Extracellular Vesicles: Biology, Mechanisms, and Therapies for Cerebrovascular Disorders
A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Physiology and Pathology".
Deadline for manuscript submissions: 30 June 2026 | Viewed by 1
Special Issue Editor
Interests: extracellular vesicles; microRNAs; stroke; vascular cognitive impairment and dementia; aging; hypertension; exercise; neuroinflammation; angiogenesis; neurogenesis
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Extracellular vesicles (EVs) are emerging as vital mediators of intercellular communication across a wide spectrum of physiological and pathological processes. Once considered cellular waste carriers, EVs are now recognized as active conveyors of bioactive molecules such as RNAs, proteins, lipids, and metabolites. Their ability to cross biological barriers, particularly the blood-brain barrier, has generated tremendous interest in their roles within the central nervous system and their potential as diagnostic biomarkers and therapeutic delivery vehicles.
Increasing evidence suggest that dysregulation of EV cargo and trafficking contributes to the pathogenesis of cerebrovascular diseases. Furthermore, engineered EVs and EV-mimetic systems have shown promise as innovative therapeutic platforms for targeted drug delivery, gene regulation, and tissue repair. Despite this progress, key challenges remain, such as limited understanding of their biodistribution and targeting mechanisms for clinical application.
The scope of this special issue is to bring together recent advances and challenges in EV biology, engineering, and translational applications, with a particular emphasis on cerebrovascular diseases. We invite original research articles, reviews, and perspectives that advance our understanding of mechanistic, diagnostic, and therapeutic dimensions of EVs in the context of cerebrovascular disorders, including stroke, vascular cognitive impairment and dementia, aneurysms, arteriovenous malformation, cerebral small vessel diseases, cerebral amyloid angiopathy, etc. Submissions covering cross-disciplinary themes, such as biomaterials, nanomedicine, or computational analysis, are also encouraged.
Dr. Jinju Wang
Guest Editor
Manuscript Submission Information
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Keywords
- extracellular vesicles
- cerebrovascular disorders
- dementia
- extracellular vesicle-based therapy
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