From Substrate to Therapy: Integrating Approaches in Arrhythmia Management
A Special Issue of Journal of Clinical Medicine (ISSN 2077-0383) belonging to the section "Cardiology".
Deadline for manuscript submissions: 20 October 2026 | Viewed by 1717
Editors
Interests: imaging; cardiac magnetic resonance; ventricular tachycardia substrate; ventricular tachycardia ablation; high density mapping; pulse field ablation
Special Issue Information
Dear Colleagues,
Improved anatomical and functional characterization of arrhythmogenic substrates has enhanced our understanding of arrhythmia mechanisms. The integration of imaging (cardiac MRI, CT and ICE) and mapping techniques (ECGi and high-density electroanatomical mapping) allows more precise characterization of the electrophysiological substrates responsible for arrhythmia initiation and maintenance. In parallel, the emergence of novel therapeutic technologies—including pulsed-field ablation and stereotactic body radiotherapy—has expanded the therapeutic landscape, enabling safe and effective targeting of complex substrates. Together, these developments are fostering a shift toward personalized, precision-guided strategies for the management of both atrial and ventricular arrhythmias.
This Special Issue brings together contributions that explore the evolving interface between arrhythmogenic substrate characterization and contemporary ablation strategies. It focuses on the integration of modern imaging modalities, non-invasive and invasive high-density mapping, and innovative ablation approaches to advance both the understanding and treatment of complex arrhythmias. By highlighting work that addresses clinical application, this Special Issue underscores strategies that enable more precise, individualized, and outcome-oriented arrhythmia management.
Topics of interest for publication include, but are not limited to, the following:
- Characterization of arrhythmogenic substrates through imaging (MRI, CT and ICE) and non-invasive mapping
- Advanced strategies for high-density invasive mapping and functional assessment of arrhythmia substrates
- Innovative approaches to target complex or difficult-to-access substrates, including bipolar ablation, coronary venous ethanol ablation, stereotactic body radiotherapy, and remote-controlled magnetic navigation systems
- Emerging therapeutic technologies and their impact on cardiac ablation outcomes, such as pulsed-field ablation and ultra-cryotherapy
Dr. Sara Vázquez-Calvo
Dr. Ivo Roca-Luque
Guest Editors
Manuscript Submission Information
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Keywords
- cardiac arrhythmias
- substrate characterization
- non-invasive mapping
- ECGi
- cardiac imaging
- high-density mapping
- emerging ablation technologies
- pulsed-field ablation
- ultra-cryotherapy
- stereotactic body radiotherapy
- personalized arrhythmia management
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