Design and Synthesis of Compounds with Potential Anti-Inflammatory Activity
A special issue of Pharmaceuticals (ISSN 1424-8247). This special issue belongs to the section "Medicinal Chemistry".
Deadline for manuscript submissions: 22 April 2026 | Viewed by 70
Special Issue Editors
Interests: synthesis; pyrrolopyrrole; pyridazines; cyclic imides; anti-inflammatory activity; analgesic activity
Special Issues, Collections and Topics in MDPI journals
Interests: synthesis; pyrimidine; pyridocarbazole; olivacine; ellipticine; anticancer; anti-inflammatory activity
Special Issue Information
Dear Colleagues,
Inflammation is the body's natural response to tissue injury or infection. When repair mechanisms fail, inflammation may become uncontrolled or chronic, contributing to the development and progression of numerous diseases, including cancer, obesity, sepsis, inflammatory bowel disease, type 2 diabetes, cardiovascular disorders, neurodegenerative diseases, and autoimmune conditions.
Given the pivotal role of inflammation in the pathogenesis of these disorders, there is a pressing need to develop novel anti-inflammatory therapeutics.
The goals of anti-inflammatory drug design include the following:
- Selectivity—Avoiding broad-based immunosuppression, which can lead to side effects.
- Specific molecular targets, including: cyclooxygenases (COX-1, COX-2), proinflammatory cytokines (TNF-α, IL-1β, IL-6), transcription factors (NF-κB, AP-1, STAT3), and receptors (TLRs, cytokine receptors, CB2). Additional relevant targets include inflammasomes (e.g., NLRP3), protein kinases (MAPK, JNK), and adhesion molecules (ICAM-1, VCAM-1), as well as P2X7 receptors and TRP channels implicated in pain, itch, and neurogenic inflammation.
- Optimization of pharmacokinetic properties—Enhancing bioavailability, metabolic stability, and effective tissue penetration.
This Special Issue invites submissions of original research and comprehensive reviews focused on recent advances and innovative approaches in the design and synthesis of compounds with potential anti-inflammatory properties.
Dr. Aleksandra Redzicka
Dr. Beata Tylińska
Dr. Anna Wójcicka
Guest Editors
Manuscript Submission Information
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Keywords
- drug design
- synthesis
- anti-inflammatory activity
- cyclooxygenases
- lipoxygenases
- cytokines
- anticancer activity
- Alzheimer's disease
- neuroinflammation
- molecular mechanisms
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