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Life
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Novel Diagnostics and Therapeutics for Ophthalmic Diseases
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Novel Diagnostics and Therapeutics for Ophthalmic Diseases

A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Medical Research".

Deadline for manuscript submissions: closed (30 April 2026) | Viewed by 1695

Special Issue Editor

Dr. Chris H. L. Lim

E-Mail Website
Guest Editor
Department of Ophthalmology, National University Hospital, Singapore 119228, Singapore
Interests: ocular surface disorders; dry eye disease; corneal ectasias; keratorefractive surgery; infective keratitis

Special Issue Information

Dear Colleagues,

Clinical ophthalmology is experiencing a period of rapid transformation, driven by technological innovation, evolving therapeutic options, and shifting demographic demands. This Special Issue seeks to explore the latest advancements, emerging trends, and persistent challenges in clinical ophthalmology. With rapid developments in diagnostic technologies, therapeutic interventions, and surgical techniques, the field continues to evolve, offering opportunities to improve patient outcomes. However, challenges such as disease complexity, accessibility to care, and the integration of novel treatments into clinical practice remain. By bringing together perspectives from research, clinical practice, and policy, this Special Issue seeks to serve as a vital resource for ophthalmologists, researchers, and allied healthcare professionals, fostering innovation and collaborative solutions.

Dr. Chris H. L. Lim
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Life is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • clinical ophthalmology
  • ophthalmic innovations
  • diagnostic technologies
  • therapeutic advancements
  • surgical techniques
  • disparity in global eye health
  • personalized medicine

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (2 papers)

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Research

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11 pages, 1105 KB  
Article
Biofeedback Fixation Training in the Rehabilitation of Patients with Geographic Atrophy
by Kristóf Vörös, Illés Kovács, Gréta Kézdy, Ágnes Élő, Zsuzsa Szilágyi, Mirella Barboni, Zsuzsa Récsán, Zoltán Zsolt Nagy and Monika Ecsedy
Life 2026, 16(1), 165; https://doi.org/10.3390/life16010165 - 19 Jan 2026
Viewed by 840
Abstract
Geographic atrophy (GA) is a progressive cause of central vision loss with limited rehabilitation options. This prospective case series aimed to evaluate the effects of biofeedback fixation training (BFT) on visual function and vision-related quality of life (QoL) in patients with GA. Eighteen [...] Read more.
Geographic atrophy (GA) is a progressive cause of central vision loss with limited rehabilitation options. This prospective case series aimed to evaluate the effects of biofeedback fixation training (BFT) on visual function and vision-related quality of life (QoL) in patients with GA. Eighteen patients with total central vision loss in one eye underwent BFT on the fellow eye (study eye) using the Macular Integrity Assessment (MAIA) system, which was used to select a new, previously chosen preferred retinal locus (PRL) to stabilize fixation or adopt a new fixation locus. Patients were followed for an average of 13.2 months (range 3–26 months). Functional outcomes included best corrected visual acuity (ETDRS chart), reading performance (Radner test), and contrast sensitivity (Spot Checks test). MAIA parameters comprised average retinal sensitivity, fixation distance and stability (P1, P2), and changes in the bivariate contour ellipse area (BCEA). Vision-related quality of life was assessed using the National Eye Institute Visual Functioning Questionnaire-25 (NEI-VFQ-25). Following BFT, visual acuity, reading ability and contrast sensitivity improved significantly (p value: p < 0.02), and fixation stability and NEI-VFQ-25 scores showed a positive trend. These findings indicate that BFT is a feasible and promising rehabilitation approach for patients with GA. Full article
(This article belongs to the Special Issue Novel Diagnostics and Therapeutics for Ophthalmic Diseases)
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6 pages, 581 KB  
Case Report
New Technique of Single-Point Scleral Fixation of the Smaller-Incision New-Generation Implantable Miniature Telescope with an 18-Month Follow-Up Period
by Agnieszka Nowosielska and Grzegorz Rotuski
Life 2026, 16(2), 274; https://doi.org/10.3390/life16020274 - 5 Feb 2026
Viewed by 494
Abstract
Background: The implantable miniature telescope is used to provide functional vision for patients with advanced AMD. However, despite the considerable cost of the device, there are strict criteria to be met for this procedure, since the patients require challenging neuroadaptation afterward, which sometimes [...] Read more.
Background: The implantable miniature telescope is used to provide functional vision for patients with advanced AMD. However, despite the considerable cost of the device, there are strict criteria to be met for this procedure, since the patients require challenging neuroadaptation afterward, which sometimes fails and leads to the necessity of device explantation. Visual outcomes also depend on the stability of the microtelescope; tilts cause unwanted optical aberrations and can lead to device luxation, with sight-threatening complications. Case report: This case presents a novel technique for fixing the ophthalmic telescope device SING-IMT™. A 76-year-old female with pre-operative visual acuity of 15 letters on the ETDRS scale underwent surgery on her left eye. The superior haptic was fixed at the 12 o’clock position with a Prolene 5-0 suture, achieving good postoperative stability. The implant was stable throughout the entire observation period. Conclusions: Implant stability is crucial for maximizing visual potential in patients with advanced AMD selected for the procedure, since visual acuity in the peripheral retina, where the perceived image eventually lands, is much lower than the macula. Therefore, there is a need to standardize surgical approaches and use objective follow-up measures to assess long-term patient satisfaction. Full article
(This article belongs to the Special Issue Novel Diagnostics and Therapeutics for Ophthalmic Diseases)
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