Special Issues

Pharmaceuticals publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Pharmacovigilance Insights: Addressing Drug Misuse and Enhancing Drug Safety submission deadline 25 Oct 2026 | 10 articles | Viewed by 17695 | Submission Open
Keywords: adverse drug reaction; pharmacovigilance; drug safety; signal detection; risk management
(This special issue belongs to the Section Pharmacology)
Research on Diagnosis, Treatment and Related Microbiota in Gastrointestinal Diseases
edited by and Brigida Barberio
submission deadline 25 Oct 2026 | 5 articles | Viewed by 7901 | Submission Open
Keywords: gut microbiota; inflammatory bowel disease; eosinophilic esophagitis; primary sclerosing cholangitis; metabolic-associated steatotic liver disease; immune checkpoint inhibitor colitis; dysbiosis; prebiotics; probiotics
(This special issue belongs to the Section Medicinal Chemistry)
Tumor Immunopharmacology, 2nd Edition submission deadline 25 Oct 2026 | 3 articles | Viewed by 5259 | Submission Open
Keywords: immunotherapy; immunomodulation; drug development; cytokine receptor antagonist; T-cell based therapies; therapeutic antibodies; drug delivery; cancer vaccine; immunoresistance; tumor-infiltrating lymphocytes (TILs); immune escape; immune checkpoint inhibitors; cytokine-based therapies; small molecule immunomodulators; combination therapy; precision oncology; tumor mutational burden (TMB); antibody-dependent cellular cytotoxicity (ADCC ); complement-dependent cytotoxicity (CDC); myeloid-derived suppressor cells (MDSCs)
(This special issue belongs to the Section Pharmacology)
Novel Therapeutic Targets in the Cardiovascular Treatment Landscape
edited by Weida Wu and
submission deadline 25 Oct 2026 | 3 articles | Viewed by 2823 | Submission Open
Keywords: cardiovascular disease; novel therapeutic targets; lipid metabolism; cardiac fibrosis and remodeling; inflammation and immune modulation; Lp(a); heart failure; RNA therapeutics; precision cardiology; cardiomyopathy
(This special issue belongs to the Section Pharmacology)
The Role of Phytochemicals in Aging and Aging-Related Diseases, 2nd Edition submission deadline 25 Oct 2026 | 3 articles | Viewed by 2715 | Submission Open
Keywords: phytochemicals; plant-based diet; dietary supplementation; pharma-nutrition; aging; aging-related diseases; prevention
(This special issue belongs to the Section Natural Products)
Epithelial Plasticity and Therapy Resistance in Cancer
edited by
submission deadline 25 Oct 2026 | 2 articles | Viewed by 2497 | Submission Open
Keywords: cancer stem cells; epithelial– mesenchymal transition; epithelial reprogramming; resistance; drug targets; resistance mechanisms; biomarker discovery
(This special issue belongs to the Section Pharmacology)
Synthesis, In Silico Prediction and Antitumor Activity of Nitrogen Heterocycle-Based Drug Development
edited by Jamerson F. De Oliveira and Paulo André Teixeira de Moraes Gomes
submission deadline 25 Oct 2026 | 2 articles | Viewed by 2009 | Submission Open
Keywords: privileged structures; nitrogen heterocycles; ADMET prediction; cancer biological target; molecular dynamic; computational studies; antitumor activity; in vitro and in vivo studies; SAR of lead compounds; molecular hybridization
(This special issue belongs to the Section Medicinal Chemistry)
Next-Generation Approaches for Cartilage Regeneration
edited by and Liam Morris
submission deadline 25 Oct 2026 | 1 articles | Viewed by 1797 | Submission Open
Keywords: cartilage regeneration; cartilage engineering; bioactive molecules (peptides/proteins/nucleic acids); biomaterials (therapeutic delivery); gene engineering (biopharmaceutical applications); chondrogenic signaling pathways; preclinical/clinical evaluation (cartilage repair); osteoarthritis (therapeutic interventions); therapeutic targets (cartilage repair); translational regenerative medicine
(This special issue belongs to the Section Biopharmaceuticals)
Development of Specific Dosage Form: Wound Dressing, 2nd Edition
edited by , , and Cristina Elena Dinu-Pirvu
submission deadline 25 Oct 2026 | 1 articles | Viewed by 1420 | Submission Open
Keywords: skin lesion; wound healing; wound dressing; regenerative medicine; biomaterials; smart biopolymers; therapeutic system; controlled delivery system; scaffolds; biocompatibility
(This special issue belongs to the Section Pharmaceutical Technology)
Natural Products for the Treatment of Prostate Cancer submission deadline 25 Oct 2026 | 1 articles | Viewed by 1091 | Submission Open
Keywords: prostate cancer; natural compounds; plants; urinary tract infections; supplements; signaling pathways
(This special issue belongs to the Section Natural Products)
Advances in and Perspectives on Oral Drug Delivery submission deadline 25 Oct 2026 | Viewed by 374 | Submission Open
Keywords: enhanced drug delivery; oral route; oral peptide delivery; 3D printing; continuous manufacturing; PBPK modeling; nanocarriers; translational pharmaceutics; low aqueous solubility and low permeability; enhanced oral bioavailability; transporter targeting; emerging materials and excipients in oral delivery; dosage form transition of already marketed drugs; examining herbal or traditional drugs oral delivery; sustained release; nanotechnology; application of cellular components such as exosomes or vesicles for oral delivery; in silico docking for PBPK; nanocarriers; lipid-based formulations; self-emulsifying drug delivery systems (SEDDS); solid dispersions; mucoadhesive systems
(This special issue belongs to the Section Pharmaceutical Technology)
Quality Control and Standardization of Plant-Based Pharmaceuticals
edited by and
submission deadline 25 Oct 2026 | Viewed by 286 | Submission Open
Keywords: quality control and standardization of plant-based products; authentication of medicinal plants; phytochemical characterization; secondary marker metabolites; pharmacological validation; safety and toxicological assessment; pharmaceutical formulation; evidence-based herbal medicine; ethnopharmacology; regulatory aspects of herbal medicines; reproducibility in natural products research
(This special issue belongs to the Section Natural Products)
Application and Translational Research of Lanthanide/Nanomaterial-Conjugated Photosensitizers in Photodynamic Therapy
edited by
submission deadline 25 Oct 2026 | Viewed by 249 | Submission Open
Keywords: lanthanide-based nanomaterials; nanomaterial-conjugated photosensitizers; photodynamic therapy (PDT); targeted delivery; upconversion luminescence; preclinical evaluation; translational research; biocompatibility
(This special issue belongs to the Section Pharmaceutical Technology)
Plant Extracts Regulating Oxidative Stress and Metabolism: Drug Discovery and Repurposing submission deadline 25 Oct 2026 | Viewed by 167 | Submission Open
Keywords: plant extracts; natural compounds; oxidative stress; redox signaling; metabolic regulation; insulin resistance; mitochondrial dysfunction; inflammation; neurodegeneration
(This special issue belongs to the Section Natural Products)
Advances in Antiparasitic Drug Research: 2nd Edition submission deadline 25 Oct 2026 | Viewed by 123 | Submission Open
Keywords: antiparasitic drug; novel drug targets; parasite resistance; drug efficacy; parasite genetics
(This special issue belongs to the Section Pharmacology)
Development of Novel Radiopharmaceuticals for SPECT and PET Imaging, 2nd Edition
edited by
submission deadline 25 Oct 2026 | Viewed by 20 | Submission Open
Keywords: oncology; theranostics; inflammation/infection diagnosis; autoimmune diseases; neurodegenerative diseases; cardiovascular diseases
(This special issue belongs to the Section Radiopharmaceutical Sciences)
Advancements in Cardiovascular and Antidiabetic Drug Therapy, 2nd Edition
edited by
submission deadline 27 Oct 2026 | 17 articles | Viewed by 37707 | Submission Open
Keywords: cardiovascular diseases; antidiabetic drugs; pharmacological interventions; sodium– glucose cotransporter 2 inhibitors; PCSK9 inhibitors; obeticholic acid; lipid-lowering agents; heart failure treatment; diabetes management; drug therapy innovations
(This special issue belongs to the Section Pharmacology)
Advances in Biotechnological Formulations for Skin Disorders: Delivery Strategies and Biocompatibility
edited by Marcel Henrique Marcondes Sari, and
submission deadline 27 Oct 2026 | 4 articles | Viewed by 14074 | Submission Open
Keywords: skin disorders; biotechnological formulations; nanocarriers; probiotic-based formulations; natural products; polysaccharides; skin delivery systems; bioactive compounds; antioxidant and anti-inflammatory effects; wound healing; safety and efficacy in skin therapies
(This special issue belongs to the Section Pharmaceutical Technology)
Bioactive Natural Extracts: Advances in Pharmacological and Therapeutic Research submission deadline 30 Oct 2026 | 8 articles | Viewed by 7099 | Submission Open
Keywords: bioactive compounds; natural extracts; pharmacological activity; drug discovery; plant-derived compounds
(This special issue belongs to the Section Natural Products)
Therapeutic Potential of Natural Extracts in Cancer Prevention and Treatment submission deadline 30 Oct 2026 | 2 articles | Viewed by 3742 | Submission Open
Keywords: natural products; anticancer therapeutic potential; cancer chemoprevention; mechanism of action and molecular targets; preclinical and clinical studies
(This special issue belongs to the Section Natural Products)
Innovative Drug Delivery Systems for Enhanced Dissolution and Bioavailability
edited by Marival Bermejo, and Covadonga Álvarez-Álvarez
submission deadline 30 Oct 2026 | 2 articles | Viewed by 2459 | Submission Open
Keywords: drug dissolution enhancement; oral bioavailability improvement; poorly soluble drugs; solid dispersions; nanoparticle drug delivery; amorphous formulations; 3D printing in pharmaceuticals; advanced drug-polymer systems; advanced excipients for solubility enhancement; controlled drug release
(This special issue belongs to the Section Pharmaceutical Technology)
Synthesis and Anticancer Activity of Biologically Active Heterocyclic Compounds
edited by and Rita Vaickelionienė
submission deadline 30 Oct 2026 | 2 articles | Viewed by 2215 | Submission Open
Keywords: heterocyclic compounds; five- or six-membered heterocycles; oxygen- and nitrogen-based heterocycles; sulfur- and nitrogen-based heterocycles; azoles; small molecules; anticancer activity; cell lines; cytotoxicity
(This special issue belongs to the Section Medicinal Chemistry)
Kynurenine Pathway: A Novel Therapeutic Opportunity—2nd Edition submission deadline 30 Oct 2026 | 1 articles | Viewed by 1457 | Submission Open
Keywords: tryptophan catabolism; redox modulation; kynurenines; immunoregulation
(This special issue belongs to the Section Pharmacology)
Innovative Organic Synthesis Approaches in Drug Design and Development submission deadline 30 Oct 2026 | Viewed by 463 | Submission Open
Keywords: sustainable organic synthesis; green chemistry; drug design and development; non-traditional solvents; Lewis acid catalysis; catalytic methodologies; photoredox and electrochemical methods; medicinal chemistry innovation
(This special issue belongs to the Section Medicinal Chemistry)
Raman Spectroscopy as a Tool for Drug Discovery, Development and Biomedical Research
edited by Panagiota Zarmpi
submission deadline 30 Oct 2026 | Viewed by 436 | Submission Open
Keywords: Raman spectroscopy; SERS; SORS; SRS; CARS; drug design; drug– target interaction; high-throughput; drug formulation; preformulation; bioequivalence; non-invasive biosensing
(This special issue belongs to the Section Medicinal Chemistry)
Targeted Radiopharmaceutical Therapies: Cutting-Edge Advances
edited by Noeen Malik
submission deadline 30 Oct 2026 | Viewed by 318 | Submission Open
Keywords: targeted radiopharmaceutical therapies (TRT); radiopharmaceuticals; radionuclide therapy; molecular radiotherapy; radioisotopes; radiochemistry; isotope production; radionuclide delivery; preclinical evaluation; clinical translation
(This special issue belongs to the Section Radiopharmaceutical Sciences)
Improving Pharmaceutical Formulation and Stability In Silico Methods submission deadline 30 Oct 2026 | Viewed by 125 | Submission Open
Keywords: in silico modeling; drugs and formulations; molecular dynamics; quantum mechanics; discrete element method; computational fluid dynamics; formulation design; dissolution; stability; manufacturing
(This special issue belongs to the Section Pharmaceutical Technology)
Adjuvant Therapies for Cancer Treatment: 2nd Edition
edited by
submission deadline 31 Oct 2026 | 12 articles | Viewed by 110138 | Submission Open
Keywords: drug repurposing; combined therapies; new compounds; drug resistance; chemosensitization; antitumoral strategies
(This special issue belongs to the Section Pharmacology)
NeuroImmunoEndocrinology
edited by , , and Oscar Adelmo Bottasso
submission deadline 31 Oct 2026 | 11 articles | Viewed by 62531 | Submission Open
Keywords: cytokines; neurotransmitters; hormones; infections; antibiotics; antidepressants; antipsychotics; drugs; stress; depression; schizophrenia; immunomodulation
(This special issue belongs to the Section Pharmacology)
Precision Oncology: Targeting Molecular Subtypes in Cancer Therapy
edited by and Jiro Ogura
submission deadline 31 Oct 2026 | 5 articles | Viewed by 7317 | Submission Open
Keywords: cancer chemotherapy; cancer genomic profiling test; next-generation sequencing; genetic variants; molecular targeted therapy; molecular tumor board; liquid biopsy
(This special issue belongs to the Section Pharmacology)
Treatment and Molecular Mechanisms of Depression
edited by and Ricieri Mocelin
submission deadline 31 Oct 2026 | 1 articles | Viewed by 5659 | Submission Open
Keywords: major depressive disorder; molecular mechanisms; neurotransmitters; epigenetic; genetic polymorphisms; inflammation; neuroinflammation; pharmacological strategies; drugs; intracellular signaling
(This special issue belongs to the Section Medicinal Chemistry)
Cholinergic Modulation, Anticholinergic Burden, and Neuroprotection: Mechanisms to Therapeutics
edited by and
submission deadline 31 Oct 2026 | 3 articles | Viewed by 4973 | Submission Open
Keywords: scopolamine; anticholinergic burden; cholinergic modulation; cognitive impairment; neuroinflammation; oxidative stress; BBB/drug delivery; PK/PD; biomarkers; network pharmacology; flavonoids/polyphenols; zebrafish models; translational neuroscience; deprescribing
(This special issue belongs to the Section Pharmacology)
Polymers, Nanoparticles and Hydrogels for Drug Delivery: Strategies and Applications
edited by Mónica de la Luz Corea Téllez, Marlon Rojas López, and Rogelio Jiménez-Juárez
submission deadline 31 Oct 2026 | 2 articles | Viewed by 2990 | Submission Open
Keywords: drug delivery; medical applications; hydrogels; polymers; nanoparticles; drug delivery system; multi-stimuli-responsive materials; nanocomposites; biofilms; biomarkers
(This special issue belongs to the Section Pharmaceutical Technology)
Exploring Natural Products with Antioxidant and Anticancer Properties, 2nd Edition submission deadline 31 Oct 2026 | 3 articles | Viewed by 2913 | Submission Open
Keywords: antioxidant; anticancer; neoplasms; natural products; cytotoxicity
(This special issue belongs to the Section Natural Products)
Pharmacological Treatments for Parasitic Diseases
edited by Maria Dichiara and
submission deadline 31 Oct 2026 | 3 articles | Viewed by 2147 | Submission Open
Keywords: parasitic diseases; antiparasitic agents; drug resistance; therapeutic strategies; drug discovery; neglected tropical diseases (NTDs); medicinal chemistry; global health
(This special issue belongs to the Section Medicinal Chemistry)
Drug Safety and Risk Management in Clinical Practice: 2nd Edition
edited by Andreea Maria Farcas
submission deadline 31 Oct 2026 | 1 articles | Viewed by 796 | Submission Open
Keywords: drug safety; adverse drug reactions; risk minimization measures; effectiveness of risk minimization measures; drug utilization studies
(This special issue belongs to the Section Pharmacology)
Application of Nuclear Magnetic Resonance (NMR) in Drug Discovery and Development
edited by Vladimir M. Gelev
submission deadline 31 Oct 2026 | Viewed by 445 | Submission Open
Keywords: biomolecular NMR; drug discovery; library screening using NMR; SAR using NMR; fragment-based drug discovery using NMR
(This special issue belongs to the Section Pharmaceutical Technology)
Cholinesterases—Structure, Mechanism, Function and Drug Discovery
edited by
submission deadline 31 Oct 2026 | Viewed by 436 | Submission Open
Keywords: cholinesterases; cholinesterase inhibitors; structure-based design of inhibitors; multi-target ligands; non-cholinergic functions; structure; allosteric sites; mechanism; non-classical functions
(This special issue belongs to the Section Medicinal Chemistry)
Investigating the Therapeutic Potential of Natural Products in Internal Diseases
edited by Roberto Pontarolo and
submission deadline 31 Oct 2026 | Viewed by 368 | Submission Open |
Keywords: natural products; internal diseases; cardiovascular diseases; diabetes; autoimmune disorders; gastrointestinal conditions; respiratory illnesses
(This special issue belongs to the Section Natural Products)
Molecular Insights and Clinical Implications in Geriatric Medicine and Drug Development
edited by , , Kornelia Kędziora-Kornatowska and
submission deadline 31 Oct 2026 | Viewed by 352 | Submission Open
Keywords: older adults; age-related diseases; biomarkers; drug development; molecular modeling; computer-aided drug design; geriatrics in laboratory medicine; laboratory tests in older patients; malnutrition diagnostics; test results versus a clinical image of an older patient
(This special issue belongs to the Section Pharmacology)
Novel Cannabinoid Receptor Ligands: Discovery, Pharmacology, and Therapeutic Applications submission deadline 31 Oct 2026 | Viewed by 338 | Submission Open
Keywords: cannabinoid receptor modulators; synthetic cannabinoids; allosteric modulation; biased signaling; covalent ligands; PROTACs; cannabinoid probes; inflammation; CNS disorders; cancer
(This special issue belongs to the Section Pharmacology)
New Structural, Biophysical and Computational Perspectives on the Use of Proteins in Drug Design and Discovery submission deadline 31 Oct 2026 | Viewed by 308 | Submission Open
Keywords: artificial intelligence; bioinformatics; computational modelling; drug discovery and design; functional proteomics; mass spectrometry; molecular dynamics; protein– ligand interactions; structural proteomics; structural biology; target identification and validation
(This special issue belongs to the Section Biopharmaceuticals)
Peptide-Based Therapeutics: Targeting Amylin, Calcitonin, and Related Receptors submission deadline 31 Oct 2026 | Viewed by 294 | Submission Open
Keywords: GPCR; amylin; obesity; diabetes; peptide-based drugs; long-acting agonists
(This special issue belongs to the Section Biopharmaceuticals)
Animal Models in Pharmacological Research: Focusing on Oncology and Related Fields
edited by Nomeda Juodžiukyniene and
submission deadline 31 Oct 2026 | Viewed by 270 | Submission Open
Keywords: animals models; veterinary; oncology; histopathology; tumor microenvironment; translational; immunotherapy; target therapy
(This special issue belongs to the Section Pharmacology)
DNA Repair Targeted Therapy: New Advances in Cancer Treatment
edited by Nimrat Chatterjee
submission deadline 31 Oct 2026 | Viewed by 266 | Submission Open
Keywords: DNA repair; cancer treatment; targeted therapy; gene-editing; immune-based therapies; DNA repair inhibitors; molecular targets; combination therapies
(This special issue belongs to the Section Biopharmaceuticals)
Pharmaceutical Sciences: Perspectives from Early-Career Investigators submission deadline 31 Oct 2026 | Viewed by 213 | Submission Open
Keywords: pharmaceutical science; drug delivery; AI-assisted drug discovery; computational drug design; nanomedicine; pharmacokinetics; pharmacodynamics; natural products; translational research; early-career researchers
Modern Drug Discovery: Computational Modeling, Chemical Synthesis, Structure–Activity Relationships, and Experimental Pharmacology
edited by and Milind V. Gaikwad
submission deadline 31 Oct 2026 | Viewed by 179 | Submission Open
Keywords: heterocyclic compounds; natural products; bioactive molecules; molecular docking; QSAR modeling; molecular dynamics; DFT; AI-driven drug design; structure– activity relationship; chemical synthesis; pharmacokinetics; pharmacodynamics; cytotoxicity; enzyme inhibition; COX-1; COX-2; anticancer; antimicrobial; antidiabetic; anti-inflammatory; neuroprotective; antifungal; antitubercular; drug discovery; nanomaterials
(This special issue belongs to the Section Medicinal Chemistry)
Plant Extracts and Phytochemicals Modulating the JAK/STAT Signaling Pathway submission deadline 31 Oct 2026 | Viewed by 174 | Submission Open
Keywords: plant extracts; phytochemicals; bioactive compounds; JAK/STAT Signaling Pathway; anti-inflammatory activity; pro-inflammatory cytokines
(This special issue belongs to the Section Natural Products)
Natural Compounds for the Prevention and Treatment of Cardiovascular Diseases submission deadline 31 Oct 2026 | Viewed by 46 | Submission Open
Keywords: bioactivity; synthesis; pharmacology; natural compounds; natural product; cardiovascular diseases
(This special issue belongs to the Section Natural Products)
New Trends in the Treatment of Neuropsychiatric Disorders submission deadline 10 Nov 2026 | 1 articles | Viewed by 1635 | Submission Open
Keywords: treatment; depression; schizophrenia; bipolar disorder; Alzheimer’ s disease
(This special issue belongs to the Section Pharmacology)
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