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Emerging Diagnosis and Therapies for Psoriasis and Chronic Inflammatory Skin Disorders

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Dermatology".

Deadline for manuscript submissions: 20 October 2026 | Viewed by 492

Editors


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Guest Editor
1. Department of Dermatology, Osakidezta Basque Health Service, Basurto University Hospital, Bilbao, Bizkaia, Spain
2. Biobizkaia Health Research Institute, Plaza de Cruces, 12, 48903 Barakaldo, Bizkaia, Spain
Interests: dermatology; psoriasis; cutaneous lymphoma; atopic dermatitis; melanoma; artificial intelligence

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Guest Editor
Department of Dermatology, Hospital Universitario de La Princesa, Universidad Autónoma de Madrid (UAM), Madrid, Spain
Interests: dermatopathology; immunodermatology; cutaneous lymphomas; psoriasis; biologic therapies; melanoma; artificial intelligence applied to dermatological diagnosis

Special Issue Information

Dear Colleagues,

Psoriasis and chronic inflammatory skin disorders represent a major global health burden, affecting hundreds of millions of individuals worldwide and significantly impairing quality of life, productivity, and psychosocial well-being. Over the past decade, remarkable advances in immunology, molecular biology, and translational research have revolutionized our understanding of their pathophysiology, leading to the development of highly targeted therapies. At the same time, innovative diagnostic tools, including imaging techniques, biomarkers, digital health solutions, and artificial intelligence, are reshaping clinical practice and research. These rapid developments create both unprecedented opportunities and important challenges in optimizing patient care, improving long-term outcomes, and implementing personalized therapeutic strategies.

Despite the expanding therapeutic armamentarium, several unmet needs remain, including early and accurate diagnosis, prediction of treatment response, long-term safety assessment, management of comorbidities, and real-world effectiveness. Moreover, increasing disease complexity, patient heterogeneity, and health system constraints demand novel, integrated approaches that bridge basic science, clinical research, and real-life practice. In this context, the field is at a pivotal moment, where emerging diagnostic technologies and innovative therapies have the potential to redefine standards of care and improve the lives of patients with chronic inflammatory skin diseases.

This Special Issue aims to present and disseminate the most recent advances related to emerging diagnostic strategies and novel therapeutic approaches in psoriasis and chronic inflammatory skin disorders. We welcome clinically original research articles, narrative or comprehensive reviews, clinical trials, real-world evidence studies, and technological innovations that contribute to advancing knowledge and clinical practice in this rapidly evolving field. Particular emphasis will be placed on multidisciplinary perspectives, personalized medicine, and digital health solutions.

Topics of interest for publication include, but are not limited to, the following:

  • Novel biologic therapies and small molecules;
  • Biomarkers and predictive models of treatment response;
  • Precision medicine and personalized therapeutic strategies;
  • Artificial intelligence and digital tools in diagnosis and disease monitoring;
  • Imaging techniques and non-invasive diagnostic methods;
  • Real-world evidence, long-term safety, and effectiveness studies;
  • Management of comorbidities and systemic involvement;
  • Patient-reported outcomes and quality of life research.

We look forward to receiving your valuable contributions and to shaping together a comprehensive and forward-looking overview of emerging diagnoses and therapies in chronic inflammatory skin diseases.

Dr. Rosa María Izu-Belloso
Dr. Maria Del Mar Llamas-Velasco
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-anonymized peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • psoriasis
  • chronic inflammatory skin diseases
  • immunopathogenesis
  • biomarkers
  • targeted therapies
  • precision medicine
  • artificial intelligence
  • biomarkers
  • real-world evidence
  • digital dermatology

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Published Papers (1 paper)

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Research

11 pages, 1313 KB  
Article
Systemic Immunomodulatory Effects of Full-Body Blue Light Therapy in Psoriasis Vulgaris Patients
by Daniel Nolberczak, Aleksandra Lesiak, Magdalena Sadowska, Igor Aleksander Bednarski, Natalia Bień and Joanna Narbutt
J. Clin. Med. 2026, 15(13), 5109; https://doi.org/10.3390/jcm15135109 - 1 Jul 2026
Viewed by 132
Abstract
Background/Objectives: Psoriasis vulgaris is a chronic inflammatory skin condition with significant psychosocial burden. While phototherapy remains one of the most widely used treatment regimens, novel modalities like blue light therapy offer UV-free alternatives with potentially more favorable safety profiles, but their systemic immunomodulatory [...] Read more.
Background/Objectives: Psoriasis vulgaris is a chronic inflammatory skin condition with significant psychosocial burden. While phototherapy remains one of the most widely used treatment regimens, novel modalities like blue light therapy offer UV-free alternatives with potentially more favorable safety profiles, but their systemic immunomodulatory effects remain poorly understood. We aimed to evaluate the impact of full-body blue light irradiation on clinical outcomes and selected systemic biochemical and immunological markers in patients with mild-to-moderate psoriasis vulgaris. Methods: This preliminary study involved 21 patients (13 females, 8 males) with mild-to-moderate psoriasis vulgaris. Participants received ten sessions of full-body blue light therapy (453 nm, 40 mW/cm2, 30 min per session). Clinical assessments (PASI, PGA, DLQI, VAS, Pruritus Scale) and serum analyses of inflammatory (TNF-α, IL-13, IL-17, IL-31), metabolic (adiponectin, 25(OH)D3), and neuroimmune markers (serotonin, kynurenic acid, quinolinic acid) were performed pre- and post-treatment. Results: Significant improvements were observed in PASI, PGA, DLQI, and pruritus scores (p < 0.05). 25(OH)D3, serotonin, and kynurenic acid levels increased significantly, while IL-31 and IL-17 levels decreased and IL-13 levels increased; TNF-α, adiponectin, and quinolinic acid levels showed no significant changes. Counterintuitively, correlation analysis demonstrated a moderate positive association between changes in IL-13 and PASI improvement (r = 0.51, p = 0.02), while changes in other biochemical parameters were not significantly associated with clinical outcomes. Conclusions: Full-body blue light therapy resulted in significant clinical improvement accompanied by heterogeneous systemic immunometabolic changes. These findings suggest complex, pathway-specific immunomodulation, but this requires further investigation in larger controlled studies. Full article
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