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Life publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Harnessing Mitochondrial Rewiring for Cancer Therapy: Novel Strategies in the Era of Precision Medicine

edited by

Theodoros Rampias

and Maria Sideridou

submission deadline 26 Jun 2026 | Viewed by 43 | Submission Open

Keywords: Oxidative stress; Metabolic rewiring; Carcinogenesis; DNA repair; Cancer therapy; Heteroplasmy

(This special issue belongs to the Section Physiology and Pathology)

Recent Advances in Physiotherapy for Musculoskeletal

edited by

Miguel Ángel Rosety-Rodríguez

and

Jorge Góngora-Rodríguez

submission deadline 30 Jun 2026 | 6 articles | Viewed by 15745 | Submission Open

Keywords: musculoskeletal rehabilitation; emerging technologies; virtual reality; artificial intelligence; inflammatory genetics; physiotherapy; sports medicine; functional recovery

(This special issue belongs to the Section Physiology and Pathology)

The Emerging Role of Microbiota in Health and Diseases

edited by Edyta Juszczuk-Kubiak and Katarzyna Góralska

submission deadline 30 Jun 2026 | 6 articles | Viewed by 12974 | Submission Open

Keywords: microbiota; eubiosis; dysbiosis; microbiota– host interaction; microbiota– gut– brain axis; microbiome; bacteria– fungi interactions; microbiota modification; holobiont; cross-feeding; microbiota related diseases; microbiota functions

(This special issue belongs to the Section Microbiology)

Current Advances in Lung Cancer Diagnosis and Treatment

edited by

Hakyoung Kim

, Daesik Yang and

Zhiwei Hu

submission deadline 30 Jun 2026 | 4 articles | Viewed by 9205 | Submission Open

Keywords: lung cancer; underlying lung disease; radiotherapy; systemic therapy; survival outcomes; complication; biomarkers

(This special issue belongs to the Section Medical Research)

Common and Novel Markers of Inflammation and Tissue Damage in Various Pathological Conditions—2nd Edition

edited by

Marzena Tylicka

Joanna Kamińska

and

Olga Koper-Lenkiewicz

submission deadline 30 Jun 2026 | 5 articles | Viewed by 7400 | Submission Open

Keywords: body fluids; cytokines; damage-associated molecular patterns (DAMPs); inflammatory response; injury; markers of inflammation and tissue damage; metalloproteinases; novel markers; pathological conditions; proteasome; tissue damage; tissue repair processes; various diseases

(This special issue belongs to the Section Physiology and Pathology)

Update on Microalgae Metabolites

edited by

Eduardo Jacob-Lopes

and

Leila Queiroz Zepka

submission deadline 30 Jun 2026 | 2 articles | Viewed by 3745 | Submission Open

Keywords: biosynthesis; culture conditions; bioactive compounds; biological activity; biorefinery; proteins; peptides; antifreeze proteins; enzymes; carbohydrates; exocellular polysaccharides; carbohydrate-binding proteins; lipids; fatty acids; chlorophylls; carotenoids; phycobiliproteins; vitamins; minerals; trace elements; sterols; secondary metabolites; downstream processing; purification; safety; regulatory issues; clinical tests

(This special issue belongs to the Section Microbiology)

Musculoskeletal Imaging: Innovations in Diagnostics and Interventional Therapies

edited by

Paolo Spinnato

submission deadline 30 Jun 2026 | 2 articles | Viewed by 3443 | Submission Open

Keywords: magnetic resonance imaging; bone and bones; computed tomography; sarcoma; interventional radiology

(This special issue belongs to the Section Medical Research)

Sialic Acid and Sialic Acid Derivatives in Biomedicine

edited by

Paola Rota

and

Marco Piccoli

submission deadline 30 Jun 2026 | 2 articles | Viewed by 3442 | Submission Open

Keywords: sialic acid; drug development; sialidase inhibitors; sialylation; sialidase; biomarker

(This special issue belongs to the Section Physiology and Pathology)

Microalgae and Their Biotechnological Potential

edited by

Fantao Kong

, Yi Xin and Yuanxue Liang

submission deadline 30 Jun 2026 | 2 articles | Viewed by 3130 | Submission Open

Keywords: microalgae; biofuels; bioproducts; lipid metabolism; synthetic biology; system engineering

(This special issue belongs to the Section Microbiology)

Latest Updates on Clinical Microbiology and Antimicrobial Resistant Infection

edited by Jun Sung Hong

submission deadline 30 Jun 2026 | 2 articles | Viewed by 3044 | Submission Open

Keywords: enterobacteriaceae; antimicrobial resistance; infection; health

(This special issue belongs to the Section Microbiology)

Pathological and Clinical Updates on Eye Diseases

edited by Pier Luigi Surico and

Rohan Bir Singh

submission deadline 30 Jun 2026 | 1 articles | Viewed by 2378 | Submission Open

Keywords: ophthalmology; eye diseases; gene therapy; ocular surface; ocular immunology; cornea

(This special issue belongs to the Section Medical Research)

Advances in Livestock Breeding, Nutrition and Metabolism

edited by

Imran Khan

submission deadline 30 Jun 2026 | 2 articles | Viewed by 2373 | Submission Open

Keywords: genetic selection; livestock breeding; genome editing; animal nutrition; precision feeding; nutritional additives; feed conversion; metabolism; animal health; sustainability

(This special issue belongs to the Section Animal Science)

Move to Thrive: Pioneering Health and Resilience Through Physical Activity

edited by

Silvana Mirella Aliberti

Franca Di Meglio

and

Daria Nurzynska

submission deadline 30 Jun 2026 | 1 articles | Viewed by 2364 | Submission Open

Keywords: physical activity; inflammation modulation; chronic disease prevention; immune system adaptation; biomechanics; rehabilitation strategies; sports medicine; aging and physical activity; disability and movement; environmental and regional influences on exercise

(This special issue belongs to the Section Physiology and Pathology)

Helicobacter pylori: 2nd Edition

edited by

Ovidiu Pop

and

Simona Gurzu

submission deadline 30 Jun 2026 | 2 articles | Viewed by 2176 | Submission Open

Keywords: H. pylori; cancers; antioxidative process; diagnostic methods

(This special issue belongs to the Section Microbiology)

Role of Machine and Deep Learning in Drug Screening

edited by

Shahid Ali

and

Teng Zhou

submission deadline 30 Jun 2026 | 1 articles | Viewed by 1656 | Submission Open

Keywords: machine learning in drug screening; deep learning in drug discovery; virtual screening; molecular docking and dynamics; personalized medicine

(This special issue belongs to the Section Pharmaceutical Science)

Advances in the Glyoxalase Pathway: Implications for Oxidative Stress Management in Cancer Therapy and in Age-Related Disease

edited by

Laura Cianfruglia

and

Salvatore Vaiasicca

submission deadline 30 Jun 2026 | 1 articles | Viewed by 1594 | Submission Open

Keywords: glyoxalase system; methylglyoxal; advanced glycation end-products; dicarbonyl stress; oxidative stress; age-related disease; cancer

(This special issue belongs to the Section Physiology and Pathology)

Research on Gastrointestinal Cancer and Nutritional Health

edited by

Irene Lidoriki

, Adam Mylonakis and Dimitrios Tsapralis

submission deadline 30 Jun 2026 | 1 articles | Viewed by 1482 | Submission Open

Keywords: dietary patterns; gastrointestinal cancer; clinical nutrition; nutritional status; nutritional assessment; metabolism; gastric cancer; esophageal cancer; pancreatic cancer; colorectal cancer

(This special issue belongs to the Section Medical Research)

Channel Proteins and Transporters in Human Health and Disease

edited by

Giorgia Scarpellino

Giorgia Chinigò

and

Roberta De Zio

submission deadline 30 Jun 2026 | Viewed by 1073 | Submission Open

Keywords: channel proteins; transporters; ion channel

(This special issue belongs to the Section Proteins and Proteomics)

Neuroimaging and Integrative Analyses in Psychiatry and Addictive Disorders

edited by Arkadiusz Komorowski

submission deadline 30 Jun 2026 | 1 articles | Viewed by 851 | Submission Open

Keywords: psychiatry; neuroimaging; forensic psychiatry; fMRI; PET; EEG; addiction; substance use disorders (SUD); psychotherapy; treatment-resistant depression (TRD); attention deficit hyperactivity disorder (ADHD)

(This special issue belongs to the Section Physiology and Pathology)

Cutting-Edge Research in Rhinology and Allergy: Unraveling Disease Mechanisms and Treatment Innovations

edited by Min-Seok Rha

submission deadline 30 Jun 2026 | 1 articles | Viewed by 631 | Submission Open

Keywords: rhinology; allergy; chronic rhinosinusitis; allergic rhinitis; asthma; precision medicine; clinical immunology; immunopathology; therapeutic innovation

Applications of Dermatoscopy in Skin Diseases: 2nd Edition

edited by

Paweł Pietkiewicz

Enzo Errichetti

and

Cristian Navarrete

submission deadline 30 Jun 2026 | 1 articles | Viewed by 617 | Submission Open

Keywords: melanoma; skin cancer; inflammoscopy; trichoscopy; ultraviolet reflectance dermatoscopy; skin of color; basal cell carcinoma; squamous cell carcinoma; nevus; digital dermoscopy

(This special issue belongs to the Section Medical Research)

Perspectives on Nutrition and Livestock Health

edited by Liuting Wu, Yan Wang and

Felix Kwame Amevor

submission deadline 30 Jun 2026 | 1 articles | Viewed by 606 | Submission Open

Keywords: nutrition; animal health; animal reproductive; animal welfare; gut microbiome

(This special issue belongs to the Section Animal Science)

Vector-Borne Diseases and One Health

edited by

Jeronimo Alencar

, Shayenne Silva and

Michail Kotsyfakis

submission deadline 30 Jun 2026 | 1 articles | Viewed by 551 | Submission Open

Keywords: vector-borne diseases; One Health; malaria; dengue; Zika; chikungunya; yellow fever; West Nile virus; Lyme disease; leishmaniasis; Chagas

(This special issue belongs to the Section Animal Science)

Cranial Base Tumors: Pathogenesis, Diagnosis, and Treatments

edited by

Andrew J. Fishman

and Marcin Szymański

submission deadline 30 Jun 2026 | 1 articles | Viewed by 502 | Submission Open

Keywords: skull base tumors; neuro-oncology; endoscopic surgery; cranial nerve preservation; AI-assisted diagnostics; multidisciplinary management

(This special issue belongs to the Section Medical Research)

New Advances in the Treatment and Assessment of Temporomandibular Joint Disorders

edited by

Łukasz Rafał Pałka

submission deadline 30 Jun 2026 | Viewed by 349 | Submission Open

Keywords: orofacial dysfunction; multifactorial etiology; advanced diagnostic technologies; biomechanical modeling of TMJ; novel imaging techniques; inflammatory and degenerative changes; interdisciplinary management; conservative therapy approaches; occlusal concepts; splint therapy design; physical therapy regimens; long-term implant treatment outcomes; personalized treatment strategies

(This special issue belongs to the Section Medical Research)

Autoimmune Disorders: From Pathophysiology to Therapeutics

edited by

Giulia Lanzolla

and Chiara Mura

submission deadline 30 Jun 2026 | Viewed by 300 | Submission Open

Keywords: autoimmunity; autoimmune diseases; polyglandular autoimmune syndromes; thyroid autoimmune disease; type 1 diabetes

(This special issue belongs to the Section Physiology and Pathology)

Update on Obstructive Sleep Apnea (OSA)

edited by

Konstantinos Chaidas

submission deadline 30 Jun 2026 | Viewed by 225 | Submission Open

Keywords: obstructive sleep apnea; snoring; sleep-disordered breathing; adult sleep apnea; pediatric sleep apnea

(This special issue belongs to the Section Physiology and Pathology)

Post-Concussion Syndrome and Functional Neurological Disorder

edited by

Ioannis Asterios Mavroudis

submission deadline 30 Jun 2026 | Viewed by 204 | Submission Open

Keywords: post-concussion syndrome; functional neurological disorder; mild traumatic brain injury; cognitive dysfunction ; neuroimaging; biomarkers; neurorehabilitation

(This special issue belongs to the Section Medical Research)

Placental Spectrum Disorders and Gynecological Oncology

edited by Gianluca Raffaello Damiani

submission deadline 30 Jun 2026 | Viewed by 168 | Submission Open

Keywords: placenta; trophoblastic tumor; mola; tumors; bleeding

(This special issue belongs to the Section Medical Research)

Advances in Bioorganic and Medicinal Chemistry

edited by Sahar Kandil

submission deadline 30 Jun 2026 | Viewed by 153 | Submission Open

Keywords: medicinal chemistry; drug discovery; biological chemistry; therapeutic targets; therapeutic agents; treatment of diseases; new therapeutic strategies

Transplant Medicine: Updates and Current Challenges

edited by Phillipe Abreu

submission deadline 30 Jun 2026 | Viewed by 126 | Submission Open

Keywords: robotic transplantation; organ transplants; transplant oncology

(This special issue belongs to the Section Medical Research)

“Out-of-the-Organics-Box” Reflections On and Scenarios for Life’s Emergence

edited by

Wolfgang Nitschke

submission deadline 30 Jun 2026 | Viewed by 125 | Submission Open

Keywords: emergence of life; thermodynamics; bioenergetics; information theory; early metabolism; metal ions in biochemistry

(This special issue belongs to the Section Origin of Life)

Sleep-Disordered Breathing: Key Pathophysiological Mechanisms and Their Clinical Implications

edited by

Jinkwan Kim

submission deadline 30 Jun 2026 | Viewed by 115 | Submission Open

Keywords: sleep-disordered breathing; sleep fragmentation; inflammation; cardiovascular disease; insulin resistance

(This special issue belongs to the Section Physiology and Pathology)

Advances and Challenges in Urothelial and Prostate Cancer: Toward Precision Urologic Oncology

edited by Sashi S. Kommu

submission deadline 30 Jun 2026 | Viewed by 104 | Submission Open

Keywords: urothelial carcinoma; prostate cancer; immunotherapy; genomics and biomarkers; precision imaging (PSMA PET; mpMRI); targeted therapies (PARP; FGFR; DDR); focal therapy and theranostics; tumour microenvironment; quality of life and survivorship; health disparities in cancer care; artificial intelligence

(This special issue belongs to the Section Medical Research)

Physical Rehabilitation for Musculoskeletal Disorders: 2nd Edition

edited by

You Gyoung Yi

submission deadline 30 Jun 2026 | Viewed by 103 | Submission Open

Keywords: physical rehabilitation; musculoskeletal disorders; pain management; range of motion; muscle strengthening; mobility enhancement; physical therapy; manual therapy; AI in rehabilitation

(This special issue belongs to the Section Medical Research)

Neural Mechanisms of Brain–Computer Interfaces

edited by

Miguel Pais-Vieira

submission deadline 30 Jun 2026 | Viewed by 83 | Submission Open

Keywords: brain– machine interfaces; neurophysiology; somatosensory cortex; motor cortex

(This special issue belongs to the Section Physiology and Pathology)

Mechanisms and Modulation of Pain: From Ion Channels to Translational Therapeutics

edited by Álvaro Yogi

submission deadline 30 Jun 2026 | Viewed by 77 | Submission Open

Keywords: pain; mechanisms; signaling pathways; ion channels; therapeutic targets; neuropathic pain; inflammatory pain; pre-clinical models

(This special issue belongs to the Section Pharmaceutical Science)

Drug Safety and Outcomes in Respiratory and Critical Care Medicine

edited by

Josef Yayan

submission deadline 30 Jun 2026 | Viewed by 77 | Submission Open

Keywords: drug safety; adverse drug reactions; pharmacovigilance; critical care medicine; respiratory diseases; clinical outcomes; intensive care pharmacotherapy; drug– drug interactions

(This special issue belongs to the Section Pharmaceutical Science)

Neurodegeneration Across Mechanisms, Epidemiology, and Emerging Therapies: Inflammation, Metabolism, Aging, and Neuromodulation

edited by Julian Benito Leon

submission deadline 30 Jun 2026 | Viewed by 68 | Submission Open

Keywords: neurodegeneration; neuroinflammation; metabolic dysfunction; aging and inflammaging; epidemiology; biomarkers; neuromodulation; transcranial magnetic stimulation (TMS)

(This special issue belongs to the Section Medical Research)

Extracellular Vesicles: Biology, Mechanisms, and Therapies for Cerebrovascular Disorders

edited by Jinju Wang

submission deadline 30 Jun 2026 | Viewed by 60 | Submission Open

Keywords: extracellular vesicles; cerebrovascular disorders; dementia; extracellular vesicle-based therapy

(This special issue belongs to the Section Physiology and Pathology)

Comprehensive Treatment and Precision Medicine Strategies for Heart Disease

edited by Serge Sicouri

submission deadline 30 Jun 2026 | Viewed by 54 | Submission Open

Keywords: precision medicine; artificial intelligence; risk stratification; machine learning; translational research; cardiovascular outcomes

(This special issue belongs to the Section Medical Research)

Rewiring Bacterial Communication: Extracellular Vesicles and Microbial Signals Across Host Interfaces

edited by Sara Carloni

submission deadline 30 Jun 2026 | Viewed by 45 | Submission Open

Keywords: bacterial extracellular vesicles (bEVs); host– microbe communication; microbiota dynamics; immune modulation; translational applications

(This special issue belongs to the Section Microbiology)

Antimicrobial Innovations

edited by

Pere Puigbò

and Miho Nakamura

submission deadline 15 Jul 2026 | 1 articles | Viewed by 4180 | Submission Open

Keywords: antimicrobial resistance; biopreservation; lactic acid bacteria; bacteriocins; bacteriophages; natural antimicrobials; antimicrobial peptides; foodborne pathogens; antimicrobial biomaterials; race for the surface; microbial growth models; food safety

(This special issue belongs to the Section Microbiology)

New Insights into Diagnosis and Therapeutic Strategies for Chronic Liver Diseases

edited by

Cristina Marginean

submission deadline 20 Jul 2026 | 5 articles | Viewed by 9807 | Submission Open

Keywords: chronic liver disease; metabolic dysfunction-associated steatotic liver disease (MASLD); metabolic dysfunction-associated steatohepatitis (MASH); drug-induced liver injury (DILI); hepatocellular carcinoma; biomarkers of liver fibrosis; imaging of liver fibrosis; CEUS; novel therapeutic strategies for CLDs

(This special issue belongs to the Section Medical Research)

Herbal Extracts in Skin Health and Disease

edited by

Josipa Bukić

submission deadline 20 Jul 2026 | Viewed by 127 | Submission Open

Keywords: herbal extracts; natural products; skin disorders; skin care

(This special issue belongs to the Section Pharmaceutical Science)

Emerging Knowledge on Human Immunodeficiency Virus

edited by

Giota Lourida

and

Dimitrios Paraskevis

submission deadline 22 Jul 2026 | 3 articles | Viewed by 24146 | Submission Open

Keywords: HIV; antiretroviral treatment; long-acting ART; pre-exposure prophylaxis; HIV surveillance; antiretroviral resistance; primary resistance; HIV epidemiology; special populations; cascade of care; HIV diagnosis

(This special issue belongs to the Section Medical Research)

Genetics, Breeding, and Reproduction of Cattle

edited by

Hailiang Zhang

and

Shanjiang Zhao

submission deadline 24 Jul 2026 | Viewed by 249 | Submission Open

Keywords: cattle; genetic selection; reproductive physiology and technology

(This special issue belongs to the Section Animal Science)

Contemporary Therapeutic Strategies for Solid Tumors

edited by Chohao Lee

submission deadline 26 Jul 2026 | 1 articles | Viewed by 335 | Submission Open

Keywords: therapeutic strategies; survival analysis; solid tumors; cancer treatment; targeted therapy; immunotherapy; precision medicine; clinical outcomes; prognostic factors

(This special issue belongs to the Section Medical Research)

Promising Therapeutic Horizons for Regenerative Medicine in Animals

edited by

Hussein M. El-Husseiny

and

Sharun Khan

submission deadline 28 Jul 2026 | Viewed by 281 | Submission Open

Keywords: stem cells; induced pluripotent stem cells (iPSCs); soft tissue engineering; in vivo and in vitro investigations; extracellular vesicles; preclinical studies; clinical studies; platelet-rich plasma; platelet-rich fibrin; cell-based therapy; cell-free therapy; orthopedics; cardiology

(This special issue belongs to the Section Animal Science)

New Insights into Parkinson’s Disease: From Molecular Basis to Therapy—2nd Edition

edited by

Kallirhoe Kalinderi

submission deadline 28 Jul 2026 | Viewed by 43 | Submission Open

(This special issue belongs to the Section Medical Research)

Displaying special issue 351-400 on page 8 of 10.

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