Exploring the Mechanisms of the Effects of Microplastics and Nanomaterials on Biological Physiological Functions
A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Physiology and Pathology".
Deadline for manuscript submissions: 31 January 2026 | Viewed by 8
Special Issue Editor
Special Issue Information
Dear Colleagues,
The increasing presence of microplastics and engineered nanomaterials in our environment and biological systems has become a pressing concern for human and ecological health. These emerging contaminants, which are characterized by their nanoscale dimensions, large surface-area-to-volume ratios, and diverse chemical compositions, can readily enter the body through inhalation, ingestion, or dermal exposure. Once internalized, these particles have the capacity to traverse epithelial and endothelial barriers, accumulating in various organs and disrupting essential physiological processes.
Mounting evidence indicates that microplastics and nanomaterials may induce oxidative stress, inflammation, mitochondrial dysfunction, endoplasmic reticulum stress, and autophagy dysregulation. Furthermore, the interaction of these cells with the immune system, gut microbiota, neural circuits, and endocrine systems can result in subtle but chronic physiological disturbances. These effects may be of particular concern to vulnerable populations, such as children, the elderly, or individuals with pre-existing conditions. Despite the growing awareness of this phenomenon, the precise molecular and cellular mechanisms underlying these effects remain largely elusive and urgently need clarification.
The present Special Issue has been conceived with the aim of exploring the mechanistic basis of how microplastics and nanomaterials affect biological systems, with a focus on physiological functions at cellular, tissue, organ, and systemic levels. Contributions employing in vitro models, animal studies, omics technologies, and imaging techniques to investigate uptake, bio-distribution, biotransformation, signaling pathway disruption, and long-term toxicity are welcomed. The submission of review articles that synthesize current knowledge and propose future research directions is also highly encouraged. The overarching objective is to facilitate the creation of evidence-based guidelines for environmental safety, risk assessment, and potential biomedical applications.
Dr. Yung-Li Wang
Guest Editor
Manuscript Submission Information
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Keywords
- microplastics
- nanomaterials
- environmental toxicology
- oxidative stress
- physiological function
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