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Recent Developments in Gynecological Endocrinology: 2nd Edition
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Recent Developments in Gynecological Endocrinology: 2nd Edition

A Special Issue of Journal of Clinical Medicine (ISSN 2077-0383) belonging to the section "Obstetrics & Gynecology".

Deadline for manuscript submissions: 20 October 2026 | Viewed by 5194

Editor

Prof. Dr. Błażej Męczekalski

E-Mail Website
Guest Editor
Department of Gynaecological Endocrinology, Poznan University of Medical Sciences, 60-535 Poznan, Poland
Interests: hypothalamic amenorrhea; menopause; polycystic ovary syndrome; premature ovarian insufficiency; hyperprolactinemia
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

It is my pleasure to invite you to contribute to the Special Issue entitled "Recent Developments in Gynecological Endocrinology: 2nd Edition”. This is one new volume; we published more than 7 papers in the first volume. For more details, please visit: https://www.mdpi.com/journal/jcm/special_issues/1J2463FXAW#info.

Gynecological endocrinology is a specific field of modern medicine that focuses on the field of physiological and pathological endocrine mechanisms related to the hypothalamic–pituitary–ovarian axis and also influences other endocrine glands (such as adrenal glands, thyroid glands, fat tissue, and others), which have an impact on women’s health and hormonal disorders.

Over the last 2–3 decades, we observed interesting developments in gynecological endocrinology, both in the sense of research and in the clinical field. At present, gynecological endocrinology must face new challenges arising in the context of etiopathogenesis, diagnosis, differential diagnosis, and novel drugs.

This Special Issue aims to discuss the recent developments in the pathophysiology, diagnosis and treatment of different disorders in the field of gynecological endocrinology.

The topics of interest for this Special Issue include menstrual disorders, hyperandrogenization, puberty and related disorders, fertility and infertility, and hormonal disorders during pregnancy, premenopause, and menopause.

This Special Issue will also cover various hot research topics such as new contraception methods, endometriosis pathophysiology and treatment, functional hypothalamic amenorrhea treatment, premature ovarian insufficiency etiology and management, and new advances in menopausal symptom treatments.

Prof. Dr. Błażej Męczekalski
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-anonymized peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • amenorrhea
  • puberty
  • PCOS
  • premature ovarian insufficiency
  • endometriosis
  • infertility
  • pregnancy
  • hormones
  • menopause

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Related Special Issue

Published Papers (2 papers)

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Review

22 pages, 2313 KB  
Review
Contemporary Approaches Towards the Optimization of Embryo Implantation
by Christian Unogu, Monika Grymowicz, Anna Szeliga, Roman Smolarczyk, Anna Kostrzak, Ewa Rudnicka, Anna Duszewska, Gregory Bala, Martyna Grymowicz, Blazej Meczekalski and Eli Y. Adashi
J. Clin. Med. 2026, 15(12), 4723; https://doi.org/10.3390/jcm15124723 - 17 Jun 2026
Viewed by 811
Abstract
Background/Objectives: Embryo implantation is a highly regulated, multistep process requiring precise synchronization between a developmentally competent blastocyst and a receptive endometrium. Despite advances in reproductive medicine, implantation failure remains a major limiting factor in assisted reproductive technology (ART), particularly in cases of recurrent [...] Read more.
Background/Objectives: Embryo implantation is a highly regulated, multistep process requiring precise synchronization between a developmentally competent blastocyst and a receptive endometrium. Despite advances in reproductive medicine, implantation failure remains a major limiting factor in assisted reproductive technology (ART), particularly in cases of recurrent implantation failure (RIF). This review aims to summarize current knowledge on the molecular, cellular, and immunological mechanisms governing embryo–endometrial interaction and to evaluate contemporary strategies for optimizing implantation outcomes. Methods: This narrative review synthesizes the current literature on embryo implantation, including studies addressing uterine receptivity, etiological factors contributing to implantation failure, and emerging diagnostic and therapeutic approaches. The review integrates findings from molecular biology, clinical ART practices, and bioengineering-based models. Key areas include transcriptomic tools such as endometrial receptivity analysis, time-lapse imaging, artificial-intelligence-based embryo selection, and advanced in vitro models (e.g., microfluidic “womb-on-a-chip” systems and three-dimensional embryo–endometrial platforms). The literature was identified through major biomedical databases, following a structured but non-systematic approach. Results: Implantation success is dependent on a complex interplay of hormonal regulation, gene expression, immune modulation, and embryo quality. Disruption of uterine receptivity during the window of implantation is a critical contributor to infertility and RIF. Multiple factors—including genetic abnormalities, maternal age, lifestyle influences, immunological imbalance, uterine pathology, and chronic endometrial conditions—are implicated in implantation failure. Emerging technologies, such as AI-assisted embryo selection, transcriptomic profiling, and advanced in vitro implantation models, provide enhanced insight into implantation dynamics and offer potential for improved clinical outcomes. Conclusions: Advances in understanding embryo implantation and the development of innovative diagnostic and therapeutic technologies hold significant promise for improving reproductive success. However, further research, validation, and standardization are required before these approaches can be fully integrated into routine clinical practice. A more personalized and mechanism-based approach to implantation may ultimately enhance ART outcomes and reduce the burden of infertility. Full article
(This article belongs to the Special Issue Recent Developments in Gynecological Endocrinology: 2nd Edition)
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22 pages, 349 KB  
Review
Spontaneous Premature Ovarian Insufficiency: Methods Under Research for Infertility Treatment
by Ranko Kutlesic, Marija Kutlesic, Jelena Milosevic-Stevanovic, Predrag Vukomanovic and Danka Mostic-Stanisic
J. Clin. Med. 2026, 15(9), 3224; https://doi.org/10.3390/jcm15093224 - 23 Apr 2026
Viewed by 4009
Abstract
Premature ovarian insufficiency (POI) is a clinical condition characterized by loss of ovarian function indicated by amenorrhea or irregular menstrual cycles for at least 4 months and elevated gonadotrophins (FSH > 25 IU/L, measured on one occasion) and low estrogen serum levels in [...] Read more.
Premature ovarian insufficiency (POI) is a clinical condition characterized by loss of ovarian function indicated by amenorrhea or irregular menstrual cycles for at least 4 months and elevated gonadotrophins (FSH > 25 IU/L, measured on one occasion) and low estrogen serum levels in women under the age of 40. Premature ovarian insufficiency can be non-iatrogenic or spontaneous (idiopathic or due to genetic, autoimmune, or metabolic reasons, or infections) and iatrogenic (a consequence of oophorectomy, chemotherapy, radiotherapy, or uterine artery embolization). Women with POI are faced not only with estrogen deficiency but also with infertility and psychological implications. Hormonal replacement therapy is effective in treating the symptoms of premature ovarian insufficiency as well as in lowering the health risk of long-term consequences of premature ovarian insufficiency. Currently, oocyte donation is the standard treatment for patients with POI desiring pregnancy. Recently developed methods for the regeneration of ovarian tissue, such as stem cell therapy, platelet-reach plasma therapy and in vitro activation of ovarian tissue, are still under research and further adequate multicentric clinical studies are needed to develop standardized effective and safe protocols for the infertility treatment of patients with premature ovarian insufficiency. Full article
(This article belongs to the Special Issue Recent Developments in Gynecological Endocrinology: 2nd Edition)
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