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Life publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Animal Reproduction and Health

edited by

Rachel Moxon

and

Ana Faustino

submission deadline 31 Dec 2025 | Viewed by 148 | Submission Open

Keywords: animal; reproduction; genetics; heritability; disease; fertility; sperm; health; pregnancy; neonatal health and development; microbiome health and development

(This special issue belongs to the Section Animal Science)

Plant Adaptation Mechanisms to Abiotic Stresses

edited by Sunchung Park and Ezekiel Ahn

submission deadline 31 Dec 2025 | Viewed by 141 | Submission Open

Keywords: abiotic stress; plant adaptation mechanisms; cold; heat; drought; salinity; flooding; waterlogging; transcription factors

(This special issue belongs to the Section Plant Science)

Move to Thrive: Pioneering Health and Resilience Through Physical Activity

edited by

Silvana Mirella Aliberti

Franca Di Meglio

and

Daria Nurzynska

submission deadline 31 Dec 2025 | Viewed by 134 | Submission Open

Keywords: physical activity; inflammation modulation; chronic disease prevention; immune system adaptation; biomechanics; rehabilitation strategies; sports medicine; aging and physical activity; disability and movement; environmental and regional influences on exercise

Brain Barrier Research: Mechanisms, Function, Regulation, and Therapeutic Medicine

edited by

Ana Catarina Duarte

submission deadline 31 Dec 2025 | Viewed by 112 | Submission Open

Keywords: brain barriers; brain homeostasis; neurodegeneration; neuroinflammation; brain drug delivery

(This special issue belongs to the Section Physiology and Pathology)

Airway Management in Emergency and Intensive Care Medicine

edited by Prashant Nasa and Tonny V. Veenith

submission deadline 31 Dec 2025 | Viewed by 112 | Submission Open

Keywords: airway management; critical care; laryngoscopy; intubation; intratracheal; emergency treatment

(This special issue belongs to the Section Medical Research)

Artificial Intelligence in Cardiovascular Diseases: Research, Technology and Clinical Practice

edited by

Dimitris Tousoulis

submission deadline 31 Dec 2025 | Viewed by 105 | Submission Open

Keywords: cardiovascular disease; artificial intelligence; atherosclerosis; atrial fibrillation; cardiomyopathy

(This special issue belongs to the Section Medical Research)

Bioactive Compounds for Medicine and Health

edited by

Christiana Charalambous

and

Alexandru Vasincu

submission deadline 31 Dec 2025 | Viewed by 94 | Submission Open

Keywords: phytochemistry; bioactive compounds; cancer; immune modulation; heart disease; diabetes; obesity; neurodegenerative diseases; neuroprotection

(This special issue belongs to the Section Pharmaceutical Science)

The Biology and Functions of Platelets: Emerging Challenges

edited by

Robert Maitta

and Miriam Andrea Duque

submission deadline 31 Dec 2025 | Viewed by 83 | Submission Open

Keywords: platelet; hemostasis; toll-like receptor; immunity; phagocytosis; transfusions; von Willebrand factor; thrombocyte

(This special issue belongs to the Section Physiology and Pathology)

Novel Biomaterial-Based Fertilizing Products and Bio-Fertilizers for Sustainable Agricultural Production: 2nd Edition

edited by

and

submission deadline 31 Dec 2025 | Viewed by 82 | Submission Open

Keywords: biomaterials and bio-nanomaterials; bio-based hydrogels and polymers; lignocellulosic biomass and its derivatives; sustainable agriculture; biodegradability; stimuli-responsive fertilizer delivery; controlled-release fertilizers; bio-synthesis processes and characterization; control/sustained fertilizer release mechanisms; bio-fertilizers; plant growth-promoting microbes; fertilizers’ use efficiency; plant physiology; productivity; and quality

(This special issue belongs to the Section Plant Science)

Origin of Life in Chemically Complex Messy Environments: 3rd Edition

edited by

Ranajay Saha

and

Alberto Vázquez-Salazar

submission deadline 31 Dec 2025 | Viewed by 80 | Submission Open

Keywords: origin of life; complex chemical systems ; prebiotic chemistry ; prebiotic metabolisms ; chemical evolution ; prebiotic catalysts

(This special issue belongs to the Section Origin of Life)

Cutting-Edge Research in Rhinology and Allergy: Unraveling Disease Mechanisms and Treatment Innovations

edited by Min-Seok Rha

submission deadline 31 Dec 2025 | Viewed by 68 | Submission Open

Keywords: rhinology; allergy; chronic rhinosinusitis; allergic rhinitis; asthma; precision medicine; clinical immunology; immunopathology; therapeutic innovation

Advancements in Heart Failure Research: 2nd Edition

edited by Tzu-Hurng Cheng,

Ju-Chi Liu

and

Po-Yuan Chen

submission deadline 31 Dec 2025 | Viewed by 67 | Submission Open

Keywords: cardiac remodeling; biomarkers; precision medicine; patient-centered care; therapeutic innovations

(This special issue belongs to the Section Physiology and Pathology)

Leveraging the Power of Enzymes in Biotechnological Applications

edited by

Shengwei Sun

submission deadline 31 Dec 2025 | Viewed by 57 | Submission Open

Keywords: enzyme; 3D structure; function/activity; enzyme engineering; beneficial variants; industrial application

Coagulation and Its Disorders: Diagnostics, Therapeutics, and Clinical Management

edited by

Anna Lisa Montemari

submission deadline 31 Dec 2025 | Viewed by 56 | Submission Open

Keywords: coagulation; bleeding disorders; disseminated intravascular coagulation; fibrinolysis; new diagnostic tools and treatment; inflammation and coagulation disorders; thrombosis; platelet disorders; coagulation alterations induced by hepatic and metabolic disorders; drug-induced coagulation alterations

Effects of Exercise and Functional Interventions on Musculoskeletal Health

edited by

Seong-Gil Kim

submission deadline 31 Dec 2025 | Viewed by 55 | Submission Open

Keywords: musculoskeletal health; exercise; physical function; joint stability; fall prevention; rehabilitation science

(This special issue belongs to the Section Medical Research)

Postharvest Softening, Flavor and Quality of Fruits: Molecular Mechanisms and Regulatory Approaches

edited by Qinggang Zhu and Yaxiu Xu

submission deadline 31 Dec 2025 | Viewed by 49 | Submission Open

Keywords: fruit softening; fruit quality; fruit flavor; molecular mechanisms; regulatory approaches

(This special issue belongs to the Section Plant Science)

Traumatic Brain Injury: Epidemiology, Diagnosis, Treatment and Biomarkers

edited by

Jeff Victoroff

and

Alfredo Conti

submission deadline 31 Dec 2025 | Viewed by 43 | Submission Open

Keywords: traumatic brain injury; neurotrauma; epidemiology; rehabilitation; neurological disorders; biomarkers

(This special issue belongs to the Section Physiology and Pathology)

Understanding Brain Disorders Through EEG and AI

edited by Debashis Das Chakladar and

Giuseppe Augusto Chiarenza

submission deadline 31 Dec 2025 | Viewed by 41 | Submission Open

Keywords: EEG; ADHD; Alzheimer’ s; Parkinson’ s; neurological disorders; machine learning; deep learning

(This special issue belongs to the Section Radiobiology and Nuclear Medicine)

Impact of Environmental Factors on the Diversity and Structure of Bacterial and Eukaryotic Communities

edited by

Jun Noda

and

Daisuke Tanaka

submission deadline 31 Dec 2025 | Viewed by 40 | Submission Open

Keywords: environmental factors; bacterial and eukaryotic communities; climate adaptation; pollution; microbial resilience; metagenomic analysis; amplicon sequencing; bioinformatics

(This special issue belongs to the Section Microbiology)

Research on Female Reproductive Health and Metabolism

edited by

Alice Bongrani

submission deadline 31 Dec 2025 | Viewed by 33 | Submission Open

Keywords: female reproduction; metabolism; nutrition; adipose tissue; hypothalamus– pituitary– gonadal axis; insulin resistance; adipocytokines; reproductive disorders; PCOS

(This special issue belongs to the Section Physiology and Pathology)

Advances in Artificial Intelligence for Medical Image Analysis: 2nd Edition

edited by

Xin Jin

submission deadline 31 Dec 2025 | Viewed by 30 | Submission Open

Keywords: artificial intelligence; medical imaging; deep learning for medical imaging; histopathological image analysis; medical diagnosis; visualization in biomedical imaging; magnetic resonance imaging (MRI); X-ray computed tomography (CT); positron emission tomography (PET); medical image fusion

(This special issue belongs to the Section Medical Research)

Biochemical Modulators in Chronic Diseases: The Antioxidant/Anti-Inflammatory Interdependence—2nd Edition

edited by

Emma Borrelli

submission deadline 31 Dec 2025 | Viewed by 28 | Submission Open

Keywords: oxidative stress; inflammation; redox modulator; anti-inflammatory agents; chronic diseases; antioxidant paradox; reactive oxygen species

(This special issue belongs to the Section Pharmaceutical Science)

An Integrated Approach on Diagnosis and Treatment of Cerebral Veins and Intracranial Dural Sinuses Thrombosis (CVT)

edited by

Dragos Catalin Jianu

and

Dafin Fior Muresanu

submission deadline 31 Dec 2025 | Viewed by 28 | Submission Open

Keywords: cerebral veins and intracranial dural sinuses thrombosis (CVT); thrombophilia; intracranial hypertension; non-enhanced computer tomography (NECT) of the head; computer tomography venography (CTV); magnetic resonance imaging (MRI) of the head; magnetic resonance venography (MRV); anticoagulation

Recent Advances in Left Ventricular Unloading Therapy

edited by Mehmet Oezkur

submission deadline 31 Dec 2025 | Viewed by 27 | Submission Open

Keywords: left ventricular unloading therapy; cardiovascular medicine; heart failure; acute myocardial infarction

(This special issue belongs to the Section Medical Research)

Language Models in Lab Coats: AI-Powered Biomedical Interpretation

edited by Sebastian Sanduleanu

submission deadline 31 Dec 2025 | Viewed by 23 | Submission Open

Keywords: radiology; large language models; artificial intelligence; radiobiology

(This special issue belongs to the Section Medical Research)

Non-Conventional Approaches in Modern Biological Analysis and Medical Diagnostics

edited by

Anna Baraniak

and

Paweł Rudnicki-Velasquez

submission deadline 31 Dec 2025 | Viewed by 12 | Submission Open

Keywords: biological samples; non-conventional analytical techniques; life science; diagnostics; proteins

Innovations in Dairy Cattle Health and Nutrition Management

edited by Rasa Želvytė and Ingrida Monkevičienė

submission deadline 15 Jan 2026 | 1 articles | Viewed by 887 | Submission Open

Keywords: innovations; dairy cattle; health; nutrition; rumen; metabolism; biomarkers

(This special issue belongs to the Section Animal Science)

Research Progress in Kidney Diseases

edited by Ane Claudia Fernandes Nunes

submission deadline 15 Jan 2026 | Viewed by 105 | Submission Open

Keywords: chronic kidney disease; acute kidney injury; hemodialysis; nephrology; renal failure; hypertension; diabetes; molecular genetics

Biological Identity and Relationships Along the Nile

edited by

Kanya Godde

submission deadline 15 Jan 2026 | Viewed by 42 | Submission Open

Keywords: Nubia; Egypt; population genetics; Nile; biological affinity

Multi-Omics Approaches for Gut Microbiota Research: Implications for Human Nutrition

edited by

Georgia Saxami

and Antonio Benedetti

submission deadline 16 Jan 2026 | Viewed by 5 | Submission Open

Keywords: gut microbiota; multi-omics; metagenomics; metabolomics; host– microbiome interactions; precision nutrition; dietary interventions

(This special issue belongs to the Section Microbiology)

Advances in Bioprinting, Tissue Engineering, and Regenerative Medicine

edited by

Adrian Neagu

submission deadline 18 Jan 2026 | 2 articles | Viewed by 2953 | Submission Open

Keywords: model tissues; scaffolds; biocompatible materials; biodegradable materials; tissue-on-a-chip; organoids

(This special issue belongs to the Section Cell Biology and Tissue Engineering)

Knee Bracing in Human Movement: Biomechanics, Artificial Intelligence, and Optimization

edited by

Zixiang Gao

and Liangliang Xiang

submission deadline 20 Jan 2026 | Viewed by 23 | Submission Open

Keywords: knee bracing; sports biomechanics; neuromechanical mechanisms; gait analysis; functional movement adaptation; AI in orthotics; AI for brace performance; musculoskeletal modeling; finite element simulation; real-time monitoring of knees; human-in-the-loop control; robotic exoskeleton integration; human– machine interaction; rehabilitation or injury prevention

Microbial Diversity and Function in Aquatic Environments

edited by Xianglong Chen and

Liang Guo

submission deadline 30 Jan 2026 | 1 articles | Viewed by 2763 | Submission Open

Keywords: aquatic environment; microbial diversity and function; element biogeochemical cycle; interaction between microorganisms and aquatic environments; metaomic approaches

(This special issue belongs to the Section Microbiology)

Advancing Nanotechnology in Cancer Theranostics

edited by

Yulia Merkher

submission deadline 30 Jan 2026 | 1 articles | Viewed by 1775 | Submission Open

Keywords: nanotechnology; cancer; nanoscale materials; nanoparticles; diagnostic accuracy; therapeutic efficacy; metastasis detection and prediction; targeted drug delivery; personalized cancer therapy

(This special issue belongs to the Section Medical Research)

Metabolic Research in Animal Nutrition

edited by

Sylwia Szymańczyk

Marek Bienko

and

Radosław P. Radzki

submission deadline 30 Jan 2026 | Viewed by 354 | Submission Open

Keywords: nutrition; supplementation; microbiota; obesity; metabolic syndrome; metabolic disorders and diseases; hormonal factors; development and metabolism; metabolomics; nutrigenomics

(This special issue belongs to the Section Animal Science)

3D Imaging and Facial Reconstruction

edited by Marios Papadakis

submission deadline 30 Jan 2026 | Viewed by 351 | Submission Open

Keywords: 3D imaging; facial plastic surgery; reconstructive surgery; virtual surgical planning; custom implants; preoperative planning; intraoperative navigation

(This special issue belongs to the Section Medical Research)

Targeting Hormonal Regulation in Prostate Cancer

edited by Marília Figueira

submission deadline 30 Jan 2026 | Viewed by 263 | Submission Open

Keywords: prostate cancer; castrate resistant prostate cancer (CRPC); metastatic prostate cancer; estrogens; estrogen receptors; drug resistance

(This special issue belongs to the Section Medical Research)

Physical Medicine and Rehabilitation: Trends and Applications—4th Edition

edited by

and

submission deadline 30 Jan 2026 | Viewed by 41 | Submission Open

Keywords: clinical physical medicine and rehabilitation; neurorehabilitation; cardiopulmonary rehabilitation; orthopedic rehabilitation; pediatric rehabilitation; geriatric rehabilitation; cancer rehabilitation; musculoskeletal pain management; physical therapy; occupational therapy; speech and swallowing therapy

(This special issue belongs to the Section Epidemiology)

New Advances in Neuroimaging and Brain Functions: 2nd Edition

edited by

Ming-Chang Chiang

and

Chiahui Yen

submission deadline 31 Jan 2026 | 3 articles | Viewed by 11525 | Submission Open

Keywords: neuroimaging; brain functions; neurological diseases; humanities and social sciences; noninvasive methods; AI deep learning

(This special issue belongs to the Section Radiobiology and Nuclear Medicine)

Pain and Therapy: Historical Perspectives and Future Directions

edited by

Francesco Scaglione

and

Arianna Pani

submission deadline 31 Jan 2026 | 4 articles | Viewed by 3693 | Submission Open

Keywords: pain; nociceptive pain; neuropathic pain; neoplastic pain; pain physiology; pain treatment

(This special issue belongs to the Section Medical Research)

Natural Products and Modern Drug Discovery: Emerging Strategies Targeting Cancer- and Disease-Related Molecular Mechanisms

edited by

Chia-Jui Weng

submission deadline 31 Jan 2026 | Viewed by 498 | Submission Open

Keywords: natural products; phytochemicals; drug discovery; bioactivity profiling; pharmacophore modeling; synthetic biology; cancer therapy; microbial metabolites

(This special issue belongs to the Section Medical Research)

Common and Novel Markers of Inflammation and Tissue Damage in Various Pathological Conditions—2nd Edition

edited by

Marzena Tylicka

Joanna Kamińska

and

Olga Koper-Lenkiewicz

submission deadline 31 Jan 2026 | 1 articles | Viewed by 445 | Submission Open

Keywords: body fluids; cytokines; damage-associated molecular patterns (DAMPs); inflammatory response; injury; markers of inflammation and tissue damage; metalloproteinases; novel markers; pathological conditions; proteasome; tissue damage; tissue repair processes; various diseases

(This special issue belongs to the Section Physiology and Pathology)

Advances in Cardiac Arrest: Prognostic Performance and Management

edited by

Kei Hayashida

submission deadline 31 Jan 2026 | Viewed by 240 | Submission Open

Keywords: cardiac arrest; resuscitation; emergency medicine; critical care medicine

(This special issue belongs to the Section Medical Research)

Pig Microbiota Metabolism and Intestinal Health

edited by

Qi-Ye Wang

submission deadline 31 Jan 2026 | Viewed by 71 | Submission Open

Keywords: pig microbiota; metabolism; intestinal health; gut microbiome; functional genomics; microbiome-host interactions; animal nutrition; disease resistance; gut barrier function; omics technologies; immune function; antibiotic reduction; feed efficiency; pathogen control; gastrointestinal health

(This special issue belongs to the Section Animal Science)

Plant–Soil Interactions Under Global Change

edited by

Tao Zhang

submission deadline 31 Jan 2026 | Viewed by 57 | Submission Open

Keywords: plant– soil interactions; biodiversity; ecosystem; agroecosystem; natural ecosystem; sustainable development

(This special issue belongs to the Section Plant Science)

Prevention, Diagnosis, and Treatment of Gestational Diseases

edited by

Andrea Suranyi

submission deadline 31 Jan 2026 | Viewed by 52 | Submission Open

Keywords: gestational diseases; gestational diabetes; preeclampsia; pregnancy complications

(This special issue belongs to the Section Medical Research)

Intracerebral Hemorrhage: Advances and Perspectives

edited by Ane Claudia Fernandes Nunes

submission deadline 31 Jan 2026 | Viewed by 52 | Submission Open

Keywords: intracerebral hemorrhage; microangiopathic disease; cerebral microhemorrhages blood– brain barrier; small vessel disease

(This special issue belongs to the Section Physiology and Pathology)

The Role of Mitochondrial Function in Cancer and Diseases and Therapeutic Explorations

edited by

Amer Ahmed

and

Barbara Illi

submission deadline 31 Jan 2026 | Viewed by 42 | Submission Open

Keywords: cancer metabolism; mitochondrial DNA (mtDNA) mutations; oxidative stress; mitophagy and autophagy; mitochondria-targeted therapy; metabolic reprograming; mitochondrial dynamics (fusion and fission); redox biology

(This special issue belongs to the Section Physiology and Pathology)

Cancer Genetics and Genomics: From Structure to Therapy

edited by Luca Járomi and Gellért Gerencsér

submission deadline 31 Jan 2026 | Viewed by 39 | Submission Open

Keywords: epigenetics; cancer therapy; multidrug resistance (MDR); accumulation; biomarkers

(This special issue belongs to the Section Genetics and Genomics)

Microbiome–Gut–Brain Connections: New Windows into Health and Disease

edited by