Novel Insights into Biomarkers and Molecular Mechanisms in Heart Failure

Dear Colleagues,

Heart failure (HF) remains a leading cause of morbidity and mortality worldwide, posing a growing public health challenge due to aging populations and the increasing burden of cardiovascular risk factors. While advances in pharmacologic and device therapies have improved outcomes, the underlying molecular mechanisms and dynamic pathophysiology of HF remain incompletely understood. This Special Issue of Life, titled “Novel Insights into Biomarkers and Molecular Mechanisms in Heart Failure”, aims to bring together cutting-edge research that deepens our understanding of the biological underpinnings of HF and identifies novel biomarkers that can enhance diagnosis, prognosis, and therapeutic stratification.

We invite original research articles, reviews, and translational studies exploring the cellular, genetic, epigenetic, and proteomic mechanisms involved in HF development and progression. Submissions may include investigations into myocardial remodeling, neurohormonal activation, inflammation, oxidative stress, metabolic dysregulation, and signaling pathways relevant to different HF phenotypes, such as HF with preserved or reduced ejection fraction. Particular emphasis is placed on identifying and validating circulating biomarkers, imaging markers, and omics-based signatures that can inform individualized patient care and facilitate early intervention.

Through this Special Issue, we seek to foster interdisciplinary collaboration and highlight innovative approaches that bridge bench and bedside. By elucidating molecular mechanisms and refining biomarker-guided strategies, this collection aims to support precision medicine in HF management and ultimately improve patient outcomes.

Dr. Chun-Chao Chen
Dr. Wen-Rui Hao
Prof. Dr. Ju-Chi Liu
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Life is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.