to the Section Biopharmaceuticals)
Advanced Technologies in Extracting and Analyzing Natural Product Bioactives submission deadline 5 Feb 2026 | 1 articles | Viewed by 1379 | Submission Open
Keywords: classical extraction; nanotechnology; active ingredients; nanozymes; nanocomposites; molecularly imprinted polymer; magnetic nanoparticles; MOFs; natural products; pre-clinical studies
(This special issue belongs to the Section Natural Products)
Advances in Topical and Mucosal Drug Delivery Systems submission deadline 15 Feb 2026 | 4 articles | Viewed by 6272 | Submission Open
Keywords: topical drug delivery; mucosal drug delivery; transdermal drug delivery; controlled release; bioavailability enhancement; formulation development
(This special issue belongs to the Section Pharmaceutical Technology)
Application of Zebrafish Model in Pharmacology and Toxicology submission deadline 15 Feb 2026 | 2 articles | Viewed by 3488 | Submission Open
Keywords: chemical safety assessment; translational research; drug screening; human exposome; environmental contaminants
(This special issue belongs to the Section Pharmacology)
Chemotherapeutic and Targeted Drugs in Antitumor Therapy submission deadline 15 Feb 2026 | 2 articles | Viewed by 2578 | Submission Open
Keywords: cancer; drug discovery; small-molecule drugs; targeted therapy; combination therapy; synergism; selectivity; immunotherapy; precision medicine
(This special issue belongs to the Section Pharmacology)
Click Chemistry-Aided Drug Discovery
edited by
submission deadline 15 Feb 2026 | Viewed by 122 | Submission Open
Keywords: click chemistry; drug discovery; structure– activity relationship; hit-to-lead; chemical probes; bio-orthogonal reactions; protein-templated reactions; bioisosteres; cycloaddition; 1; 2; 3-triazole
(This special issue belongs to the Section Medicinal Chemistry)
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