Research on Gastrointestinal Cancer and Nutritional Health

A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Medical Research".

Deadline for manuscript submissions: 31 October 2025 | Viewed by 366

Special Issue Editors


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Guest Editor
1. Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA
2. Department of Occupational Medicine, Cambridge Health Alliance, Cambridge, MA, USA
Interests: clinical nutrition; oncology; gastrointestinal cancer surgery; public health; geriatrics; sarcopenia
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Guest Editor
First Department of Surgery, Laiko Hospital, Medical School, National and Kapodistrian University, Athens, Greece
Interests: gastrointestinal cancer; gastric cancer surgery; esophageal cancer surgery; pancreatic cancer surgery; oncology; nutrition

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Guest Editor
Department of Surgery, Ierapetra General Hospital, Ierapetra, Greece
Interests: gastrointestinal cancer; gastric cancer surgery; esophageal cancer surgery; pancreatic cancer surgery; oncology; nutrition

Special Issue Information

Dear Colleagues,

Gastrointestinal (GI) cancers remain a significant global health challenge, contributing to high morbidity and mortality rates. Given the direct impact of nutrition on the GI system, its role in the prevention, progression, and management of GI cancers is critical, with nutrition influencing key risk factors, treatment outcomes, and overall patient quality of life. Moreover, nutritional status significantly affects both short- and long-term outcomes in patients diagnosed with GI cancer, particularly following surgery and/or adjuvant therapies. Despite growing evidence linking dietary behavior, dietary patterns, specific nutrients/foods, and inflammation to GI cancer pathophysiology, many questions remain unanswered.

This Special Issue aims to explore the complex interplay between nutrition and GI cancers, addressing key topics such as the epidemiological associations between diet and GI cancer development, dietary interventions for prevention and treatment, the impact of malnutrition and cachexia on cancer progression, gut microbiome interactions, and the role of precision nutrition in patient care. By bringing together cutting-edge studies, we seek to advance our understanding of how nutritional interventions can reduce the risk of developing GI cancer and improve clinical outcomes and overall well-being for individuals affected by these cancers.

We welcome original research, systematic reviews, and clinical studies that contribute to this vital area of investigation. 

Dr. Irene Lidoriki
Dr. Adam Mylonakis
Dr. Dimitrios Tsapralis
Guest Editors

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Keywords

  • dietary patterns
  • gastrointestinal cancer
  • clinical nutrition
  • nutritional status
  • nutritional assessment
  • metabolism
  • gastric cancer
  • esophageal cancer
  • pancreatic cancer
  • colorectal cancer

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Published Papers (1 paper)

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Research

15 pages, 547 KiB  
Article
Exploring the Link Between Nutritional and Functional Status and Short-Term Postoperative Outcomes in Patients Undergoing Pancreatic Cancer Surgery
by Irene Lidoriki, Maximos Frountzas, Eva Karanikki, Adam Mylonakis, Alexandros Kozadinos, Iliana Tsikrikou, Maria Kyriakidou, Lysandros Karydakis, Dimitrios Stefanoudakis, Maria Lampou, Michail Vailas, Evangelos Felekouras, Konstantinos G. Toutouzas and Dimitrios Schizas
Life 2025, 15(5), 803; https://doi.org/10.3390/life15050803 - 18 May 2025
Viewed by 216
Abstract
Background: Patients with pancreatic cancer are at increased risk of malnutrition and functional decline. This study aimed to identify preoperative nutritional and functional risk factors associated with postoperative complications. Methods: Adult patients with pancreatic cancer admitted to two university surgical departments in Athens, [...] Read more.
Background: Patients with pancreatic cancer are at increased risk of malnutrition and functional decline. This study aimed to identify preoperative nutritional and functional risk factors associated with postoperative complications. Methods: Adult patients with pancreatic cancer admitted to two university surgical departments in Athens, Greece, were included. Preoperative laboratory values, nutritional status, and functional status were assessed. Results: Among 96 patients included in this study, postoperative complications occurred in 69 (71.9%). Complication rates were significantly higher in patients with severe malnutrition (87.9% vs. 62.7%, p = 0.015), low Geriatric Nutritional Risk Index (GNRI) (90.5% vs. 66.2%, p = 0.023), low handgrip strength (91.7% vs. 61.5%, p = 0.037), and low gait speed (90.5% vs. 63.6%, p = 0.027). Major complications were linked to lower hemoglobin (Hb) (11.5 ± 1.9 vs. 12.8 ± 1.7 g/dL, p = 0.001), lower hematocrit (HCT) (34.7 ± 5.4% vs. 38.4 ± 4.7%, p = 0.001), and severe malnutrition (42.4% vs. 23.7%, p = 0.05). Lower Hb, lower HCT, malnutrition, and greater waist circumference were associated with postoperative mortality. Longer hospital stays were correlated with weaker handgrip strength and slower gait speed. Conclusion: Preoperative malnutrition and impaired functional status are significant predictors of adverse postoperative outcomes in pancreatic cancer surgery. Full article
(This article belongs to the Special Issue Research on Gastrointestinal Cancer and Nutritional Health)
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