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Journal of Clinical Medicine publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Regional Anesthesia in Pain Management
edited by Jaime L. Baratta
submission deadline 20 Jan 2026 | 1 articles | Viewed by 432 | Submission Open
Keywords: acute pain; perioperative medicine; general anesthesiology; regional anesthesia; orthopedic anesthesia; multimodal analgesia
(This special issue belongs to the Section Anesthesiology)
Clinical Comparisons of Nonpharmaceutical and Pharmaceutical Analgesia
edited by and
submission deadline 20 Jan 2026 | Viewed by 402 | Submission Open
Keywords: acute pain; chronic pain; postoperative pain; non-pharmaceutical; pharmaceutical; analgesia; clinical
(This special issue belongs to the Section Anesthesiology)
Beyond the Kidney: Managing Chronic Kidney Disease in the Era of Cardio-Metabolic-Kidney Syndrome submission deadline 20 Jan 2026 | Viewed by 357 | Submission Open
Keywords: chronic kidney disease; disease-modifying therapy; physical exercise; cardio-metabolic-kidney syndrome; SGLT2 in-hibitors; MRA; renal nutrition; innovative therapies; low protein diet
(This special issue belongs to the Section Nephrology & Urology)
Clinical Updates and Current Challenges in Obstetrical Anesthesia
edited by Michael Froelich
submission deadline 20 Jan 2026 | Viewed by 346 | Submission Open
Keywords: obstetrical anesthesia; clinical innovation; practice guidelines; neuraxial techniques; enhanced recovery; risk stratification; maternal safety; multimodal analgesia; health systems innovation; global and low-resource care
(This special issue belongs to the Section Obstetrics & Gynecology)
Metabolic Dysregulation Across the Spectrum from Anorexia Nervosa to Obesity
edited by Andriana C. Kaliora
submission deadline 20 Jan 2026 | Viewed by 284 | Submission Open
Keywords: metabolic dysregulation; anorexia nervosa; obesity; environmental factors in metabolic health; gut microbiota and metabolism; hormonal regulation of appetite; inflammation and metabolic disorders; dietary influence on metabolism
(This special issue belongs to the Section Endocrinology & Metabolism)
Innovations and Evolution of Extracorporeal Organ Support in Critical Care
edited by , and Antonella Tosi
submission deadline 20 Jan 2026 | Viewed by 280 | Submission Open
Keywords: critical care; extracorporeal organ support; critical care nephrology; cardiology; ARDS; sepsis; blood purification; liver support
(This special issue belongs to the Section Intensive Care)
Innovations in Infertility Treatment and Assisted Reproductive Technologies (ARTs)
edited by Diana Alecsandru
submission deadline 20 Jan 2026 | Viewed by 262 | Submission Open
Keywords: infertility; assisted reproductive technology (ARTs); fertility preservation; in vitro fertilization (IVF); reproductive endocrinology
(This special issue belongs to the Section Obstetrics & Gynecology)
Bronchoscopy and Interventional Pulmonology
edited by Bryan S. Benn and
submission deadline 20 Jan 2026 | Viewed by 250 | Submission Open
Keywords: navigation-guided bronchoscopy; Robotic-guided bronchoscopy; 3D imaging integration; lung nodule/peripheral pulmonary lesion marking; transbronchial lung cryobiopsy and interstitial lung disease; malignant and benign central airway obstruction and stenosis; airway stents; pleuroscopic procedures; bronchoscopic lung volume reduction
(This special issue belongs to the Section Respiratory Medicine)
Haemophilia: Current Treatment and Clinical Outcomes, Challenges and Opportunities: 2nd Edition
edited by
submission deadline 20 Jan 2026 | Viewed by 239 | Submission Open
Keywords: haemophilia A and B; FVIII EHL; FIX EHL; prophylaxis; emicizumab; health-related quality of life; population pharmacokinetics
(This special issue belongs to the Section Hematology)
From Dual Diagnosis to Dual Disorder(s): Bridging Comorbidity and Integrated Clinical Understanding submission deadline 20 Jan 2026 | Viewed by 233 | Submission Open
Keywords: dual diagnosis; dual disorder; psychiatric comorbidity; addiction; integrated care; self-medication; substance use; mental illness; treatment models
(This special issue belongs to the Section Mental Health)
Clinical Application of Echocardiography in Heart Disease: 2nd Edition
edited by
submission deadline 20 Jan 2026 | Viewed by 177 | Submission Open
Keywords: transthoracic echocardiography; transesophageal echocardiography; stress echocardiography; valve disease; coronary artery disease; myocardial disease; pericardial disease; aortic disease; congenital heart disease
(This special issue belongs to the Section Cardiology)
Recent Management of Hip Fractures
edited by
submission deadline 20 Jan 2026 | Viewed by 172 | Submission Open
Keywords: hip fracture; internal fixation; hemiarthroplasty; arthroplasty and fixation; osteoporosis management; fracture prevention; multidisciplinary care; surgical treatment; rehabilitation strategies
(This special issue belongs to the Section Orthopedics)
New Insights in Trauma and Emergency Surgery
edited by Kai Oliver Jensen and Valentin Neuhaus
submission deadline 20 Jan 2026 | Viewed by 171 | Submission Open
Keywords: trauma and emergency surgery; multiple trauma; orthopedic trauma; surgery; concepts in trauma
(This special issue belongs to the Section Emergency Medicine)
Emerging Trends in Multiple Myeloma
edited by
submission deadline 20 Jan 2026 | Viewed by 163 | Submission Open
Keywords: multiple myeloma; personalized medicine; high-risk disease; cellular therapies; refractory disease
(This special issue belongs to the Section Hematology)
Current Trends and Future Challenges in Heart Failure
edited by Oren Caspi and
submission deadline 20 Jan 2026 | Viewed by 163 | Submission Open
Keywords: heart failure; guideline-directed therapy; digital health; biomarkers; multidisciplinary care; artificial intelligence; cardiorenal syndrome; remote hemodynamic monitoring; cardiac amyloidosis; exercise rehabilitation
(This special issue belongs to the Section Cardiology)
Preventive Strategies and Novel Treatments for Rheumatoid Arthritis
edited by
submission deadline 20 Jan 2026 | Viewed by 163 | Submission Open
Keywords: rheumatoid arthritis; antibodies; biologics; JAK; environment; susceptibility; therapeutic strategies
(This special issue belongs to the Section Immunology & Rheumatology)
Therapeutic Strategies for Obesity and Diabetes in Cardiovascular Disease Patients
edited by Davide D'Andrea
submission deadline 20 Jan 2026 | Viewed by 162 | Submission Open
Keywords: obesity; diabetes; cardiovascular complications; diabetes management; pharmacological treatment; bariatric surgery; regular monitoring
(This special issue belongs to the Section Cardiovascular Medicine)
Advances in Chronic Pain Research and Therapy
edited by Elena Makovac
submission deadline 20 Jan 2026 | Viewed by 160 | Submission Open
Keywords: chronic pain; pain perception; brain-body interactions; therapeutic effectiveness; integrated approach
(This special issue belongs to the Section Clinical Rehabilitation)
Clinical Update on Aortic Valve Disease Treatments
edited by
submission deadline 20 Jan 2026 | Viewed by 145 | Submission Open
Keywords: aortic valve disease; minimally invasive surgery; transcatheter procedures; echocardiography; diagnosis; therapy; innovation
(This special issue belongs to the Section Cardiology)
Lung Transplantation: Current Challenges and New Perspectives
edited by Reinaldo E. Rampolla and Pedro A. Catarino
submission deadline 20 Jan 2026 | Viewed by 141 | Submission Open
Keywords: lung transplantation; interstitial lung diseases; pulmonary hypertension; chronic obstructive pulmonary disease; bronchiectasis; extra corporeal membrane oxygenation; robotic lung transplantation
(This special issue belongs to the Section Respiratory Medicine)
Clinical Advances, Opportunities, and Challenges in Digestive Diseases of the Foregut
edited by Valentin Mocanu and
submission deadline 20 Jan 2026 | Viewed by 135 | Submission Open
Keywords: obesity; achalasia; reflux; malrotation; therapeutic endoscopy
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Pulmonary Disease and Comorbidities, Clinical and Epidemiological Studies: From Neonates to Adults
edited by
submission deadline 20 Jan 2026 | Viewed by 122 | Submission Open
Keywords: pulmonary disorders; comorbidity; neonatal lung disease; pediatric pulmonology; adult respiratory disease; chronic respiratory conditions; clinical epidemiology; pulmonary function testing; diagnostic imaging; lung biomarkers; risk factors
(This special issue belongs to the Section Respiratory Medicine)
Clinical Advances in Urologic Oncology: 2nd Edition
edited by Saum Ghodoussipour
submission deadline 20 Jan 2026 | Viewed by 122 | Submission Open
Keywords: bladder cancer; kidney cancer; prostate cancer; testis cancer; penile cancer; minimally invasive; cancer treatment
(This special issue belongs to the Section Nephrology & Urology)
New Clinical Perception of Cardiac Rehabilitation
edited by and Mario Pacileo
submission deadline 20 Jan 2026 | Viewed by 120 | Submission Open
Keywords: cardiac rehabilitation; digital health; exercise therapy; cardiovascular prevention; chronic disease management; psychosocial support; personalized medicine
(This special issue belongs to the Section Clinical Rehabilitation)
Surgical Management of Vascular Diseases: Challenges and Innovations in the 21st Century
edited by Reinhardt T. Grundmann
submission deadline 20 Jan 2026 | Viewed by 111 | Submission Open
Keywords: abdominal aortic aneurysm; carotid stenosis; peripheral vascular disease; endovascular therapy; open surgery; vascular disease and cancer outcomes; clinical trial; meta-analysis; surgical innovation
(This special issue belongs to the Section Cardiovascular Medicine)
The Association Between Cancer and Cardiovascular Diseases: Insights After a Quarter of the Century
edited by Tomer Ziv-Baran and Elena Izkhakov
submission deadline 20 Jan 2026 | Viewed by 111 | Submission Open
Keywords: cancer survivors; cardiovascular disease; cardio-oncology; chemotherapy; radiation therapy; immunotherapy; multidisciplinary approach
(This special issue belongs to the Section Epidemiology & Public Health)
Macular Diseases: From Diagnosis to Treatment
edited by
submission deadline 22 Jan 2026 | 1 articles | Viewed by 518 | Submission Open
Keywords: age-related macular degeneration; retinal vascular diseases; intraocular tumours; retinal imaging; OCT; OCT angiography; anti-VEGF; laser therapy; macular surgery; gene therapy; biomarkers; progression; intravitreal injections; biomarkers
(This special issue belongs to the Section Ophthalmology)
Personalized Modern Oncological Strategies for Breast Cancer Treatment
edited by Vlad Alexandru Gata, Maximilian Muntean and
submission deadline 22 Jan 2026 | Viewed by 96 | Submission Open
Keywords: breast cancer; targeted and immune therapies; predictive biomarkers; surgical de-escalation; MRI of the breast; breast reconstruction
(This special issue belongs to the Section General Surgery)
Application of Artificial Intelligence in Cardiology submission deadline 23 Jan 2026 | 6 articles | Viewed by 4587 | Submission Open
Keywords: artificial intelligence; cardiology; clinical practice; valvular heart disease; arrhythmias; device therapy; machine learning
(This special issue belongs to the Section Cardiology)
Clinical Advances and New Challenges in Laparoscopic Surgery
edited by Ionut Bogdan Diaconescu and Matei Bratu
submission deadline 23 Jan 2026 | Viewed by 128 | Submission Open
Keywords: laparoscopic surgery; trauma surgery; surgical oncology; abdominal surgery; colorectal surgery; general surgery; minimally invasive surgery; gastrointestinal surgery; hernia surgery; surgery; advance laparoscopic surgery; cancer surgery
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Clinical Advances in Glaucoma: Current Status and Prospects
edited by Rubén Sánchez-Jean, and Federico Sáenz-Francés San Baldomero
submission deadline 24 Jan 2026 | 2 articles | Viewed by 4134 | Submission Open
Keywords: glaucoma surgery; new techniques; minimally invasive glaucoma surgery; intraocular pressure; optometry; IOLs designs
(This special issue belongs to the Section Ophthalmology)
Pediatric Pulmonology: Recent Developments and Emerging Trends
edited by Athina L. Papadopoulou
submission deadline 25 Jan 2026 | 5 articles | Viewed by 19462 | Submission Open
Keywords: definition of breath sounds; lung– gut axis pathophysiology; disease endotypes and phenotypes; asthma management in children; bronchiolitis spectrum; pediatric bronchopulmonary dysplasia; pulmonary function testing in pediatric patients; pediatric sleep-disordered breathing; neonatal respiratory distress syndrome; childhood interstitial lung diseases; pulmonary hypertension in children; biomarkers in pediatric lung diseases; allergy and the lungs; diagnostic and therapeutic challenges in bronchoscopy; gene therapy in cystic fibrosis
(This special issue belongs to the Section Clinical Pediatrics)
Personalized Medicine for the Management of Non-Communicable Disease (NCDs)
edited by , Giulio Geraci and
submission deadline 25 Jan 2026 | 7 articles | Viewed by 13832 | Submission Open
Keywords: personalized medicine; precision medicine; non-communicable disease; cardiovascular disease; cancer; diabetes; chronic obstructive pulmonary disease; cognitive impairment; atherosclerosis; lipids; inflammation; immunity; therapy
(This special issue belongs to the Section Epidemiology & Public Health)
Clinical Updates on Cardiac and Vascular Toxicities from Antineoplastic Drugs and Beyond
edited by
submission deadline 25 Jan 2026 | 5 articles | Viewed by 13132 | Submission Open
Keywords: cardiotoxicity; vascular toxicity; cardio-oncology; immune checkpoint inhibitors; anthracyclines; tyrosine kinase inhibitors; HER2; proteasome inhibitors; platinum; antimetabolites; microtubule inhibitors
(This special issue belongs to the Section Cardiovascular Medicine)
Clinical Risks and Perinatal Outcomes in Pregnancy and Childbirth: 2nd Edition
edited by Apostolos Mamopoulos and
submission deadline 25 Jan 2026 | 6 articles | Viewed by 13123 | Submission Open
Keywords: pregnancy complications; perinatal outcomes; childbirth; hypertension; diabetes; fetal growth restriction; stillbirth; preterm delivery
(This special issue belongs to the Section Obstetrics & Gynecology)
Male Fertility in the Modern Age: Challenges and Opportunities
edited by
submission deadline 25 Jan 2026 | 2 articles | Viewed by 12214 | Submission Open
Keywords: male infertility; semen parameters; sperm selection; IVF/ICSI
(This special issue belongs to the Section Reproductive Medicine & Andrology)
Keratoconus: Current Status and Prospects
edited by and Isabel Lema
submission deadline 25 Jan 2026 | 3 articles | Viewed by 10053 | Submission Open
Keywords: keratoconus; prevention; diagnostic; biomarker discovery; genetics; exposome; treatment; personalized medicine; major challenges; technological advances
(This special issue belongs to the Section Ophthalmology)
Prevention, Diagnosis and Treatment of Oral Mucosal Diseases
edited by
submission deadline 25 Jan 2026 | 3 articles | Viewed by 9800 | Submission Open
Keywords: oral mucosal diseases; oral mucositis; oral precancerous lesions; oral cancer; oral potentially malignant disorders; OPMDs; oral leukoplakia
(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)
Interventional Cardiology—Challenges and Solutions
edited by
submission deadline 25 Jan 2026 | 3 articles | Viewed by 4505 | Submission Open
Keywords: chronic total occlusion; highly calcified coronary or lower extremity arteries; stentless percutaneous coronary intervention; chronic limb threatening ischemia; instent restenosis in the extremity artery diseases; endovascular therapy for pulmonary thromboembolism; transcatheter aortic valve replacemment for the bicuspid aortic valve; transcatheter aortic valve replacement for the valve-in-valve procedure; endovascular therapy for tricospid valve regurgitation; transcatheter edge-to-edge repair for mitral valve regurgitation
(This special issue belongs to the Section Cardiovascular Medicine)
Clinical Advances in Treatment for Venous Thromboembolism
edited by and Georgia Kaiafa
submission deadline 25 Jan 2026 | 3 articles | Viewed by 4464 | Submission Open
Keywords: venous thromboembolism; anticoagulation; cancer-associated thrombosis; thrombosis in MPNs; thrombosis in multiple myeloma; antiphospholipidic syndrome; thrombosis in PNH; thrombosis in hemoglobinopathies; thrombophilia; pregnancy and thrombophilia; reversal of anticoagulants; thromboprophylaxis
(This special issue belongs to the Section Hematology)
Foot and Ankle Surgery: Current Advances and Prospects
edited by
submission deadline 25 Jan 2026 | 4 articles | Viewed by 4449 | Submission Open
Keywords: foot and ankle surgery; foot pathologies; ankle disease and trauma; diabetic foot; epidemiology; clinical anatomy; foot orthoses; weight-bearing CT
(This special issue belongs to the Section Orthopedics)
Autism Spectrum Disorder: Diagnosis, Treatment, and Management
edited by
submission deadline 25 Jan 2026 | 1 articles | Viewed by 4095 | Submission Open
Keywords: adult autism (including autism spectrum disorders); neurodevelopmental disorders; clinical diagnostics; digital diagnostics; artificial intelligence; multimodal treatments
(This special issue belongs to the Section Mental Health)
Clinical Updates in Cardiac Electrophysiology: 2nd Edition
edited by Kenneth C. Bilchick
submission deadline 25 Jan 2026 | 1 articles | Viewed by 3245 | Submission Open
Keywords: arrhythmias; atrial fibrillation; cardiac electrophysiology; heart rhythm disorders; ablation; ventricular tachycardia; remote monitoring; digital health; artificial intelligence; cardiac magnetic resonance
(This special issue belongs to the Section Cardiology)
Clinical Diagnostic and Therapeutic Approaches in Cardiac Amyloidosis
edited by Grigorios Giamouzis
submission deadline 25 Jan 2026 | 1 articles | Viewed by 3150 | Submission Open
Keywords: cardiac amyloidosis; transthyretin amyloidosis; hypertrophic cardiomyopathy; cardiac imaging; heart failure
(This special issue belongs to the Section Cardiology)
Inflammatory Bowel Diseases: Clinical Advances and Emerging Therapies submission deadline 25 Jan 2026 | 2 articles | Viewed by 2822 | Submission Open
Keywords: inflammatory bowel disease (IBD); ulcerative colitis; Crohn’ s disease; gut inflammation; bowel perforation
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Advancements in Individualized Plastic and Reconstructive Surgery: Second Edition
edited by , Peter Niclas Broer and Denis C. Ehrl
submission deadline 25 Jan 2026 | 2 articles | Viewed by 1760 | Submission Open
Keywords: patient-specific reconstructive procedures; microsurgical precision techniques; autologous tissue transplantation; digital imaging and customization; biomaterials in reconstructive surgery; tissue engineering for plastic reconstruction; flap surgery innovations; personalized cleft surgery; personalized aesthetic surgery
(This special issue belongs to the Section Plastic, Reconstructive and Aesthetic Surgery/Aesthetic Medicine)
Ocular Surface Disease: Epidemiology, Diagnosis and Management submission deadline 25 Jan 2026 | Viewed by 925 | Submission Open
Keywords: dry eye disease; risk factors; ocular surface disease; inflammatory biomarkers; anterior segment imaging; emerging therapies
(This special issue belongs to the Section Ophthalmology)
Shoulder and Elbow Surgery: Clinical Updates and Perspectives
edited by Taku Hatta, Akihiko Hasegawa and Takuma Yuri
submission deadline 25 Jan 2026 | 1 articles | Viewed by 718 | Submission Open
Keywords: rotator cuff injuries; shoulder arthroplasty; elbow surgery; shoulder surgery; shoulder and elbow disease; arthroscopic surgery; orthopedic surgery
(This special issue belongs to the Section Orthopedics)
Kidney Transplantation: Challenges, Advances and Lessons Learnt submission deadline 25 Jan 2026 | 1 articles | Viewed by 632 | Submission Open
Keywords: kidney transplantation; nephrology; transplant medicine; patient selection criteria; immunosuppressive treatment; long-term outcomes; graft survival; complication; multi-organ transplant consideration; innovation
(This special issue belongs to the Section Nephrology & Urology)
Machine Learning and Artificial Intelligence in Neurosurgery
edited by Jan Oliver Neumann and
submission deadline 25 Jan 2026 | Viewed by 529 | Submission Open
Keywords: artificial intelligence; neurosurgery; neuro-oncology; spinal neurosurgery; neuro-ICU; stereotactic neurosurgery; pre-operative planning
(This special issue belongs to the Section Clinical Neurology)
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