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Life
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Comorbidities of Migraine: Clinical and Research Perspectives
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Comorbidities of Migraine: Clinical and Research Perspectives

A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Medical Research".

Deadline for manuscript submissions: 31 May 2026 | Viewed by 577

Special Issue Editor

Dr. Claudio Tana

E-Mail Website
Guest Editor
Internal Medicine Unit, Manduria Hospital, ASL Taranto, Taranto, Italy
Interests: internal medicine; comorbidity; aging; digital health; clinical governance
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Migraine is a multifaceted neurological disorder that extends far beyond the boundaries of headache. In recent years, increasing attention has been paid to its complex network of comorbidities, ranging from cardiovascular and cerebrovascular disorders to psychiatric, metabolic, gastrointestinal, and autoimmune conditions. These comorbidities not only increase the overall disease burden and reduce quality of life but also provide crucial insights into the shared biological pathways linking migraine with systemic dysfunction.

This Special Issue, “Comorbidities of Migraine: Clinical and Research Perspectives”, will provide a comprehensive platform for the exchange of new data and conceptual advances on the multidimensional nature of migraine. We invite submissions addressing epidemiological trends, genetic and molecular mechanisms, neuroinflammatory and neuroendocrine pathways, and the bidirectional interactions between migraine and its comorbid conditions. Contributions exploring novel therapeutic targets, personalized treatment strategies, or multidisciplinary approaches integrating neurology, internal medicine, and psychiatry are particularly welcome.

By combining clinical observations with experimental research, this Special Issue will promote a more integrated understanding of migraine and its systemic implications, fostering translational insights to improve both prevention and care.

Dr. Claudio Tana
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Life is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • migraine
  • pain
  • headache
  • comorbidities
  • internal medicine
  • complex disorders

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Published Papers (1 paper)

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Research

12 pages, 437 KB  
Article
OUtcome and Clinical Characteristics of Primary Headache in Patients with Sarcoidosis: The OUCH! Study
by Claudio Tana, Nicol Bernardinello, Giacomo Giulianelli, Samanta Moffa, Francesco Cinetto, Laura Martino, Lucia Buzzelli, Maria Adele Giamberardino, Francesco Cipollone, Filippo Martone, Marco Tana, Livia Moffa and Paolo Spagnolo
Life 2026, 16(5), 762; https://doi.org/10.3390/life16050762 - 2 May 2026
Viewed by 231
Abstract
Background: Headache is a frequent but often underestimated complaint in patients with sarcoidosis. In clinical practice, headache is commonly interpreted as secondary to neurosarcoidosis, potentially overlooking the presence of primary headache disorders, particularly migraine. The prevalence and clinical relevance of migraine in sarcoidosis [...] Read more.
Background: Headache is a frequent but often underestimated complaint in patients with sarcoidosis. In clinical practice, headache is commonly interpreted as secondary to neurosarcoidosis, potentially overlooking the presence of primary headache disorders, particularly migraine. The prevalence and clinical relevance of migraine in sarcoidosis remain insufficiently characterized. Objective: To investigate the prevalence and clinical characteristics of migraine in patients with sarcoidosis and to explore its association with pulmonary functional outcomes. Methods: The OUtcome and Clinical characteristics of primary Headache in patients with Sarcoidosis (OUCH!) Study is a multicenter, retrospective, observational study including adult patients evaluated at pulmonology outpatient clinics and headache centers between January 2019 and January 2021. Demographic, clinical, radiological, and pulmonary function data were collected. Patients were stratified according to the presence or absence of migraine. Pulmonary function parameters were compared using non-parametric statistical tests. Results: Seventy-two patients with sarcoidosis were included; 21 (29.2%) were diagnosed with migraine. Migraine prevalence was higher than expected for the general population. Pulmonary involvement was the most frequent disease manifestation. Patients with migraine showed significantly lower DLCO values compared with those without migraine (median ( IQR): 55 (40–70) vs. 78 (65–90); p = 0.0009). No significant differences were observed in spirometric parameters or radiological patterns between groups. Conclusions: Migraine is a common comorbidity in sarcoidosis and is associated with reduced DLCO, suggesting a link with greater functional disease burden rather than structural lung damage. Migraine should be recognized as a primary headache disorder in this population, rather than automatically attributed to neurosarcoidosis. These findings support a multidisciplinary, patient-centered approach and warrant prospective studies to clarify shared inflammatory, vascular, and neuroimmune mechanisms. Full article
(This article belongs to the Special Issue Comorbidities of Migraine: Clinical and Research Perspectives)
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