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Journal of Clinical Medicine publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Endoscopic Management of Pancreaticobiliary Diseases

edited by

Kamran Ayub

submission deadline 30 Jul 2026 | Viewed by 29 | Submission Open

Keywords: pancreaticobiliary endoscopy; endoscopic ultrasound (EUS); endoscopic retrograde cholangiopancreatography (ERCP); biliary drainage; gallbladder drainage; lumen-opposing metal stents; cholangioscopy; pancreatoscopy; confocal laser endomicroscopy; pancreatic cysts; molecular diagnostics; lithotripsy (electrohydraulic and laser); radiofrequency ablation (RFA); photodynamic therapy (PDT); pancreatic and biliary tumors; interventional endoscopy; altered anatomy access; diagnostic and therapeutic endoscopy

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Effects of Exercise Training on Physiological and Functional Outcomes in Age and Frailty

edited by

Dihogo Gama de Matos

and

Rodrigo Villar

submission deadline 30 Jul 2026 | Submission Open

Keywords: exercise training ; older adults ; frailty ; cardiovascular system ; autonomic system ; quality of life ; healthy aging ; functional capacity

(This special issue belongs to the Section Geriatric Medicine)

Psychogerontology: Psychological Insights into Aging

edited by Sónia Martins and

Sara Lima

submission deadline 31 Jul 2026 | Viewed by 442 | Submission Open

Keywords: psychogerontology; aging process; adjustment; mental health; psychopatology; personality; emotions; well-being; spir-ituality; quality of life; caregiving; psychogerontology assessment and interventions

(This special issue belongs to the Section Mental Health)

Clinical Application of Physical Therapy in Neurorehabilitation: 3rd Edition

edited by

Sofia Straudi

and

Roberto Cano de la Cuerda

submission deadline 31 Jul 2026 | Viewed by 41 | Submission Open

Keywords: physical therapy; technology-aided rehabilitation; exercise; neurorehabilitation; neuroplasticity; engagement; self-management

(This special issue belongs to the Section Clinical Rehabilitation)

Neuro-Psychiatric Disorders: Updates on Diagnosis and Treatment—2nd Edition

edited by

Georgios Floros

submission deadline 31 Jul 2026 | Viewed by 25 | Submission Open

Keywords: neuropsychiatric disorder; diagnosis; treatment; neurobiology; organic psychiatry

(This special issue belongs to the Section Mental Health)

The Future Direction of Medical Imaging in Hepato-Bilio-Pancreatic Oncology: Challenges and Opportunities

edited by

Nicolò Brandi

submission deadline 31 Jul 2026 | Viewed by 23 | Submission Open

Keywords: MRI; CT; molecular imaging; radiomics; imaging; radiogenomics; precision medicine; outcome prediction; cholangiocarcinoma; pancreatic cancer; imaging biomarkers; treatment response

(This special issue belongs to the Section Nuclear Medicine & Radiology)

Breakthroughs in the Treatment of Colorectal Cancer

edited by Laura Fortuna and

Andrea Bottari

submission deadline 31 Jul 2026 | Viewed by 23 | Submission Open

Keywords: colorectal cancer; targeted therapy; minimally invasive surgery; immune– oncology integration; enhanced recovery protocols; multidisciplinary care

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Interventional Cardiology: Evolving Evidence and Emerging Horizons

edited by

Jacek Bil

submission deadline 31 Jul 2026 | Viewed by 17 | Submission Open

Keywords: coronary artery disease; percutaneous coronary intervention; drug-coated balloon; intravascular imaging; fractional flow reserve; transcatheter aortic valve implantation; transcatheter mitral valve repair; clinical outcomes

(This special issue belongs to the Section Cardiology)

Sports Cardiology: Current Clinical Status and Outlook into the Future

edited by Aakash Bavishi and Matthew W Martinez

submission deadline 10 Aug 2026 | Viewed by 56 | Submission Open

Keywords: sports cardiology; athletes; cardiac imaging; hypertrophic cardiomyopathy; screening; electrocardiogram; electrophysiology; echocardiography; sudden cardiac death

(This special issue belongs to the Section Cardiology)

New Insights into Glaucoma: 2nd Edition

edited by

Su-Ho Lim

and

Daniel Laroche

submission deadline 10 Aug 2026 | Viewed by 35 | Submission Open

Keywords: glaucoma; intraocular pressure (IOP); risk calculators; glaucoma screening glaucoma surgery; cataract surgery; trabeculectomy; glaucoma drainage devices; minimally invasive glaucoma surgery (MIGS); artificial intelligence (AI)

(This special issue belongs to the Section Ophthalmology)

Neurovascular Canvas: From Basic Science to Clinical Breakthroughs

edited by

Ciro De Luca

, Nicola Giannini and

Alessandro Viganò

submission deadline 15 Aug 2026 | Viewed by 54 | Submission Open

Keywords: neurovascular unit (NVU); neurodegeneration; vascular biology; stroke; disease modeling

(This special issue belongs to the Section Clinical Neurology)

Spine Surgery: Novel Challenges and Opportunities

edited by

Tae-Hwan Kim

submission deadline 15 Aug 2026 | Viewed by 29 | Submission Open

Keywords: spine surgery; surgical outcomes; postoperative care; complications; epidemiology; diagnostic imaging; biomaterials; biomechanics; machine learning; artificial intelligence; predictive modeling; minimally invasive techniques; population-based studies; clinical decision-making

(This special issue belongs to the Section Orthopedics)

Redefining Hemodialysis: Beyond Diffusion to Precision Therapy

edited by

Stefano Stuard

and Sagar Nigwekar

submission deadline 15 Aug 2026 | Viewed by 1 | Submission Open

Keywords: digitalized medical governance; precision dialysis; convective clearance; advanced membranes; hemodynamic stability; artificial intelligence; digital biomarkers; personalized prescription; cardiovascular protection; patient-reported outcome measures; clinical trial emulation

(This special issue belongs to the Section Nephrology & Urology)

Advances in the Diagnosis and Management of Age-Related Macular Degeneration: 3rd Edition

edited by Tsutomu Yasukawa

submission deadline 20 Aug 2026 | Viewed by 158 | Submission Open

Keywords: age-related macular degeneration; angiography; anti-vascular endothelial growth factor therapy; geographic atrophy; macular neovascularization; multimodal imaging; ophthalmology; optical coherence tomography; photodynamic therapy; retinal pigment epithelium

(This special issue belongs to the Section Ophthalmology)

Current Trends and Innovations in Coronary Artery Disease and Myocardial Ischemia: Second Edition

edited by

Edoardo Conte

submission deadline 20 Aug 2026 | Viewed by 63 | Submission Open

Keywords: coronary artery disease; fractional flow reserve; invasive coronary angiography; cardiac CT; cardiac MRI

(This special issue belongs to the Section Cardiovascular Medicine)

New Insights into Gastrointestinal Surgery: Advances in Techniques and Treatment Approaches

edited by Gabriella Teresa Capolupo

submission deadline 20 Aug 2026 | Viewed by 61 | Submission Open

Keywords: gastroenterology; gastrointestinal surgery; colorectal surgery; robotic surgery; technologies; minimally invasive surgery

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Anterior Segment Disorders

edited by Itay Lavy and

Nir Erdinest

submission deadline 20 Aug 2026 | Viewed by 28 | Submission Open

Keywords: anterior segment disorders; corneal disease; cataract surgery; ocular surface disease; surgical outcomes; surgical techniques; artificial intelligence in diagnosis; diagnostic imaging; pharmacological and surgical interventions; refractive errors; anterior uveitis; keratitis; corneal ectasia; quality of life

(This special issue belongs to the Section Ophthalmology)

Physical Therapy in Musculoskeletal Disorders: Prevention, Diagnosis, Clinical Management and Treatment—2nd Edition

edited by

Rubén Cuesta-Barriuso

submission deadline 20 Aug 2026 | Viewed by 28 | Submission Open

Keywords: physical therapy; musculoskeletal disorders; prevention; diagnosis; clinical management; treatment

(This special issue belongs to the Section Clinical Rehabilitation)

Clinical Updates on Reproductive Endocrinology in Children and Adolescents

edited by

Charikleia Stefanaki

submission deadline 20 Aug 2026 | Viewed by 26 | Submission Open

Keywords: reproductive endocrinology; adolescents; male hypogonadism; female hypogonadism; reproductive metabolism; PCOS; POF; receptor abnormalities; menstrual cycle; transgender health; CAH; ovaries; gonads; hormones; sex development; amenorrhea; estrogen resistance; androgen resistance; teen pregnancy; oncology; preservation of fertility

(This special issue belongs to the Section Clinical Pediatrics)

Retinal Diseases: Recent Advances in Diagnosis and Treatment—2nd Edition

edited by Dario Giorgio and Dario Pasquale Mucciolo

submission deadline 20 Aug 2026 | Viewed by 24 | Submission Open

Keywords: retinal diseases; retinal degeneration; macular degeneration; OCT; retinal imaging

(This special issue belongs to the Section Ophthalmology)

Diagnosis and Clinical Management in Hematologic Oncology

edited by Sunil Lakhwani and José María Raya-Sánchez

submission deadline 20 Aug 2026 | Viewed by 19 | Submission Open

Keywords: hematologic malignancies; lymphoma; multiple myeloma; acute leukemia; myeloproliferative neoplasms; molecular diagnostics; targeted therapy; immunotherapy; prognostic biomarkers; clinical management

(This special issue belongs to the Section Hematology)

Advances in the Management of Cervical Spine Trauma

edited by

Jong-Beom Park

and

Sung-kyu Kim

submission deadline 20 Aug 2026 | Viewed by 17 | Submission Open

Keywords: cervical spine trauma; cervical fracture; high cervical injury; subaxial injury; surgical management; occipitocervical fusion; C1 fracture; C2 fracture; spinal stability; trauma imaging; spinal cord injury; neurological outcome

(This special issue belongs to the Section Orthopedics)

Clinical Advances in Orthopedic Infections: 2nd Edition

edited by

Hyonmin Choe

submission deadline 20 Aug 2026 | Viewed by 13 | Submission Open

Keywords: orthopedic surgery; orthopedic infections; periprosthetic joint infection; surgical site infection; infection management

(This special issue belongs to the Section Orthopedics)

Precision Neuroimaging in Mental and Behavioral Health Research

edited by Thomas Vanicek and Arkadiusz Komorowski

submission deadline 20 Aug 2026 | Viewed by 12 | Submission Open

Keywords: psychiatry; neuroimaging; addiction; substance use disorders (SUD); attention deficit hyperactivity disorder (ADHD); imaging genomics; imaging transcriptomics

(This special issue belongs to the Section Mental Health)

Enhancing and Rehabilitation of Gait and Mobility in Chronic Stroke

edited by

Maria-Arantzazu Ruescas-Nicolau

Marco Iosa

and

María Luz Sánchez-Sánchez

submission deadline 20 Aug 2026 | Viewed by 12 | Submission Open

Keywords: chronic stroke; gait rehabilitation; mobility; physical therapy; technology-assisted interventions; assessment

(This special issue belongs to the Section Clinical Neurology)

Targeting Extravalvular Burden Associated with Valvular Heart Disease

edited by

Giovanni La Canna

submission deadline 20 Aug 2026 | Viewed by 4 | Submission Open

Keywords: valvular heart disease; systemic disorder; extravalvular burden; valve dysfunction; valve intervention; multimodality imaging

(This special issue belongs to the Section Cardiology)

Clinical Approaches of Intracranial Aneurysm and Subarachnoid Hemorrhage

edited by Sylvia Bele

submission deadline 20 Aug 2026 | Viewed by 3 | Submission Open

Keywords: aSAH; clipping or coiling; extracranial complications; cerebral vasospasm; ICU treatment

(This special issue belongs to the Section Clinical Neurology)

Breaking the Barrier: Early Detection of Pancreatic Ductal Adenocarcinoma (PDAC)

edited by

Ewa Małecka-Wojciesko

submission deadline 20 Aug 2026 | Viewed by 1 | Submission Open

Keywords: pancreatic ductal adenocarcinoma (PDAC); pancreatic cancer; IPMN; PDAC screening; early PDAC detection; PDAC biomarkers; CT; NMR

(This special issue belongs to the Section Oncology)

Non-Pharmacological Therapies and Exercise Interventions in Clinical Populations

edited by

Jorge Sánchez-Infante

submission deadline 20 Aug 2026 | Viewed by 1 | Submission Open

Keywords: non-pharmacological interventions; physiotherapy approaches; physical activity; acute and chronic diseases; acute and chronic pain

(This special issue belongs to the Section Clinical Rehabilitation)

Recent Advances in Hypercholesterolemia

edited by Ana Catarina Alves

submission deadline 20 Aug 2026 | Submission Open

Keywords: hypercholesterolemia; cardiovascular risk; molecular diagnostics; variants of uncertain significance (VUS); functional characterisation; precision medicine; lipid-lowering therapy

(This special issue belongs to the Section Endocrinology & Metabolism)

Updates on Embolization and Embolotherapy for Benign Prostatic Hyperplasia and Men’s Health

edited by Sandeep L. Bagla, Ari J. Isaacson and Abin Sajan

submission deadline 20 Aug 2026 | Submission Open

Keywords: benign prostatic hyperplasia; prostatic artery embolization; men’ s health; lower urinary tract symptoms; embolization therapy; radiation safety; prostate cancer and radiotherapy

(This special issue belongs to the Section Nephrology & Urology)

Contemporary Coronary Intervention: Innovation, Evidence, and Patient-Centred Outcomes

edited by Kevin Liou

submission deadline 20 Aug 2026 | Submission Open

Keywords: coronary intervention; patient-centered approaches; revascularisation; imaging-guided strategies; clinical outcomes

(This special issue belongs to the Section Cardiology)

The Liver–Kidney Axis in Metabolic Diseases: Biomarkers and Clinical Implications

edited by

Anna Di Sessa

submission deadline 20 Aug 2026 | Submission Open

Keywords: liver; kidney; cross-organ crosstalk; mechanisms; biomarkers; metabolic diseases; clinical implications

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Clinical Outcomes of Glaucoma Surgery: Visual Acuity, Effectiveness and Quality of Life

edited by

Gloria Roberti

and

Manuele Michelessi

submission deadline 21 Aug 2026 | Viewed by 17 | Submission Open

Keywords: glaucoma surgery; visual acuity; intraocular pressure; surgical outcomes; trabeculectomy; microinvasive glaucoma surgery; postoperative complications; functional vision

(This special issue belongs to the Section Ophthalmology)

Advancements in Cardiomyopathies: Diagnosis, Treatment and Management—2nd Edition

edited by

Cinzia Forleo

and

Maria Cristina Carella

submission deadline 24 Aug 2026 | Viewed by 19 | Submission Open

Keywords: cardiomyopathies; multimodality imaging; cardiac magnetic resonance; genetic testing; cardiogenetics; genetic cardiovascular disease; rare cardiovascular diseases; risk stratification; genotype– phenotype correlations; rare variant interpretation; arrhythmias

(This special issue belongs to the Section Cardiology)

Current and Emerging Strategies in Ischemic Stroke: Diagnosis, Treatment, and Prevention

edited by

Dougho Park

Hyoung Seop Kim

and

Jong Hun Kim

submission deadline 25 Aug 2026 | Viewed by 29 | Submission Open

Keywords: diagnosis; digital medicine; epidemiology; ischemic stroke; machine learning; neurorehabilitation; prevention; stroke imaging; treatment

(This special issue belongs to the Section Clinical Neurology)

Knee Arthroplasty: Recent Advances and Future Challenges

edited by Matteo Marullo

submission deadline 25 Aug 2026 | Viewed by 16 | Submission Open

Keywords: knee arthroplasty; implant design; robotic surgery; revision surgery; biomechanics; clinical outcomes; perioperative care; fast-track surgery; digital orthopedics; partial knee replacement

(This special issue belongs to the Section Orthopedics)

Clinical Updates in Heart Failure: Innovations in Diagnosis, Therapy and Management

edited by Paolo Severino

submission deadline 28 Aug 2026 | Viewed by 18 | Submission Open

Keywords: heart failure; HFrEF therapy; HFpEF phenotyping; right ventricular dysfunction; renal congestion assessment; diuretic resistance; NT-proBNP dynamics; cardiac imaging; post-discharge management

(This special issue belongs to the Section Cardiology)

Optimizing the Surgical Journey: From Abdominal Operation to Recovery

edited by

Alessio Giordano

and Carlo Bergamini

submission deadline 1 Sep 2026 | Viewed by 26 | Submission Open

Keywords: surgical complications; comanagement; comorbidities; elective surgical procedure; emergency surgery procedure; multidisciplinary approach; hospitalist

(This special issue belongs to the Section General Surgery)

Current Challenges in Clinical Dentistry: 3rd Edition

edited by

Eiji Tanaka

and

Susumu Abe

submission deadline 15 Sep 2026 | Viewed by 38 | Submission Open

Keywords: artificial intelligence; clinical dentistry; cutting-edge device and technology; dental material; challenging hypothesis; preventive dentistry; sleep medicine; digital dentistry; smart dentistry; stomatognathic function

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

Treatment and Clinical Management of Necrotizing Pancreatitis

edited by

Apostolos Gaitanidis

submission deadline 20 Sep 2026 | Viewed by 39 | Submission Open

Keywords: necrotizing pancreatitis; infected necrosis; step-up approach; necrosectomy; minimally invasive surgery; artificial intelligence; lumen-apposing metal stent; pancreatic necrosis

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Management in Dry Eye Disease: Current Strategies and Emerging Protocols

edited by Sunil Shah and Raquel Gil-Cazorla

submission deadline 20 Sep 2026 | Viewed by 28 | Submission Open

Keywords: dry eye disease; ocular surface; diagnostics; inflammation; biomarkers; emerging therapies

(This special issue belongs to the Section Ophthalmology)

Advances in the Diagnosis and Management of Sarcoidosis

edited by

Carlos Feijoo-Massó

, Pilar Brito-Zerón and Miriam Akasbi Montalvo

submission deadline 25 Sep 2026 | Viewed by 19 | Submission Open

Keywords: sarcoidosis; diagnosis; biomarkers; imaging; immunopathogenesis; biologic therapy; prognosis; interstitial lung disease

(This special issue belongs to the Section Immunology & Rheumatology)

Fibromyalgia: Diagnostic Progress and Therapeutic Advances

edited by

Casandra Isabel Montoro Aguilar

submission deadline 17 Nov 2026 | Viewed by 47 | Submission Open

Keywords: fibromyalgia; chronic pain; central sensitization; diagnostic biomarkers; advanced imaging; molecular markers; autonomic nervous system; cardiovascular regulation; emotional processing; cognitive dysfunction; fatigue; pain modulation; neuromodulation; tDCS

(This special issue belongs to the Section Clinical Neurology)

Dental Care: Oral and Systemic Disease Prevention: 2nd Edition

edited by

Kacper Nijakowski

submission deadline 31 Dec 2026 | 1 articles | Viewed by 1498 | Submission Open

Keywords: oral health; oral diseases; oral manifestations; systemic diseases; oral care; dental prevention; dental caries; periodontal disease; oral medicine; dentistry; oral microbiome; salivary diagnostics; AI-assisted tools

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

Aortic Diseases: Modern Strategies in Diagnosis, Management, and Prevention of Complications

edited by

Petroula N. Nana

, Tilo Kölbel and José Ignacio F. Torrealba

submission deadline 20 Jul 2027 | Viewed by 129 | Submission Open

Keywords: aortic aneurysm; aortic dissection; genetic aortic disease; acute aortic syndromes; endovascular repair; complica-tions; outcomes

(This special issue belongs to the Section Vascular Medicine)

Insights into Urological Surgery: Evolving Practices, Trends, and Emerging Challenges

edited by