Advances in Solid-Phase Peptide and Oligonucleotide Synthesis: Methods, Mechanisms, and Therapeutic Applications
A special issue of Pharmaceuticals (ISSN 1424-8247). This special issue belongs to the section "Biopharmaceuticals".
Deadline for manuscript submissions: 30 November 2026 | Viewed by 4217
Special Issue Editors
Interests: peptide sciences; drug design; medicinal chemistry
Interests: peptide-based drug delivery; siRNA; anticancer drug; peptide therapeutics; peptide–drug conjugate; antimicrobial peptides; neurotherapeutics
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Solid-phase synthesis remains one of the most powerful and versatile techniques for the preparation of bioactive molecules, enabling the rapid assembly, modification, and optimization of peptides and oligonucleotides (TIDEs) with therapeutic potential. Over the past decade, significant advances have been made in resin chemistry, coupling reagents, automation, and orthogonal protection strategies—paving the way for the more sustainable and scalable synthesis of complex TIDEs.
This Special Issue aims to highlight cutting-edge developments in solid-phase peptide and oligonucleotide synthesis, covering innovations in methodology, automation, linker and protecting group design, and hybrid chemoenzymatic approaches. We also welcome studies focused on structure–activity relationships, conjugation strategies, post-synthetic modifications, and the application of synthetic peptides and oligonucleotides in drug discovery, diagnostics, and biotechnology.
By bringing together contributions from both academia and industry, this Special Issue seeks to bridge the gap between synthetic innovation and therapeutic application, showcasing how advances in chemical synthesis continue to transform modern medicinal chemistry and molecular therapeutics.
Dr. Danah AlShaer
Dr. Rakesh Tiwari
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceuticals is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- solid-phase peptide synthesis (SPPS)
- oligonucleotide synthesis
- hybrid chemical–enzymatic methods
- peptide therapeutics
- drug design and discovery
- sustainable synthesis
- automation and process optimization
- resin and linker chemistry
- post-synthetic modification
- structure–activity relationships
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