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Life
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Update on Obstructive Sleep Apnea (OSA)
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Update on Obstructive Sleep Apnea (OSA)

A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Physiology and Pathology".

Deadline for manuscript submissions: 30 June 2026 | Viewed by 1280

Special Issue Editor

Dr. Konstantinos Chaidas

E-Mail Website
Guest Editor
Ear, Nose, and Throat Department, University Hospital of Alexandroupolis, School of Medicine, Democritus University of Thrace, Alexandroupolis, Greece
Interests: obstructive sleep apnoea; snoring; robotic surgery; thyroid surgery; parathyroid surgery; head and neck; paediatric otorhinolaryngology; rhinology
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Obstructive sleep apnea (OSA) is the most common form of sleep-disordered breathing and is characterized by recurrent episodes of complete or partial upper airway obstruction during sleep, resulting in oxygen desaturation, autonomic dysfunction and sleep fragmentation. It can affect both children and adults, and the main clinical symptoms include loud snoring, witnessed apneas and breathing difficulties during sleep. Overnight polysomnography is the gold-standard method for diagnosing OSA. Although OSA is common, it is a frequently unrecognized cause of serious disability with serious health and social consequences. If untreated, OSA may cause impaired cognitive ability, road traffic accidents, cardiovascular morbidity and all-cause mortality. 

Various therapeutic options for OSA exist. CPAP is the standard treatment for adult OSA, although its clinical application can be compromised by intolerance and poor compliance, while adenotonsillectomy is the primary treatment option for children with OSA and adenotonsillar hypertrophy.

We encourage authors to submit original or review articles on related topics in the field of sleep apnea.

For access to our previous publications, please visit:

The first volume of this Special Issue (https://www.mdpi.com/journal/life/special_issues/O_S_A) and the second volume (https://www.mdpi.com/journal/life/special_issues/6T762OATJ0).

Dr. Konstantinos Chaidas
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Life is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • obstructive sleep apnea
  • snoring
  • sleep-disordered breathing
  • adult sleep apnea
  • pediatric sleep apnea

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Published Papers (2 papers)

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11 pages, 395 KB  
Article
The Relationship Between Hepcidin and the Severity of Obstructive Sleep Apnea Syndrome and Obesity
by Hikmet Coban, Emine Ayan, Mustafa Colak, Nurhan Sarioglu, Gulcin Yilmaz Gunes, Fuat Erel, Merve Yumrukuz Senel and Merve Akış Yılmaz
Life 2026, 16(4), 629; https://doi.org/10.3390/life16040629 - 8 Apr 2026
Viewed by 374
Abstract
The effects of chronic intermittent hypoxia associated with obstructive sleep apnea (OSA) on iron metabolism remain incompletely understood. This study aimed to evaluate whether serum hepcidin levels are associated with OSA severity independently of obesity and systemic inflammation. A total of 136 patients [...] Read more.
The effects of chronic intermittent hypoxia associated with obstructive sleep apnea (OSA) on iron metabolism remain incompletely understood. This study aimed to evaluate whether serum hepcidin levels are associated with OSA severity independently of obesity and systemic inflammation. A total of 136 patients who underwent polysomnography for suspected OSA between April and December 2025 were included in the study. Participants were classified into control and OSA groups according to the Apnea–Hypopnea Index (AHI), and the OSA group was further categorized as mild, moderate, or severe. Demographic and anthropometric characteristics and Epworth Sleepiness Scale scores were recorded. Serum hepcidin levels were measured using an ELISA method and compared between groups, and their associations with clinical and polysomnographic parameters were analyzed. Serum hepcidin levels were significantly higher in patients with OSA than in the control group (48.83 ± 11.92 vs. 41.53 ± 12.43 ng/mL; p < 0.001) and increased progressively with disease severity. Hepcidin levels were not significantly correlated with conventional iron parameters but showed a strong positive association with the Oxygen Desaturation Index (ODI). In multivariable regression analysis, the positive relationship between AHI and serum hepcidin levels remained significant after adjustment for body mass index and C-reactive protein levels (p < 0.001). These findings suggest that elevated serum hepcidin levels in OSA are linked to hypoxic stress independently of obesity and systemic inflammation, indicating that hepcidin may represent a potential biomarker reflecting disease severity in OSA. Full article
(This article belongs to the Special Issue Update on Obstructive Sleep Apnea (OSA))
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9 pages, 731 KB  
Systematic Review
Standalone Transoral Robotic Surgery for Obstructive Sleep Apnoea: A Systematic Literature Review of Clinical Outcomes
by Konstantinos Chaidas and Stavroula Mouratidou
Life 2026, 16(2), 332; https://doi.org/10.3390/life16020332 - 14 Feb 2026
Viewed by 483
Abstract
Transoral robotic surgery (TORS) offers a targeted surgical option for addressing base of tongue (BOT) and epiglottic obstruction in selected obstructive sleep apnoea (OSA) cases; however, most published evidence evaluates TORS within multilevel approaches, limiting understanding of single-level outcomes. A PRISMA-guided systematic review [...] Read more.
Transoral robotic surgery (TORS) offers a targeted surgical option for addressing base of tongue (BOT) and epiglottic obstruction in selected obstructive sleep apnoea (OSA) cases; however, most published evidence evaluates TORS within multilevel approaches, limiting understanding of single-level outcomes. A PRISMA-guided systematic review of PubMed, Embase, and Central Cochrane was conducted from inception to March 2025, aiming to evaluate objective sleep outcomes and patient-reported measures following single-level TORS BOT surgery. Inclusion criteria were adult patients with moderate-to-severe OSA and CPAP failure/intolerance, with evidence of BOT hypertrophy. Of 219 screened records, five studies met the inclusion criteria with 105 patients. Eighty-six (81.9%) were male with a combined mean age of 45.2 years and BMI of 28.2 kg/m2. Combined mean AHI improved from 34.2 preoperatively to 14.7 events/hour postoperatively. Reported surgical success ranged from 54.2% to 100%. Where reported, ESS improved postoperatively with a combined mean reduction from 13 to 4.5. Most commonly reported complications were dysgeusia (n = 16, 15.2%), dysphagia/odynophagia (n = 14, 13.3%), and postoperative bleeding (n = 10, 9.5%). Single-level TORS BOT appears to improve objective and subjective outcomes in carefully selected patients, although heterogeneity and inconsistency of reported outcomes limit definitive conclusions and highlight the need for standardised outcome reporting and follow-up. Full article
(This article belongs to the Special Issue Update on Obstructive Sleep Apnea (OSA))
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