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Pharmaceuticals publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue polices and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Topoisomerases as Targets for Novel Drug Discovery

edited by

Andrej Perdih

submission deadline 20 Jun 2025 | 8 articles | Viewed by 25897 | Submission Open

Keywords: topoisomerase; type I topoisomerase; type II topoisomerase; DNA Gyrase; DNA topology; catalytic inhibitors; topo II poisons; DNA gyrase inhibitors; Novel bacterial topoisomerase inhibitors (NBTI); anticancer agents; antibacterial agents

(This special issue belongs to the Section Medicinal Chemistry)

Structural and Computationally Driven Molecule Design in Drug Discovery: 2nd Edition

edited by

Halil İbrahim Ciftci

Belgin Sever

and

Hasan Demirci

submission deadline 20 Jun 2025 | 5 articles | Viewed by 4812 | Submission Open

Keywords: structural dynamics studies; computer-aided drug design; molecular dynamics simulations; molecular docking; virtual screening; QSAR; in silico ADMET; artificial intelligence (AI) techniques

(This special issue belongs to the Section Medicinal Chemistry)

Stem Cells and Organoids as Tools for Drug Development

edited by Daniela Omodei

submission deadline 20 Jun 2025 | 2 articles | Viewed by 4505 | Submission Open

Keywords: stem cells; patient-derived cells; iPSCs (induced pluripotent stem cells); organoids; drug development; drug screening; drug toxicity; preclinical and clinical drug research; novel therapeutics; disease modeling; personalized medicine; precision medicine

(This special issue belongs to the Section Biopharmaceuticals)

Biological and Pharmacological Research on Indole-3-Carbinol (I3C) and Its Derivatives

edited by

Federica Centofanti

submission deadline 20 Jun 2025 | 2 articles | Viewed by 2427 | Submission Open

Keywords: indole-3-carbinol; natural and synthetic derivatives of I3C; synthetic procedures; biosynthetic processes; in vitro; in vivo and clinical studies; mechanism of action; biological properties; pharmacological properties; potential therapeutic applications in health and disease

(This special issue belongs to the Section Pharmacology)

Classical and Quantum Molecular Simulations in Drug Design

edited by

Osvaldo Andrade Santos-Filho

submission deadline 20 Jun 2025 | 1 articles | Viewed by 1479 | Submission Open

Keywords: molecular dynamics simulations; monte carlo simulations; docking simulations; free energy calculations; QM/MM modeling

(This special issue belongs to the Section Medicinal Chemistry)

Hsp90 Inhibitors: Progress, Challenges, and Opportunities in Drug Discovery and Development

edited by

Giusy Tassone

Ilaria D'Agostino

and

Samuele Maramai

submission deadline 20 Jun 2025 | Viewed by 346 | Submission Open

Keywords: Hsp90; drug discovery; synthesis; chaperone; therapeutic potential; cancer treatment; neurodegenerative diseases; infection resistance mechanisms; research advancements; therapeutic development

(This special issue belongs to the Section Medicinal Chemistry)

Novel Strategies in Gangliosidoses Therapy

edited by Jeanine Jarnes

submission deadline 22 Jun 2025 | Viewed by 257 | Submission Open

Keywords: gangliosidoses; small molecules; gene therapies; enzyme replacement; palliative care

(This special issue belongs to the Section Pharmacology)

Advances in Natural Extracts for Cancer Treatment: Targeting Melanoma Cells

edited by

Margarete Dulce Bagatini

submission deadline 22 Jun 2025 | Viewed by 57 | Submission Open

Keywords: natural extracts; natural products; cancer treatment; melanoma cells; active/biological compounds; mechanisms of action; combination therapy; alternative treatment options; skin cancer; biological effects

(This special issue belongs to the Section Natural Products)

Endocrine Diseases and Pharmacogenomics

edited by

Leonidas A. Phylactou

Vassos Neocleous

and

Pavlos Fanis

submission deadline 23 Jun 2025 | Viewed by 44 | Submission Open

Keywords: inherited endocrine disorders; pharmacogenomics; pharmacogenetics; genome sequencing; clinical trials

(This special issue belongs to the Section Pharmacology)

Metal Nanoparticles’ Biological Activity and Pharmaceutical Applications

edited by

Elitsa L. Pavlova

and

Debbie Crans

submission deadline 25 Jun 2025 | 8 articles | Viewed by 27213 | Submission Open

Keywords: metal nanoparticles; redox reactions; biological activity; pharmaceuticals; cytotoxicity; antibacterial effect; oxidative stress; disease; safety; in vivo applications

(This special issue belongs to the Section Medicinal Chemistry)

Exploring Natural Products with Antioxidant and Anticancer Properties

edited by

Sikiru Olaitan Balogun

and

Edson Lucas Dos Santos

submission deadline 25 Jun 2025 | 7 articles | Viewed by 15362 | Submission Open

Keywords: antioxidant; anticancer; neoplasms; natural products; cytotoxicity

(This special issue belongs to the Section Natural Products)

New Advances in Antiarrhythmic Drugs

edited by

Norbert Szentandrássy

submission deadline 25 Jun 2025 | 7 articles | Viewed by 12829 | Submission Open

Keywords: antiarrhythmic drugs; ion channel blockers; cardiac action potential; sudden cardiac death; cardiac arrhythmia; proarrhythmic action

(This special issue belongs to the Section Pharmacology)

Pharmacoepidemiology and Pharmacovigilance in Drug Therapy: New Issues, Challenges, and Applications

edited by Loreta Kubilienė

submission deadline 25 Jun 2025 | 2 articles | Viewed by 1955 | Submission Open

Keywords: pharmacoepidemiology; pharmacovigilance; drug safety monitoring; regulatory practices; hospitalization; adverse drug events; drug safety; preventability

(This special issue belongs to the Section Pharmacology)

Medicinal Chemistry of Metal Complexes: Design, Synthesis and Evaluation

edited by Bojana B. Zmejkovski,

Goran Kaluđerović

and

Nebojša Pantelić

submission deadline 25 Jun 2025 | 1 articles | Viewed by 660 | Submission Open

Keywords: metal complexes; medicinal chemistry; bioinorganic chemistry; coordination chemistry; organometallics; metal-based drugs; biological activity; toxicology; biomedical application; drug delivery

(This special issue belongs to the Section Medicinal Chemistry)

Molecular Mechanisms and Treatment of Brain Cancer: Recent Advances and Future Trends

edited by

Terezia Kiskova

submission deadline 25 Jun 2025 | Viewed by 297 | Submission Open

Keywords: brain cancer; molecular mechanism; treatment; diagnosis; in vitro; in vivo; models

(This special issue belongs to the Section Pharmacology)

Management of Pain in Oral Mucositis

edited by

Carlos Roldan

and Thomas Chai

submission deadline 25 Jun 2025 | Viewed by 288 | Submission Open

Keywords: oral mucositis; oral pain; pain management; cancer; cancer therapy

(This special issue belongs to the Section Pharmacology)

Pharmaceuticals for Inflammatory Bowel Disease (IBD)

edited by

Phurpa Wangchuk

submission deadline 25 Jun 2025 | Viewed by 153 | Submission Open

Keywords: inflammatory bowel disease; IBD symptoms; IBD pathogenesis; IBD treatments

(This special issue belongs to the Section Pharmacology)

Pediatric Drug Therapy: Safety, Efficacy, and Personalized Medicine

edited by

Catherine M. T. Sherwin

submission deadline 25 Jun 2025 | Viewed by 89 | Submission Open

Keywords: pediatric pharmacotherapy; drug safety in children; pediatric drug efficacy; personalized medicine in pediatrics; pediatric pharmacokinetics; pediatric pharmacodynamics; pharmacogenomics in children; pediatric clinical trials; pediatric dosing strategies; pediatric drug formulations

(This special issue belongs to the Section Pharmacology)

Dysregulation of Cyclic AMP and Cyclic PIP Synthesis: Implications for Disease and Advances in Therapeutic Development

edited by

Heinrich K Wasner

submission deadline 25 Jun 2025 | Viewed by 89 | Submission Open

Keywords: reversible protein phosphorylation; cyclic AMP; cyclic PIP; signal transduction; cyclic AMP antagonist

(This special issue belongs to the Section Medicinal Chemistry)

Pharmacological Activities and Therapeutic Potential of Novel Drug Derivatives

edited by

Stoyanka Atanasova

and

Vera Gledacheva

submission deadline 25 Jun 2025 | Viewed by 56 | Submission Open

Keywords: novel drug derivatives; synthesis; drug design; therapeutic potential; biological activity; pharmacological activity

(This special issue belongs to the Section Pharmacology)

Population Pharmacokinetics and Pharmacogenetics

edited by

Seung-Hyun Jeong

submission deadline 25 Jun 2025 | Viewed by 52 | Submission Open

Keywords: pharmacokinetics; pharmacogenetics; precision medicine; population pharmacometrics model; mathematical modeling; dosage regimen; inter-subject variability

(This special issue belongs to the Section Pharmacology)

Gene Delivery and Its Application in Pharmaceutical Science

edited by Xuanyu Chen and Wen Xiao

submission deadline 25 Jun 2025 | Viewed by 38 | Submission Open

Keywords: microRNAs; neuronal reprogramming; gene therapy; adeno-associated virus; neurodegenerative diseases; brain injury; spinal cord injury; tumor

(This special issue belongs to the Section Pharmaceutical Technology)

Exploring Biomarkers and Pharmacotherapies for Substance Use Disorders

edited by

Ani Gasparyan

Daniela Navarro

and

Jorge Manzanares

submission deadline 27 Jun 2025 | 3 articles | Viewed by 5169 | Submission Open

(This special issue belongs to the Section Pharmacology)

Pharmaceutical Formulation Characterization Design

edited by

Tamás Sovány

and

Katalin Kristó

submission deadline 30 Jun 2025 | 6 articles | Viewed by 6578 | Submission Open

Keywords: quality by design; factorial design; design space; solid dosage forms; risk assessment; critical process parameters; quality target product profile

(This special issue belongs to the Section Pharmaceutical Technology)

Natural Compounds as Potential Anticancer, Anti-inflammatory and Antioxidant Agents in Medicine

edited by

Justyna Stefanowicz-Hajduk

submission deadline 30 Jun 2025 | 4 articles | Viewed by 4582 | Submission Open

Keywords: phytochemistry of plant extracts; plant secondary metabolites; clinical applications; in vitro; in vivo; ex vivo studies; cell and tissue cultures

(This special issue belongs to the Section Natural Products)

Computational Predictions of Molecules with Potential Therapeutic Effects

edited by

Whelton Miller

submission deadline 30 Jun 2025 | 2 articles | Viewed by 2463 | Submission Open

Keywords: biophysics; medicinal chemistry; drug discovery; molecular docking; molecular dynamics; structure-activity relationships; computer-aided drug design (CADD)

(This special issue belongs to the Section Medicinal Chemistry)

Boron-Containing Compounds: Identification, Synthesis, Biological Actions and Pharmacology

edited by

Marvin Antonio Soriano-Ursúa

and

Andrei Biță

submission deadline 30 Jun 2025 | 1 articles | Viewed by 947 | Submission Open

Keywords: boron; drug development; drug discovery; bioactive boron compounds; bioinorganic chemistry; inorganic biological chemistry; synthesis; natural boron compounds; chemical characterization

(This special issue belongs to the Section Medicinal Chemistry)

Integrating Medicinal Chemistry and Mass Spectrometry: New Opportunities and Challenges

edited by

Francesco Fiorentino

submission deadline 30 Jun 2025 | Viewed by 166 | Submission Open

Keywords: drug discovery; medicinal chemistry; mass spectrometry; chemical biology; structural biology

(This special issue belongs to the Section Medicinal Chemistry)

Advances in Biotechnological Formulations for Skin Disorders: Delivery Strategies and Biocompatibility

edited by Marcel Henrique Marcondes Sari,

Raul Edison Luna Lazo

and

Luana Mota Ferreira

submission deadline 30 Jun 2025 | Viewed by 137 | Submission Open

Keywords: skin disorders; biotechnological formulations; nanocarriers; probiotic-based formulations; natural products; polysaccharides; skin delivery systems; bioactive compounds; antioxidant and anti-inflammatory effects; wound healing; safety and efficacy in skin therapies

(This special issue belongs to the Section Pharmaceutical Technology)

A Commemorative Special Issue in Honor of Professor Carlos Alberto Manssour Fraga: Medicinal Chemistry’s Efforts to Discover Novel Bioactive Molecules for Complex Diseases

edited by Luzineide Tinoco and

Pedro De Sena Murteira Pinheiro

submission deadline 30 Jun 2025 | Viewed by 80 | Submission Open

Keywords: medicinal chemistry; bioactive molecules; complex diseases; cardiovascular diseases; diabetes; cancer; neurodegenerative disorders; drug discovery; synthetic chemistry; target identification; structure– activity relationship; preclinical evaluation

(This special issue belongs to the Section Medicinal Chemistry)

Mesenchymal Stromal/Stem Cells (MSCs): Translating Innovation from Bench to Bedside

edited by

Miomir Knezevic

and Sofia M. Calado

submission deadline 30 Jun 2025 | Viewed by 75 | Submission Open

Keywords: mesenchymal stem cells (MSCs); drug delivery systems; translational medicine; cell-based therapy; regenerative medicine; targeted delivery; therapeutic applications

(This special issue belongs to the Section Pharmacology)

Research on the Cureless Amyotrophic Lateral Sclerosis (ALS)

edited by

Halilibrahim Ciftci

Belgin Sever

and

Rumiana Tzoneva

submission deadline 30 Jun 2025 | Viewed by 61 | Submission Open

Keywords: neurodegenerative disorders; amyotrophic lateral sclerosis (ALS); superoxide dismutase (SOD1); TAR DNA binding protein 43 (TDP-43); oxidative stress; apoptosis; protein aggregation

(This special issue belongs to the Section Pharmacology)

Pharmacotherapy of Diseases Affecting Urinary Tract

edited by

Priscila de Souza

submission deadline 30 Jun 2025 | Viewed by 50 | Submission Open

Keywords: natural products; plant extracts and isolated compounds; synthesized compounds; modified compounds; drug repositioning; kidney stone; urolithiasis; diuresis; urinary tract; urinary tract infection; cystitis; urethritis; nephritis; renal hypertension; diabetic nephropathy; nephrotoxicity; renal failure; urinary incontinence; overactive bladder; prostatitis; prostatic hyperplasia

(This special issue belongs to the Section Pharmacology)

Pharmacological Modulation of Lipoproteins, 2nd edition

edited by

Soumaya Ben-Aicha

submission deadline 30 Jun 2025 | Viewed by 38 | Submission Open

Keywords: lipoproteins; lipid-lowering drugs; hypercholesterolemia; LDL; HDL; health disorder

Recent Advances in Overcoming Therapy Resistance in Cancer

edited by

Manoj K. Pandey

submission deadline 30 Jun 2025 | Viewed by 29 | Submission Open

Keywords: cancer therapy resistance; hematological malignancies; solid tumors; targeted therapies; tumor microenvironment; drug resistance mechanisms; epigenetic factors; translational oncology; novel therapeutic strategies; biomarkers of resistance

Purinergic Signaling in Cancer Therapy: From Mechanisms to Targeting Strategies

edited by

Margarete Dulce Bagatini

submission deadline 30 Jun 2025 | Viewed by 23 | Submission Open

Keywords: purinergic signaling; cancer; ATP; adenosine; purinergic receptors; immune modulation; tumor progression; therapeutic potential

(This special issue belongs to the Section Pharmacology)

Pharmacology of Antidepressants: Recent Advances

edited by

Anna Wiktorowska-Owczarek

submission deadline 5 Jul 2025 | Viewed by 56 | Submission Open

Keywords: new mechanisms of antidepressants action; new targets for antidepressant therapy; rapid-acting antidepressants; inflammation in depression; gut– microbiota– brain axis in depression; probiotic as an antidepressant; quo vadis pharmacology of antidepressants

(This special issue belongs to the Section Pharmacology)

Photodynamic Therapy for Cancer: Recent Advances

edited by

Cristina Pacheco-Soares

submission deadline 5 Jul 2025 | Viewed by 40 | Submission Open

Keywords: photodynamic therapy; cancer treatment; photosensitizers; targeted therapy; combination therapies; mechanisms of action; molecular biology

(This special issue belongs to the Section Pharmaceutical Technology)

Organ Regeneration by Application of Biomaterials and Stem Cells Technology Tools

edited by

Saima Imran

submission deadline 12 Jul 2025 | 1 articles | Viewed by 1930 | Submission Open

Keywords: stem cells; biomaterial; biocompatibility; regenerative medicine; tissue engineering; acellular matrix; decellularization; disease modeling

(This special issue belongs to the Section Biopharmaceuticals)

Pharmaceutical Application of Essential Oils

edited by

Paweł Kwiatkowski

submission deadline 12 Jul 2025 | 1 articles | Viewed by 1266 | Submission Open

Keywords: essential oils; bacteria; fungi; alternative therapy; antimicrobial resistance; mechanism of action

(This special issue belongs to the Section Natural Products)

Discovering Novel Drugs from Plants

edited by

Yung-Chia Chen

submission deadline 15 Jul 2025 | Viewed by 216 | Submission Open

Keywords: natural products; drug discovery; bioactive compound; extraction; ethnopharmacology; preclinical test

(This special issue belongs to the Section Natural Products)

Neuroblastoma Pathogenesis and Therapy

edited by

Saurabh Agarwal

submission deadline 20 Jul 2025 | 3 articles | Viewed by 12718 | Submission Open

Keywords: Neuroblastoma; Pediatric cancers; Neural crest; Pathogenesis; Metastasis; Epigenetics; Therapeutic approach; Tumorigenesis; Signaling mechanisms; Epithelial-to-mesenchymal transition

(This special issue belongs to the Section Pharmacology)

Application of Gastrointestinal Peptides in Medicine

edited by

Predrag Sikirić

Sven Seiwerth

and Anita Škrtić

submission deadline 20 Jul 2025 | 1 articles | Viewed by 2055 | Submission Open

Keywords: brain– gut axes; gut peptides; gut peptide therapy; peptides; healing; heart failure

(This special issue belongs to the Section Pharmacology)

Potential Pharmacotherapeutic Targets in Neurodegenerative Diseases

edited by

Cláudio Viegas-Junior

submission deadline 20 Jul 2025 | Viewed by 151 | Submission Open

Keywords: neurodegenerative diseases; neuroinflammation; neuroprotection; molecular targets; therapeutic drugs

(This special issue belongs to the Section Pharmacology)

2D and 3D Culture Systems: Current Trends and Biomedical Applications

edited by

Juliana Mara Serpeloni

, Colus Ilce Mara and

Diego Luís Ribeiro

submission deadline 25 Jul 2025 | 3 articles | Viewed by 4144 | Submission Open

Keywords: spheroids; organoids; 3D cultures; tissue engineering; disease modelling; regenerative medicine; cell-extracellular matrix interaction; drug screening

(This special issue belongs to the Section Biopharmaceuticals)

Biomedical Properties, Developments and Therapeutic Potential of Sesquiterpenoid Lactones and Natural Compounds

edited by

Normand Garcia-Hernandez

Rosa Ordoñez Razo

and Israel Ramírez-Sánchez

submission deadline 25 Jul 2025 | 3 articles | Viewed by 4048 | Submission Open

Keywords: therapeutic potential; natural compounds; biological activity; traditional medicine; sesquiterpene lactone; pharmacological activities; terpenoids; flavonoids

(This special issue belongs to the Section Natural Products)

Novel Imidazole Derivatives in Medicinal Chemistry

edited by Dorota Olender,

Justyna Żwawiak

and

Lucjusz Zaprutko

submission deadline 25 Jul 2025 | 1 articles | Viewed by 2979 | Submission Open

Keywords: imidazole; nitroimidazole derivatives; biological activities; synthesis; heterocyclic drug discovery

(This special issue belongs to the Section Medicinal Chemistry)

Orodispersible and Innovative Dosage Forms: Advances in Preparation Technologies, Direct Compression, and Co-Processed Excipients

edited by

Witold Brniak

and

Aleksander Mendyk

submission deadline 25 Jul 2025 | 1 articles | Viewed by 1691 | Submission Open

Keywords: orodispersible films; buccal films; chewable tablets; orodispersible granules; buccal dosage forms; mucoadhesive dosage forms; tabletability; modified release tablets; minitablets

(This special issue belongs to the Section Pharmaceutical Technology)

Self-Assembling Nanostructures for Cancer Therapy

edited by

André Moreni Lopes

submission deadline 25 Jul 2025 | 1 articles | Viewed by 1332 | Submission Open

Keywords: drug delivery systems; polymeric micelles; polymeric vesicles (polymersomes); surfactants; amphiphilic copolymers; stimuli-responsive polymers; cancer therapy; drugs; biopharmaceuticals; dual delivery

(This special issue belongs to the Section Pharmaceutical Technology)

Natural Products as an Alternative for Treatment of Human Diseases

edited by Eduardo Lira,

Jackson Guedes

and Raimundo Gonçalves De Oliveira Junior

submission deadline 25 Jul 2025 | Viewed by 133 | Submission Open

Keywords: medicinal plants; herbal remedies; natural products; traditional medicine

(This special issue belongs to the Section Natural Products)

Displaying special issue 301-350 on page 7 of 8.

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