Advances in the Glyoxalase Pathway: Implications for Oxidative Stress Management in Cancer Therapy and in Age-related Disease
A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Physiology and Pathology".
Deadline for manuscript submissions: 30 November 2025 | Viewed by 74
Special Issue Editors
Interests: oxidative stress and redox signaling; inflammation; glyoxalase system; aging and age-related disease
Interests: neurobiology of aging; inflammation; aging and age-related disease
Special Issue Information
Dear Colleagues,
The glyoxalase system, discovered in 1913, represents a ubiquitous enzymatic network, and it is considered one of the most important pathways for the detoxification of methylglyoxal (MG) and advanced glycation end-products (AGEs). The glyoxalase system is composed of two enzymes—glyoxalase 1 (GLO1) and glyoxalase 2 (GLO2)—and a catalytic amount of reduced glutathione (GSH). GLO1 is a rate-limiting enzyme that catalyzes the conversion of the MGO-GSH hemithioacetal to the thioester S-d-lactoylglutathione. GLO2 catalyzes the hydrolysis of SLG to D-lactic acid, regenerating the GSH consumed in the first reaction. Since glyoxalase system plays an important role in biological metabolism, its impairment and/or the elevated levels of MG and AGEs are often associated with several pathologies, including cancer and age-related diseases.
For this Special Issue, we invite authors to submit contributions in the form of original research articles or review articles to provide a comprehensive update on the glyoxalase system and the consequences of its impairment in relation to its role in the pathophysiology of several diseases. It is hoped that this Special Issue will contribute to the establishment of possible therapeutic approaches for conditions associated with oxidative stress and dicarbonyl accumulation
Dr. Laura Cianfruglia
Dr. Salvatore Vaiasicca
Guest Editors
Manuscript Submission Information
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Keywords
- glyoxalase system
- methylglyoxal
- advanced glycation end-products
- dicarbonyl stress
- oxidative stress
- age-related disease
- cancer
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