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Journal of Clinical Medicine publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Sports Cardiology: Current Clinical Status and Outlook into the Future
edited by Aakash Bavishi and Matthew W Martinez
submission deadline 10 Apr 2027 | 4 articles | Viewed by 2947 | Submission Open
Keywords: sports cardiology; athletes; cardiac imaging; hypertrophic cardiomyopathy; screening; electrocardiogram; electrophysiology; echocardiography; sudden cardiac death
(This special issue belongs to the Section Cardiology)
Clinical Advances in Cardiothoracic Anesthesiology
edited by
submission deadline 10 Apr 2027 | 3 articles | Viewed by 2844 | Submission Open
Keywords: cardiac anesthesiology; thoracic anesthesiology; precision medicine; prevention of organ dysfunction; mechanical circulatory support; minimally invasive surgery
(This special issue belongs to the Section Anesthesiology)
New Insights into Glaucoma: 2nd Edition
edited by and
submission deadline 10 Apr 2027 | 2 articles | Viewed by 2282 | Submission Open
Keywords: glaucoma; intraocular pressure (IOP); risk calculators; glaucoma screening glaucoma surgery; cataract surgery; trabeculectomy; glaucoma drainage devices; minimally invasive glaucoma surgery (MIGS); artificial intelligence (AI)
(This special issue belongs to the Section Ophthalmology)
Clinical Updates on Acromegaly
edited by , Jowita Halupczok-Żyła, Aleksandra Gilis-Januszewska and Przemysław Witek
submission deadline 10 Apr 2027 | 2 articles | Viewed by 1973 | Submission Open
Keywords: acromegaly; GH; IGH-1; growth hormone-secreting pituitary adenoma; pituitary adenoma
(This special issue belongs to the Section Endocrinology & Metabolism)
Current Challenges and Perspectives in Aortic Valve Replacement
edited by , Quentin Fischer and David Del Val
submission deadline 10 Apr 2027 | 1 articles | Viewed by 1810 | Submission Open
Keywords: aortic valve replacement; transcatheter aortic valve implantation (TAVI); surgical aortic valve replacement; prosthesis–patient mismatch; structural heart disease; heart team; valve durability; coronary access; valve-in-valve
(This special issue belongs to the Section Cardiovascular Medicine)
Crohn’s Disease: Ongoing Challenges and Future Directions in Diagnosis and Monitoring
edited by Laura Maria Minordi and
submission deadline 10 Apr 2027 | Viewed by 126 | Submission Open
Keywords: Crohn’s disease; imaging; endoscopy; complications; advanced therapies; radiomic; surgery
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Advances in Functional Diagnostics and Physiotherapy of Musculoskeletal Disorders submission deadline 10 Apr 2027 | Viewed by 102 | Submission Open
Keywords: functional diagnostics; physiotherapy; rehabilitation; musculoskeletal system; functional assessment; gait analysis; movement biomechanics; postural control; postural stability; muscle strength; muscle tone; digital technologies in rehabilitation; objective measurement methods
(This special issue belongs to the Section Clinical Rehabilitation)
Clinical Advances in Swallowing Disorders: Advancing Measurement Science in Dysphagia
edited by Phoebe Macrae
submission deadline 10 Apr 2027 | Viewed by 77 | Submission Open
Keywords: dysphagia; measurement science; outcome measurement; psychometrics; swallowing physiology; instrumental assessment; quantitative measurement; measurement methodology; biomarkers; patient-reported outcome measures (PROMs); artificial intelligence
(This special issue belongs to the Section Otolaryngology)
Advances in Musculoskeletal Rehabilitation and Functional Movement
edited by
submission deadline 13 Apr 2027 | 6 articles | Viewed by 6552 | Submission Open
Keywords: corrective exercise; functional training; biomechanics; resistance training; movement impairment; electromyography; muscle activation; musculoskeletal rehabilitation
(This special issue belongs to the Section Clinical Rehabilitation)
Hypertension and Cardiovascular Disease: Clinical Updates and Perspectives: 2nd Edition
edited by and Nicola Virtuoso
submission deadline 15 Apr 2027 | 7 articles | Viewed by 6129 | Submission Open
Keywords: hypertension management; cardiovascular risk assessment; novel antihypertensive therapies; hypertension in pregnancy; hypertensive emergencies; cardiovascular disease prevention; pharmacological interventions for cardiovascular disease
(This special issue belongs to the Section Cardiovascular Medicine)
Plastic and Reconstructive Surgery: Clinical Advances and Future Opportunities
edited by Rami S Kantar
submission deadline 15 Apr 2027 | 5 articles | Viewed by 4919 | Submission Open
Keywords: plastic surgery; reconstructive surgery; cleft lips; palates; post-traumatic reconstruction; facial transplantation; craniofacial surgery; cleft surgery
(This special issue belongs to the Section Plastic, Reconstructive and Aesthetic Surgery/Aesthetic Medicine)
New Perspectives and Innovations in Critical Illness submission deadline 15 Apr 2027 | 3 articles | Viewed by 2403 | Submission Open
Keywords: critical illness; intensive care; ECMO; hemodynamic management; shock physiology; cardiovascular support
(This special issue belongs to the Section Intensive Care)
Future-Proof Care for Patients with Kidney Stones
edited by and Oliver Wiseman
submission deadline 15 Apr 2027 | 3 articles | Viewed by 1407 | Submission Open
Keywords: effectiveness; resilience; prevention; care pathways; urolithiasis; kidney stones; PCNL; URS; ESWL; quality of life
(This special issue belongs to the Section Nephrology & Urology)
Retinal Diseases: Recent Advances in Diagnosis and Treatment—2nd Edition
edited by Dario Giorgio and Dario Pasquale Mucciolo
submission deadline 15 Apr 2027 | 1 articles | Viewed by 817 | Submission Open
Keywords: retinal diseases; retinal degeneration; macular degeneration; OCT; retinal imaging
(This special issue belongs to the Section Ophthalmology)
Advances in Retinal Diseases—Mechanisms, Diagnostics, and Emerging Therapies, 2nd Edition
edited by
submission deadline 15 Apr 2027 | 1 articles | Viewed by 545 | Submission Open
Keywords: inherited retinal diseases; age-related macular degeneration; diabetic retinopathy; multimodal retinal imaging; treatment
(This special issue belongs to the Section Ophthalmology)
Clinical Updates on Reproductive Endocrinology in Children and Adolescents submission deadline 15 Apr 2027 | Viewed by 470 | Submission Open
Keywords: reproductive endocrinology; adolescents; male hypogonadism; female hypogonadism; reproductive metabolism; PCOS; POF; receptor abnormalities; menstrual cycle; transgender health; CAH; ovaries; gonads; hormones; sex development; amenorrhea; estrogen resistance; androgen resistance; teen pregnancy; oncology; preservation of fertility
(This special issue belongs to the Section Clinical Pediatrics)
Revisional and Conversion Bariatric Surgery: Safety and Outcomes
edited by Jerry Dang and Thomas H. Shin
submission deadline 15 Apr 2027 | Viewed by 297 | Submission Open
Keywords: revisional bariatric surgery; conversion surgery; weight recurrence; surgical outcomes; sleeve gastrectomy; roux-en-y gastric bypass; post-bariatric complications; GERD
(This special issue belongs to the Section General Surgery)
Gene Correction and Regenerative Therapies for Inherited Retinal Diseases: Clinical Perspectives
edited by Sushma Kalmodia
submission deadline 15 Apr 2027 | Viewed by 290 | Submission Open
Keywords: gene therapy; AAV; IRD; retinal organoids; RPE
(This special issue belongs to the Section Ophthalmology)
Biomarkers in Cancer Diagnosis and Prognosis
edited by Gina Gheorghe
submission deadline 15 Apr 2027 | Viewed by 277 | Submission Open
Keywords: cancer biomarkers; cancer diagnosis; cancer prognosis; liquid biopsy; precision oncology; tumor microenvironment; treatment response; personalized medicine
(This special issue belongs to the Section Oncology)
Contemporary Advances in Cardiomyopathies: Diagnosis, Risk Assessment and Therapeutic Innovation
edited by Maria Cristina Carella and
submission deadline 15 Apr 2027 | Viewed by 151 | Submission Open
Keywords: cardiomyopathies; cardiovascular genetics; cardiac magnetic resonance; advanced cardiovascular imaging; heart failure; sports cardiology; precision medicine
(This special issue belongs to the Section Cardiology)
The Role of Non-Radiological Imaging in Interventional Arrhythmology Procedures: Challenges and New Perspectives
edited by and Stefano Bandino
submission deadline 15 Apr 2027 | Viewed by 119 | Submission Open
Keywords: cardiac interventional arrhythmology; cardiac ultrasound; echocardiography; near-zero x-ray; electroanatomical mapping; intracardiac echocardiography; thoracic ultrasound
(This special issue belongs to the Section Cardiology)
Sports Injury Rehabilitation and Clinical Recovery Strategies submission deadline 15 Apr 2027 | Viewed by 101 | Submission Open
Keywords: sports injury; rehabilitation; recovery; return to sport; return to performance; mechanobiology; load management; neuromuscular control; digital health; injury prevention
(This special issue belongs to the Section Sports Medicine)
New Advances in Foot and Ankle Surgery: Innovation, Imaging and Personalized Treatment
edited by
submission deadline 15 Apr 2027 | Viewed by 21 | Submission Open
Keywords: foot and ankle surgery; minimally invasive surgery; weight-bearing CT; 3D imaging; total ankle replacement; ankle cartilage lesions; deformity correction; hallux valgus; ankle instability; patient-specific planning
(This special issue belongs to the Section Orthopedics)
Cardiac Arrest: From Prevention to Survivorship—Advancing the Chainmail of Survival submission deadline 16 Apr 2027 | Viewed by 253 | Submission Open
Keywords: cardiac arrest; cardiopulmonary resuscitation (CPR); emergency medicine; emergency department; critical care; basic life support (BLS); advanced life support (ALS); chain of survival; chainmail of survival
(This special issue belongs to the Section Emergency Medicine)
Peripheral Arterial Disease: Advances in Diagnosis, Revascularization, and Limb Preservation submission deadline 17 Apr 2027 | Viewed by 19 | Submission Open
Keywords: peripheral arterial disease; chronic limb-threatening ischemia; revascularization; limb preservation; endovascular treatment; vascular surgery; open surgical revascularization; hybrid revascularization; diabetic foot; wound healing; tissue perfusion; vascular imaging; artificial intelligence; machine learning; 3D modelling; infrared thermography; amputation; limb salvage; clinical decision support; precision vascular surgery
(This special issue belongs to the Section Vascular Medicine)
Clinical Advances in Hepatology submission deadline 18 Apr 2027 | 3 articles | Viewed by 4478 | Submission Open
Keywords: cirrhosis; portal hypertension; non-invasive tests; viral hepatitis; MASLD; HCC
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Challenges in Diagnosis and Treatment of Infertility—2nd Edition
edited by Konstantinos A. Zikopoulos
submission deadline 20 Apr 2027 | 7 articles | Viewed by 30002 | Submission Open
Keywords: fertility; regeneration; age-related infertility; preimplantation diagnosis; precision assessment; individualized fertility needs; clinical diagnosis; in vitro fertilization
(This special issue belongs to the Section Reproductive Medicine & Andrology)
Pancreatic Disorder, Pancreatitis, and Pancreatic Cancer: Interconnections, Clinical Challenges, and Therapeutic Advances submission deadline 20 Apr 2027 | 3 articles | Viewed by 10444 | Submission Open
Keywords: pancreatic disorder; pancreatitis; pancreatic cancer; translational research; diagnosis; treatment
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Sepsis and Septic Shock: Diagnosis, Treatment, and Prognosis
edited by Luigi Carbone and Daniela Pugliese
submission deadline 20 Apr 2027 | 6 articles | Viewed by 6671 | Submission Open
Keywords: sepsis; septic shock; diagnosis and screening tools; risk stratification; machine learning; advanced therapies
(This special issue belongs to the Section Intensive Care)
Kidney Transplantation: State-of-the-Art Knowledge
edited by , Georgios Geropoulos and Kyriakos Psarras
submission deadline 20 Apr 2027 | 3 articles | Viewed by 5892 | Submission Open
Keywords: kidney transplantation; end-stage renal disease; immunosuppression; organ donation; graft survival; graft rejection
(This special issue belongs to the Section Nephrology & Urology)
Hidradenitis Suppurativa: Clinical Diagnosis, Treatment, and Management
edited by Piotr K. Krajewski
submission deadline 20 Apr 2027 | 5 articles | Viewed by 5106 | Submission Open
Keywords: hidradenitis suppurativa; acne inversa; clinical diagnosis; disease severity assessment; biologic therapy; surgical management; comorbidities; quality of life; multidisciplinary care; real world evidence
(This special issue belongs to the Section Dermatology)
New Clinical Advances in Chronic Asthma—2nd Edition
edited by Vitaliano Nicola Quaranta
submission deadline 20 Apr 2027 | 4 articles | Viewed by 5027 | Submission Open
Keywords: chronic asthma; breathlessness; coughing; inhaled corticosteroids (ICS); long-acting beta-agonists (LABAs); personalized treatment; chronic rhinosinusitis; nasal polyps; bronchiectasis; endotypes; oral corticosteroids
(This special issue belongs to the Section Respiratory Medicine)
Non-Pharmacological Therapies and Exercise Interventions in Clinical Populations submission deadline 20 Apr 2027 | 5 articles | Viewed by 4977 | Submission Open
Keywords: non-pharmacological interventions; physiotherapy approaches; physical activity; acute and chronic diseases; acute and chronic pain
(This special issue belongs to the Section Clinical Rehabilitation)
Etiology, Diagnosis, and Management of Upper Gastrointestinal Disorders: 2nd Edition
edited by
submission deadline 20 Apr 2027 | 2 articles | Viewed by 4433 | Submission Open
Keywords: esophagus; stomach; duodenum; DGBI; FGIDs; helicobacter; eosinophilic esophagitis
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Clinical Outcomes of Glaucoma Surgery: Visual Acuity, Effectiveness and Quality of Life submission deadline 20 Apr 2027 | 6 articles | Viewed by 4221 | Submission Open
Keywords: glaucoma surgery; visual acuity; intraocular pressure; surgical outcomes; trabeculectomy; microinvasive glaucoma surgery; postoperative complications; functional vision
(This special issue belongs to the Section Ophthalmology)
Infectious Diseases and Host Responses: Clinical, Immunological, and Outcome-Orientated Perspectives
edited by
submission deadline 20 Apr 2027 | 4 articles | Viewed by 4173 | Submission Open
Keywords: microbiology; infection; resistance; epidemiology; microbiome; prevention; therapy
(This special issue belongs to the Section Infectious Diseases)
Cardiovascular Prevention and Epidemiology: Innovations and Insights Bridging Research and Practice for Effective Risk Reduction
edited by and Maria Maiello
submission deadline 20 Apr 2027 | 5 articles | Viewed by 3894 | Submission Open
Keywords: cardiovascular prevention; risk reduction; epidemiology; innovations; risk stratification; population health
(This special issue belongs to the Section Cardiovascular Medicine)
Anesthesia and Intensive Care: Clinical Practices and Prospects
edited by
submission deadline 20 Apr 2027 | 4 articles | Viewed by 3841 | Submission Open
Keywords: artificial intelligence; clinical decision support; perioperative risk stratification; perioperative patient safety; hemodynamic optimization
(This special issue belongs to the Section Intensive Care)
Clinical Therapeutic Advances of Mitral Regurgitation
edited by
submission deadline 20 Apr 2027 | 5 articles | Viewed by 3797 | Submission Open
Keywords: mitral regurgitation; mitral valve prolapse; cardiovascular interventions; heart surgery; echocardiography; mag-netic resonance imaging; computed tomography
(This special issue belongs to the Section Cardiovascular Medicine)
Enhancing and Rehabilitation of Gait and Mobility in Chronic Stroke submission deadline 20 Apr 2027 | 1 articles | Viewed by 3749 | Submission Open
Keywords: chronic stroke; gait rehabilitation; mobility; physical therapy; technology-assisted interventions; assessment
(This special issue belongs to the Section Clinical Neurology)
Advances in the Diagnosis and Management of Age-Related Macular Degeneration: 3rd Edition
edited by Tsutomu Yasukawa
submission deadline 20 Apr 2027 | 4 articles | Viewed by 3318 | Submission Open
Keywords: age-related macular degeneration; angiography; anti-vascular endothelial growth factor therapy; geographic atrophy; macular neovascularization; multimodal imaging; ophthalmology; optical coherence tomography; photodynamic therapy; retinal pigment epithelium
(This special issue belongs to the Section Ophthalmology)
Advances in Cardiac Surgery: Techniques, Outcomes, and Innovations
edited by , Horatiu Suciu and
submission deadline 20 Apr 2027 | 5 articles | Viewed by 3066 | Submission Open
Keywords: endoscopic cardiac surgery; minimally invasive cardiac surgery; MIMS; mini-AVR; MIDCAB; TCRAT; LVAD; heart transplant; congenital heart disease
(This special issue belongs to the Section Cardiology)
Clinical Advances in Geriatric Acute Care: Multimorbidity, Frailty, and Integrated Diagnostics submission deadline 20 Apr 2027 | 4 articles | Viewed by 2712 | Submission Open
Keywords: geriatric medicine; frailty; multidimensional assessment; lung ultrasound; point-of-care ultrasound; acute care of older adults; transitional care
(This special issue belongs to the Section Geriatric Medicine)
Orthopaedic Trauma and Bone Healing: Recent Advances and Future Perspectives
edited by Gheorghe Tomoaia and Daniel Oltean-Dan
submission deadline 20 Apr 2027 | 4 articles | Viewed by 2684 | Submission Open
Keywords: orthopaedic trauma; fractures; minimally invasive fixation; bone healing; biomaterials; periprosthetic fractures; artificial intelligence; rehabilitation; complications; orthopaedic surgery
(This special issue belongs to the Section Orthopedics)
Advances in the Management of Cervical Spine Trauma submission deadline 20 Apr 2027 | 4 articles | Viewed by 2654 | Submission Open
Keywords: cervical spine trauma; cervical fracture; high cervical injury; subaxial injury; surgical management; occipitocervical fusion; C1 fracture; C2 fracture; spinal stability; trauma imaging; spinal cord injury; neurological outcome
(This special issue belongs to the Section Orthopedics)
Endocrine Surgery: Current Treatment and Future Options
edited by Pietro Princi and
submission deadline 20 Apr 2027 | 1 articles | Viewed by 2550 | Submission Open
Keywords: endocrine surgery; thyroid surgery; parathyroid surgery; adrenal gland surgery; neuroendocrine neoplasms; thyroid cancer; thyroid cancer treatment; surgical endocrinology; robotic endocrine surgery; laparoscopic adrenalectomy; ret-roperitoneoscopic adrenalectomy; parathyroidectomy; benign thyroid disease; thyroid ablation
(This special issue belongs to the Section General Surgery)
Clinical Updates and Perspectives in Atrial Fibrillation
edited by Riyaz Somani and
submission deadline 20 Apr 2027 | 3 articles | Viewed by 2474 | Submission Open
Keywords: atrial fibrillation; catheter ablation; risk prediction; stroke prevention; digital health and artificial intelligence
(This special issue belongs to the Section Cardiology)
Advances in Trauma and Orthopedic Surgery: 3rd Edition submission deadline 20 Apr 2027 | 3 articles | Viewed by 2437 | Submission Open
Keywords: trauma; fracture; fracture fixation; osteosynthesis; biomechanics; bone; approach; nonunion; joint replacement; outcome
(This special issue belongs to the Section Orthopedics)
Heart Failure and Transplant Cardiology: Latest Advances and Prospects
edited by Monika Budnik
submission deadline 20 Apr 2027 | 4 articles | Viewed by 2306 | Submission Open
Keywords: heart failure; heart transplantation; bridge to transplant; mechanical circulatory support; cardiomyopathies
(This special issue belongs to the Section Cardiology)
From Clinical Diagnosis to Effective Treatment of Cardiomyopathy submission deadline 20 Apr 2027 | 2 articles | Viewed by 2218 | Submission Open
Keywords: hypertrophic cardiomyopathy; dilated cardiomyopathy; non-ischemic cardiomyopathy; cardiac MRI; PET/CT; PET/MRI; cardiac imaging; sudden cardiac death
(This special issue belongs to the Section Cardiology)
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