Design and Synthesis of Compounds with Potential Anti-Inflammatory Activity

A special issue of Pharmaceuticals (ISSN 1424-8247). This special issue belongs to the section "Medicinal Chemistry".

Deadline for manuscript submissions: 22 April 2026 | Viewed by 29

Special Issue Editors


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Guest Editor
Department of Medicinal Chemistry, Faculty of Pharmacy, Wroclaw Medical University, 50-367 Wrocław, Poland
Interests: synthesis; pyrrolopyrrole; pyridazines; cyclic imides; anti-inflammatory activity; analgesic activity
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
Department of Organic Chemistry and Pharmaceutical Technology, Faculty of Pharmacy, Wroclaw Medical University, Borowska 211A, 50-556 Wrocław, Poland
Interests: synthesis; pyrimidine; pyridocarbazole; olivacine; ellipticine; anticancer; anti-inflammatory activity

E-Mail Website
Guest Editor
Department of Organic Chemistry and Pharmaceutical Technology, Faculty of Pharmacy, Wroclaw Medical University, Borowska 211A, 50-556 Wrocław, Poland
Interests: synthesis; pyrrolopyridines; naphthyridines; pyridopyridazines; biological activity

Special Issue Information

Dear Colleagues,

Inflammation is the body's natural response to tissue injury or infection. When repair mechanisms fail, inflammation may become uncontrolled or chronic, contributing to the development and progression of numerous diseases, including cancer, obesity, sepsis, inflammatory bowel disease, type 2 diabetes, cardiovascular disorders, neurodegenerative diseases, and autoimmune conditions.

Given the pivotal role of inflammation in the pathogenesis of these disorders, there is a pressing need to develop novel anti-inflammatory therapeutics.

The goals of anti-inflammatory drug design include the following:

  • Selectivity—Avoiding broad-based immunosuppression, which can lead to side effects.
  • Specific molecular targets, including: cyclooxygenases (COX-1, COX-2), proinflammatory cytokines (TNF-α, IL-1β, IL-6), transcription factors (NF-κB, AP-1, STAT3), and receptors (TLRs, cytokine receptors, CB2). Additional relevant targets include inflammasomes (e.g., NLRP3), protein kinases (MAPK, JNK), and adhesion molecules (ICAM-1, VCAM-1), as well as P2X7 receptors and TRP channels implicated in pain, itch, and neurogenic inflammation.
  • Optimization of pharmacokinetic properties—Enhancing bioavailability, metabolic stability, and effective tissue penetration.

This Special Issue invites submissions of original research and comprehensive reviews focused on recent advances and innovative approaches in the design and synthesis of compounds with potential anti-inflammatory properties.

Dr. Aleksandra Redzicka
Dr. Beata Tylińska
Dr. Anna Wójcicka
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceuticals is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • drug design
  • synthesis
  • anti-inflammatory activity
  • cyclooxygenases
  • lipoxygenases
  • cytokines
  • anticancer activity
  • Alzheimer's disease
  • neuroinflammation
  • molecular mechanisms

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This special issue is now open for submission.
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