Research on the Pathogenesis and Association of Diabetes and Metabolic Syndrome
A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Physiology and Pathology".
Deadline for manuscript submissions: 30 April 2026 | Viewed by 11
Special Issue Editor
Special Issue Information
Dear Colleagues,
Diabetes mellitus and metabolic syndrome are closely interrelated clinical entities, both in pathophysiology and epidemiology. Their coexistence significantly increases the risk of cardiovascular disease, microvascular complications, atherosclerotic cardiovascular disease, heart failure, and stroke. Insulin resistance is central to both diabetes mellitus and metabolic syndrome. In metabolic syndrome, insulin resistance precedes and predicts the development of type 2 diabetes mellitus. Chronic low-grade inflammation and adipose tissue dysfunction are key drivers of both conditions, contributing to endothelial dysfunction, atherogenesis, and progressive β-cell failure. Although the association between diabetes mellitus and metabolic syndrome are well known and widely studied, physicians and researchers should not underestimate the enormous impact of pathophysiology and other endocrine dysfunctions. New developments in genetics, pathophysiology, medical equipment, bioengineering, and pharmacology open new horizons for the diagnosis and management of patients with diabetes mellitus and metabolic syndrome. An understanding of pathogenesis is needed to facilitate the precocious diagnosis and assessment of the risk profile, pre-existing cardiovascular pathologies and clinical outcomes in diabetic patients with metabolic syndrome as well as in those with pathophysiology and endocrine dysfunctions.
This Special Issue focuses on original articles and reviews referring to groundbreaking research regarding the association between diabetes mellitus and metabolic syndrome for metabolic dysfunctions and cardiovascular pathologies.
Dr. Gwo-Ping Jong
Guest Editor
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Keywords
- diabetes mellitus
- insulin resistance
- metabolic syndrome
- obesity
- coronary artery disease
- endothelial dysfunction
- stroke
- hypertension
- peripheric arterial disease
- metabolic dysfunction
- hyperlipidemia
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