Pharmaceuticals

Natural Compounds as Potential Anticancer, Anti-inflammatory and Antioxidant Agents in Medicine

edited by

submission deadline 31 Dec 2025 | 4 articles | Viewed by 9374 | Submission Open

Keywords: phytochemistry of plant extracts; plant secondary metabolites; clinical applications; in vitro; in vivo; ex vivo studies; cell and tissue cultures

(This special issue belongs to the Section Natural Products)

Drug Target Exploration and Drug Design & Development Based on Small Molecule

edited by

Giulia Culletta

and

Marco Tutone

submission deadline 31 Dec 2025 | 4 articles | Viewed by 5461 | Submission Open

Keywords: small molecules; drug design and development; target exploration; anticancer drugs; anti-inflammatory drugs; neuromodulation; natural compounds; nutraceuticals; virtual screenings

(This special issue belongs to the Section Pharmacology)

Pharmacotherapy of Endometriosis

edited by

Jang-Kyung Park

, Dong Il Kim and

Soo-Hyun Sung

submission deadline 31 Dec 2025 | 3 articles | Viewed by 5110 | Submission Open

Keywords: endometriosis; pharmacotherapy; integrative medicine; herbal medicine herbal formulations; plant-based compounds; herbal extracts; pharmacopuncture; pelvic pain; infertility

(This special issue belongs to the Section Pharmacology)

Pharmacology of Heart Failure

edited by

Wioletta Szczurek-Wasilewicz

and

Bożena Szyguła-Jurkiewicz

submission deadline 31 Dec 2025 | 1 articles | Viewed by 3529 | Submission Open

Keywords: heart failure; pharmacological treatment; drug interactions; side effect; comorbidities

(This special issue belongs to the Section Pharmacology)

Recent Strategies for Delivery of Plant-Based Active Ingredients

edited by

Federica De Gaetano

and

Cinzia Anna Ventura

submission deadline 31 Dec 2025 | 1 articles | Viewed by 1329 | Submission Open

Keywords: drug delivery; polymeric nanoparticles; lipid nanosystems; inclusion complexes; polymeric cyclodextrins; protein carriers; inorganic delivery systems; nanostructured carriers; chemical– physical characterization; in vitro/ex vivo/in vivo evaluation

(This special issue belongs to the Section Pharmaceutical Technology)

PET/CT for Diagnosis, Treatment Planning and Prognosis Prediction in Oncology and Inflammatory Diseases

edited by

Alessio Rizzo

and

Giorgio Treglia

submission deadline 31 Dec 2025 | 1 articles | Viewed by 1116 | Submission Open

Keywords: nuclear medicine; PET/CT; radiopharmaceuticals; theragnostics; oncology; inflammation; personalised medicine

(This special issue belongs to the Section Radiopharmaceutical Sciences)

Next-Generation Antinfective Agents

edited by

Fiorella Meneghetti

and

Daniela Barlocco

submission deadline 31 Dec 2025 | 1 articles | Viewed by 823 | Submission Open

Keywords: small molecules; peptides; peptidomimetics; bacterial infections; fungi; virus; parasites; drug design; computational tools; biology assays; resistance mechanisms

(This special issue belongs to the Section Medicinal Chemistry)

Recent Advances in the Research of Drug Delivery System: Materials, Preparation Methods, and Mechanisms

edited by

Haixia Chen

submission deadline 31 Dec 2025 | 1 articles | Viewed by 649 | Submission Open

Keywords: drug delivery system; preparation; material; mechanism; application; bioactivities; targeted delivery

(This special issue belongs to the Section Pharmaceutical Technology)

Applications of Nerve Growth Factor in Pharmaceuticals

edited by

Lorenzo Di Sarno

and Antonio Chiaretti

submission deadline 31 Dec 2025 | 1 articles | Viewed by 609 | Submission Open

Keywords: nerve growth factor; neurotrophins; neuroplasticity; brain injury; neuronal survival

(This special issue belongs to the Section Pharmacology)

Characterization and Quality Control of Biopharmaceuticals Using the Multi-Attribute Method (MAM): Advantages and Challenges

edited by Jingzhong Guo

submission deadline 31 Dec 2025 | Viewed by 479 | Submission Open

Keywords: analytical characterization; critical quality attribute (CQA); the multi-attribute method (MAM); new peak detection (NPD); post-translational modifications (PTM); product quality attribute (PQA); peptide mapping (PM); quality by design (QbD); quality control (QC); structure– activity relationship (SAR)

(This special issue belongs to the Section Biopharmaceuticals)

Heterocyclic Chemistry in Modern Drug Development

edited by

Anna Kasprzycka

and

Magdalena Skonieczna

submission deadline 31 Dec 2025 | Viewed by 203 | Submission Open

Keywords: heterocycles; drug design; drug development; green synthesis; organic synthesis; synthetic biology; enzyme inhibitors; medicinal chemistry; cell biology; in vitro assay

(This special issue belongs to the Section Medicinal Chemistry)

Advances in Enzyme Inhibitors and Protein Degraders as Anticancer Agents

edited by

David J. Leaver

and

Li Li

submission deadline 31 Dec 2025 | Viewed by 114 | Submission Open

Keywords: anticancer agents; mechanism of action; epigenetics; PROTAC; antibody– drug conjugates; enzymes

(This special issue belongs to the Section Medicinal Chemistry)

Novel Heterocyclic Compounds as Potential Anti-Inflammatory and/or Anticancer Agents

edited by Ester Colarusso and

Assunta Giordano

submission deadline 31 Dec 2025 | Viewed by 102 | Submission Open

Keywords: drug discovery; medicinal chemistry; privileged scaffolds; heterocyclic compounds; anticancer activity; anti-inflammatory activity

(This special issue belongs to the Section Medicinal Chemistry)

Novel Developments in Antileishmanial and Antitrypanosomal Agents

edited by

Exequiel Porta

, Guillermo Labadie and Brian Suárez Mantilla

submission deadline 31 Dec 2025 | Viewed by 92 | Submission Open

Keywords: antileishmanial; antitrypanosomal; Chagas disease; human African Trypanosomiasis (sleeping sickness); leishmaniasis; drug discovery; medicinal chemistry; natural products; drug repurposing; trypanosomatids

(This special issue belongs to the Section Medicinal Chemistry)

New Perspective on Natural Compounds for the Prevention and Treatment of Cardiovascular Diseases

edited by

Daniel Dias Rufino Arcanjo

and

Maria do Carmo de Carvalho e Martins

submission deadline 31 Dec 2025 | Viewed by 69 | Submission Open

Keywords: bioactivity; synthesis; pharmacology; natural compounds; natural product; cardiovascular diseases

Natural and Synthetic Bioactive Products for Treatment of Immune-Mediated Diseases

edited by

Fernando Calzada

,

Miguel Valdes

and

Jesica Ramírez-Santos

submission deadline 31 Dec 2025 | Viewed by 69 | Submission Open

Keywords: diabetes; cancer; diarrhea; viral infections; bacterial infections; fungical infections; drug development; medicinal chemistry; phytochemistry; pharmacognosy; synthesis

(This special issue belongs to the Section Natural Products)

Infectious Disease Epidemiology and Pharmaceutical Development in the Era of Antimicrobial Resistance (AMR)

edited by Victoria Birlutiu

submission deadline 31 Dec 2025 | Viewed by 65 | Submission Open

Keywords: antimicrobial resistance (AMR); antibiotic stewardship; multidrug-resistant organisms (MDROs); infectious disease epidemiology; rapid diagnostics; antimicrobial surveillance; therapeutic development; resistance mechanisms

(This special issue belongs to the Section Pharmacology)

New Perspective on Bioactive Peptides from Natural Sources: Current Applications and Future Directions

edited by

Daniel Dias Rufino Arcanjo

and

José Roberto de Souza de Almeida Leite

submission deadline 31 Dec 2025 | Viewed by 51 | Submission Open

Keywords: bioactivity; bioassays; bioproducts; functional foods; immunogenicity; nutraceuticals; pharmacology; plant-derived peptides; skin secretion; toxicology; venom

Advances in Regulatory Mechanisms and Therapeutic Potential of Non-Coding RNAs in Neurodegenerative Diseases

edited by

Paola Ruffo

and Maurizio Grassano

submission deadline 31 Dec 2025 | Viewed by 39 | Submission Open

Keywords: non-coding RNAs; microRNAs; long non-coding RNAs; circular RNAs; neurodegeneration; Alzheimer's disease; Parkinson's disease; amyotrophic lateral sclerosis; gene regulation; biomarkers; RNA therapeutics; neuroinflammation; synaptic dysfunction; translational neuroscience

(This special issue belongs to the Section Biopharmaceuticals)

Green Synthesis and Biological Evaluation of Nitrogen-Containing Heterocycles

edited by Mario Komar,

Marija Paurević

and

Maja Molnar

submission deadline 31 Dec 2025 | Viewed by 38 | Submission Open

Keywords: N-containing heterocycles; microwave-assisted synthesis; ultrasound-assisted synthesis; mechanochemical synthesis; deep eutectic solvents; biomass-derived solvents; biological evaluation; computational methods

(This special issue belongs to the Section Medicinal Chemistry)

Emerging Therapies for Diabetes and Obesity

edited by Pedro Cisternas

submission deadline 15 Jan 2026 | Viewed by 77 | Submission Open

Keywords: insulin resistance; adipose tissue dysfunction; antidiabetic agents; metabolic disease; metabolic inflammation; pharmacological interventions

(This special issue belongs to the Section Pharmacology)

The Pharmacology of Bisphosphonates: New Advances

edited by

Ewa Chmielewska

and

Paweł Kafarski

submission deadline 20 Jan 2026 | 6 articles | Viewed by 4484 | Submission Open

Keywords: bisphosphonates; bisphosphonic acids; pharmacology of bisphosphonates; pharmacokinetics; pharmacodynamics; hypocalcemia; osteonecrosis; gastrointestinal disturbances; delivery systems of bisphosphonates; bisphosphonate prodrugs; osteoporosis; breast cancer; prostate cancer; hypercalcemia; antiresorptive properties; antibacterial properties; anti-cancer properties; antiparasitic activity; antiprotozoal properties; antiviral properties; effects of drugs on the metabolism and biomechanical properties of bone tissue; properties and effects of bisphosphonates in in vitro and/or in vivo experimental models of bone disorders; different bisphosphonates in an in vitro experimental model of bone disease

(This special issue belongs to the Section Pharmacology)

Biological and Pharmacological Research on Indole-3-Carbinol (I3C) and Its Derivatives

edited by

Federica Centofanti

submission deadline 20 Jan 2026 | 3 articles | Viewed by 4086 | Submission Open

Keywords: indole-3-carbinol; natural and synthetic derivatives of I3C; synthetic procedures; biosynthetic processes; in vitro; in vivo and clinical studies; mechanism of action; biological properties; pharmacological properties; potential therapeutic applications in health and disease

(This special issue belongs to the Section Pharmacology)

Pharmacological Activities and Therapeutic Potential of Novel Drug Derivatives

edited by

Stoyanka Atanasova

and

Vera Gledacheva

submission deadline 20 Jan 2026 | 2 articles | Viewed by 2526 | Submission Open

Keywords: novel drug derivatives; synthesis; drug design; therapeutic potential; biological activity; pharmacological activity

(This special issue belongs to the Section Pharmacology)

Resveratrol: Pharmacological Mechanisms and Therapeutic Potential as a Natural Product

edited by

Dumitriţa Rugină

and

Roxana Pop

submission deadline 20 Jan 2026 | Viewed by 516 | Submission Open

Keywords: resveratrol; natural compound pharmacology; therapeutic potential; drug development; biomedical research

(This special issue belongs to the Section Natural Products)

2D and 3D Culture Systems: Current Trends and Biomedical Applications

edited by

Juliana Mara Serpeloni

, Colus Ilce Mara and

Diego Luís Ribeiro

submission deadline 25 Jan 2026 | 4 articles | Viewed by 7265 | Submission Open

Keywords: spheroids; organoids; 3D cultures; tissue engineering; disease modelling; regenerative medicine; cell-extracellular matrix interaction; drug screening

(This special issue belongs to the Section Biopharmaceuticals)

A Commemorative Special Issue in Honor of Professor Carlos Alberto Manssour Fraga: Medicinal Chemistry’s Efforts to Discover Novel Bioactive Molecules for Complex Diseases

edited by

Luzineide Tinoco

and

Pedro De Sena Murteira Pinheiro

submission deadline 25 Jan 2026 | 4 articles | Viewed by 5736 | Submission Open

Keywords: medicinal chemistry; bioactive molecules; complex diseases; cardiovascular diseases; diabetes; cancer; neurodegenerative disorders; drug discovery; synthetic chemistry; target identification; structure– activity relationship; preclinical evaluation

(This special issue belongs to the Section Medicinal Chemistry)

Pharmacoepidemiology and Pharmacovigilance in Drug Therapy: New Issues, Challenges, and Applications

edited by Loreta Kubilienė

submission deadline 25 Jan 2026 | 5 articles | Viewed by 5698 | Submission Open

Keywords: pharmacoepidemiology; pharmacovigilance; drug safety monitoring; regulatory practices; hospitalization; adverse drug events; drug safety; preventability

(This special issue belongs to the Section Pharmacology)

Therapeutic Potential of Aldehyde Dehydrogenases

edited by

Ilias Tsochantaridis

and

Georgia-Persephoni Voulgaridou

submission deadline 25 Jan 2026 | Viewed by 478 | Submission Open

Keywords: ALDH; cancer; cancer stem cells; diabetes; Parkinson’ s disease; Alzheimer’ s disease; ALDH inhibitors; ALDH signaling; CSC-based therapeutics; therapeutic strategies

(This special issue belongs to the Section Medicinal Chemistry)

Clinical Advances in the Neuropharmacological Treatment of Substance Use Disorders: 2nd Edition

edited by

Stefania Chiappini

submission deadline 25 Jan 2026 | 1 articles | Viewed by 395 | Submission Open

Keywords: neuropharmacology; drug abuse; addiction; substance abuse

(This special issue belongs to the Section Pharmacology)

Dysregulation of Cyclic AMP and Cyclic PIP Synthesis: Implications for Disease and Advances in Therapeutic Development

edited by

Heinrich K Wasner

submission deadline 25 Jan 2026 | Viewed by 201 | Submission Open

Keywords: reversible protein phosphorylation; cyclic AMP; cyclic PIP; signal transduction; cyclic AMP antagonist

(This special issue belongs to the Section Medicinal Chemistry)

Research Progress and Drug Intervention Strategies for Oral Health-Related Diseases

edited by

Claudia Florina Bogdan-Andreescu

and Mariana Pacurar

submission deadline 25 Jan 2026 | Viewed by 160 | Submission Open

Keywords: oral health; dental caries; periodontal diseases; drug intervention; biomaterials; biomarkers; microbiome; pharmacogenomics; targeted therapy; oral drug delivery; oral disease prevention

(This special issue belongs to the Section Pharmacology)

Advances in Drug Treatment for Pediatric Gastroenterology

edited by Roxana Elena Matran, Iulia Florentina Ţincu and

Corina Pienar

submission deadline 25 Jan 2026 | Viewed by 69 | Submission Open

Keywords: biologics; Crohn’ s disease; ulcerative colitis; eosinophilic esophagitis; autoimmune hepatitis; probiotics; inflammatory bowel disease

(This special issue belongs to the Section Pharmacology)

Current Advances, Applications and Future Development of Transition Metal Complexes, 2nd Edition

edited by

Domenico Iacopetta

submission deadline 25 Jan 2026 | Viewed by 49 | Submission Open

Keywords: transition metal complexes; synthesis; catalysis; ligands; biological activity; applications; enzyme inhibition

(This special issue belongs to the Section Medicinal Chemistry)

Pharmacogenomics and Ethnic Diversity: Optimizing Drug Response Across Populations

edited by

Fernanda Rodrigues-Soares

and Gisely Cardoso De Melo

submission deadline 25 Jan 2026 | Viewed by 36 | Submission Open

Keywords: pharmacogenomics; pharmacogenetics; ethnic groups; population genetics; ancestry; drug response

(This special issue belongs to the Section Pharmacology)

Therapeutic Drug Monitoring: Techniques and Applications in Pharmaceutical Analysis

edited by Ivana Cizmarova and

Juraj Piestansky

submission deadline 25 Jan 2026 | Viewed by 12 | Submission Open

Keywords: Therapeutic Drug Monitoring (TDM); bioanalytical method development; LC-MS/MS; sample preparation; method validation; pharmacokinetics; pharmacodynamics; individualized dosing; precision medicine; clinical applications

Gut Microbiota Modulation: Probiotics, Postbiotics and Other Bioactive Compounds—2nd Edition

edited by

Inês Brandão

and

Christophe Ruis Espírito Santo

submission deadline 25 Jan 2026 | Viewed by 7 | Submission Open

Keywords: gut microbiota; bioactive compounds; immune system; nutrition respiratory health

Pharmacotherapy of Inflammatory Bowel Disease, 2nd Edition

edited by

Wolfgang Kruis

submission deadline 25 Jan 2026 | Viewed by 5 | Submission Open

Keywords: treatment of Crohn's Disease; treatment of ulcerative colitis; mesalamine for ulcerative colitis; mesalamine for Crohn's Disease; antibody strategies in IBD; small molecules for IBD; conservative management of Crohn's fistula; therapy for extraintestinal manifestations; new endpoints for treatment

(This special issue belongs to the Section Pharmacology)

Osteosarcomas: Treatment Strategies, 2nd Edition

edited by

See-Hyoung Park

submission deadline 26 Jan 2026 | 3 articles | Viewed by 4744 | Submission Open

Keywords: osteosarcoma; anti-cancer; apoptosis; natural compounds; target; drug

(This special issue belongs to the Section Pharmacology)

Pharmacological Modulation of Inflammation in Autoimmune Diseases and Cancer

edited by

Donato Colangelo

and

Stelvio Tonello

submission deadline 27 Jan 2026 | Viewed by 35 | Submission Open

Keywords: microenvironment; TRAP; NET; tumor niche; exosomes; neuromodulation of tumor growth; autoimmune diseases; pharmacology; biomarkers

(This special issue belongs to the Section Pharmacology)

Drug Candidates for the Treatment of Oral Cancer and Oral Cancer Pain, 2nd Edition

edited by

Cara B. Gonzales

submission deadline 27 Jan 2026 | Viewed by 31 | Submission Open

Keywords: oral cancer; oral cancer pain; drug discovery; natural compounds; immunotherapy; small molecule inhibitors; biomarkers

(This special issue belongs to the Section Pharmacology)

Ischemic Stroke: Current and Emerging Treatment Strategies

edited by Mikahela A. López-Morales and

Macarena Hernández-Jiménez

submission deadline 30 Jan 2026 | Viewed by 75 | Submission Open

Keywords: ischemic stroke; cerebrovascular disease; neuroprotection; neurorepair; pharmacotherapy; therapeutic approaches

(This special issue belongs to the Section Pharmacology)

NeuroImmunoEndocrinology

edited by

Lenin Pavón

,

Daniel Ortuño-Sahagún

,

Gilberto Perez-Sanchez

and Oscar Adelmo Bottasso

submission deadline 31 Jan 2026 | 9 articles | Viewed by 20640 | Submission Open

Keywords: cytokines; neurotransmitters; hormones; infections; antibiotics; antidepressants; antipsychotics; drugs; stress; depression; schizophrenia; immunomodulation

(This special issue belongs to the Section Pharmacology)

Antibiotic Resistance in Gram-Negative Bacteria: The Threat from the Pink Corner, 2nd Edition

edited by

Bruno Silvester Lopes

and

Alfizah Hanafiah

submission deadline 31 Jan 2026 | 1 articles | Viewed by 2292 | Submission Open

Keywords: gram-negative; pseudomonas; acinetobacter; campylobacter; helicobacter; klebsiella; enterobacteriaceae; arcobacter; phages; complementary alternative medicine; antimicrobial peptides; food security; hospital acquired infections; microbiome; gram negative pathogens; antibiotic resistance; virulence and other molecular mechanisms

(This special issue belongs to the Section Medicinal Chemistry)

Novel Therapeutic Targets and Strategies for Drug Addiction and Medication-Induced Toxicity

edited by

Marilise Escobar Bürger

, Hecson Jesser Segat, Camila Simonetti Pase and Vinicia Garsella Metz

submission deadline 31 Jan 2026 | Viewed by 339 | Submission Open

Keywords: neuropsychopharmacology; toxicology; drug addiction; animal models; complementary and integrative medicines; abuse drugs; psychostimulants; anxiolytics; addictive substances; prescription drug misuse; pharmacological interventions; public health; illicit and legal substances

(This special issue belongs to the Section Pharmacology)

Heterocyclic Compounds in Targeted Cancer Therapy: Advances in Medicinal Chemistry and Drug Development

edited by

Gabriele La Monica

and

Annamaria Martorana

submission deadline 31 Jan 2026 | Viewed by 213 | Submission Open

Keywords: heterocyclic compounds; targeted cancer therapy; medicinal chemistry; structure– activity relationship (SAR); computational drug design; small-molecule therapeutics; synthetic methodologies; bioactive heterocycles; green chemistry in drug discovery; in silico screening

(This special issue belongs to the Section Medicinal Chemistry)

Novel Drug Candidates for the Treatment of Cardiac and Renal Diseases

edited by

Ana Karina Aranda-Rivera

,

José Pedraza Chaverri

and Diana Barrera-Oviedo

submission deadline 31 Jan 2026 | Viewed by 202 | Submission Open

Keywords: kidney diseases; cardiac diseases; cardiorenal syndrome; treatments; chronic kidney diseases; drugs; dyslipidemia; oxidative stress

(This special issue belongs to the Section Pharmacology)

Guanidine-Based Drugs: Research on Synthesis and Antifungal, Antiviral, and Anticancer Activities

edited by

Eduardo René Pérez González

,

Eduardo Henrique Zampieri

, Francisco Jaime Bezerra Mendonça-Junior,

Eduardo Maffud Cilli

and

Ana Marisa Fusco Almeida

submission deadline 31 Jan 2026 | Viewed by 168 | Submission Open

Keywords: guanidine derivatives; medicinal chemistry; SAR analysis; neglected diseases; antiparasitic; antifungal; antiviral; anticancer; drug development

(This special issue belongs to the Section Medicinal Chemistry)

Dopamine Receptor: Novel Opportunities for Drug Developments

edited by Pegi Pavletić and

Fabio Del Bello

submission deadline 31 Jan 2026 | Viewed by 93 | Submission Open

Keywords: dopamine receptors (DRs); GPCR; drug discovery; in silico drug design; drug optimization; molecular modelling; targeted protein degradation; DMPK; neurological disorders; cancer

(This special issue belongs to the Section Medicinal Chemistry)

Advances in Targeting Mitochondrial Sirtuins for Treatment of Metabolic Diseases Such as Type 2 Diabetes and Obesity

edited by Linh Ho and

Tibebe Woldemariam

submission deadline 31 Jan 2026 | Viewed by 91 | Submission Open

Keywords: mitochondrial sirtuins; Sirt3; Sirt5; metabolic disorders; type 2 diabetes; drug targets; insulin resistance; reactive oxygen species (ROS)

(This special issue belongs to the Section Pharmacology)

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