Environmental Contaminants: Impacts on Reproduction and Embryonic Development

A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Reproductive and Developmental Biology".

Deadline for manuscript submissions: 20 May 2026 | Viewed by 1594

Special Issue Editor


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Guest Editor
Department of Biological, Geological and Environmental Sciences, University of Catania, 95124 Catania, Italy
Interests: in vivo and in vitro assay; toxicology; nanotoxicology; Danio rerio; embryonic development; biomarkers; cytotoxicity; gametes
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Special Issue Information

Dear Colleagues,

I would like to lead a Special Issue for the journal Life dedicated to the effect of environmental chemicals on embryonic development and reproduction. Global pollution has led to the accumulation of many environmental contaminants, such as metals, persistent organic pollutants (POPs), chemical compounds, and pharmaceuticals. In particular, drug residues have caused growing concerns due to their harmful effects on living organisms. Commonly used pharmaceutical products, such as antibiotics, analgesics, antihistamines, and antidepressants, are frequently detected in aquatic and terrestrial ecosystems due to their incomplete removal in wastewater treatment processes. Therefore, the abuse of pharmaceutical products will lead to an increase in their concentrations in the environment and inevitably to their bioaccumulation in organisms, with consequences for human health. These compounds, even at very low concentrations, can interfere with critical biological processes, negatively affecting embryonic development as well as reproductive capacity. Embryonic development is one of the most sensitive windows to environmental chemicals and can also lead to long-lasting health effects.

In this Special Issue, I encourage the submission of any original articles and reviews with a focus on the effects of pharmaceutical products present in the environment, with particular attention to their mechanisms of action and consequences for embryonic development, without excluding reproductive health, and for male and female gametes. New investigations are needed to improve the knowledge on the effects of pharmaceutical products on embryonic malformations, altered reproductive behavior, and reduced fertility.

Dr. Elena Maria Scalisi
Guest Editor

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Keywords

  • environmental contaminants
  • embryonic development
  • fertility
  • toxicity
  • chemicals

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Published Papers (1 paper)

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Research

17 pages, 2475 KB  
Article
Paroxetine Triggers Inflammatory State on Zebrafish Early Embryonic Development
by Elena Maria Scalisi, Agata Scalisi, Stefania Indelicato, Antonio Salvaggio, Fabiano Capparucci, Roberta Pecoraro and Maria Violetta Brundo
Life 2025, 15(10), 1591; https://doi.org/10.3390/life15101591 - 11 Oct 2025
Viewed by 1259
Abstract
Paroxetine (PRX) is a common antidepressant, also frequently used by pregnant women to treat depression and anxiety associated with pregnancy; thus, we should increase warnings about its intake. The increased presence of paroxetine in the environment raises concerns about unintended exposure to it, [...] Read more.
Paroxetine (PRX) is a common antidepressant, also frequently used by pregnant women to treat depression and anxiety associated with pregnancy; thus, we should increase warnings about its intake. The increased presence of paroxetine in the environment raises concerns about unintended exposure to it, with consequences for embryonic development. However, the effect of PRX on early embryonic development, particularly on the embryonic brain, is still poorly studied, so this study aimed to investigate its toxicological profile on embryonated eggs of Danio rerio. Embryos of D. rerio were exposed to 1, 10, and 100 μg/L of PRX using the ZFET test. The results showed that exposure to PRX does not interfere with embryonic development but causes adverse effects in larvae, including heartbeats and an inflammatory state, with production of ROS and apoptotic cells on their head. Finally, the immunofluorescence assay for the biomarker acetylcholinesterase showed a decrease in its activity in exposed groups. Therefore, paroxetine is able to reach the nervous system during embryonic development with negative consequences. Full article
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