Phytochemicals in Focus: Bioactivity, Safety, and Therapeutic Potential

A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Plant Science".

Deadline for manuscript submissions: 30 April 2026 | Viewed by 410

Special Issue Editor


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Guest Editor
Institute of Food and Agricultural Sciences, University of Florida, Gainesville, FL, USA
Interests: phytohormones; plant-microbe interactions; abiotic stresses; plant breeding; plant metabolites; plant protection; soil microbiology; microbial cleaning of polluted lands

Special Issue Information

Dear Colleagues,

This Special Issue aims to gather cutting-edge research focused on the biological activity, safety evaluation, and therapeutic potential of phytochemicals derived from medicinal plants, herbs, and other botanical sources. Plant-derived compounds are increasingly recognized for their diverse pharmacological actions, including antioxidant, antimicrobial, anti-inflammatory, and cytoprotective properties.

We welcome studies that investigate the in vitro and in vivo biological effects of phytochemicals, particularly in relation to oxidative stress modulation, free radical scavenging, and cellular protection. Research evaluating the antibacterial, antifungal, antiviral, and antiparasitic properties of plant extracts and isolated compounds is especially encouraged.

Submissions addressing the toxicity, safety profiles, and risk assessment of natural products are also considered essential, particularly for their application in pharmaceuticals, nutraceuticals, and food systems.

We invite original research articles and reviews that contribute to the understanding of how phytochemicals can be safely and effectively utilized for therapeutic purposes.

Dr. Naeem Khan
Guest Editor

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Keywords

  • phytochemicals
  • antioxidant activity
  • antimicrobial properties
  • toxicity evaluation
  • natural products
  • medicinal plants and bioactivity
  • oxidative stress plant extracts
  • therapeutic potential
  • safety assessment
  • bioactive compounds

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Published Papers (1 paper)

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Research

25 pages, 14917 KB  
Article
Medicinal Plant Rhizospheres as Reservoirs of Aspergillus-Derived Phytochemicals with Antimicrobial and Insecticidal Potential
by Sidra Farooq, Asif Mehmood, Nasir Ali, Amjad Khan and Naeem Khan
Life 2025, 15(12), 1886; https://doi.org/10.3390/life15121886 - 10 Dec 2025
Viewed by 194
Abstract
The rhizosphere, a dynamic interface shaped by plant root exudates, fosters microbial communities with significant biochemical potential. This study investigated the interplay between soil properties and fungal bioactivity in the rhizospheres of Withania coagulans and Justicia adhatoda in Pakistan. Physicochemical analysis revealed silty [...] Read more.
The rhizosphere, a dynamic interface shaped by plant root exudates, fosters microbial communities with significant biochemical potential. This study investigated the interplay between soil properties and fungal bioactivity in the rhizospheres of Withania coagulans and Justicia adhatoda in Pakistan. Physicochemical analysis revealed silty loam textures with divergent phosphorus [25.7 vs. 71.5 mg/kg] and potassium [108 vs. 78 mg/kg] levels, alongside near-neutral pH, influencing microbial dynamics. Two fungal isolates, Aspergillus luchuensis and A. flavus, were identified through morphological traits and ITS-region sequencing. Gas chromatography-mass spectrometry [GC-MS] profiling of ethyl acetate extracts uncovered 30 and 25 previously uncharacterized metabolites in A. luchuensis and A. flavus, respectively, including bioactive compounds such as tetradecanoic acid and nonadecane. Bioassays demonstrated broad-spectrum efficacy against multidrug-resistant clinical isolates, with A. flavus exhibiting notable inhibition against Salmonella typhi [31.7 mm zone] and A. luchuensis against Shigella spp. [23 mm]. Both extracts suppressed Lemna minor growth by 70%, indicating phytotoxic potential, and displayed species-specific insecticidal activity, inducing 70% mortality by A. luchuensis against Blattodea and 50% by A. flavus against the same species. These findings underscore the rhizosphere’s role as a reservoir of bioactive fungi, with Aspergillus spp. producing metabolites of pharmaceutical and agrochemical relevance. The study highlights the necessity for advanced structural elucidation and ecotoxicological assessments to harness these compounds, advocating integrated approaches combining metabolomics and genomic mining to unlock novel biotechnological applications. Full article
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