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Pharmaceuticals publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Application of Computer Simulation in Drug Design

edited by

Alessia Bono

and

Antonino Lauria

submission deadline 31 Jan 2026 | Viewed by 72 | Submission Open

Keywords: in silico; drug design; drug discovery; molecular docking; molecular dynamics simulations; structure-based; ligand-based; virtual screening; drug repurposing

(This special issue belongs to the Section Medicinal Chemistry)

The Regulatory Roles of the Gut Microbiota in Multisystem Diseases

edited by

Mario Caldarelli

and

Rossella Cianci

submission deadline 31 Jan 2026 | Viewed by 70 | Submission Open

Keywords: microbiota; multisystem diseases; bacteriophage therapy; metabolic disorders; precision medicine

(This special issue belongs to the Section Pharmacology)

Development of Antibacterial Drugs to Combat Drug-Resistant Bacteria: 2nd Edition

edited by

Adriána Liptáková

and Iryna Voronkina

submission deadline 31 Jan 2026 | Viewed by 69 | Submission Open

Keywords: development of antibacterial drugs; drug-resistant bacteria; antimicrobial resistance; new therapeutic solutions; improvement of existing therapies; nosocomial infections

(This special issue belongs to the Section Pharmacology)

Natural Products for Skin Applications

edited by

Octavia Gligor

and

Ana-Maria Vlase

submission deadline 31 Jan 2026 | Viewed by 62 | Submission Open

Keywords: bioactive compounds; plant extracts; topic preparations; skincare; cutaneous applications; skin cancer; medicinal plants; modern extraction techniques; optimized/standardized extracts; phytochemical analysis; health outcomes of plant extracts; bioaccessability of compounds from various vegetal matrices; drug– vegetal extract interactions at metabolic level

(This special issue belongs to the Section Natural Products)

Design, Synthesis and Biological Evaluation of Small Molecules for the Treatment of Solid Tumors

edited by

Aleksandra Sochacka-Ćwikła

Małgorzata Strzelecka

and

Żaneta Czyżnikowska

submission deadline 31 Jan 2026 | Viewed by 44 | Submission Open

Keywords: anticancer drugs; small-molecule agents; targeted therapy; solid cancers; drug delivery systems; drug resistance; approval characteristic; FDA; EMA

(This special issue belongs to the Section Medicinal Chemistry)

Radiopharmaceuticals in Cancer Disorders: Clinical and Pharmaceutical Perspectives

edited by

Marta Rusek

submission deadline 31 Jan 2026 | Viewed by 27 | Submission Open

Keywords: radiopharmaceuticals; cancer theranostics; targeted radionuclide therapy; molecular imaging; pharmaceutical development

(This special issue belongs to the Section Radiopharmaceutical Sciences)

Promising Natural Products with Anti-Inflammatory and Antioxidant Bioactivities: Extraction, Identification, and Biological Evaluation

edited by Sara Vieira and

Lillian Barros

submission deadline 31 Jan 2026 | Viewed by 27 | Submission Open

Keywords: bioactive compounds; extraction techniques; anti-inflammatory activity; antioxidant activity; inflammation; inflammatory molecules; signaling pathways

(This special issue belongs to the Section Natural Products)

Drug Therapy for Rheumatological Diseases

edited by

Shivani Garg

submission deadline 31 Jan 2026 | Viewed by 26 | Submission Open

Keywords: rheumatology; drug therapy; biologics; DMARDs; therapeutic drug monitoring; shared decision-making; autoimmune diseases; chronic disease management; safety vs. efficacy of rheumatic disease therapy

(This special issue belongs to the Section Pharmacology)

Advances in Targeted Therapy for Gastrointestinal Cancers

edited by

Juraj Prejac

and

Marin Golčić

submission deadline 31 Jan 2026 | Viewed by 22 | Submission Open

Keywords: targeted therapy; gastrointestinal cancers; molecular targets; drug resistance; biomarkers; immunotherapy; precision medicine; translational research; clinical trials; tumor microenvironment

(This special issue belongs to the Section Pharmacology)

Pharmaceutical Blood Products

edited by

Victor Tuan Giam Chuang

, Masaki Otagiri and

Kazuaki Taguchi

submission deadline 31 Jan 2026 | Viewed by 8 | Submission Open

Keywords: pharmaceutical blood products; plasma-derived therapeutics; recombinant blood factors; cellular therapies; immunoglobulins; fractionation technologies; viral inactivation; hemophilia treatments; gene-editing approaches; clinical efficacy

(This special issue belongs to the Section Biopharmaceuticals)

Advances in Topical and Mucosal Drug Delivery Systems

edited by

Michelle Franz-Montan

submission deadline 15 Feb 2026 | 1 articles | Viewed by 598 | Submission Open

Keywords: topical drug delivery; mucosal drug delivery; transdermal drug delivery; controlled release; bioavailability enhancement; formulation development

(This special issue belongs to the Section Pharmaceutical Technology)

Chemotherapeutic and Targeted Drugs in Antitumor Therapy

edited by

Angéla Takács

and

László Kőhidai

submission deadline 15 Feb 2026 | Viewed by 419 | Submission Open

Keywords: cancer; drug discovery; small-molecule drugs; targeted therapy; combination therapy; synergism; selectivity; immunotherapy; precision medicine

(This special issue belongs to the Section Pharmacology)

Click Chemistry-Aided Drug Discovery

edited by

Damien Bosc

submission deadline 15 Feb 2026 | Viewed by 24 | Submission Open

Keywords: click chemistry; drug discovery; structure– activity relationship; hit-to-lead; chemical probes; bio-orthogonal reactions; protein-templated reactions; bioisosteres; cycloaddition; 1; 2; 3-triazole

(This special issue belongs to the Section Medicinal Chemistry)

Application of Zebrafish Model in Pharmacology and Toxicology

edited by

Geonildo Rodrigo Disner

and

Mônica Lopes-Ferreira

submission deadline 15 Feb 2026 | Viewed by 5 | Submission Open

Keywords: chemical safety assessment; translational research; drug screening; human exposome; environmental contaminants

(This special issue belongs to the Section Pharmacology)

Biological Properties of Nanostructures Incorporated in Polymeric Matrices

edited by

Isabella Macário Ferro Cavalcanti

submission deadline 22 Feb 2026 | Viewed by 12 | Submission Open

Keywords: antimicrobial resistance; cancer; diseases; nanotechnology; polimer

(This special issue belongs to the Section Pharmaceutical Technology)

Medicinal Chemistry of Thiazine and Oxazine Derivatives: Trends and Future Directions as Therapeutic Drugs

edited by

Berenika M. Szczȩśniak-Siȩga

and

Żaneta Czyżnikowska

submission deadline 22 Feb 2026 | Submission Open

Keywords: thiazine; oxazine; morpholine; thiomorpholine; benzothiazine; phenothiazine; synthesis; drug; anti-inflammatory; anticancer

(This special issue belongs to the Section Medicinal Chemistry)

Medicinal Plants: A Natural Approach to Inflammatory Diseases and Conditions Related to Oxidative Stress

edited by

Sandra Barbalho

and

Adriano Araujo

submission deadline 25 Feb 2026 | 6 articles | Viewed by 11488 | Submission Open

Keywords: medicinal plants; phytocompounds; natural products; inflammatory diseases; oxidative stress

(This special issue belongs to the Section Natural Products)

Advances in Biotechnological Formulations for Skin Disorders: Delivery Strategies and Biocompatibility

edited by Marcel Henrique Marcondes Sari,

Raul Edison Luna Lazo

and

Luana Mota Ferreira

submission deadline 25 Feb 2026 | 1 articles | Viewed by 2067 | Submission Open

Keywords: skin disorders; biotechnological formulations; nanocarriers; probiotic-based formulations; natural products; polysaccharides; skin delivery systems; bioactive compounds; antioxidant and anti-inflammatory effects; wound healing; safety and efficacy in skin therapies

(This special issue belongs to the Section Pharmaceutical Technology)

Targeting Epigenetic Regulation for Cancer Therapy

edited by

Bence Raposa

and

John M. Macharia

submission deadline 25 Feb 2026 | Viewed by 62 | Submission Open

Keywords: epigenetics; chromatin remodeling; histone modifications; non-coding RNAs; gene regulation; cancer therapy; epigenetic biomarkers; therapeutic targets

(This special issue belongs to the Section Pharmacology)

Advances in Perinatal Pharmacology

edited by

Khaled Abduljalil

and

Raj Badhan

submission deadline 25 Feb 2026 | Viewed by 6 | Submission Open

Keywords: maternal; perinatal; neonatal; pharmacology; placenta; pregnancy

(This special issue belongs to the Section Pharmacology)

Innovative Applications and Performance Optimization of Biodegradable Polymers in Drug Delivery

edited by

Nikolaos D. Bikiaris

submission deadline 25 Feb 2026 | Viewed by 2 | Submission Open

Keywords: biodegradable polymers; drug delivery systems; controlled release; polymeric nanoparticles; targeted drug delivery; in vivo drug delivery; sustained release formulations

(This special issue belongs to the Section Pharmaceutical Technology)

Advances in the Mechanism of Action and the Therapeutic Role of Phytopharmaceuticals

edited by Maria-Eleni Grafakou and

Jörg Heilmann

submission deadline 28 Feb 2026 | 1 articles | Viewed by 859 | Submission Open

Keywords: medicinal plants; natural products; phytochemistry; biological activities; mechanism of action; biotransformation; microbiome

(This special issue belongs to the Section Natural Products)

New Horizons in Drug Development Targeting Depression

edited by

Michał Górski

, Joanna Fojcik, Agnieszka Koźmin-Burzyńska and Marek Krzystanek

submission deadline 28 Feb 2026 | Viewed by 314 | Submission Open

Keywords: treatment-resistant depression; novel antidepressants; glutamatergic system; personalized medicine; psychoactive therapies

(This special issue belongs to the Section Pharmacology)

Pyrazole and Its Derivatives: Drug Design, Synthesis, and Biological Evaluation

edited by

Matteo Lusardi

and

Marco Ponassi

submission deadline 28 Feb 2026 | Viewed by 89 | Submission Open

Keywords: medicinal chemistry; drug design; drug discovery; pyrazole-based compounds; innovative synthesis; structure– activity relationships; biological activities; drug-like properties

(This special issue belongs to the Section Medicinal Chemistry)

Molecular Insights and Clinical Implications in Geriatric Medicine and Drug Development

edited by

Katarzyna Mądra-Gackowska

Marcin Gackowski

, Kornelia Kędziora-Kornatowska and

Iga Hołyńska-Iwan

submission deadline 28 Feb 2026 | Viewed by 53 | Submission Open

Keywords: older adults; age-related diseases; biomarkers; drug development; molecular modeling; computer-aided drug design; geriatrics in laboratory medicine; laboratory tests in older patients; malnutrition diagnostics; test results versus a clinical image of an older patient

(This special issue belongs to the Section Pharmacology)

Advances in Natural Products: Basic, Therapeutic, and Computational Approaches in Chronic and Infectious Diseases

edited by

Maira Huerta-Reyes

Gil Alfonso Magos-Guerrero

Oscar Barrera-Vázquez

and

Michael Danilenko

submission deadline 28 Feb 2026 | Viewed by 39 | Submission Open

Keywords: natural products; chronic diseases; infectious diseases; computational; in silico

(This special issue belongs to the Section Natural Products)

Discovery of Natural Products to Promote the Wound Healing

edited by

Ying Li

submission deadline 28 Feb 2026 | Viewed by 14 | Submission Open

Keywords: natural ingredients; natural biomedical polymers; drug delivery; nanomedicine; hydrogels; wound healing

The Emerging Field of Critical Care Psychiatry: Pharmacologic Treatment from ICU to Post-ICU Recovery

edited by Shixie Jiang,

Matthew Gunther

and Jose R. Maldonado

submission deadline 28 Feb 2026 | Viewed by 11 | Submission Open

Keywords: critical care psychiatry; ICU psychiatry; delirium; encephalopathy; cognitive impairment; neurocognitive disorders; dementia; post-intensive care syndrome; depression; anxiety; trauma; insomnia; sleep disturbances; mental health; behavioral health

(This special issue belongs to the Section Pharmacology)

Vitamin D and Its Derivatives in Pharmacology: Mechanisms and Therapeutic Applications

edited by

Agnieszka Sliwinska

submission deadline 28 Feb 2026 | Viewed by 9 | Submission Open

Keywords: vitamin D; synthesis and metabolism; vitamin D derivatives; vitamin D deficiency related diseases; clinical trials on vitamin D and/or its derivatives

(This special issue belongs to the Section Pharmacology)

Applications of Pharmacogenomics in Precision Medicine

edited by Kariofyllis Karamperis, Branka Zukic and

Fernanda Rodrigues-Soares

submission deadline 28 Feb 2026 | Viewed by 4 | Submission Open

Keywords: personalized medicine; pharmacogenomics; drug– gene interactions; adverse drug reactions; pharmacogenomic biomarkers; multi-omics; population pharmacogenomics; precision therapeutics

(This special issue belongs to the Section Pharmacology)

New Perspective of Antiviral Drugs

edited by

Grigoris Zoidis

submission deadline 28 Feb 2026 | Submission Open

Keywords: antiviral drugs; antiviral agents; small organic molecules; metal complexes; natural products

(This special issue belongs to the Section Medicinal Chemistry)

Bioactive Substances and Skin Health: The Role of Pharmacy and Nutrition—Properties and Technology

edited by

Francisco Rivas

, Margarita López-Viota and Rafael Jesús Giménez Martínez

submission deadline 1 Mar 2026 | 4 articles | Viewed by 16602 | Submission Open

Keywords: supplements; bioactive substances; skin health

(This special issue belongs to the Section Pharmaceutical Technology)

Medications: Interactions with Diet, Herbs, Dietary Supplements and Probiotics

edited by

Francisco Rivas

, María Isabel Valverde Merino and Maria José Zarzuelo Romero

submission deadline 1 Mar 2026 | 3 articles | Viewed by 6833 | Submission Open

Keywords: food– drug interactions; dietary supplements; probiotics; herb– drug interaction

(This special issue belongs to the Section Pharmacology)

Innovations in Chemotherapy: From Synthetic to Natural Agents and Combined Therapies

edited by Stefano Ruga

submission deadline 1 Mar 2026 | Viewed by 150 | Submission Open

Keywords: chemotherapy; immunotherapy; innovative drugs; natural compounds; combination therapy; targeted therapy; customized administration; drug stability; drug storage

(This special issue belongs to the Section Pharmacology)

Exploring Natural Products with Antioxidant and Anticancer Properties, 2nd Edition

edited by

Sikiru Olaitan Balogun

and

Edson Lucas Dos Santos

submission deadline 25 Mar 2026 | Viewed by 15 | Submission Open

Keywords: antioxidant; anticancer; neoplasms; natural products; cytotoxicity

(This special issue belongs to the Section Natural Products)

Metal Nanoparticles’ Biological Activity and Pharmaceutical Applications, 2nd Edition

edited by

Elitsa L. Pavlova

and

Debbie C. Crans

submission deadline 25 Mar 2026 | Viewed by 3 | Submission Open

Keywords: metal nanoparticles; redox reactions; biological activity; pharmaceuticals; cytotoxicity; antibacterial effect; oxidative stress; disease; safety; in vivo applications

(This special issue belongs to the Section Medicinal Chemistry)

Discovery and Validation of Novel Antimicrobial Molecules for the Treatment of Multidrug-Resistant Bacterial Infections

edited by

Paolo Gaibani

and Rocco Latorre

submission deadline 27 Mar 2026 | Viewed by 211 | Submission Open

Keywords: antibiotics therapy; multidrug resistance; bacterial infection

(This special issue belongs to the Section Pharmacology)

Peptide-Based Drug Discovery: Innovations and Breakthroughs

edited by

Santo Previti

submission deadline 31 Mar 2026 | Viewed by 45 | Submission Open

Keywords: drug discovery; peptide-based compounds; peptidomimetics; target modulation; structure– activity relationship studies; hit molecules; AI-driven drug discovery; ligand-based drug design; structure-based drug design; computer-aided drug design

(This special issue belongs to the Section Medicinal Chemistry)

Design, Synthesis and Pharmacological Evaluation of Novel Opioid/Non-Opioid Hybrid Compounds

edited by Justyna Piekielna-Ciesielska and

Katarzyna Gach-Janczak

submission deadline 31 Mar 2026 | Viewed by 21 | Submission Open

Keywords: opioid; opioid hybrids; pain; opioid-related side-effects; tolerance; addiction; neurotransmitters

(This special issue belongs to the Section Medicinal Chemistry)

Natural Products and Bioactive Compounds for the Prevention and Treatment of Non-Communicable Chronic Diseases

edited by

Priscila de Souza

submission deadline 26 Apr 2026 | Viewed by 14 | Submission Open

Keywords: natural products; phytochemicals; chronic diseases; functional foods; herbal medicine; non-communicable diseases; ethnopharmacology; bioactivity

(This special issue belongs to the Section Natural Products)

Computational Methods in Drug Development

edited by

Yunjie Zhao

submission deadline 26 May 2026 | 7 articles | Viewed by 10097 | Submission Open

Keywords: computational modeling; DNA/RNA and protein; drug discovery and design; systems biology; channels and membranes; biomedical data analysis; artificial intelligence; molecule docking and scoring

(This special issue belongs to the Section Medicinal Chemistry)

Applications of Stem Cells and Organoids in Disease Modeling, Drug Discovery and Clinical Evaluation

edited by Daniela Omodei

submission deadline 31 May 2026 | Viewed by 24 | Submission Open

Keywords: stem cells; patient-derived cells; iPSCs (induced pluripotent stem cells); organoids; drug development; drug screening; drug toxicity; preclinical and clinical drug research; novel therapeutics; disease modeling; personalized medicine; precision medicine

(This special issue belongs to the Section Pharmacology)

Extracts and Essential Oils from Medicinal Plants: Biological Activities, Applications, and Perspectives

edited by

Stefan Tyski

Agnieszka E. Laudy

and

Mariola Kozłowska

submission deadline 30 Jun 2026 | Viewed by 53 | Submission Open

Keywords: medicinal plants; spices and herbs; bioactive compounds; antimicrobial agents; plant extracts; essential oils; phytochemical analysis; microbiological analysis; natural medicines

(This special issue belongs to the Section Natural Products)

Displaying special issue 301-350 on page 7 of 7.

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