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Pharmaceuticals publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Development of Novel Radiopharmaceuticals for SPECT and PET Imaging

edited by

Bianca Gutfilen

submission deadline 24 Jul 2025 | 5 articles | Viewed by 5043 | Submission Open

Keywords: oncology; theranostics; inflammation/infection diagnosis; autoimmune diseases; neurodegenerative diseases; cardiovascular diseases

(This special issue belongs to the Section Radiopharmaceutical Sciences)

Fluoroquinolones

edited by

Cecilia Bove

and

Nuno Manuel Xavier

submission deadline 25 Jul 2025 | 6 articles | Viewed by 18876 | Submission Open

Keywords: fluoroquinolones; fluoroquinolone-associated disability; antibiotic safety; fluoroquinolone toxicity; antibiotic stewardship

(This special issue belongs to the Section Pharmacology)

Biomedical Properties, Developments and Therapeutic Potential of Sesquiterpenoid Lactones and Natural Compounds

edited by

Normand Garcia-Hernandez

Rosa Ordoñez Razo

and Israel Ramírez-Sánchez

submission deadline 25 Jul 2025 | 8 articles | Viewed by 10344 | Submission Open

Keywords: therapeutic potential; natural compounds; biological activity; traditional medicine; sesquiterpene lactone; pharmacological activities; terpenoids; flavonoids

(This special issue belongs to the Section Natural Products)

Design, Synthesis and Biological Evaluation with Potential Anti-inflammatory Activity

edited by

Berenika M. Szczȩśniak-Siȩga

Żaneta Czyżnikowska

and

Aleksandra Redzicka

submission deadline 25 Jul 2025 | 4 articles | Viewed by 7621 | Submission Open

Keywords: anti-inflammatory; COX/LOX; IL-6; JAK; STAT3; p38MAPK; TNF-α ; asthma; Alzheimer's disease; cancer

(This special issue belongs to the Section Medicinal Chemistry)

Novel Imidazole Derivatives in Medicinal Chemistry

edited by Dorota Olender,

Justyna Żwawiak

and

Lucjusz Zaprutko

submission deadline 25 Jul 2025 | 1 articles | Viewed by 5479 | Submission Open

Keywords: imidazole; nitroimidazole derivatives; biological activities; synthesis; heterocyclic drug discovery

(This special issue belongs to the Section Medicinal Chemistry)

Calcium Channels as Therapeutic Targets

edited by

Gary J. Stephens

David Adams

and

Hussein N. Rubaiy

submission deadline 25 Jul 2025 | 3 articles | Viewed by 5032 | Submission Open

Keywords: voltage-gated Ca2+ channels; TRP channels; Ca2+-permeable TRP and ASIC channels; STIM/orai channels; Ca2+ channel structure and function; Ca2+ channel toxins; Ca2+ channelopathies; neuropharmacology; pain; epilepsy; neurodegenerative and neuropsychiatric disorders

(This special issue belongs to the Section Pharmacology)

Natural Products as an Alternative for Treatment of Human Diseases

edited by Eduardo Lira,

Jackson Guedes

and Raimundo Gonçalves De Oliveira Junior

submission deadline 25 Jul 2025 | 4 articles | Viewed by 4087 | Submission Open

Keywords: medicinal plants; herbal remedies; natural products; traditional medicine

(This special issue belongs to the Section Natural Products)

Self-Assembling Nanostructures for Cancer Therapy

edited by

André Moreni Lopes

submission deadline 25 Jul 2025 | 3 articles | Viewed by 3430 | Submission Open

Keywords: drug delivery systems; polymeric micelles; polymeric vesicles (polymersomes); surfactants; amphiphilic copolymers; stimuli-responsive polymers; cancer therapy; drugs; biopharmaceuticals; dual delivery

(This special issue belongs to the Section Pharmaceutical Technology)

Orodispersible and Innovative Dosage Forms: Advances in Preparation Technologies, Direct Compression, and Co-Processed Excipients

edited by

Witold Brniak

and

Aleksander Mendyk

submission deadline 25 Jul 2025 | 1 articles | Viewed by 2376 | Submission Open

Keywords: orodispersible films; buccal films; chewable tablets; orodispersible granules; buccal dosage forms; mucoadhesive dosage forms; tabletability; modified release tablets; minitablets

(This special issue belongs to the Section Pharmaceutical Technology)

Artificial Intelligence-Assisted Drug Discovery

edited by Aldo Sena De Oliveira

submission deadline 25 Jul 2025 | 2 articles | Viewed by 2243 | Submission Open

Keywords: artificial intelligence; drug discovery; machine learning; medicinal chemistry; computational chemistry; virtual screening; ADMET predictions; de novo drug design; multi-target ligands; drug repositioning

(This special issue belongs to the Section Medicinal Chemistry)

Innovative Approaches to Radiopharmaceuticals: Advances in Design, Labeling, and Applications

edited by Shvan J. Raheem and

Justin J. Bailey

submission deadline 25 Jul 2025 | 1 articles | Viewed by 2117 | Submission Open

Keywords: radiochemistry; radiopharmaceutical; radiotracers

(This special issue belongs to the Section Radiopharmaceutical Sciences)

From the Simple to the Complex in the Formation of Supramolecular Devices Based on Cyclodextrins and Polymer Derivatives Applied in the Scope of Health

edited by

Eduardo Sobarzo-Sánchez

and Ana María Méndez-Torres

submission deadline 25 Jul 2025 | 2 articles | Viewed by 1959 | Submission Open

Keywords: cyclodextrin; supramolecular devices; synthetic and natural polymers; chronic inflammation; nanoparticles and drug carriers

Medicinal Chemistry of Indole and Quinoline Derivatives: Trends and Future Directions as Therapeutic Drugs, 2nd Edition

edited by

Florence McCarthy

submission deadline 25 Jul 2025 | 1 articles | Viewed by 1697 | Submission Open

Keywords: indole; quinoline; heterocycle; pharmaceutical discovery and development

(This special issue belongs to the Section Medicinal Chemistry)

Emerging Trends in Liquid Chromatography and Mass Spectrometry-Based Analyses of Pharmaceuticals

edited by

Martina Bortolami

Paola Di Matteo

and

Rita Petrucci

submission deadline 25 Jul 2025 | Viewed by 1260 | Submission Open

Keywords: pharmacokinetic analyses; drug metabolites; drug delivery systems; biological matrices; environmental samples; environmental monitoring

(This special issue belongs to the Section Medicinal Chemistry)

Anti-Inflammatory and Antithrombotic Natural Bioactives for Drug Development: Current Status and Future Perspectives

edited by

Alexandros Tsoupras

submission deadline 25 Jul 2025 | 1 articles | Viewed by 1161 | Submission Open

Keywords: chronic disorders; bioactives; natural sources; sustainable sources; pharmaceuticals; drug discovery; structure– activity relationship; synergism; health promotion; bio-functional; drugs; inflammation; thrombosis; platelets; cancer; CVD; neurodegenerative; neuroprotective; anti-inflammatory; cardio-protective; anti-cancer; anti-tumor; anti-thrombotic; antiplatelet; anticoagulant

(This special issue belongs to the Section Natural Products)

Innovations in Solid Dispersions for Drug Delivery

edited by Qun Zhou

submission deadline 25 Jul 2025 | Viewed by 379 | Submission Open

Keywords: solid dispersions; chemistry; properties; crystal; delivery systems

(This special issue belongs to the Section Pharmaceutical Technology)

Novel Therapeutic Approaches for Chronic Urticaria: Advances and Challenges

edited by Luis Felipe Ensina

submission deadline 28 Jul 2025 | Viewed by 192 | Submission Open

Keywords: chronic urticaria; current management; biosimilar pharmaceuticals; biologic drugs; monoclonal antibodies; tyrosine kinase inhibitors

(This special issue belongs to the Section Pharmacology)

Natural Pharmacons: Biologically Active Plant-Based Pharmaceuticals—4th Edition

edited by

Dejan Stojković

and

Marina Soković

submission deadline 29 Jul 2025 | 3 articles | Viewed by 2372 | Submission Open

Keywords: chemical characterization of natural preparations; therapeutic potential of natural matrices in cardiovascular diseases; diabetes; cancer; and neurodegenerative diseases; antimicrobial activity; antioxidant activity; anti-enzymatic activity; anti-inflammatory activity; mechanism of pharmacological actions; structure– activity relationship studies

(This special issue belongs to the Section Natural Products)

Recent Advances in Cancer Diagnosis and Therapy

edited by

Adriana Grigoraș

and

Hsin-Sheng Yang

submission deadline 30 Jul 2025 | 3 articles | Viewed by 3954 | Submission Open

Keywords: early diagnosis; advanced therapy; biomarkers; immunohistochemistry; molecular diagnosis; metastasis; prognosis; targeted therapies; combination therapies; cancer pharmacology

(This special issue belongs to the Section Pharmacology)

Drug Discovery, Development, and Synthesis for Glioblastoma

edited by

Shizue Mito

, Sue Anne Chew and

Mitsuhiro Arisawa

submission deadline 30 Jul 2025 | 1 articles | Viewed by 1431 | Submission Open

Keywords: glioblastoma; drug design; drug synthesis; anticancer; natural products; biomolecules; combination therapy; pharmaceuticals

(This special issue belongs to the Section Pharmacology)

Green Synthesis and Biological Evaluation of Quinazolinone-Based Compounds

edited by Mario Komar,

Marija Paurević

and

Maja Molnar

submission deadline 30 Jul 2025 | Viewed by 358 | Submission Open

Keywords: synthesis in deep eutectic solvents; microwave-assisted synthesis; ultrasound-assisted synthesis; mechanochemical synthesis; quinazolinones; biological activity; computational methods

(This special issue belongs to the Section Medicinal Chemistry)

Pharmacological Advances for Treatment in Hypertension 2.0

edited by

Arquimedes Gasparotto Junior

submission deadline 31 Jul 2025 | 2 articles | Viewed by 4043 | Submission Open

Keywords: antihypertensive; cardioprotective; herbal medicine; hypertension; medicinal plants

(This special issue belongs to the Section Pharmacology)

Recent Advances in Ocular Pharmacology

edited by

Lampros Lamprogiannis

and

Ioannis Tsinopoulos

submission deadline 31 Jul 2025 | 2 articles | Viewed by 3392 | Submission Open

Keywords: ophthalmology; ocular diseases; drug delivery; drug targeting; controlled drug release; eye drops; biopolymers; nanomedicine; clinical applications; clinical trials

(This special issue belongs to the Section Pharmacology)

Advancements in Cardiovascular and Antidiabetic Drug Therapy, 2nd Edition

edited by

Alfredo Caturano

submission deadline 31 Jul 2025 | 5 articles | Viewed by 3186 | Submission Open

Keywords: cardiovascular diseases; antidiabetic drugs; pharmacological interventions; sodium– glucose cotransporter 2 inhibitors; PCSK9 inhibitors; obeticholic acid; lipid-lowering agents; heart failure treatment; diabetes management; drug therapy innovations

(This special issue belongs to the Section Pharmacology)

Antibiotic Resistance in Gram-Negative Bacteria: The Threat from the Pink Corner, 2nd Edition

edited by

Bruno Silvester Lopes

and

Alfizah Hanafiah

submission deadline 31 Jul 2025 | 1 articles | Viewed by 2247 | Submission Open

Keywords: gram-negative; pseudomonas; acinetobacter; campylobacter; helicobacter; klebsiella; enterobacteriaceae; arcobacter; phages; complementary alternative medicine; antimicrobial peptides; food security; hospital acquired infections; microbiome; gram negative pathogens; antibiotic resistance; virulence and other molecular mechanisms

(This special issue belongs to the Section Medicinal Chemistry)

Therapeutic Potential of Silver Nanoparticles (AgNPs), 2nd Edition

edited by

Goreti Pereira

submission deadline 31 Jul 2025 | 3 articles | Viewed by 1751 | Submission Open

Keywords: metallic nanostructures; plasmonic nanomaterials; photothermal therapy; photodynamic therapy; antimicrobial; antioxidant; anticancer

(This special issue belongs to the Section Medicinal Chemistry)

The Application of Pharmacogenetics in Toxicity Prevention and Drug Effect Improvement

edited by Pura Ballester

submission deadline 31 Jul 2025 | 2 articles | Viewed by 1736 | Submission Open

Keywords: pharmacogenetics; drug toxicity prevention; efficacy enhancement; pharmaceutical research; precision medicine; therapeutic optimization

(This special issue belongs to the Section Pharmacology)

Medicinal Plants: Exploring Plant-Based Bioactive Compounds for Cancer and Metabolic Diseases Prevention and Intervention

edited by

Lucas Fornari Laurindo

and

Sandra Barbalho

submission deadline 31 Jul 2025 | 2 articles | Viewed by 1177 | Submission Open

Keywords: cancer; metastasis; tumor growth; tumor spread; bioactive compounds; phytochemicals; medicinal plants; phytochemistry; cancer prevention; cancer intervention; metabolic diseases; metabolism; diabetes; MAFLD; dyslipidemia

(This special issue belongs to the Section Natural Products)

Emerging Therapeutics for the Prevention of Chemotherapy-Induced Cardiotoxicity: Advances and Future Perspectives

edited by

Luigi Spadafora

Marco Bernardi

, Sarto Sarto and

Vincenzo Quagliariello

submission deadline 31 Jul 2025 | 1 articles | Viewed by 1095 | Submission Open

Keywords: cardio-oncology; chemotherapy-induced cardiotoxicity; cardioprotective agents; biomarkers; heart failure prevention; precision medicine; pharmacological innovation; molecular targets; cancer survivorship; multidisciplinary care

(This special issue belongs to the Section Pharmacology)

Recent Advances in Natural Product-Based Nanostructured Systems: 2nd Edition

edited by

Luís Alexandre Muehlmann

and

João Paulo Longo

submission deadline 31 Jul 2025 | 1 articles | Viewed by 1024 | Submission Open

Keywords: natural product; nanostructured systems; nanotechnology; nanostructures; nanocarriers; bioactive compounds

(This special issue belongs to the Section Natural Products)

Advances and Future Trends in Development of Novel Antifungals and Antifungal Therapy

edited by

Radu Tamaian

submission deadline 31 Jul 2025 | Viewed by 868 | Submission Open

Keywords: antifungals; antifungal drug discovery; antifungal resistance; repositioning of non-antifungal drugs to antifungals; unconventional antifungal drug targets and signaling pathways

(This special issue belongs to the Section Medicinal Chemistry)

Next-Generation Antinfective Agents

edited by

Fiorella Meneghetti

and

Daniela Barlocco

submission deadline 31 Jul 2025 | 1 articles | Viewed by 673 | Submission Open

Keywords: small molecules; peptides; peptidomimetics; bacterial infections; fungi; virus; parasites; drug design; computational tools; biology assays; resistance mechanisms

(This special issue belongs to the Section Medicinal Chemistry)

Advancing Cardio-Oncology: Mechanisms of Cardiotoxicity and Therapeutic Options for Old and New Anticancer Drugs

edited by

Vera Marisa Costa

submission deadline 31 Jul 2025 | Viewed by 195 | Submission Open

Keywords: cardio-oncology; anticancer therapies; cardiac dysfunction; hypertension; heart failure; intercellular communication; treatment; prevention; diagnosis; cardiac remodeling

(This special issue belongs to the Section Pharmacology)

Identification and Extraction of Bioactive Compounds from Marine Life

edited by

Monde Mc Millan Ntwasa

and Wilfred T. Mabusela

submission deadline 31 Jul 2025 | Viewed by 163 | Submission Open

Keywords: natural products; marine life; bioactive compounds; cancer; antimicrobials

(This special issue belongs to the Section Natural Products)

Scientific Evidence-Based Applications of Polyamines in Pharmaceuticals Science

edited by Kuniyasu Soda

submission deadline 5 Aug 2025 | Viewed by 190 | Submission Open

Keywords: polyamine; spermine; spermidine; health; senescence; age-related; disease

(This special issue belongs to the Section Pharmacology)

The Role of Phytochemicals in Aging and Aging-Related Diseases

edited by

Giovanni Scapagnini

Sergio Davinelli

and

Alessandro Medoro

submission deadline 15 Aug 2025 | 7 articles | Viewed by 14712 | Submission Open

Keywords: phytochemicals; plant-based diet; dietary supplementation; pharma-nutrition; aging; aging-related diseases; prevention

(This special issue belongs to the Section Natural Products)

Innovative Tools for Drug Analysis and Therapeutic Drug Monitoring (TDM)

edited by

Juraj Piestansky

and

Andrej Kovac

submission deadline 15 Aug 2025 | 8 articles | Viewed by 10617 | Submission Open

Keywords: therapeutic drug monitoring; analysis of drugs; separation analytical methods; mass spectrometry; bioanalysis; quality control; dosage forms; green analytical chemistry

(This special issue belongs to the Section Pharmacology)

Interdisciplinary Approaches to Preventing and Treating Inflammatory and Oxidative Diseases with Medicinal Plants and Bioactive Compounds

edited by

Lucas Fornari Laurindo

and

Sandra Barbalho

submission deadline 15 Aug 2025 | 1 articles | Viewed by 1633 | Submission Open

Keywords: interdisciplinary studies; inflammation; inflammatory diseases; oxidative stress; oxidative diseases; pro-inflammatory; pro-oxidative; neurodegenerative diseases; cardiovascular diseases; cancer; medicine; rheumatological diseases; endocrinological diseases; gastroenterological diseases; dermatological diseases; pulmonary diseases; dentistry; nutrition; dietetics; therapy; medicinal plants; bioactive compounds; phytochemicals; phytochemistry

(This special issue belongs to the Section Natural Products)

Natural Products in Internal Diseases: From Preclinical Research to Clinical Translation

edited by Roberto Pontarolo,

Luana Mota Ferreira

and

Raul Edison Luna Lazo

submission deadline 15 Aug 2025 | 1 articles | Viewed by 980 | Submission Open

Keywords: natural products; internal diseases; cardiovascular diseases; diabetes; autoimmune disorders; gastrointestinal conditions; respiratory illnesses

Potential Therapeutic Targets for the Management of Diabetes Mellitus, Obesity and Cancer

edited by Marisa Jádna Silva Frederico and

Fátima Regina Mena Barreto Silva

submission deadline 15 Aug 2025 | Viewed by 241 | Submission Open

Keywords: diabetes; obesity; cancer; pharmacological targets

(This special issue belongs to the Section Pharmacology)

Enzyme Inhibitors: Potential Therapeutic Approaches, 2nd Edition

edited by

Phaedra Eleftheriou

submission deadline 15 Aug 2025 | Viewed by 205 | Submission Open

Keywords: enzymes; inhibitors; competitive; uncompetitive; non-competitive; drug target; pharmaceutical approach; disease treatment

(This special issue belongs to the Section Medicinal Chemistry)

Glial Cells as Drug Targets for Schizophrenia

edited by

Kumlesh Kumar Dev

and Paraskevi Papakyriakopoulou

submission deadline 15 Aug 2025 | Viewed by 160 | Submission Open

Keywords: schizophrenia; astrocytes; oligodendrocytes; microglia

(This special issue belongs to the Section Pharmacology)

Small-Molecule Inhibitors for Novel Therapeutics

edited by

Gustavo Provensi

and Simone Giovannuzzi

submission deadline 20 Aug 2025 | 4 articles | Viewed by 8302 | Submission Open

Keywords: small molecules; enzyme inhibition/activation; protein modulation; novel therapeutics; high-throughput screening; target proteins; drug delivery

Integrating Machine Learning (ML) into Medicinal Chemistry and Cheminformatics

edited by

Vartika Tomar

submission deadline 20 Aug 2025 | 5 articles | Viewed by 5361 | Submission Open

Keywords: small molecules; molecular descriptors; molecular similarity; structure-based and ligand-based screening; homology modeling; molecular docking; drug– receptor docking; biological activity

(This special issue belongs to the Section Medicinal Chemistry)

Design, Synthesis and Development of Novel Antiviral Agents

edited by

Antonio Lupia

submission deadline 20 Aug 2025 | 3 articles | Viewed by 4513 | Submission Open

Keywords: viruses; emerging viral diseases; infectious diseases; antiviral agents; small molecules; structure− activity relationship (SAR) studies; drug design (DD) and synthesis; computer-aided drug discovery (CADD); medicinal chemistry

(This special issue belongs to the Section Medicinal Chemistry)

Computational (In Silico) Approaches for Drug Target Discovery and Disposition

edited by

Frederico Severino Martins

and

Leonardo Luiz Borges

submission deadline 20 Aug 2025 | 1 articles | Viewed by 1352 | Submission Open

Keywords: computational drug discovery; in silico modeling; drug target identification; pharmacokinetics (pk); physiologically based pharmacokinetics (PBPK); physiologically based biokinetics (PBBK); physiologically based biopharmaceutics (PBBM); ADME/Tox; machine learning in drug development; systems pharmacology

Pharmaceutical Process Engineering: Experimental and Computational Innovation

edited by Marcial Gonzalez and Francesco Destro

submission deadline 22 Aug 2025 | Viewed by 137 | Submission Open

Keywords: pharmaceutical process engineering; process development; process analytical technology (PAT); process analytical chemistry (PAC); quality by design (QbD); sustainable manufacturing; drug product quality; biopharmaceuticals

(This special issue belongs to the Section Pharmaceutical Technology)

New Approaches to Fighting Infectious Diseases: Overcoming the Antimicrobial Resistance in Current Treatments

edited by

Antonia Efstathiou

and

Dimitra K. Toubanaki

submission deadline 25 Aug 2025 | 11 articles | Viewed by 35126 | Submission Open

Keywords: infectious diseases; antimicrobial resistance; parasites; viruses; bacteria; treatment approaches; therapeutics; chemotherapy; targeted drug design; natural products

(This special issue belongs to the Section Medicinal Chemistry)

Natural Products in Health Promotion and Disease Prevention 2025

edited by

Marco G. Alves

and

Ariane Zamoner

submission deadline 25 Aug 2025 | 8 articles | Viewed by 15181 | Submission Open

Keywords: natural products; nutraceuticals; bioactive compounds; traditional medicine; drug discovery

(This special issue belongs to the Section Natural Products)

Tumor Immunopharmacology

edited by

Marco A. Velasco-Velázquez

submission deadline 25 Aug 2025 | 4 articles | Viewed by 12761 | Submission Open

Keywords: immunotherapy; immunomodulation; drug development; cytokine receptor antagonist; T-cell based therapies; therapeutic antibodies; drug delivery; cancer vaccine

(This special issue belongs to the Section Pharmacology)

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