Special Issues

Pharmaceuticals publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Fluoroquinolones, 2nd Edition
edited by and
submission deadline 27 Apr 2026 | Viewed by 70 | Submission Open
Keywords: fluoroquinolones; fluoroquinolone-associated disability; antibiotic safety; fluoroquinolone toxicity; antibiotic stewardship
(This special issue belongs to the Section Pharmacology)
Advances in Medicinal Chemistry: 2nd Edition
edited by
submission deadline 30 Apr 2026 | 3 articles | Viewed by 3583 | Submission Open
Keywords: drug discovery; novel drug targets; drug discovery; drug design and development; synthetic methods for drugs; analytical methodologies; in silico screening; structure and ligand-based drug design; structure– activity relationships (SAR); drug metabolism
(This special issue belongs to the Section Medicinal Chemistry)
Pharmacological Activity and Application of Polyphenolic Compounds
edited by
submission deadline 30 Apr 2026 | Viewed by 1071 | Submission Open
Keywords: phenolic compounds; biological potential; pharmacological activity; phenolic applications; health promoters; chronic diseases
(This special issue belongs to the Section Natural Products)
Effects of Drug Abuse and Its Consequences on Health submission deadline 30 Apr 2026 | Viewed by 521 | Submission Open
Keywords: psychoactive substances; drug abuse; toxicological effects; neurotoxicity; substance use disorder; biomarkers of toxicity; public health impact; addiction mechanisms; harm reduction strategies; novel psychoactive substance (NPS)
(This special issue belongs to the Section Medicinal Chemistry)
Innovative Organic Synthesis Approaches in Drug Design and Development submission deadline 30 Apr 2026 | Viewed by 221 | Submission Open
Keywords: sustainable organic synthesis; green chemistry; drug design and development; non-traditional solvents; Lewis acid catalysis; catalytic methodologies; photoredox and electrochemical methods; medicinal chemistry innovation
(This special issue belongs to the Section Medicinal Chemistry)
Therapeutic Potential of Natural Plant-Derived Compounds in Glioblastoma and Other Brain Tumors submission deadline 30 Apr 2026 | Viewed by 140 | Submission Open
Keywords: glioblastoma; GBM; brain tumors; natural plant‑derived compounds; phytochemicals; blood– brain barrier; signaling targets; tumor microenvironment; therapeutic opportunities; targeted therapy
(This special issue belongs to the Section Natural Products)
Neuropharmacology of Plant Extracts and Their Active Compounds (Second Edition) submission deadline 30 Apr 2026 | Viewed by 118 | Submission Open
Keywords: medicinal plant; mental disorder; preclinical; clinical
(This special issue belongs to the Section Natural Products)
New Trends in the Treatment of Neuropsychiatric Disorders submission deadline 30 Apr 2026 | Viewed by 84 | Submission Open
Keywords: treatment; depression; schizophrenia; bipolar disorder; Alzheimer’ s disease
(This special issue belongs to the Section Pharmacology)
The Therapeutic Potential of Neurotrophin Signaling in Neurodegenerative Disorders
edited by Konstantina Chanoumidou, and
submission deadline 30 Apr 2026 | Viewed by 80 | Submission Open
Keywords: central nervous system; neurodegeneration; neuroinflammation; therapy; neurotrophin receptors; regeneration; myelination
(This special issue belongs to the Section Pharmacology)
Innovative Drug Delivery and Mitochondrial-Targeted Therapies
edited by José Antonio Jara Sandoval and Alfredo E. Molina-Berríos
submission deadline 30 Apr 2026 | Viewed by 79 | Submission Open
Keywords: drug delivery; mitochondrial-targeted therapies; mitochondrial dysfunction; novel formulations; therapeutic strategies; mitocans; targeting mitochondria
(This special issue belongs to the Section Pharmacology)
Computational Predictions of Molecules with Potential Therapeutic Effects: 2nd Edition
edited by
submission deadline 30 Apr 2026 | Viewed by 39 | Submission Open
Keywords: biophysics; medicinal chemistry; drug discovery; molecular docking; molecular dynamics; structure-activity relationships; computer-aided drug design (CADD)
(This special issue belongs to the Section Pharmacology)
Ophthalmic Drugs and Pharmacology
edited by Christin Henein and Sahar Awwad
submission deadline 1 May 2026 | Viewed by 97 | Submission Open
Keywords: ophthalmic diseases; optic neuropathies; eye diseases; glaucoma; corneal disorders; retinal degeneration; ocular surface disease
(This special issue belongs to the Section Pharmacology)
Innovative Computational and Experimental Strategies in Antimicrobial Drug Discovery submission deadline 10 May 2026 | Viewed by 40 | Submission Open
Keywords: antimicrobial resistance; multidrug resistance; small molecules; novel antimicrobial entities; in silico drug discovery; in vitro screening; innovative strategies; drug repurposing; structure– activity relationship; rational drug design
(This special issue belongs to the Section Medicinal Chemistry)
Allosteric Drug Design in the AI Era
edited by Lydia Siragusa and
submission deadline 15 May 2026 | Viewed by 80 | Submission Open
Keywords: allosteric modulation; artificial intelligence in drug discovery; computational pharmacology; allosteric sites prediction; structure-based drug design
(This special issue belongs to the Section AI in Drug Development)
Metals in Cancer Research: Beyond Platinum Metallodrugs
edited by and
submission deadline 15 May 2026 | Viewed by 57 | Submission Open
Keywords: anticancer drugs; metal complexes; non-platinum; drug resistance; targeted therapy
(This special issue belongs to the Section Medicinal Chemistry)
Novel Drug Compositions for Ischemic Stroke: Mechanisms and Clinical Applications submission deadline 20 May 2026 | 2 articles | Viewed by 1956 | Submission Open
Keywords: ischemic stroke; novel delivery systems; nanomedicine; nanotechnology; neuroregenerative therapy; neurorepair; new and emerging treatments; pharmacotherapy; tissue engineering
(This special issue belongs to the Section Pharmacology)
Solid State Chemistry and Materials Science in Pharmaceutical Research: From Solid Forms to Advanced Dosage Forms
edited by Norbert Nagel, Wenqian Chen and Raimundo Ho
submission deadline 20 May 2026 | Viewed by 140 | Submission Open
Keywords: solid forms; solid form screening; pharmaceutical salts; polymorphism; hydrates; co-crystals; materials science; manufacturing process understanding; solid dosage forms; semi-solid dosage forms; pharmaceutical amorphous solid dispersions; enabling formulations; crystal structure prediction; material science tetrahedron; computational chemistry; structure-property relationships
(This special issue belongs to the Section Pharmaceutical Technology)
Pharmacogenomics for Precision Medicine, 2nd Edition
edited by
submission deadline 23 May 2026 | Viewed by 8 | Submission Open
Keywords: pharmacogenomics in precise therapy; tailored medicine; pharmacoeconomics; personalized medicine; education in pharmacogenomics and precise medicine; future directions in pharmacogenomics; pharmacogenomics and phenotype; host-bacteria interaction in pharmacogenomics; genotype; epigenetic variation; and gene expression axis in pharmacogenomics
(This special issue belongs to the Section Pharmacology)
Artificial Intelligence-Assisted Drug Discovery
edited by Aldo Sena De Oliveira
submission deadline 25 May 2026 | 2 articles | Viewed by 9936 | Submission Open
Keywords: artificial intelligence; drug discovery; machine learning; medicinal chemistry; computational chemistry; virtual screening; ADMET predictions; de novo drug design; multi-target ligands; drug repositioning
(This special issue belongs to the Section Medicinal Chemistry)
Therapeutic Methods Against Acute and Chronic Diseases and Oxidative Stress
edited by
submission deadline 25 May 2026 | 3 articles | Viewed by 7479 | Submission Open
Keywords: natural antioxidant; synthetic agents; acute diseases; chronic diseases; oxidative stress
(This special issue belongs to the Section Medicinal Chemistry)
The Therapeutic Potential of Cannabidiol submission deadline 25 May 2026 | 1 articles | Viewed by 3429 | Submission Open
Keywords: cannabidiol; endocannabinoid system; pain; anti-inflammatory agents; muscle spasticity; pain management; chronic pain
(This special issue belongs to the Section Natural Products)
Sirtuins as Novel Biological Targets for Pharmacological Intervention in Physiology and Pathology—2nd Edition submission deadline 25 May 2026 | 3 articles | Viewed by 2797 | Submission Open
Keywords: sirtuins; metabolism; cancer; hypoxia; damage recovery; cell death
(This special issue belongs to the Section Pharmacology)
Innovations in Therapeutic Strategies for Retinal and Neurodegenerative Diseases
edited by and Won-Kyu Ju
submission deadline 25 May 2026 | 1 articles | Viewed by 2379 | Submission Open
Keywords: glaucoma; Alzheimer's diseases; retinal disease; neuroprotection; neuroinflammation
(This special issue belongs to the Section Pharmacology)
Metal Complexes in Medicinal Chemistry: From Coordination Chemistry to Pharmaceutical Applications
edited by and Cristina Núñez González
submission deadline 25 May 2026 | 1 articles | Viewed by 740 | Submission Open
Keywords: medicinal inorganic chemistry; metallodrugs; coordination compounds; bioinorganic chemistry; anticancer agents; antimicrobial agents; therapeutic applications; diagnostic applications; bioactive metal complexes; drug development
(This special issue belongs to the Section Medicinal Chemistry)
Antidiabetic Agents: New Drug Discovery Insights and Prospects
edited by Rosanna Maccari
submission deadline 25 May 2026 | Viewed by 156 | Submission Open
Keywords: diabetes mellitus; drug design; drug discovery; drug development; drug synthesis; computational-aided drug design; molecular targets; biological activity; structure– activity relationships
(This special issue belongs to the Section Medicinal Chemistry)
Research Advances in Targeted Therapy for Facial Skin Diseases
edited by , and Diogo Pazzini Bomfim
submission deadline 25 May 2026 | Viewed by 84 | Submission Open
Keywords: facial dermatoses; targeted therapy; biologics; precision dermatology; acne vulgaris; topical drug delivery
(This special issue belongs to the Section Pharmacology)
Deregulated Signaling Pathways and Innovative Therapeutic Approaches in Cancer
edited by and Ioannis S. Pappas
submission deadline 25 May 2026 | Viewed by 74 | Submission Open
Keywords: anti-cancer therapeutic approaches; innovative therapeutics; molecular biology; deregulated signaling pathways; oncogenes; tumor repressor partners; antioxidant mechanisms; mAbs; targeted therapies
(This special issue belongs to the Section Pharmacology)
Natural Products in Diabetes Mellitus: 3rd Edition submission deadline 25 May 2026 | Viewed by 72 | Submission Open
Keywords: natural products; hypoglycemia; phenolic compounds; diabetes mellitus; therapeutic; ROS
(This special issue belongs to the Section Natural Products)
Advances in Solid-Phase Peptide and Oligonucleotide Synthesis: Methods, Mechanisms, and Therapeutic Applications submission deadline 25 May 2026 | Viewed by 64 | Submission Open
Keywords: solid-phase peptide synthesis (SPPS); oligonucleotide synthesis; hybrid chemical– enzymatic methods; peptide therapeutics; drug design and discovery; sustainable synthesis; automation and process optimization; resin and linker chemistry; post-synthetic modification; structure– activity relationships
(This special issue belongs to the Section Biopharmaceuticals)
Natural Bioactive Substances: Microencapsulation Technologies, Pharmacological Efficacies and Sustainable Application in Pharmaceuticals submission deadline 25 May 2026 | Viewed by 60 | Submission Open
Keywords: natural bioactive substances; microencapsulation technologies; pharmacological efficacy; sustainable pharmaceutical application; drug carrier materials; bioavailability; controlled release; green pharmacy
(This special issue belongs to the Section Pharmaceutical Technology)
Impact of Drug Transporter Gene Variation on Pharmacokinetics and Clinical Outcomes in Chronic Disease Therapy submission deadline 25 May 2026 | Viewed by 59 | Submission Open
Keywords: drug transporter gene variants; chronic diseases; pharmacokinetics; clinical therapeutic effects; individualized medication; ABCB1; SLC22A family; SLCO1B1
(This special issue belongs to the Section Pharmacology)
Hepatitis B and Delta Virus Infections: Mechanistic Insights and Clinical Drug Therapy
edited by Daniele Lombardo
submission deadline 25 May 2026 | Viewed by 54 | Submission Open
Keywords: chronic hepatitis B; hepatitis delta virus coinfection; hepatocellular carcinoma risk; antiviral drug development; HBV functional cure strategies; immune modulation in hepatitis; pharmacological therapies for viral hepatitis
(This special issue belongs to the Section Pharmacology)
Natural Products for Treating Hypertension and Blood Sugar submission deadline 25 May 2026 | Viewed by 53 | Submission Open
Keywords: antihypertensive; diabetes; cardioprotective; herbal medicine; hypertension; medicinal plants; natural products
(This special issue belongs to the Section Natural Products)
Histamine Receptors: Ligand Design, Pharmacology, and Therapeutic Applications submission deadline 25 May 2026 | Viewed by 46 | Submission Open
Keywords: histamine receptors; drug discovery; ligand design; antagonist/inverse agonist; pharmacology; therapeutic applications; multi-target directed ligands; molecular modeling
(This special issue belongs to the Section Pharmacology)
Peptide-Based Therapeutics: Targeting Amylin, Calcitonin, and Related Receptors submission deadline 25 May 2026 | Viewed by 42 | Submission Open
Keywords: GPCR; amylin; obesity; diabetes; peptide-based drugs; long-acting agonists
(This special issue belongs to the Section Biopharmaceuticals)
Development of Specific Dosage Form: Wound Dressing, 2nd Edition
edited by , , and Cristina Elena Dinu-Pirvu
submission deadline 25 May 2026 | Viewed by 32 | Submission Open
Keywords: skin lesion; wound healing; wound dressing; regenerative medicine; biomaterials; smart biopolymers; therapeutic system; controlled delivery system; scaffolds; biocompatibility
(This special issue belongs to the Section Pharmaceutical Technology)
DNA Repair Targeted Therapy: New Advances in Cancer Treatment
edited by Nimrat Chatterjee
submission deadline 25 May 2026 | Viewed by 12 | Submission Open
Keywords: DNA repair; cancer treatment; targeted therapy; gene-editing; immune-based therapies; DNA repair inhibitors; molecular targets; combination therapies
(This special issue belongs to the Section Biopharmaceuticals)
Natural Products for the Treatment of Prostate Cancer submission deadline 25 May 2026 | Viewed by 4 | Submission Open
Keywords: prostate cancer; natural compounds; plants; urinary tract infections; supplements; signaling pathways
(This special issue belongs to the Section Natural Products)
Computational Methods in Drug Development
edited by
submission deadline 26 May 2026 | 9 articles | Viewed by 21523 | Submission Open
Keywords: computational modeling; DNA/RNA and protein; drug discovery and design; systems biology; channels and membranes; biomedical data analysis; artificial intelligence; molecule docking and scoring
(This special issue belongs to the Section Medicinal Chemistry)
Sex Differences in Pharmaceutical Practice: 2nd Edition submission deadline 28 May 2026 | Viewed by 52 | Submission Open
Keywords: sex; differences; drugs; kinetics; dynamics; preclinical; clinical; research
(This special issue belongs to the Section Medicinal Chemistry)
Pharmacotherapy of Dyslipidemias, 2nd Edition submission deadline 29 May 2026 | 3 articles | Viewed by 12898 | Submission Open
Keywords: atherosclerosis; dyslipidemia; endothelial dysfunction; fatty acids; high-fat diet; hyperlipidemia; hypertriglyceridemia; polyunsaturated fatty acids; PUFA; statins
(This special issue belongs to the Section Medicinal Chemistry)
Small Molecule Drug Discovery: Driven by In-Silico Techniques
edited by
submission deadline 29 May 2026 | 1 articles | Viewed by 3329 | Submission Open
Keywords: drug discovery; nutraceuticals; virtual screening; docking; molecular dynamics; pharmacophore; lead compound
(This special issue belongs to the Section Medicinal Chemistry)
Precision Oncology: Targeting Molecular Subtypes in Cancer Therapy
edited by and Jiro Ogura
submission deadline 29 May 2026 | 3 articles | Viewed by 2798 | Submission Open
Keywords: cancer chemotherapy; cancer genomic profiling test; next-generation sequencing; genetic variants; molecular targeted therapy; molecular tumor board; liquid biopsy
(This special issue belongs to the Section Pharmacology)
Investigating the Therapeutic Potential of Natural Products in Internal Diseases
edited by Roberto Pontarolo and
submission deadline 29 May 2026 | Viewed by 3 | Submission Open
Keywords: natural products; internal diseases; cardiovascular diseases; diabetes; autoimmune disorders; gastrointestinal conditions; respiratory illnesses
(This special issue belongs to the Section Natural Products)
Exploring Novel Therapies and Drug Efficacy for Inflammatory Bowel Disease submission deadline 30 May 2026 | Viewed by 90 | Submission Open
Keywords: Crohn's disease; ulcerative colitis; pharmacology; antioxidants; novel therapies; gut microbiome; inflammation
(This special issue belongs to the Section Pharmacology)
Small-Molecule Inhibitors for Novel Therapeutics
edited by and Simone Giovannuzzi
submission deadline 31 May 2026 | 4 articles | Viewed by 18762 | Submission Open
Keywords: small molecules; enzyme inhibition/activation; protein modulation; novel therapeutics; high-throughput screening; target proteins; drug delivery
Novel Anticancer Drug Development and Toxicity Reduction Strategies
edited by
submission deadline 31 May 2026 | 3 articles | Viewed by 3389 | Submission Open
Keywords: cancer; targeted therapy; anticancer drug; structure-based computational technique; combination therapy; nanocarriers; hydrogels
(This special issue belongs to the Section Medicinal Chemistry)
Polymers, Nanoparticles and Hydrogels for Drug Delivery: Strategies and Applications
edited by Mónica de la Luz Corea Téllez, Marlon Rojas López, and Rogelio Jiménez-Juárez
submission deadline 31 May 2026 | 1 articles | Viewed by 212 | Submission Open
Keywords: drug delivery; medical applications; hydrogels; polymers; nanoparticles; drug delivery system; multi-stimuli-responsive materials; nanocomposites; biofilms; biomarkers
(This special issue belongs to the Section Pharmaceutical Technology)
Advances in Theranostic Radiopharmaceuticals
edited by
submission deadline 31 May 2026 | Viewed by 125 | Submission Open
Keywords: theranostics; radiopharmacy; targeted alpha therapy; preclinical imaging; radiobiology; radioisotope production; molecular radiotherapy; positron emission tomography; single photon emission tomography
(This special issue belongs to the Section Radiopharmaceutical Sciences)
Targeting the NLRP3: From Novel Inhibitor Design to Clinic Trials and Therapeutic Applications
edited by and
submission deadline 31 May 2026 | Viewed by 121 | Submission Open
Keywords: NLRP3 inflammasome; selective and direct NLRP3 inhibitors; drug discovery; clinical trial; therapeutic applications
(This special issue belongs to the Section Biopharmaceuticals)
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