Special Issues

Pharmaceuticals publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Chirality in Drugs
edited by
submission deadline 26 Dec 2025 | Viewed by 30 | Submission Open
Keywords: chirality; chiral drugs; chiral resolution; asymmetric synthesis; chiral analysis; chiroptical spectroscopy
(This special issue belongs to the Section Medicinal Chemistry)
Natural Compounds as Potential Anticancer, Anti-inflammatory and Antioxidant Agents in Medicine submission deadline 31 Dec 2025 | 4 articles | Viewed by 9336 | Submission Open
Keywords: phytochemistry of plant extracts; plant secondary metabolites; clinical applications; in vitro; in vivo; ex vivo studies; cell and tissue cultures
(This special issue belongs to the Section Natural Products)
Drug Target Exploration and Drug Design & Development Based on Small Molecule submission deadline 31 Dec 2025 | 4 articles | Viewed by 5315 | Submission Open
Keywords: small molecules; drug design and development; target exploration; anticancer drugs; anti-inflammatory drugs; neuromodulation; natural compounds; nutraceuticals; virtual screenings
(This special issue belongs to the Section Pharmacology)
Pharmacotherapy of Endometriosis
edited by , Dong Il Kim and
submission deadline 31 Dec 2025 | 3 articles | Viewed by 4980 | Submission Open
Keywords: endometriosis; pharmacotherapy; integrative medicine; herbal medicine herbal formulations; plant-based compounds; herbal extracts; pharmacopuncture; pelvic pain; infertility
(This special issue belongs to the Section Pharmacology)
Pharmacology of Heart Failure submission deadline 31 Dec 2025 | 1 articles | Viewed by 3496 | Submission Open
Keywords: heart failure; pharmacological treatment; drug interactions; side effect; comorbidities
(This special issue belongs to the Section Pharmacology)
Recent Strategies for Delivery of Plant-Based Active Ingredients submission deadline 31 Dec 2025 | 1 articles | Viewed by 1321 | Submission Open
Keywords: drug delivery; polymeric nanoparticles; lipid nanosystems; inclusion complexes; polymeric cyclodextrins; protein carriers; inorganic delivery systems; nanostructured carriers; chemical– physical characterization; in vitro/ex vivo/in vivo evaluation
(This special issue belongs to the Section Pharmaceutical Technology)
PET/CT for Diagnosis, Treatment Planning and Prognosis Prediction in Oncology and Inflammatory Diseases submission deadline 31 Dec 2025 | 1 articles | Viewed by 1104 | Submission Open
Keywords: nuclear medicine; PET/CT; radiopharmaceuticals; theragnostics; oncology; inflammation; personalised medicine
(This special issue belongs to the Section Radiopharmaceutical Sciences)
Next-Generation Antinfective Agents submission deadline 31 Dec 2025 | 1 articles | Viewed by 792 | Submission Open
Keywords: small molecules; peptides; peptidomimetics; bacterial infections; fungi; virus; parasites; drug design; computational tools; biology assays; resistance mechanisms
(This special issue belongs to the Section Medicinal Chemistry)
Recent Advances in the Research of Drug Delivery System: Materials, Preparation Methods, and Mechanisms
edited by
submission deadline 31 Dec 2025 | 1 articles | Viewed by 636 | Submission Open
Keywords: drug delivery system; preparation; material; mechanism; application; bioactivities; targeted delivery
(This special issue belongs to the Section Pharmaceutical Technology)
Applications of Nerve Growth Factor in Pharmaceuticals
edited by and Antonio Chiaretti
submission deadline 31 Dec 2025 | 1 articles | Viewed by 598 | Submission Open
Keywords: nerve growth factor; neurotrophins; neuroplasticity; brain injury; neuronal survival
(This special issue belongs to the Section Pharmacology)
Characterization and Quality Control of Biopharmaceuticals Using the Multi-Attribute Method (MAM): Advantages and Challenges
edited by Jingzhong Guo
submission deadline 31 Dec 2025 | Viewed by 477 | Submission Open
Keywords: analytical characterization; critical quality attribute (CQA); the multi-attribute method (MAM); new peak detection (NPD); post-translational modifications (PTM); product quality attribute (PQA); peptide mapping (PM); quality by design (QbD); quality control (QC); structure– activity relationship (SAR)
(This special issue belongs to the Section Biopharmaceuticals)
Heterocyclic Chemistry in Modern Drug Development submission deadline 31 Dec 2025 | Viewed by 201 | Submission Open
Keywords: heterocycles; drug design; drug development; green synthesis; organic synthesis; synthetic biology; enzyme inhibitors; medicinal chemistry; cell biology; in vitro assay
(This special issue belongs to the Section Medicinal Chemistry)
Advances in Enzyme Inhibitors and Protein Degraders as Anticancer Agents
edited by and
submission deadline 31 Dec 2025 | Viewed by 110 | Submission Open
Keywords: anticancer agents; mechanism of action; epigenetics; PROTAC; antibody– drug conjugates; enzymes
(This special issue belongs to the Section Medicinal Chemistry)
Novel Heterocyclic Compounds as Potential Anti-Inflammatory and/or Anticancer Agents
edited by Ester Colarusso and
submission deadline 31 Dec 2025 | Viewed by 97 | Submission Open
Keywords: drug discovery; medicinal chemistry; privileged scaffolds; heterocyclic compounds; anticancer activity; anti-inflammatory activity
(This special issue belongs to the Section Medicinal Chemistry)
Novel Developments in Antileishmanial and Antitrypanosomal Agents
edited by , Guillermo Labadie and Brian Suárez Mantilla
submission deadline 31 Dec 2025 | Viewed by 91 | Submission Open
Keywords: antileishmanial; antitrypanosomal; Chagas disease; human African Trypanosomiasis (sleeping sickness); leishmaniasis; drug discovery; medicinal chemistry; natural products; drug repurposing; trypanosomatids
(This special issue belongs to the Section Medicinal Chemistry)
Natural and Synthetic Bioactive Products for Treatment of Immune-Mediated Diseases submission deadline 31 Dec 2025 | Viewed by 69 | Submission Open
Keywords: diabetes; cancer; diarrhea; viral infections; bacterial infections; fungical infections; drug development; medicinal chemistry; phytochemistry; pharmacognosy; synthesis
(This special issue belongs to the Section Natural Products)
New Perspective on Natural Compounds for the Prevention and Treatment of Cardiovascular Diseases submission deadline 31 Dec 2025 | Viewed by 68 | Submission Open
Keywords: bioactivity; synthesis; pharmacology; natural compounds; natural product; cardiovascular diseases
Infectious Disease Epidemiology and Pharmaceutical Development in the Era of Antimicrobial Resistance (AMR)
edited by Victoria Birlutiu
submission deadline 31 Dec 2025 | Viewed by 65 | Submission Open
Keywords: antimicrobial resistance (AMR); antibiotic stewardship; multidrug-resistant organisms (MDROs); infectious disease epidemiology; rapid diagnostics; antimicrobial surveillance; therapeutic development; resistance mechanisms
(This special issue belongs to the Section Pharmacology)
New Perspective on Bioactive Peptides from Natural Sources: Current Applications and Future Directions submission deadline 31 Dec 2025 | Viewed by 49 | Submission Open
Keywords: bioactivity; bioassays; bioproducts; functional foods; immunogenicity; nutraceuticals; pharmacology; plant-derived peptides; skin secretion; toxicology; venom
Advances in Regulatory Mechanisms and Therapeutic Potential of Non-Coding RNAs in Neurodegenerative Diseases
edited by and Maurizio Grassano
submission deadline 31 Dec 2025 | Viewed by 38 | Submission Open
Keywords: non-coding RNAs; microRNAs; long non-coding RNAs; circular RNAs; neurodegeneration; Alzheimer's disease; Parkinson's disease; amyotrophic lateral sclerosis; gene regulation; biomarkers; RNA therapeutics; neuroinflammation; synaptic dysfunction; translational neuroscience
(This special issue belongs to the Section Biopharmaceuticals)
Green Synthesis and Biological Evaluation of Nitrogen-Containing Heterocycles
edited by Mario Komar, and
submission deadline 31 Dec 2025 | Viewed by 37 | Submission Open
Keywords: N-containing heterocycles; microwave-assisted synthesis; ultrasound-assisted synthesis; mechanochemical synthesis; deep eutectic solvents; biomass-derived solvents; biological evaluation; computational methods
(This special issue belongs to the Section Medicinal Chemistry)
Emerging Therapies for Diabetes and Obesity
edited by Pedro Cisternas
submission deadline 15 Jan 2026 | Viewed by 71 | Submission Open
Keywords: insulin resistance; adipose tissue dysfunction; antidiabetic agents; metabolic disease; metabolic inflammation; pharmacological interventions
(This special issue belongs to the Section Pharmacology)
The Pharmacology of Bisphosphonates: New Advances submission deadline 20 Jan 2026 | 6 articles | Viewed by 4417 | Submission Open
Keywords: bisphosphonates; bisphosphonic acids; pharmacology of bisphosphonates; pharmacokinetics; pharmacodynamics; hypocalcemia; osteonecrosis; gastrointestinal disturbances; delivery systems of bisphosphonates; bisphosphonate prodrugs; osteoporosis; breast cancer; prostate cancer; hypercalcemia; antiresorptive properties; antibacterial properties; anti-cancer properties; antiparasitic activity; antiprotozoal properties; antiviral properties; effects of drugs on the metabolism and biomechanical properties of bone tissue; properties and effects of bisphosphonates in in vitro and/or in vivo experimental models of bone disorders; different bisphosphonates in an in vitro experimental model of bone disease
(This special issue belongs to the Section Pharmacology)
Biological and Pharmacological Research on Indole-3-Carbinol (I3C) and Its Derivatives submission deadline 20 Jan 2026 | 3 articles | Viewed by 4068 | Submission Open
Keywords: indole-3-carbinol; natural and synthetic derivatives of I3C; synthetic procedures; biosynthetic processes; in vitro; in vivo and clinical studies; mechanism of action; biological properties; pharmacological properties; potential therapeutic applications in health and disease
(This special issue belongs to the Section Pharmacology)
Pharmacological Activities and Therapeutic Potential of Novel Drug Derivatives submission deadline 20 Jan 2026 | 2 articles | Viewed by 2478 | Submission Open
Keywords: novel drug derivatives; synthesis; drug design; therapeutic potential; biological activity; pharmacological activity
(This special issue belongs to the Section Pharmacology)
Resveratrol: Pharmacological Mechanisms and Therapeutic Potential as a Natural Product submission deadline 20 Jan 2026 | Viewed by 511 | Submission Open
Keywords: resveratrol; natural compound pharmacology; therapeutic potential; drug development; biomedical research
(This special issue belongs to the Section Natural Products)
2D and 3D Culture Systems: Current Trends and Biomedical Applications
edited by , Colus Ilce Mara and
submission deadline 25 Jan 2026 | 4 articles | Viewed by 7238 | Submission Open
Keywords: spheroids; organoids; 3D cultures; tissue engineering; disease modelling; regenerative medicine; cell-extracellular matrix interaction; drug screening
(This special issue belongs to the Section Biopharmaceuticals)
A Commemorative Special Issue in Honor of Professor Carlos Alberto Manssour Fraga: Medicinal Chemistry’s Efforts to Discover Novel Bioactive Molecules for Complex Diseases submission deadline 25 Jan 2026 | 4 articles | Viewed by 5651 | Submission Open
Keywords: medicinal chemistry; bioactive molecules; complex diseases; cardiovascular diseases; diabetes; cancer; neurodegenerative disorders; drug discovery; synthetic chemistry; target identification; structure– activity relationship; preclinical evaluation
(This special issue belongs to the Section Medicinal Chemistry)
Pharmacoepidemiology and Pharmacovigilance in Drug Therapy: New Issues, Challenges, and Applications
edited by Loreta Kubilienė
submission deadline 25 Jan 2026 | 5 articles | Viewed by 5605 | Submission Open
Keywords: pharmacoepidemiology; pharmacovigilance; drug safety monitoring; regulatory practices; hospitalization; adverse drug events; drug safety; preventability
(This special issue belongs to the Section Pharmacology)
Therapeutic Potential of Aldehyde Dehydrogenases submission deadline 25 Jan 2026 | Viewed by 473 | Submission Open
Keywords: ALDH; cancer; cancer stem cells; diabetes; Parkinson’ s disease; Alzheimer’ s disease; ALDH inhibitors; ALDH signaling; CSC-based therapeutics; therapeutic strategies
(This special issue belongs to the Section Medicinal Chemistry)
Clinical Advances in the Neuropharmacological Treatment of Substance Use Disorders: 2nd Edition
edited by
submission deadline 25 Jan 2026 | 1 articles | Viewed by 354 | Submission Open
Keywords: neuropharmacology; drug abuse; addiction; substance abuse
(This special issue belongs to the Section Pharmacology)
Dysregulation of Cyclic AMP and Cyclic PIP Synthesis: Implications for Disease and Advances in Therapeutic Development
edited by
submission deadline 25 Jan 2026 | Viewed by 199 | Submission Open
Keywords: reversible protein phosphorylation; cyclic AMP; cyclic PIP; signal transduction; cyclic AMP antagonist
(This special issue belongs to the Section Medicinal Chemistry)
Research Progress and Drug Intervention Strategies for Oral Health-Related Diseases
edited by and Mariana Pacurar
submission deadline 25 Jan 2026 | Viewed by 160 | Submission Open
Keywords: oral health; dental caries; periodontal diseases; drug intervention; biomaterials; biomarkers; microbiome; pharmacogenomics; targeted therapy; oral drug delivery; oral disease prevention
(This special issue belongs to the Section Pharmacology)
Advances in Drug Treatment for Pediatric Gastroenterology
edited by Roxana Elena Matran, Iulia Florentina Ţincu and
submission deadline 25 Jan 2026 | Viewed by 61 | Submission Open
Keywords: biologics; Crohn’ s disease; ulcerative colitis; eosinophilic esophagitis; autoimmune hepatitis; probiotics; inflammatory bowel disease
(This special issue belongs to the Section Pharmacology)
Current Advances, Applications and Future Development of Transition Metal Complexes, 2nd Edition
edited by
submission deadline 25 Jan 2026 | Viewed by 49 | Submission Open
Keywords: transition metal complexes; synthesis; catalysis; ligands; biological activity; applications; enzyme inhibition
(This special issue belongs to the Section Medicinal Chemistry)
Pharmacogenomics and Ethnic Diversity: Optimizing Drug Response Across Populations
edited by and Gisely Cardoso De Melo
submission deadline 25 Jan 2026 | Viewed by 34 | Submission Open
Keywords: pharmacogenomics; pharmacogenetics; ethnic groups; population genetics; ancestry; drug response
(This special issue belongs to the Section Pharmacology)
Pharmacotherapy of Inflammatory Bowel Disease, 2nd Edition
edited by
submission deadline 25 Jan 2026 | Viewed by 2 | Submission Open
Keywords: treatment of Crohn's Disease; treatment of ulcerative colitis; mesalamine for ulcerative colitis; mesalamine for Crohn's Disease; antibody strategies in IBD; small molecules for IBD; conservative management of Crohn's fistula; therapy for extraintestinal manifestations; new endpoints for treatment
(This special issue belongs to the Section Pharmacology)
Gut Microbiota Modulation: Probiotics, Postbiotics and Other Bioactive Compounds—2nd Edition submission deadline 25 Jan 2026 | Viewed by 1 | Submission Open
Keywords: gut microbiota; bioactive compounds; immune system; nutrition respiratory health
Therapeutic Drug Monitoring: Techniques and Applications in Pharmaceutical Analysis
edited by Ivana Cizmarova and
submission deadline 25 Jan 2026 | Submission Open
Keywords: Therapeutic Drug Monitoring (TDM); bioanalytical method development; LC-MS/MS; sample preparation; method validation; pharmacokinetics; pharmacodynamics; individualized dosing; precision medicine; clinical applications
Osteosarcomas: Treatment Strategies, 2nd Edition
edited by
submission deadline 26 Jan 2026 | 3 articles | Viewed by 4680 | Submission Open
Keywords: osteosarcoma; anti-cancer; apoptosis; natural compounds; target; drug
(This special issue belongs to the Section Pharmacology)
Pharmacological Modulation of Inflammation in Autoimmune Diseases and Cancer submission deadline 27 Jan 2026 | Viewed by 34 | Submission Open
Keywords: microenvironment; TRAP; NET; tumor niche; exosomes; neuromodulation of tumor growth; autoimmune diseases; pharmacology; biomarkers
(This special issue belongs to the Section Pharmacology)
Drug Candidates for the Treatment of Oral Cancer and Oral Cancer Pain, 2nd Edition
edited by
submission deadline 27 Jan 2026 | Viewed by 30 | Submission Open
Keywords: oral cancer; oral cancer pain; drug discovery; natural compounds; immunotherapy; small molecule inhibitors; biomarkers
(This special issue belongs to the Section Pharmacology)
Ischemic Stroke: Current and Emerging Treatment Strategies
edited by Mikahela A. López-Morales and
submission deadline 30 Jan 2026 | Viewed by 60 | Submission Open
Keywords: ischemic stroke; cerebrovascular disease; neuroprotection; neurorepair; pharmacotherapy; therapeutic approaches
(This special issue belongs to the Section Pharmacology)
NeuroImmunoEndocrinology
edited by , , and Oscar Adelmo Bottasso
submission deadline 31 Jan 2026 | 9 articles | Viewed by 20415 | Submission Open
Keywords: cytokines; neurotransmitters; hormones; infections; antibiotics; antidepressants; antipsychotics; drugs; stress; depression; schizophrenia; immunomodulation
(This special issue belongs to the Section Pharmacology)
Novel Therapeutic Targets and Strategies for Drug Addiction and Medication-Induced Toxicity
edited by , Hecson Jesser Segat, Camila Simonetti Pase and Vinicia Garsella Metz
submission deadline 31 Jan 2026 | Viewed by 338 | Submission Open
Keywords: neuropsychopharmacology; toxicology; drug addiction; animal models; complementary and integrative medicines; abuse drugs; psychostimulants; anxiolytics; addictive substances; prescription drug misuse; pharmacological interventions; public health; illicit and legal substances
(This special issue belongs to the Section Pharmacology)
Heterocyclic Compounds in Targeted Cancer Therapy: Advances in Medicinal Chemistry and Drug Development submission deadline 31 Jan 2026 | Viewed by 210 | Submission Open
Keywords: heterocyclic compounds; targeted cancer therapy; medicinal chemistry; structure– activity relationship (SAR); computational drug design; small-molecule therapeutics; synthetic methodologies; bioactive heterocycles; green chemistry in drug discovery; in silico screening
(This special issue belongs to the Section Medicinal Chemistry)
Novel Drug Candidates for the Treatment of Cardiac and Renal Diseases
edited by , and Diana Barrera-Oviedo
submission deadline 31 Jan 2026 | Viewed by 201 | Submission Open
Keywords: kidney diseases; cardiac diseases; cardiorenal syndrome; treatments; chronic kidney diseases; drugs; dyslipidemia; oxidative stress
(This special issue belongs to the Section Pharmacology)
Guanidine-Based Drugs: Research on Synthesis and Antifungal, Antiviral, and Anticancer Activities submission deadline 31 Jan 2026 | Viewed by 166 | Submission Open
Keywords: guanidine derivatives; medicinal chemistry; SAR analysis; neglected diseases; antiparasitic; antifungal; antiviral; anticancer; drug development
(This special issue belongs to the Section Medicinal Chemistry)
Advances in Targeting Mitochondrial Sirtuins for Treatment of Metabolic Diseases Such as Type 2 Diabetes and Obesity
edited by Linh Ho and
submission deadline 31 Jan 2026 | Viewed by 91 | Submission Open
Keywords: mitochondrial sirtuins; Sirt3; Sirt5; metabolic disorders; type 2 diabetes; drug targets; insulin resistance; reactive oxygen species (ROS)
(This special issue belongs to the Section Pharmacology)
Dopamine Receptor: Novel Opportunities for Drug Developments
edited by Pegi Pavletić and
submission deadline 31 Jan 2026 | Viewed by 80 | Submission Open
Keywords: dopamine receptors (DRs); GPCR; drug discovery; in silico drug design; drug optimization; molecular modelling; targeted protein degradation; DMPK; neurological disorders; cancer
(This special issue belongs to the Section Medicinal Chemistry)
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