Novel Drug Compositions for Ischemic Stroke: Mechanisms and Clinical Applications
A special issue of Pharmaceuticals (ISSN 1424-8247). This special issue belongs to the section "Pharmacology".
Deadline for manuscript submissions: 25 September 2025 | Viewed by 451
Special Issue Editors
Interests: neuropharmacology; neuroprotection; cerebral ischemia; stroke; stem cells; pharmacotherapy; neuroscience; nanomedicine
Special Issue Information
Dear Colleagues,
Ischemic stroke is one of the leading causes of disability and mortality, with limited treatment options available for effective recovery. Recent research has focused on developing novel drugs and innovative procedures to address the complexities of ischemic brain injury, aiming to improve patient outcomes. Innovative drug compositions targeting neuroprotection, tissue repair, and enhanced cerebral blood flow have gained significant attention, with strategies ranging from small molecules and biologics to novel drug delivery systems. Key mechanisms under investigation include the modulation of excitotoxicity, oxidative stress, inflammation, and apoptosis, which play pivotal roles in neuronal damage. Moreover, the blood–brain barrier remains a major challenge in drug delivery, but recent advancements in nanotechnology and targeted carriers offer promising solutions. The clinical translation of these therapies is also a focal point, with ongoing preclinical and clinical trials assessing their safety and efficacy.This Special Issue provides a unique platform to cover the mechanisms underlying ischemic stroke and the development of new therapeutic agents designed to intervene at critical stages of the ischemic cascade. By bringing together cutting-edge research on novel drug compositions, we aim at highlighting their potential in transforming ischemic stroke treatment. Investigating both molecular mechanisms and clinical implications, this collection will pave the way for future breakthroughs in stroke therapy and improved patient care.
We look forward to your valuable contributions to advancing stroke therapeutics!
Prof. Dr. Jasenka Mrsic-Pelcic
Dr. Anja Harej Hrkać
Guest Editors
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Keywords
- ischemic stroke
- novel delivery systems
- nanomedicine
- nanotechnology
- neuroregenerative therapy
- neurorepair
- new and emerging treatments
- pharmacotherapy
- tissue engineering
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