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Journal of Clinical Medicine publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Clinical Highlights in Uveal Melanoma

edited by Tomasz Chorągiewicz and

Joanna Dolar-Szczasny

submission deadline 25 Nov 2025 | 1 articles | Viewed by 1924 | Submission Open

Keywords: choroidal melanoma; uveal melanoma; radiotherapy; enucleation; brachytherapy

(This special issue belongs to the Section Ophthalmology)

Interstitial Lung Disease Secondary to Autoimmune Disorders: Recent Advances and Novel Perspectives

edited by

Gaetano La Rocca

Gianluca Sambataro

and Francesco Ferro

submission deadline 25 Nov 2025 | 1 articles | Viewed by 1547 | Submission Open

Keywords: interstitial lung disease; lung involvement; connective tissue diseases; rheumatoid arthritis; systemic vasculitis; radiomics; lung ultrasound; biomarkers; pathogenetic immunological pathways; therapeutic targets

(This special issue belongs to the Section Respiratory Medicine)

Clinical Advances in Spinal Neurosurgery

edited by Jang-Won Yoon

submission deadline 25 Nov 2025 | 2 articles | Viewed by 1486 | Submission Open

Keywords: minimally invasive spine surgery; lateral lumbar interbody fusion; endoscopic spine surgery; patient-reported out-comes; functional assessment; perioperative care; surgical decision-making

(This special issue belongs to the Section Clinical Neurology)

Modern Blood Banking and Transfusion in Clinical Practice: Second Edition

edited by

Pilar Solves

submission deadline 25 Nov 2025 | 1 articles | Viewed by 1417 | Submission Open

Keywords: blood transfusion therapy; patient blood management; restrictive transfusion; cell therapy; platelet transfusion

(This special issue belongs to the Section Hematology)

Treatment and Prognosis of Spinal Surgery

edited by Andy Ton and Shane Shahrestani

submission deadline 25 Nov 2025 | 2 articles | Viewed by 1358 | Submission Open

Keywords: spinal surgery; minimally invasive surgery (MIS); robotic-assisted surgery; patient-reported outcomes (PROs); postoper-ative outcomes; predictive analytics; radiographic predictors; endoscopic; disk arthroplasty; single position surgery

(This special issue belongs to the Section Clinical Neurology)

Clinical Advances in Surgical Treatment for Hepato–Pancreatic–Biliary (HPB) Diseases

edited by

Spiros G. Delis

submission deadline 25 Nov 2025 | 1 articles | Viewed by 1250 | Submission Open

Keywords: pancreas surgery; liver resection; minimal invasive approach; virtual reality; robotic surgery; MDT

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Hospital-Acquired Infections in the Elderly

edited by Nadya Kagansky and Emily Lubart

submission deadline 25 Nov 2025 | 1 articles | Viewed by 1188 | Submission Open

Keywords: hospital-acquired infections (HAIs); elderly patients; infection control; microbial resistance; epidemiology; risk factors; prevention strategies; treatment options; diagnostic accuracy

(This special issue belongs to the Section Epidemiology & Public Health)

Advances in the Clinical Management of Perioperative Anesthesia: 2nd Edition

edited by Alessia Mattei, Rita Cataldo and

Alessandro Strumia

submission deadline 25 Nov 2025 | 2 articles | Viewed by 1097 | Submission Open

Keywords: perioperative outcomes (surgical; anesthetic; medical); evidence-based care; perioperative guidelines and consensus statements; preoperative evaluation and risk scores; preoperative testing; surgical optimization and enhanced surgical recovery programs; intensive care unit

(This special issue belongs to the Section Anesthesiology)

Current Clinical Advances in Urinary Incontinence

edited by Adolf Lukanovic, David Lukanović and Mija Blaganje

submission deadline 25 Nov 2025 | 1 articles | Viewed by 1079 | Submission Open

Keywords: female urinary incontinence; stress urinary incontinence; overactive bladder; diagnosis; prevention; conservative treatment; minimally invasive treatment; surgery; mid-urethral sling; new approach; energy-based devices

(This special issue belongs to the Section Nephrology & Urology)

Advances in Fertility Preservation

edited by Dunja Maria Baston-Büst

submission deadline 25 Nov 2025 | 1 articles | Viewed by 1031 | Submission Open

Keywords: fertility preservation; gonadotoxic treatment; chemotherapy; transgender; cryopreservation; ejaculate; testicular tissue; mature oocytes; immature oocytes; ovarian tissue; ovarian cortex

(This special issue belongs to the Section Obstetrics & Gynecology)

Diabetic Foot: Emerging Prevention Strategies and Epidemiology

edited by

Vilma Urbančič-Rovan

submission deadline 25 Nov 2025 | 1 articles | Viewed by 1023 | Submission Open

Keywords: diabetic foot; foot clinics; epidemiology; prevention; screening; amputation; podiatry

(This special issue belongs to the Section Endocrinology & Metabolism)

Clinical Updates in Reproductive Endocrinology: 2nd Edition

edited by Iwona Bojar and

Dorota Raczkiewicz

submission deadline 25 Nov 2025 | 1 articles | Viewed by 1007 | Submission Open

Keywords: reproductive endocrinology; endocrine diseases in pregnancy; infertility; endocrine diagnostics in infertility; long-term consequences of endocrine disorders; therapy for endocrine disorders

(This special issue belongs to the Section Obstetrics & Gynecology)

Emerging Treatment Options in Aortic Valve Disease and Aortic Stenosis

edited by Borut Geršak and Robert Phillip Gallegos

submission deadline 25 Nov 2025 | 1 articles | Viewed by 929 | Submission Open

Keywords: aortic stenosis; minimally invasive surgery; transcatheter aortic valve replacement; surgical treatment; diagnostic strategies; re-operation/redo AVR; calcified root; valve in valve

(This special issue belongs to the Section Cardiology)

Approaches and Challenges in Oral Rehabilitation

edited by

Yoko Hasegawa

and Takayuki Kosaka

submission deadline 25 Nov 2025 | 1 articles | Viewed by 914 | Submission Open

Keywords: oral rehabilitation; oral health; systemic health; dental innovation; neuroplasticity

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

Recent Advances in Adverse Pregnancy and Neonatal Outcomes

edited by

Sae-kyung Choi

submission deadline 25 Nov 2025 | 1 articles | Viewed by 878 | Submission Open

Keywords: maternal and fetal; adverse pregnancy; neonatal outcomes; newborns; cesarean section

(This special issue belongs to the Section Obstetrics & Gynecology)

Endometriosis: Current Insights and Treatments

edited by Mercedes Espada Vaquero

submission deadline 25 Nov 2025 | Viewed by 458 | Submission Open

Keywords: endometriosis; chronic pelvic pain; pelvic floor dysfunction; hormonal treatment; gynecological surgery; diagnosis; hysteroscopy; infertility

(This special issue belongs to the Section Obstetrics & Gynecology)

Ischemic Stroke: Diagnosis, Treatment, and Management

edited by

Maria Luisa Zedde

and Rosario Pascarella

submission deadline 25 Nov 2025 | Viewed by 422 | Submission Open

Keywords: ischemic stroke; diagnosis; treatment; stroke unit; stroke care; stroke etiology; thrombolysis; EVT; rare causes of stroke; cerebral vein thrombosis

(This special issue belongs to the Section Clinical Neurology)

New Insights in Paediatric Endocrinology

edited by

Marco Fiore

submission deadline 25 Nov 2025 | Viewed by 274 | Submission Open

Keywords: endocrinology; pediatrics; hormones; therapy and treatment; adolescents; newborns

(This special issue belongs to the Section Clinical Pediatrics)

Anemia: Clinical Updates in Diagnosis, Management, and Treatment

edited by

Joan-Lluis Vives-Corrons

submission deadline 25 Nov 2025 | Viewed by 243 | Submission Open

Keywords: anemia; diagnostic tools; hematology; artificial intelligence; targeted therapy; hereditary hemolytic anemia

(This special issue belongs to the Section Hematology)

Interstitial Lung Diseases: New Treatments Based on Treatable Traits

edited by Francesco Amati

submission deadline 25 Nov 2025 | Viewed by 237 | Submission Open

Keywords: interstitial lung diseases; progressive pulmonary fibrosis; phenotypes; endotypes; treatment; precision medicine

(This special issue belongs to the Section Respiratory Medicine)

Recent Advances in Diagnosis and Treatment of Comorbid Disorders in Interstitial Lung Diseases

edited by

Giacomo Sica

and Domenica Francesca Mariniello

submission deadline 25 Nov 2025 | Viewed by 223 | Submission Open

Keywords: interstitial lung disease; ILD; progressive pulmonary fibrosis; artificial intelligence; management

(This special issue belongs to the Section Respiratory Medicine)

Enhancing Safety and Outcomes in Complex Spine Surgery

edited by Ahmed Ramadan Sadek

submission deadline 25 Nov 2025 | Viewed by 218 | Submission Open

Keywords: spinal surgery; spinal deformity; scoliosis; sciatica; back and neck pain

(This special issue belongs to the Section Clinical Neurology)

New Horizons in Aortic Valve Replacement

edited by Abdellaziz Dahou

submission deadline 25 Nov 2025 | Viewed by 179 | Submission Open

Keywords: aortic valve; aortic stenosis; TAVR; SAVR; valve durability; aortic valve replacement; transcatheter aortic valve replacement; surgical aortic valve replacement

(This special issue belongs to the Section Cardiology)

Advances in Ablation Therapy for Atrial Fibrillation: Innovations and Clinical Applications

edited by Ioanna Koniari

submission deadline 25 Nov 2025 | Viewed by 166 | Submission Open

Keywords: atrial fibrillation; ablation; PFA; PVI; non-thermal energy; mapping system

(This special issue belongs to the Section Cardiology)

Ventricular Assist Devices: Clinical Advances in Practice and Future Perspectives

edited by Balakrishnan M. Mahesh

submission deadline 25 Nov 2025 | Viewed by 158 | Submission Open

Keywords: ventricular assist device; mechanical circulatory support; pulsatile pneumatic devices; microaxial intraventricular de-vices; magnetically levitated devices; cardiac transplantation; donor circulatory death; normothermic regional perfusion

(This special issue belongs to the Section Cardiology)

The Use of Circulating Extracellular Vesicles as a Tool in the Diagnosis, Monitoring and Treatment of Disease

edited by

Antonio Casado-Díaz

submission deadline 25 Nov 2025 | Viewed by 157 | Submission Open

Keywords: circulating extracellular vesicles; regenerative medicine; biomarker; diagnosis; exosomes; liquid biopsy

(This special issue belongs to the Section Clinical Laboratory Medicine)

Minimally Invasive Laparoendoscopic Procedures in Abdominal Emergencies

edited by

Eugen Tãrcoveanu

Costel Bradea

and

Alin Mihai Vasilescu

submission deadline 25 Nov 2025 | Viewed by 134 | Submission Open

Keywords: laparoscopic surgery; robotic surgery; minimally invasive surgery; hepatobiliary surgery; pancreatic surgery; gastrointestinal surgery; general surgery; emergency surgery; trauma; recent advances in laparoscopic surgery; surgical training in laparoscopy; endoscopic surgery; the feasibility and safety of laparoscopic; endoscopic co-operative surgery for the treatment of digestive pathology

(This special issue belongs to the Section General Surgery)

Treatment and Digital Outcome Assessment in Orthopaedic Trauma

edited by Benedikt Johannes Braun and

Meir Tibi Marmor

submission deadline 25 Nov 2025 | Viewed by 114 | Submission Open

Keywords: orthopaedic trauma; digital outcome assessment; wearable sensors; patient-reported outcomes; machine learning (or artificial intelligence)

(This special issue belongs to the Section Orthopedics)

New Approaches in Open and Minimally Invasive Surgery for Abdominal Oncologic Surgery

edited by

Alessandro Coppola

and Immacolata Iannone

submission deadline 25 Nov 2025 | Viewed by 111 | Submission Open

Keywords: surgical oncology; early diagnosis; minimally invasive surgery; personalized medicine; combined therapy; gastrointestinal cancer; oligometastatic cancer; peritoneal disease

(This special issue belongs to the Section General Surgery)

Surgery in the Era of Neoadjuvant Immune Checkpoint Inhibitors Therapy for Thoracic Oncology

edited by

Mohsen Ibrahim

submission deadline 25 Nov 2025 | Viewed by 109 | Submission Open

Keywords: neoadjuvant therapy; immune checkpoint inhibitors; unresectable disease; lung cancer; locally advanced lung cancer

(This special issue belongs to the Section General Surgery)

Clinical Innovation in Endoscopic Sinus and Anterior Skull Base Surgery

edited by

Samiul Muquit

and

Marios Stavrakas

submission deadline 27 Nov 2025 | Viewed by 164 | Submission Open

Keywords: rhinology; endoscopic anterior skull base surgery; anterior skull base surgery; endoscopic sinus surgery; chronic rhinosinusitis (CRS); otolaryngology

(This special issue belongs to the Section Otolaryngology)

Management of Complex Infective Endocarditis

edited by Shekhar Saha, Tulio Caldonazo and Mateo Marin-Cuartas

submission deadline 27 Nov 2025 | Viewed by 107 | Submission Open

Keywords: infective endocarditis; imaging; diagnosis; cardiac surgery; pathogens; antibiotic treatment; risk estimation

(This special issue belongs to the Section Cardiology)

Advances in the Diagnosis and Management of Age-Related Macular Degeneration: 2nd Edition

edited by Tsutomu Yasukawa

submission deadline 28 Nov 2025 | 8 articles | Viewed by 9896 | Submission Open

Keywords: age-related macular degeneration; angiography; antivascular endothelial growth factor therapy; choroidal neovascularization; geographic atrophy; multimodal imaging; ophthalmology; optical coherence tomography; photodynamic therapy; retinal pigment epithelium

(This special issue belongs to the Section Ophthalmology)

New Trends in Mechanical Ventilation

edited by

Jan P. Mulier

submission deadline 28 Nov 2025 | 2 articles | Viewed by 6897 | Submission Open

Keywords: positive pressure ventilation; negative pressure ventilation; constant flow ventilation; PEEP; lung recruitment; obesity; laparoscopy; ARDS; atelectasis; total lung compliance

(This special issue belongs to the Section Anesthesiology)

Advances in Spine Surgery: Best Practices and Future Directions

edited by Martin N. Stienen and

Stefan Motov

submission deadline 28 Nov 2025 | 6 articles | Viewed by 6077 | Submission Open

Keywords: minimally invasive spine surgery; spinal endoscopy; spinal robotics; spinal navigation; ERAS; machine learning; artificial intelligence; complication management; revision surgery; spinal deformity; innovation; future direction

(This special issue belongs to the Section Clinical Neurology)

Current Practices in Cardiovascular Perfusion and Recovery

edited by

Irbaz Hameed

submission deadline 28 Nov 2025 | 1 articles | Viewed by 2257 | Submission Open

Keywords: organ perfusion; ex vivo perfusion; ischemia– reperfusion injury; organ recovery; transplantation; machine perfusion; organ preservation

(This special issue belongs to the Section Cardiology)

Advancements in Anterior Cruciate Ligament Injury: From Diagnosis to the Return-to-Sports: 2nd Edition

edited by Alexandre Hardy and Nicolas Bouguennec

submission deadline 28 Nov 2025 | 3 articles | Viewed by 2065 | Submission Open

Keywords: anterior cruciate ligament reconstruction (ACLR); timing of ACLR; ramp lesion; meniscal lesion; lateral extra-articular procedure

(This special issue belongs to the Section Sports Medicine)

Clinical Updates in Heart Transplantation

edited by

Giacomo Bianchi

submission deadline 28 Nov 2025 | 2 articles | Viewed by 1434 | Submission Open

Keywords: heart transplantation; ex vivo heart preservation; immunosuppression; xenotransplantation; pre-clinical models; dilated cardiomyopathy; amyloidosis; congenital heart disease

(This special issue belongs to the Section Cardiology)

Innovations in Thoracic Surgery and Disease Management: Integrating Genomics, Technology, and Multidisciplinary Care

edited by

Marco Scarci

and

Savvas Lampridis

submission deadline 28 Nov 2025 | Viewed by 242 | Submission Open

Keywords: thoracic surgery; thoracic disease; genomic medicine; artificial intelligence; advanced imaging; multidisciplinary care; minimally invasive surgery; robotic surgery; precision medicine

(This special issue belongs to the Section Respiratory Medicine)

Novel Treatments for Vestibular Migraine

edited by

Teru Kamogashira

submission deadline 28 Nov 2025 | Viewed by 182 | Submission Open

Keywords: neuromodulation therapy; sympathetic nerve stimulation; CGRP-targeted therapy; dietary interventions; elimination diets; ketogenic diet; low-glycemic index diet; nutritional supplements; pathophysiology of vestibular migraine; clinical adoption of VM therapies

(This special issue belongs to the Section Otolaryngology)

State of the Art in Hepato-Pancreato-Biliary (HPB) Surgery

edited by

Pantelis Antonakis

and Konstantinos Bramis

submission deadline 28 Nov 2025 | Viewed by 158 | Submission Open

Keywords: hepato-pancreato-biliary (HPB) surgery; robotic surgery; laparoscopic surgery; liver resection; liver transplantation; pancreatectomy; liver thermoablation; extrahepatic cholangiocarcinoma; benign biliary disease; pancreatic neuroendocrine tumors; non-colorectal/non-neuroendocrine oligometastatic liver disease

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Novel Diagnostic and Therapeutic Opportunities in Inflammatory and Oncological Diseases in the Gastrointestinal Tract

edited by

Adam Fabisiak

and Hubert Zatorski

submission deadline 28 Nov 2025 | Viewed by 127 | Submission Open

Keywords: cancer; inflammation; diagnosis; treatment; microbiota; gastrointestinal tract; gastroenterology; immunology

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

New Challenges in Maternal-Fetal Medicine

edited by Marzena Laskowska

submission deadline 29 Nov 2025 | 6 articles | Viewed by 13981 | Submission Open

Keywords: thrombocytopenia in pregnancy; multiple pregnancies; placental abruption; DIC; sepsis; chorioamnionitis; cholestasis; postpartum hemorrhage; emergency cervical cerclage; problems in pregnancy and labor; pregnancy complications; spina bifida; fetal well-being evaluation

(This special issue belongs to the Section Obstetrics & Gynecology)

Clinical Advances in Critical Care Medicine

edited by Pietro Caironi

submission deadline 30 Nov 2025 | 14 articles | Viewed by 45584 | Submission Open

Keywords: critical care; artificial intelligence; extra-corporeal life support; mechanical ventilation; sepsis; infection; airway management; acute kidney injury; biomarkers; trauma

(This special issue belongs to the Section Intensive Care)

Bruxism and Temporomandibular Disorders: Current Advances and Future Challenges

edited by

Grzegorz Zieliński

and

Eiji Tanaka

submission deadline 30 Nov 2025 | 21 articles | Viewed by 38395 | Submission Open

Keywords: TMDs; TMJ; rehabilitation; physiotherapy; craniofacial disorder; oral health; biomechanics; masticatory muscles; electromyography; parafunction; nocturnal bruxism; tooth contact habit

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

Recent Advances in Reconstructive Urology and Prosthetic Surgery

edited by Francisco E. Martins, Maurice Garcia and Jay Simhan

submission deadline 30 Nov 2025 | 4 articles | Viewed by 14350 | Submission Open

Keywords: male and female urogenital reconstruction; urologic trauma; urologic prosthetics; erectile dysfunction; urinary incontinence; artificial urinary sphincter; gender-affirming surgery; transgender; phalloplasty; vaginoplasty

(This special issue belongs to the Section Nephrology & Urology)

What’s New in Cardiomyopathies: Diagnosis, Treatment and Management

edited by

Cinzia Forleo

submission deadline 30 Nov 2025 | 6 articles | Viewed by 13514 | Submission Open

Keywords: cardiomyopathies; multimodality imaging; cardiac magnetic resonance; genetic testing; cardiogenetics; genetic cardiovascular disease; rare cardiovascular diseases

(This special issue belongs to the Section Cardiology)

Advancements in Cornea Transplantation

edited by Giulia Coco and Davide Romano

submission deadline 30 Nov 2025 | 8 articles | Viewed by 10663 | Submission Open

Keywords: corneal transplant; keratoplasty; DMEK; DSAEK; PK; cornea

(This special issue belongs to the Section Ophthalmology)

Maxillo-Facial Surgery: New Insights and Technologies in Head and Neck

edited by Federica Ruggiero

submission deadline 30 Nov 2025 | 6 articles | Viewed by 10036 | Submission Open

Keywords: oral and maxilla-facial surgery; orthognathic surgery; cranio-facial surgery; head and neck surgery; augmented reality; navigation; finite element modeling; virtual surgical planning; patient-specific implants

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

Pediatric Dentistry: Recent Advances, Current Issues and Future Challenges

edited by

Liliana Szyszka-Sommerfeld

and

Krzysztof Woźniak

submission deadline 30 Nov 2025 | 5 articles | Viewed by 9651 | Submission Open

Keywords: pediatric dentistry; recent advances; current issues; future challenges; orthodontic issues; preventive strategies; access to care disparities; behavioral management; multidisciplinary collaboration; oral health

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

Displaying special issue 101-150 on page 3 of 31.

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