Diabetes, Microbiome, and Inflammation: Mechanisms and Therapeutic Perspectives
A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Medical Research".
Deadline for manuscript submissions: closed (30 April 2026) | Viewed by 481
Special Issue Editors
Interests: microbiome; metagenomics; gut microbiota; microbial diversity; antimicrobials
Special Issues, Collections and Topics in MDPI journals
2. National Institute of Diabetes, Nutrition and Metabolic Diseases, Bucharest, Romania.
Interests: microbiome; diabetes; gut microbiota
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Diabetes mellitus remains a pressing global health challenge, with increasing incidence and complex systemic complications. Despite decades of research, the underlying pathogenic mechanisms have not yet been fully elucidated. Recent advances highlight the central role of the microbiome in shaping host metabolism, immunity, and inflammatory pathways. Dysbiosis and chronic low-grade inflammation are now recognized as key drivers of both the onset and progression of diabetes and related complications.
This Special Issue will provide a platform for multidisciplinary discussions to enhance our understanding of the dynamic interplay between diabetes, the microbiome, and inflammation. We welcome submissions addressing, but not limited to, the following areas:
- Mechanistic insights into host–microbiome–immune interactions in diabetes pathogenesis;
- Inflammatory pathways linking dysbiosis to insulin resistance, β-cell dysfunction, and metabolic syndrome;
- Microbiome alterations across type 1, type 2, gestational, and secondary forms of diabetes;
- Microbial metabolites as modulators of systemic and tissue-specific inflammation;
- Microbiome-based biomarkers of chronic inflammation, disease risk, and therapeutic response;
- Anti-inflammatory and microbiome-targeted interventions (dietary strategies, probiotics, prebiotics, postbiotics, synbiotics, pharmacological approaches, FMT);
- Links between inflammation, microbiome shifts, and diabetic complications (cardiovascular, renal, neurological, ocular);
- Translational and clinical research on microbiome–inflammation–diabetes interactions in precision medicine.
We encourage original research papers, reviews, systematic analyses, perspectives, and short communications that will advance our knowledge in this interdisciplinary field.
We look forward to receiving your valuable contributions and compiling a comprehensive resource on this timely topic.
Dr. Gratiela Pircalabioru
Dr. Octavian Savu
Guest Editors
Manuscript Submission Information
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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Life is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- diabetes mellitus
- microbiome
- microbiota metabolites
- metabolic disease
- dysbiosis
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