Current Approaches and Future Directions in the Treatment of Gynecologic Tumors: Molecular Biology, Diagnostic Advancements and Targeted Therapeutic Strategies—2nd Edition

A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Medical Research".

Deadline for manuscript submissions: 30 May 2026 | Viewed by 1070

Special Issue Editor


E-Mail Website
Guest Editor
Faculty of Dentistry, Carol Davila University of Medicine and Pharmacy, 010221 Bucharest, Romania
Interests: gynecologic oncology; gynecologic cancer surgery; minimally invasive surgery; immunology and genetics of tumors; endometriosis; oncofertility
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The first edition of this Special Issue was a success and we intend to publish a second, so we invite you to submit your research for publication.

https://www.mdpi.com/journal/life/special_issues/835LFD07G1

Gynecologic tumors are a serious public health problem due to associations with high rates of morbidity and mortality. In recent years, a multidisciplinary integrative approach has enabled significant progress in this field, which has led to a better understanding of molecular mechanisms and advanced diagnostic methods, facilitating the implementation of targeted therapies. Although oncologic medicine is becoming increasingly personalized, several knowledge gaps and unsolved problems remain. Thus, future scientific research should offer new perspectives to better decipher the biology of tumor processes, early diagnosis criteria, and therapeutic strategies to improve prognoses.

In this Special Issue, through the lens of the latest medical research, I aim to highlight the continuously growing role of the integrative approach to the management of gynecologic tumors regarding intervention in biomolecular mechanisms, diagnostic criteria, and therapeutic strategies.

Dr. Valentin Nicolae Varlas
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Life is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • gynecologic tumors
  • cervical cancer
  • ovarian cancer
  • endometrial cancer
  • vulvar cancer
  • vaginal cancer
  • gestational trophoblastic disease
  • molecular mechanisms
  • diagnostic advancements
  • novel therapies

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.

Further information on MDPI's Special Issue policies can be found here.

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:

Review

19 pages, 752 KB  
Review
Global Comparative Review of Guidelines for Cervical Adenocarcinoma In Situ
by Giovanni Delli Carpini, Camilla Cicoli, Marco Bernardi, Jasmine Saee, Martina Petrini, Valentina Ferrari, Jacopo Di Giuseppe, Luca Giannella, Giuseppe Vizzielli and Andrea Ciavattini
Life 2026, 16(3), 461; https://doi.org/10.3390/life16030461 - 11 Mar 2026
Viewed by 744
Abstract
Background: The approach to adenocarcinoma in situ (AIS) is challenged by diagnostic complexity, limited high-quality evidence, and heterogeneous guidance. Methods: We conducted a narrative comparative review of global guidelines/recommendations (2012–2025; search updated 1 October 2025), extracting data across 38 topics related to AIS [...] Read more.
Background: The approach to adenocarcinoma in situ (AIS) is challenged by diagnostic complexity, limited high-quality evidence, and heterogeneous guidance. Methods: We conducted a narrative comparative review of global guidelines/recommendations (2012–2025; search updated 1 October 2025), extracting data across 38 topics related to AIS management and classifying indications into five categories of coverage/consensus. Results: Twenty documents from national or supranational bodies were included. A cross-guideline consensus emerged on eight core items (colposcopy for any glandular cytologic abnormality; role of HPV test; mandatory histologic confirmation; excisional treatment for histologic AIS; re-excision when margins are involved; criteria and type of hysterectomy; and expert/centralized management). Operational variability emerged in the excisional technique, pathways for discordant results, management during pregnancy, and follow-up protocols. Divergent guidance was most evident for indications to endocervical sampling, criteria for conservative management, and the need for hysterectomy after completed childbearing. Limited-coverage consensus involved the technique of initial histologic sampling, endometrial assessment, and pathways for cytology subtypes. Several areas remained unaddressed. Conclusions: While the essential management of AIS is well defined, uncertainty increases when treatment must be personalized. A core outcome set and rigorous multicenter studies are needed to reduce heterogeneity and enable truly evidence-based personalization. Full article
Show Figures

Figure 1

Back to TopTop