Sialic Acid and Sialic Acid Derivatives in Biomedicine

A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Physiology and Pathology".

Deadline for manuscript submissions: 26 November 2025 | Viewed by 980

Special Issue Editors

Department of Biomedical, Surgical and Dental Sciences, Università degli Studi di Milano, 20133 Milan, Italy
Interests: sialic acid chemistry and biochemistry; antiviral agents; sialidase inhibitors; pharmacological tools for cardiac and musculoskeletal disorders

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Guest Editor
Laboratory of Stem Cells for Tissue Engineering, IRCCS Policlinico San Donato, Piazza Malan 2, 20097 Milan, Italy
Interests: cardiovascular diseases; sialidase Neu3; sialidase inhibitors; sialic acid biochemistry; strategies for cardioprotection

Special Issue Information

Dear Colleagues,

We are pleased to announce the release of a new Special Issue dedicated to the exploration of sialic acid, a pivotal element in glycobiology with significant implications for health and disease. Under the guidance of Dr. Paola Rota and Dr. Marco Piccoli, this Special Issue delves into the multifaceted roles of sialic acid within biological systems, encompassing its crucial functions in cellular communication, pathogen interactions, and its potential as a biomarker for various diseases.

Sialic acid research is at the cutting edge of numerous scientific fields, from elucidating fundamental cellular mechanisms to pioneering innovative therapeutic approaches. This Special Issue aims to consolidate research that investigates the biosynthesis, modification, and functional significance of sialic acid, alongside its promising applications in drug development and diagnostics.

We invite potential authors to submit a brief abstract or tentative title to our editorial office for consideration. If your topic aligns with the scope of this Special Issue, you will be invited to submit a full manuscript. We are particularly interested in contributions covering, but not limited to, the following topics:

  • Structural and functional analysis of sialic acid and its derivatives.
  • The role of sialic acid in cellular communication and immune response.
  • Sialic acid as a target for therapeutic intervention in infectious and chronic diseases.
  • Technological advances in the detection and analysis of sialic acid.
  • The influence of sialylation on the function and stability of proteins.

Join us in advancing the frontiers of sialic acid research and contribute to this important dialogue in biomedicine.

Dr. Paola Rota
Dr. Marco Piccoli
Guest Editors

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Keywords

  • sialic acid
  • drug development
  • sialidase inhibitors
  • sialylation
  • sialidase
  • biomarker

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Published Papers (1 paper)

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Research

19 pages, 3174 KiB  
Article
Expression of 9-O-Acetylated Sialic Acid in HPV+ Oral Squamous Cell Carcinoma Cells
by Hugo Sánchez-Martínez, Victoria Jiménez-Castillo, Daniela Illescas-Barbosa, Beatriz Xochitl Ávila-Curiel, María Teresa Hernández-Huerta, Risk Díaz-Castillejos, Rafael Torres-Rosas, Edgar Zenteno, Mohamed Alí Pereyra-Morales and Carlos Josué Solórzano-Mata
Life 2025, 15(4), 663; https://doi.org/10.3390/life15040663 - 17 Apr 2025
Viewed by 585
Abstract
Oral squamous cell carcinoma (OSCC) is a common type of head and neck malignancy that represents a significant global health issue. Sialylations are common events in tumor transformation, proliferation, metastasis, and immune evasion. Modifications in sialylation can be detected by lectins, whose changes [...] Read more.
Oral squamous cell carcinoma (OSCC) is a common type of head and neck malignancy that represents a significant global health issue. Sialylations are common events in tumor transformation, proliferation, metastasis, and immune evasion. Modifications in sialylation can be detected by lectins, whose changes in OSCC have been related to grade, invasion, and metastasis. The presence of 9-O-acetylated sialic acid (Neu5,9Ac2) in OSCC cells and its potential expression, modification, and role are unknown. This study aimed to analyze the expression of Neu5,9Ac2 using the Macrobrachium rosenbergii lectin (MrL) that recognizes this sialic acid (Neu5Ac) residue and also compare its effect on the SCC-152 cell line (CRL-3240, ATCC) and immortalized keratinocytes (HaCaT) as a control. We observed by immunocytochemistry that SCC-152 cells expressed more Neu5,9Ac2 compared to HaCaT cells; the specificity of MrL was confirmed after the sialidase treatment of cells in which the loss of lectin’s recognition of Neu5,9Ac2 was observed. The electrophoretic profile was similar between both cell line types; however, the Western blot showed differences in the glycoprotein patterns recognized by lectin for each cell type. MrL increased the proliferation of SCC-152 cells, as well as the integrity and morphology of the colonies. Therefore, our results suggest that Neu5,9Ac2 glycosylated receptors could be involved in the survival and proliferation of OSCC cells, which offers a promising avenue for developing diagnostic and prognostic tools (tumor markers) against oral squamous cell carcinoma in the future. Full article
(This article belongs to the Special Issue Sialic Acid and Sialic Acid Derivatives in Biomedicine)
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