Immunopathology of Oral Mucosal Disease

Dear Colleagues,

As we are all aware, oral mucosal diseases, including lichen planus, mucous membrane pemphigoid or recurrent aphthous stomatitis, and oral potentially malignant disorders (OPMDs) such as leukoplakia and erythroplakia, represent a significant global medical burden. They are affecting millions worldwide, causing chronic inflammation, pain, and a heightened risk of progression to oral squamous cell carcinoma (OSCC). All of these conditions arise from dysregulated immune responses involving T-cell-mediated cytotoxicity, autoantibody production, cytokine storms, and immune evasion in premalignant states, often triggered by a genetic predisposition, microbial factors, or environmental risk factors such as tobacco consumption. We are pleased to invite you to contribute to this Special Issue, “Immunopathology of Oral Mucosal Disease”, which will highlight the mechanisms behind these disease to advance precision medicine in oral health.

This Special Issue will consolidate cutting-edge research on the immunological underpinnings of oral mucosal diseases (including OPMDs and OSCC) by elucidating immune-mediated pathogenesis, identifying novel diagnostic/prognostic biomarkers and exploring innovative therapeutic strategies such as biologics and checkpoint inhibitors. It will bridge basic science with clinical translation, addressing unmet needs in risk stratification for malignant progression and personalized management.

We welcome original research articles, systematic reviews, and meta-analyses for this Special Issue.

We look forward to receiving your contributions.

Kind regards,

Dr. Dinko Martinovic
Guest Editor

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