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Journal of Clinical Medicine publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Advancing Clinical Medicine Through Artificial Intelligence (AI) and Digital Technology: 2nd Edition submission deadline 31 Dec 2026 | 5 articles | Viewed by 9084 | Submission Open
Keywords: artificial intelligence; clinical medicine; medical imaging; precision medicine; clinical decision support systems; patient care; healthcare practices; early disease detection; patient outcomes
(This special issue belongs to the Section Machine Learning and Artificial Intelligence in Clinical Medicine)
Progress in Clinical Diagnosis and Therapy in Ophthalmology
edited by
submission deadline 31 Dec 2026 | 8 articles | Viewed by 7346 | Submission Open
Keywords: ophthalmic imaging; artificial intelligence in ophthalmology; retinal diseases; corneal transplantation; glaucoma diagnostics; ocular therapeutics; personalized medicine; ocular genetics
(This special issue belongs to the Section Ophthalmology)
Early Prevention and Diagnosis of Atherosclerosis: From Clinical Progression to Patient Management submission deadline 31 Dec 2026 | 3 articles | Viewed by 6160 | Submission Open
Keywords: atherosclerosis; atherothrombotic molecular pathways; cardiovascular risk; monitoring of goals; pharmacological and non-pharmacological prevention; carotid and peripheral interventions
(This special issue belongs to the Section Cardiovascular Medicine)
Clinical Advancements in Intraocular Lens Power Calculation Methods
edited by and Thomas Kohnen
submission deadline 31 Dec 2026 | 4 articles | Viewed by 5458 | Submission Open
Keywords: emmetropia; IOL power calculation; effective lens position; refractive lens exchange; IOL; refractive surgery; biometry
(This special issue belongs to the Section Ophthalmology)
Dental Care: Oral and Systemic Disease Prevention: 2nd Edition
edited by
submission deadline 31 Dec 2026 | 4 articles | Viewed by 5316 | Submission Open
Keywords: oral health; oral diseases; oral manifestations; systemic diseases; oral care; dental prevention; dental caries; periodontal disease; oral medicine; dentistry; oral microbiome; salivary diagnostics; AI-assisted tools
(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)
Anemia: Clinical Updates in Diagnosis, Management, and Treatment submission deadline 31 Dec 2026 | 2 articles | Viewed by 2723 | Submission Open
Keywords: anemia; diagnostic tools; hematology; artificial intelligence; targeted therapy; hereditary hemolytic anemia
(This special issue belongs to the Section Hematology)
Cardiovascular Autonomic Function: From Bench to Bedside—2nd Edition
edited by and
submission deadline 31 Dec 2026 | 2 articles | Viewed by 2723 | Submission Open
Keywords: dysautonomia; heart rate variability; autonomic function testing; cardiovascular autonomic function; autonomic neuroscience; syncope; orthostatic hypotension; baroreflex; autonomic molecular mechanisms
(This special issue belongs to the Section Cardiology)
Acute and Chronic Hemodialysis: Clinical Updates and Advances
edited by
submission deadline 31 Dec 2026 | 3 articles | Viewed by 2375 | Submission Open
Keywords: hemoadsorption; hemodiafiltration; medium cut-off membranes; expanded hemodialysis; vascular calcifications; renal anemia; vascular access; anticoagulation; ICU nephrology; acute kidney injury
(This special issue belongs to the Section Nephrology & Urology)
How Clinicians See the Use of AI in Psychiatry
edited by
submission deadline 31 Dec 2026 | 1 articles | Viewed by 1447 | Submission Open
Keywords: artificial intelligence; psychiatry; patient care; psychotherapy
(This special issue belongs to the Section Mental Health)
Challenges and Solutions in Geriatric Fracture
edited by Detlef Van der Velde and
submission deadline 31 Dec 2026 | 2 articles | Viewed by 1361 | Submission Open
Keywords: geriatric; fracture; frailty; hip fracture; comorbidity; perioperative optimization; orthogeriatrics; rehabilitation; shared decision-making; postoperative outcomes; mortality and morbidity; functional recovery; multidisciplinary care; quality of life; recovery; mobility; palliative care
(This special issue belongs to the Section Geriatric Medicine)
Advances in Artificial Intelligence Applications for Invasive and Non-Invasive Cardiovascular Procedures
edited by and Rahul Chaudhary
submission deadline 31 Dec 2026 | 1 articles | Viewed by 746 | Submission Open
Keywords: artificial intelligence and machine learning; interventional cardiology; electrophysiology; cardiovascular imaging; remote patient monitoring; digital biomarkers; clinical decision support
(This special issue belongs to the Section Cardiovascular Medicine)
Innovations in Heart Failure: Clinical and Surgical Perspectives
edited by and Vincenzo Tarzia
submission deadline 31 Dec 2026 | Viewed by 293 | Submission Open
Keywords: heart failure; heart transplantation; mechanical circulatory support; optimal medical therapy; LVAD; multidisciplinary care
(This special issue belongs to the Section Cardiology)
Critical Care Medicine: Innovation and Long-Term Patient Outcomes
edited by Charlie Corke
submission deadline 31 Dec 2026 | Viewed by 182 | Submission Open
Keywords: critical care innovation; patient-centred outcomes; goals-of-care decision-making; advanced organ sup-port; ethical and sustainable intensive care
(This special issue belongs to the Section Intensive Care)
Advances in Gynecological Cancers: Diagnosis, Treatment, and Care
edited by , Dariusz Wydra and
submission deadline 31 Dec 2026 | Viewed by 162 | Submission Open
Keywords: preinvasive cervical disease; cervical cancer; endometrial cancer; ovarian cancer; borderline ovarian tumors; rare tumors; uterine sarcoma; vulvar cancer; vaginal cancer; fertility sparing management; biomarkers; precision medicine; targeted therapy; immunotherapy; early detection
(This special issue belongs to the Section Obstetrics & Gynecology)
State of the Art of Corneal: Current Status and Prospects
edited by Justyna Izdebska
submission deadline 31 Dec 2026 | Viewed by 119 | Submission Open
Keywords: corneal diseases; corneal transplantation; OCT; corneal imaging; refractive surgery; keratoconus; graft survival; immunosuppression
(This special issue belongs to the Section Ophthalmology)
Multiparametric Ultrasound Techniques for Liver Disease Assessments
edited by Francesco Giangregorio
submission deadline 5 Jan 2027 | 2 articles | Viewed by 7777 | Submission Open
Keywords: ultrasound; multiparametric ultrasound; hepatic ultrasound; contrast-enhanced ultrasound; contrast agents; diffuse hepatic diseases; focal liver lesions; hepatic elastography; liver stiffness; hepatic endosonography; hepatic EUS
(This special issue belongs to the Section Nuclear Medicine & Radiology)
Challenging ICU Dogma: Where Routine Practice and Evidence Collide
edited by and Nobutake Shimojo
submission deadline 10 Jan 2027 | 2 articles | Viewed by 13483 | Submission Open
Keywords: critical care; intensive care unit (ICU); clinical dogma; de-implementation; medical reversal; routine practices; clinical decision-making
(This special issue belongs to the Section Intensive Care)
New Clinical Advances in Pancreatobiliary Diseases
edited by
submission deadline 10 Jan 2027 | 4 articles | Viewed by 7116 | Submission Open
Keywords: pancreatobiliary diseases; EUS; ERCP; interventional endoscopy; targeted therapy; pancreatobiliary cancer
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Thyroid Disorders: New Clinical Diagnosis and Management submission deadline 10 Jan 2027 | 2 articles | Viewed by 3968 | Submission Open
Keywords: thyroid disorders; clinical diagnosis; ultrasound; elastography; thyroid cancer; thyroiditis; hyperthyroidism; hypothyroidism; advanced imaging
(This special issue belongs to the Section Endocrinology & Metabolism)
Dialysis Versus Transplantation: Navigating Treatment Strategies in Chronic Kidney Disease
edited by
submission deadline 10 Jan 2027 | Viewed by 234 | Submission Open
Keywords: chronic kidney disease; kidney failure; dialysis; kidney transplantation; renal replacement therapy; hemodialysis; peritoneal dialysis; pre-emptive transplantation; patient-centered care; quality of life; precision nephrology; biomarkers; artificial intelligence; health disparities; treatment decision-making
(This special issue belongs to the Section Nephrology & Urology)
Clinical Management of Attention Deficit Hyperactivity Disorder (ADHD) submission deadline 15 Jan 2027 | 4 articles | Viewed by 11630 | Submission Open
Keywords: ADHD; addiction; neurodevelopmental disorders; levomethadone
(This special issue belongs to the Section Mental Health)
Updates on Treatment of Chronic Kidney Disease: Novel Approaches and Future Directions
edited by Pietro C. Dattolo and
submission deadline 15 Jan 2027 | 3 articles | Viewed by 7065 | Submission Open
Keywords: chronic kidney disease; CKD treatment; SGLT2 inhibitors; GLP-1 receptor agonists; non-steroidal MRAs; precision medicine; renal replacement therapy; novel therapeutics; clinical trials; nephrology
(This special issue belongs to the Section Nephrology & Urology)
Clinical Updates on Pediatric Surgery
edited by Carlos Theodore Huerta and Eduardo Alfonso Perez
submission deadline 15 Jan 2027 | 4 articles | Viewed by 3445 | Submission Open
Keywords: pediatric surgery; robotic-assisted surgery; artificial intelligence; enhanced recovery after surgery; minimally inva-sive surgery; augmented reality
(This special issue belongs to the Section Clinical Pediatrics)
Pediatric Pulmonology: Current Hurdles and Future Perspectives
edited by Isabel Delgado-Pecellín and Anselmo Andrés-Martín
submission deadline 15 Jan 2027 | 2 articles | Viewed by 3439 | Submission Open
Keywords: interstitial lung diseases; neonatal screening; complex chronic patients; home mechanical ventilation; severe asthma; telemonitoring; lung development; cystic fibrosis; genetics
(This special issue belongs to the Section Clinical Pediatrics)
Current Challenges in Oral and Maxillofacial Surgery submission deadline 15 Jan 2027 | 2 articles | Viewed by 3019 | Submission Open
Keywords: oral and maxillofacial surgery; surgical management; virtual surgical planning; postoperative management; orthog-nathic surgery; reconstructive techniques; minimally invasive surgery; digital technologies; 3D printing
(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)
Clinical Innovation in Endoscopic Sinus and Anterior Skull Base Surgery submission deadline 15 Jan 2027 | 2 articles | Viewed by 2294 | Submission Open
Keywords: rhinology; endoscopic anterior skull base surgery; anterior skull base surgery; endoscopic sinus surgery; chronic rhinosinusitis (CRS); otolaryngology
(This special issue belongs to the Section Otolaryngology)
Clinical Diagnosis and Management of Erectile Dysfunction
edited by Maurizio De Rocco Ponce and
submission deadline 15 Jan 2027 | 2 articles | Viewed by 2127 | Submission Open
Keywords: erectile dysfunction; clinical management; cardiovascular disease; penile prosthesis; personalized medicine; hipogonadism
(This special issue belongs to the Section Reproductive Medicine & Andrology)
Cutting Edge Research on Total Knee Arthroplasty
edited by
submission deadline 15 Jan 2027 | 2 articles | Viewed by 2007 | Submission Open
Keywords: total knee arthroplasty; robotic-assisted surgery; computer-navigated arthroplasty; implant design; kinematic alignment; enhanced recovery pathways; patient-reported outcomes; artificial intelligence in orthopedics; revision surgery
(This special issue belongs to the Section Orthopedics)
Aortic Surgery: State of the Art and Future Directions submission deadline 15 Jan 2027 | 2 articles | Viewed by 1362 | Submission Open
Keywords: aortic surgery; aortic aneurysm; aortic dissection; aortic arch; biomaterials; endovascular approach; FET; TEVAR
(This special issue belongs to the Section Cardiovascular Medicine)
Complications Related to Coronary Artery Disease and Secondary Prevention Strategies
edited by Nazanin Rajai
submission deadline 15 Jan 2027 | Viewed by 365 | Submission Open
Keywords: coronary artery disease; complications; secondary prevention; myocardial infarction; cardiovascular risk; heart failure; arrhythmias; imaging; biomarkers; cardiovascular pharmacotherapy
(This special issue belongs to the Section Cardiovascular Medicine)
Advances in Spine Surgery: Best Practices and Future Directions
edited by Martin N. Stienen and
submission deadline 20 Jan 2027 | 9 articles | Viewed by 16038 | Submission Open
Keywords: minimally invasive spine surgery; spinal endoscopy; spinal robotics; spinal navigation; ERAS; machine learning; artificial intelligence; complication management; revision surgery; spinal deformity; innovation; future direction
(This special issue belongs to the Section Clinical Neurology)
Effect of Long-Term Insomnia on Mental Health—2nd Edition submission deadline 20 Jan 2027 | 2 articles | Viewed by 13440 | Submission Open
Keywords: anxiety; alcohol and substance use disorders; behavioral addiction; burnout; cognitive dysfunction; depression; eating disorders; gaming addiction; problematic internet/social media use; insomnia; long-term insomnia; mood disorders; post-traumatic stress disorder; stress
(This special issue belongs to the Section Mental Health)
Endodontic Disease: Prevalence, Risk Factors, and Treatment Outcome submission deadline 20 Jan 2027 | 4 articles | Viewed by 11416 | Submission Open
Keywords: endodontics; apical periodontitis; pulpitis; root canal treatment; risk factors; treatment outcomes; regenerative endodontics
(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)
Clinical Management and Long-Term Prognosis in Intensive Care submission deadline 20 Jan 2027 | 9 articles | Viewed by 10687 | Submission Open
Keywords: intensive care; post-intensive care syndrome; patient safety; improved survival; mental health; mechanical ventilation
(This special issue belongs to the Section Intensive Care)
Glaucoma Surgery: Current Challenges and Future Perspectives submission deadline 20 Jan 2027 | 8 articles | Viewed by 8706 | Submission Open
Keywords: glaucoma; filtration surgery; trabeculectomy; MIGS; scarring; anti-metabolites; wound healing; anti-fibrotics
(This special issue belongs to the Section Ophthalmology)
Targeted Diagnosis and Treatment of Shoulder and Elbow Disease: 2nd Edition submission deadline 20 Jan 2027 | 4 articles | Viewed by 8036 | Submission Open
Keywords: anterolateral deltoid split; joint pain; axillary nerve injury; rotator cuff injuries; shoulder arthroplasty; shoulder impingement syndrome; proximal humeral fracture; rehabilitation; exercise; physiotherapy; rehabilitative relapses
(This special issue belongs to the Section Orthopedics)
Acute Medical Threats: Evidence-Driven Strategies in Emergency Medicine submission deadline 20 Jan 2027 | 4 articles | Viewed by 7353 | Submission Open
Keywords: emergency medicine protocols; acute medical care; trauma management; resuscitation; critical care; infectious disease preparedness
(This special issue belongs to the Section Emergency Medicine)
Clinical Advances in Skin Cancer: A Closer Look at Non-Melanoma Types
edited by Andrea Paradisi
submission deadline 20 Jan 2027 | 4 articles | Viewed by 7163 | Submission Open
Keywords: basal cell carcinoma; squamous cell carcinoma; actinic keratosis; diagnosis; treatment; non-melanoma skin cancer (NMSC)
(This special issue belongs to the Section Dermatology)
Molecular Injection Therapy in Orthopedic and Musculoskeletal Disorders: Conservative Approaches and Innovative Treatments
edited by , Paolo Domenico Parchi and Andrea del Chiaro
submission deadline 20 Jan 2027 | 5 articles | Viewed by 7103 | Submission Open
Keywords: injection therapy; conservative approaches; medical devices; collagen; polyribonucleotide; plasma-rich platelets; hyaluronic acids; anti-inflammatory therapy; tendinitis, osteoarthritis, musculoskeletal disorder, pain reduction; regenerative medicine; new clinical approaches; physiotherapy; comparative studies: surgery vs. conservative approaches
(This special issue belongs to the Section Orthopedics)
Heart Failure: Challenges and Future Options
edited by Pedro Caravaca-Pérez and Marta Farrero-Torres
submission deadline 20 Jan 2027 | 7 articles | Viewed by 6946 | Submission Open
Keywords: heart failure; cardiorenal syndrome; heart transplantation; ventricular assist devices; biomarkers; precision medicine; advanced therapies; diuretic resistance; risk stratification; multidisciplinary care
(This special issue belongs to the Section Cardiovascular Medicine)
Advances in Minimally Invasive Otolaryngology: Precision Techniques and Functional Outcomes
edited by Giovanni Colombo and
submission deadline 20 Jan 2027 | 5 articles | Viewed by 5973 | Submission Open
Keywords: advances in otolaryngology; endoscopic surgery; head and neck surgery; functional outcomes; quality of life
(This special issue belongs to the Section Otolaryngology)
Hospital-Acquired Infections: Insights, Prevention, and Control Strategies
edited by
submission deadline 20 Jan 2027 | 4 articles | Viewed by 4864 | Submission Open
Keywords: healthcare-acquired infections; bloodstream infections; hospital‐acquired pneumonia; intestinal infections; clostridium difficile; surgical site infections; urinary tract infections; emergency department
(This special issue belongs to the Section Epidemiology & Public Health)
Clinical Updates in Transfusion Medicine and Patient Blood Management submission deadline 20 Jan 2027 | 1 articles | Viewed by 4782 | Submission Open
Keywords: anaemia; bleeding; blood transfusion; patient blood management; transfusion medicine
(This special issue belongs to the Section Hematology)
Artificial Intelligence and Machine Learning in Clinical Practice
edited by Theodosis Kalamatianos and
submission deadline 20 Jan 2027 | 6 articles | Viewed by 4566 | Submission Open
Keywords: artificial intelligence in healthcare; medical image/signal analysis; clinical decision support systems; predictive analytics; personalized medicine; explainable AI; diagnosis; prognosis
(This special issue belongs to the Section General Surgery)
Advancements in the Treatment of Myeloproliferative Neoplasms and Myelodysplastic Syndromes
edited by Ivan Krečak, Marko Skelin and Zinaida Perić
submission deadline 20 Jan 2027 | 4 articles | Viewed by 4078 | Submission Open
Keywords: myeloproliferative neoplasms; myelodysplastic syndromes; treatment; risk stratification; prognosis
(This special issue belongs to the Section Hematology)
Deep Vein Thrombosis and Pulmonary Embolism: Clinical Treatment and Management—Second Edition submission deadline 20 Jan 2027 | 3 articles | Viewed by 3599 | Submission Open
Keywords: pulmonary embolism; thrombophilia; deep vein thrombosis; venous thromboembolism; anticoagulation therapy; thrombectomy; bleeding; cancer-associated thrombosis
(This special issue belongs to the Section Hematology)
Artificial Intelligence in Exercise, Rehabilitation and Health Promotion: A Clinical Perspective
edited by and
submission deadline 20 Jan 2027 | 3 articles | Viewed by 3487 | Submission Open
Keywords: artificial intelligence; machine learning and deep learning; large language models (LLMs); explainable AI; exercise and physical activity; rehabilitation and sports medicine; clinical applications; chronic disease and preventive health; digital health and big data analytics
(This special issue belongs to the Section Sports Medicine)
Clinical Perspectives on Obesity and Bariatric Surgery: Outcomes and Complications
edited by Dilhana S. Badurdeen
submission deadline 20 Jan 2027 | 4 articles | Viewed by 3467 | Submission Open
Keywords: obesity; bariatric surgery; metabolic surgery; Roux-en-Y Gastric Bypass (RYGB); sleeve gastrectomy; revisional bariatric surgery; complications; outcomes; weight loss maintenance; metabolic syndrome; type 2 diabetes remission; nutritional deficiencies; gastrointestinal adaptation; quality of life; long-term follow-up
(This special issue belongs to the Section General Surgery)
Bronchoscopy and Interventional Pulmonology
edited by Bryan S. Benn and
submission deadline 20 Jan 2027 | 4 articles | Viewed by 3132 | Submission Open
Keywords: navigation-guided bronchoscopy; Robotic-guided bronchoscopy; 3D imaging integration; lung nodule/peripheral pulmonary lesion marking; transbronchial lung cryobiopsy and interstitial lung disease; malignant and benign central airway obstruction and stenosis; airway stents; pleuroscopic procedures; bronchoscopic lung volume reduction
(This special issue belongs to the Section Respiratory Medicine)
Clinical Insights in Pediatric Dentistry
edited by
submission deadline 20 Jan 2027 | 2 articles | Viewed by 3115 | Submission Open
Keywords: pediatric dentistry; caries management; dental trauma; preventive dentistry; behavior management; interdisciplinary care; clinical innovations
(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)
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