Sleep-Disordered Breathing: Key Pathophysiological Mechanisms and Their Clinical Implications
A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Physiology and Pathology".
Deadline for manuscript submissions: 30 June 2026 | Viewed by 7
Special Issue Editor
Interests: obstructive sleep apnoea; sleep fragmentation; inflammation; exosome and biomarkers; cardio-metabolic disease; epigenetics; mesenchymal stem cell
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Sleep-disordered breathing (SDB) is a condition characterized by abnormal respiratory events during sleep. The underlying pathophysiology of this condition involves recurrent upper airway collapse, resulting from obesity, anatomical predisposition, neuromuscular dysfunction, and compromised pharyngeal dilator muscle activity during sleep. The cyclical pattern of airway obstruction, hypoxemia, and arousal triggers a cascade of pathological mechanisms that extend far beyond respiratory dysfunction. Intermittent hypoxia activates the sympathetic nervous system, leading to increased risk of hypertension and cardiovascular disease. Oxidative stress and systemic inflammation have been demonstrated to contribute to endothelial dysfunction and accelerated atherosclerosis. Moreover, the impact of SDB on metabolic homeostasis is significant, manifesting in the disruption of glucose metabolism, the development of insulin resistance, and the alteration of adipokine regulation. Recently, neuroinflammation and compromised glymphatic clearance during fragmented sleep have been demonstrated to contribute to cognitive impairment and neurodegenerative processes. In this Special Issue, we will cover recent outstanding findings regarding treatment strategies, biomarkers, and the pathophysiological mechanisms of diseases associated with SDB. This integrated approach is expected to provide readers with a better understanding of the pathophysiological consequences of SDB, from basic research to clinical practice.
Dr. Jinkwan Kim
Guest Editor
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Keywords
- sleep-disordered breathing
- sleep fragmentation
- inflammation
- cardiovascular disease
- insulin resistance
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