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Journal of Clinical Medicine publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Management of Pregnancy Complications: 2nd Edition

edited by Ariel Many

submission deadline 20 Feb 2026 | 2 articles | Viewed by 2389 | Submission Open

Keywords: high-risk pregnancy; preterm labor; fetal growth restriction; gestational diabetes; twins; hypertensive disorders during pregnancy; preeclampsia; IUGR; prenatal genetics; congenital anomaly detection; cesarean section; complications of labor and delivery

(This special issue belongs to the Section Obstetrics & Gynecology)

Advancements in Cardiac Electrophysiology Through Biomedical Engineering for Abnormality Monitoring and Detection in Clinical Practice

edited by Ilaria Marcantoni and Michela Casella

submission deadline 20 Feb 2026 | 2 articles | Viewed by 2292 | Submission Open

Keywords: electrocardiogram; cardiac electrophysiology; cardiac risk index; cardiac arrhythmias; electrocardiographic alternans; long QT syndrome; heart electrical system anomalies; monitoring of heart electrical system; prevention; biomedical engineering in electrocardiology; cardiac signal processing; cardiac image processing

(This special issue belongs to the Section Cardiology)

Global Expert Views on Clinical Aesthetic Plastic Surgery

edited by

Won Lee

and

Seong Hwan Kim

submission deadline 20 Feb 2026 | 1 articles | Viewed by 2194 | Submission Open

Keywords: aesthetic surgery; cosmetic surgery; dermal fillers; facial plastic surgery; soft tissue fillers; filler complications; ultrasound guided filler injection; hyaluronic acid filler

(This special issue belongs to the Section Plastic, Reconstructive and Aesthetic Surgery/Aesthetic Medicine)

Advances in Diagnosis and Therapeutic Strategies for Uveal Melanoma

edited by Yong Qin

submission deadline 20 Feb 2026 | 1 articles | Viewed by 2164 | Submission Open

Keywords: uveal melanoma; immunotherapy; targeted therapy; biomarker; disease management; drug development; drug resistance

(This special issue belongs to the Section Ophthalmology)

New Perspectives in Acute Coronary Syndrome

edited by Makoto Natsumeda

submission deadline 20 Feb 2026 | 2 articles | Viewed by 2161 | Submission Open

Keywords: acute coronary syndrome; PCI; interventional cardiology; coronary imaging; antiplatelet therapy; stentless PCI strategy; CABG; revascularization

(This special issue belongs to the Section Cardiology)

Traumatic Brain Injury—Clinical Translational Approaches, Demographic Change, and Neuro-Critical Care

edited by

Peter Radermacher

and Thomas Kapapa

submission deadline 20 Feb 2026 | 1 articles | Viewed by 2063 | Submission Open

Keywords: intracranial hypertension; cerebral perfusion pressure; decompressive craniectomy; brain tissue oxygenation; brain tissue microdialysis; blood brain barrier; neuro-critical care

(This special issue belongs to the Section Brain Injury)

Advances in Knee Surgery and Musculoskeletal Rehabilitation: 2nd Edition

edited by

Giulio Maria Marcheggiani Muccioli

and

Giada Lullini

submission deadline 20 Feb 2026 | 1 articles | Viewed by 1975 | Submission Open

Keywords: computer-assisted surgical navigation; smart cutting guides; robotic-assisted surgery; fast-track; telemedicine; tele-rehabilitation; virtual reality

(This special issue belongs to the Section Orthopedics)

Surgical Precision: The Impact of AI and Robotics in General Surgery

edited by Tamara M. H. Gall

submission deadline 20 Feb 2026 | 2 articles | Viewed by 1960 | Submission Open

Keywords: robotic surgery; artificial intelligence in surgery; surgical training; AR in surgery; 3D imaging; surgical navigation

(This special issue belongs to the Section General Surgery)

New Insights in the Diagnosis, Treatment and Monitoring of Anemia, Inflammation and Infection

edited by

Christian Hönemann

submission deadline 20 Feb 2026 | 1 articles | Viewed by 1925 | Submission Open

Keywords: anemia; inflammation; infection; diagnostic tools; therapeutic strategies

(This special issue belongs to the Section Hematology)

Epidemiology of Hyperglycemia in Pregnancy and Its Maternofetal Adverse Outcomes

edited by

Giuseppe Seghieri

submission deadline 20 Feb 2026 | 3 articles | Viewed by 1876 | Submission Open

Keywords: gestational diabetes; diabetes in pregnancy; risk factors; epidemiology; maternofetal adverse outcomes in pregnancies with hypergliycemia; temporal trends

(This special issue belongs to the Section Endocrinology & Metabolism)

Thrombosis: Latest Advances and Prospects

edited by Manila Gaddh

submission deadline 20 Feb 2026 | 1 articles | Viewed by 1831 | Submission Open

Keywords: thromboembolism; venous thrombosis; arterial thrombosis; anticoagulation

(This special issue belongs to the Section Hematology)

Pancreatitis: Current Perspectives on Diagnosis and Management

edited by

Alberto Maringhini

submission deadline 20 Feb 2026 | 2 articles | Viewed by 1823 | Submission Open

Keywords: acute pancreatitis; chronic pancreatitis; pancreatitis; pancreatic cancer; eco-endoscopy; gallstones; biliary stones

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Current Advances and Future Perspectives of Ischemic Stroke

edited by

Marzia Baldereschi

submission deadline 20 Feb 2026 | 1 articles | Viewed by 1623 | Submission Open

Keywords: acute ischemic stroke care; neuroimaging in ischemic stroke; alteplase and tenecteplase; endovascular treatments; recanalization and reperfusion; prognostication in stroke patients; blood– brain barrier in ischemic stroke; bi-omarkers in ischemic stroke; omics in stroke

(This special issue belongs to the Section Clinical Neurology)

Clinical Updates in Stem Cell Transplants

edited by Daniele Avenoso and Michele Malagola

submission deadline 20 Feb 2026 | 2 articles | Viewed by 1506 | Submission Open

Keywords: AML; CML; lymphoma; allo-HSCT; GVHD; MDS; AA

(This special issue belongs to the Section Hematology)

Advances in Neurological Rehabilitation: Innovations and Clinical Insights

edited by

Anna Berardi

submission deadline 20 Feb 2026 | 1 articles | Viewed by 1506 | Submission Open

Keywords: rehabilitation; neurology; assessment; occupational therapy; disability; inclusion

(This special issue belongs to the Section Clinical Neurology)

Integrating Psychological Science into Chronic Pain Management: Emerging Approaches and Insights

edited by Scott G. Ravyts and Margot De Kooning

submission deadline 20 Feb 2026 | 2 articles | Viewed by 1408 | Submission Open

Keywords: chronic primary pain; nociplastic pain; coping strategies; depression; anxiety; trauma

(This special issue belongs to the Section Mental Health)

Clinical Rehabilitation Update on Alzheimer’s Disease and Dementia

edited by

Blanca Gonzalez-Sanchez

María Jiménez-Palomares

and

Juan Rodríguez-Mansilla

submission deadline 20 Feb 2026 | 1 articles | Viewed by 1379 | Submission Open

Keywords: cognition; dementia; rehabilitation; exercise; memory; physical activity; Alzheimer’ s disease; non-pharmacological therapies

(This special issue belongs to the Section Clinical Rehabilitation)

Innovations in Personalized Therapy and Clinical Outcomes for Myopia and Ocular Disorders

edited by

Clara Martinez-Perez

submission deadline 20 Feb 2026 | 2 articles | Viewed by 1149 | Submission Open

Keywords: myopia; refractive errors; visual development; childhood eye disorders; vision screening; diagnostic tools in optometry; vision-related quality of life; therapeutic strategies in optometry; artificial intelligence; public health; eye care innovation; multidisciplinary vision science

(This special issue belongs to the Section Ophthalmology)

Management of Endometriosis: Evidence-Based Updated by Collective Clinical Experience and New Perspectives from Research

edited by

Philippe R. Koninckx

, Arnaud Wattiez and

Sun-Wei Guo

submission deadline 20 Feb 2026 | 2 articles | Viewed by 1128 | Submission Open

Keywords: endometriosis; guidelines; surgery; medical treatment; training; heuristics

(This special issue belongs to the Section Clinical Guidelines)

Advanced Hysteroscopic Technology for Gynecological Disease

edited by

Guglielmo Stabile

Luigi Nappi

and

Felice Sorrentino

submission deadline 20 Feb 2026 | 1 articles | Viewed by 1086 | Submission Open

Keywords: hysteroscopy; new technology; therapy; mini-invasive approach; laser; diagnosis; outcomes

(This special issue belongs to the Section Obstetrics & Gynecology)

Clinical Insights and Emerging Strategies in Chronic Pain Management

edited by

Cheol Lee

submission deadline 20 Feb 2026 | 1 articles | Viewed by 1047 | Submission Open

Keywords: chronic pain; neuropathic pain; multimodal pain management; digital health; real-world evidence; interdiscipli-nary care

(This special issue belongs to the Section Anesthesiology)

Current Opinion of Reconstructive and Aesthetic Breast Surgery

edited by

Lukas Prantl

, Konstantin Frank and Vanessa Brébant

submission deadline 20 Feb 2026 | 1 articles | Viewed by 973 | Submission Open

Keywords: reconstructive breast surgery; lipofilling; microsurgery; aesthetic breast surgery; PROM; digital anthropometry; autologous fat transfer; ADM; synthetic mesh; BIA-ALCL; BII

(This special issue belongs to the Section General Surgery)

Deep Vein Thrombosis and Pulmonary Embolism: Clinical Treatment and Management—Second Edition

edited by

Pablo Demelo-Rodríguez

submission deadline 20 Feb 2026 | 1 articles | Viewed by 967 | Submission Open

Keywords: pulmonary embolism; thrombophilia; deep vein thrombosis; venous thromboembolism; anticoagulation therapy; thrombectomy; bleeding; cancer-associated thrombosis

(This special issue belongs to the Section Hematology)

Clinical Updates and Personalized Medicine in Hepatocellular Carcinoma and Liver Transplantation

edited by Adriano Pellicelli

submission deadline 20 Feb 2026 | 1 articles | Viewed by 961 | Submission Open

Keywords: hepatocellular carcinoma; transarterial chemoembolization (TACE); transarterial radioembolization (TARE); liver transplant; immune checkpoint inhibitors (ICI); tyrosine kinase inhibitor; liver function assessment; Child-Pugh score; bridging to liver transplantation; immuno escape

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Cardio-Oncology: Clinical Advances in Cardiotoxicity Detection, Imaging and Therapeutic Strategies

edited by

Nicola Maurea

and

Alfredo Mauriello

submission deadline 20 Feb 2026 | 1 articles | Viewed by 900 | Submission Open

Keywords: cardio-oncology; cardiovascular toxicity; targeted therapies; echocardiography; PET/CT

(This special issue belongs to the Section Cardiology)

Breast Cancer: Symptoms, Types, Causes & Treatment

edited by Min-Jeong Cho and Sara Myers

submission deadline 20 Feb 2026 | 2 articles | Viewed by 894 | Submission Open

Keywords: ductal carcinoma in situ (DCIS); breast cancer; breast cancer prevention; minimally invasive surgery; innovative imaging technologies

(This special issue belongs to the Section Obstetrics & Gynecology)

Hepatobiliary Surgery: State of the Art and Future Perspectives

edited by

Teresa Perra

and

Alberto Porcu

submission deadline 20 Feb 2026 | 1 articles | Viewed by 890 | Submission Open

Keywords: hepatobiliary surgery; cholangiocarcinoma; hepatocellular carcinoma; liver metastases; benign liver lesions

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Updates on Neurosurgical Techniques, Management, and Outcomes for Intracranial Hemorrhages

edited by Bruno Splavski

submission deadline 20 Feb 2026 | 1 articles | Viewed by 810 | Submission Open

Keywords: minimally invasive neurosurgery; neuro-intervention endovascular techniques; intracranial hemorrhage; stroke; hemorrhagic; ischemic; neurosurgical decision-making; long-term outcomes in neurosurgery

(This special issue belongs to the Section Clinical Neurology)

Advances in Maternal–Fetal Medicine

edited by

C. Andrew Combs

submission deadline 20 Feb 2026 | 1 articles | Viewed by 748 | Submission Open

Keywords: maternal– fetal medicine; obstetric ultrasound; preterm birth; preeclampsia; pregnancy complications; artificial intelligence

(This special issue belongs to the Section Obstetrics & Gynecology)

Advances and Updates in Migraine

edited by

Hartmut Göbel

and Carl H. Göbel

submission deadline 20 Feb 2026 | 1 articles | Viewed by 745 | Submission Open

Keywords: migraine; chronic migraine; headache disorders; CGRP antibodies; gepants; ditans; triptans; precision medicine; neuromodulation; comorbidities; disability burden; pediatric migraine; ICHD-3 classification; neurotransmitters; preventive therapy; translational headache research

(This special issue belongs to the Section Clinical Neurology)

Clinical Translation of Technological Innovations in Diabetes Therapeutics

edited by

Nowreen Haq

submission deadline 20 Feb 2026 | 1 articles | Viewed by 736 | Submission Open

Keywords: diabetes management; remote patient monitoring (RPM); artificial intelligence (AI); machine learning (ML); wearable sensors; point-of-care diagnostics; centrifugal microfluidics; glucose monitoring

(This special issue belongs to the Section Endocrinology & Metabolism)

Age-Related Macular Degeneration: Challenges and Opportunities

edited by Deepayan Kar

submission deadline 20 Feb 2026 | 1 articles | Viewed by 718 | Submission Open

Keywords: age-related macular degeneration; imaging biomarkers; visual function testing; optical coherence tomography; anti-VEGF; complement; artificial intelligence

(This special issue belongs to the Section Ophthalmology)

Breakthroughs in Spine Biomechanics: Diagnostics and Treatment Approaches for Body Posture, Scoliosis and Chronic Back Pain

edited by

Maciej Rachwał

and

Joanna Baran

submission deadline 20 Feb 2026 | 1 articles | Viewed by 715 | Submission Open

Keywords: spinal biomechanics; spinal pathologies; idiopathic scoliosis; postural abnormalities; spinal pain syndromes; spinal deformities; chronic spinal pain

(This special issue belongs to the Section Orthopedics)

Orthopedic Trauma: Diagnosis, Treatment and Rehabilitation

edited by

Emmanouil Liodakis

submission deadline 20 Feb 2026 | 1 articles | Viewed by 675 | Submission Open

Keywords: orthopedic trauma; fragility fractures; biomechanics; bone defect; pelvic ring; acetabular fractures; amputation; re-habilitation

(This special issue belongs to the Section Orthopedics)

Diagnosis and Treatment of Gastrointestinal Malignancies

edited by

Carmelo Laface

and Gianmauro Numico

submission deadline 20 Feb 2026 | 1 articles | Viewed by 672 | Submission Open

Keywords: gastrointestinal cancers; immunotherapy; targeted therapy; chemotherapy; microsatellite instability; driver mutations

(This special issue belongs to the Section Oncology)

Advances in the Field of Cutaneous Malignancies: Background and Clinical Management

edited by

and

submission deadline 20 Feb 2026 | 1 articles | Viewed by 660 | Submission Open

Keywords: dermatology; skin cancer; diagnosis; melanoma; basal cell carcinoma; squamous cell carcinoma; imaging; artificial intelligence; dermoscopy; treatment

(This special issue belongs to the Section Dermatology)

Cancer Immunotherapy: Recent Advances and Clinical Challenges

edited by

Antonello Veccia

submission deadline 20 Feb 2026 | 1 articles | Viewed by 627 | Submission Open

Keywords: immune checkpoint inhibitors; solid tumors; early-stage disease; metastatic disease; prognostic factors; biomarkers; resistance mechanisms

(This special issue belongs to the Section Oncology)

Current Opinion in Dental Implant Surgery and Peri-Implant Disease

edited by

Giorgio Lombardo

and Giovanni Corrocher

submission deadline 20 Feb 2026 | 1 articles | Viewed by 610 | Submission Open

Keywords: dental implant surgery; dental implantology; peri-implant disease; oral surgery; dental implantology

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

Clinical Update on Cardiac Rehabilitation

edited by

Bruno Bordoni

submission deadline 20 Feb 2026 | Viewed by 605 | Submission Open

Keywords: cardiac rehabilitation; cardiovascular disease; physiotherapy; interprofessional intervention; exercise training; nutritional counseling; psychosocial support; secondary prevention; rehabilitation modalities; rehabilitation tools

(This special issue belongs to the Section Clinical Rehabilitation)

New Insights into Orthodontic Treatment

edited by Federico Brugnami and Simonetta Meuli

submission deadline 20 Feb 2026 | 1 articles | Viewed by 583 | Submission Open

Keywords: digital orthodontics; clear aligners; artificial intelligence; digital superimpositions; cone beam computed tomography; growing patients; periodontal patients; maxillofacial surgery; long-term stability; prediction of orthodontic movements

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

Rising Star: Advanced Physical Therapy and Expansion

edited by

Hyolyun Roh

submission deadline 20 Feb 2026 | 1 articles | Viewed by 543 | Submission Open

Keywords: physical therapy; digital therapeutic technology; geriatric diseases; pediatric; psychology of physical therapies; clinical approach

(This special issue belongs to the Section Clinical Rehabilitation)

Current Challenges and Innovations in Emergency Medicine: From Prehospital Care to Critical Decision-Making in the Emergency Department

edited by

Efstratios Karagiannidis

, Barbara P. Fyntanidou and Aikaterini Apostolopoulou

submission deadline 20 Feb 2026 | 1 articles | Viewed by 528 | Submission Open

Keywords: emergency medicine; prehospital care; triage strategies; acute care; point-of-care diagnostics; artificial intelligence; telemedicine; emergency department; patient flow; healthcare systems; burnout in emergency care

(This special issue belongs to the Section Emergency Medicine)

Novel Developments in Digestive Endoscopy

edited by

Arnaldo Amato

submission deadline 20 Feb 2026 | 1 articles | Viewed by 519 | Submission Open

Keywords: endoscopy for IBD; AI in endoscopy; therapeutic endoscopy; EUS; interventional EUS; AI in digestive endoscopy; quality in endoscopy

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Treatment and Long-Term Outcome of Fracture

edited by

Corrado Ciatti

Edoardo Bori

and Fabrizio Quattrini

submission deadline 20 Feb 2026 | 1 articles | Viewed by 517 | Submission Open

Keywords: traumatology; osteosynthesis; plating; nailing; osteosynthesis devices; surgical technique; approach

(This special issue belongs to the Section Orthopedics)

State of the Art in Interventional Cardiology

edited by Antonios Karanasos

submission deadline 20 Feb 2026 | Viewed by 441 | Submission Open

Keywords: interventional cardiology; intravascular imaging; structural interventions; TAVI; vascular access; percutaneous coronary intervention; coronary stenting; cardiovascular diseases

(This special issue belongs to the Section Cardiology)

Current Trends and Future Challenges in Percutaneous Coronary Intervention

edited by Deniz Mutlu

submission deadline 20 Feb 2026 | 1 articles | Viewed by 426 | Submission Open

Keywords: PCI; IVUS; OCT; FFR; physiology; CT-guided PCI; complex PCI; CTO; bifurcation; coronary complications; mechanical circulatory support

(This special issue belongs to the Section Cardiovascular Medicine)

Clinical Applications of Cardiac Imaging: 2nd Edition

edited by Maria Concetta Pastore

submission deadline 20 Feb 2026 | 1 articles | Viewed by 425 | Submission Open

Keywords: cardiac imaging; echocardiography; magnetic resonance imaging; computed tomography; nuclear imaging; heart failure; valvular heart disease; congenital heart disease

(This special issue belongs to the Section Cardiology)

Novel Research in Pediatric Dentistry: 2nd Edition

edited by Christian Hirsch and

Katrin Bekes

submission deadline 20 Feb 2026 | 1 articles | Viewed by 403 | Submission Open

Keywords: early childhood caries; primary teeth; caries prevention; caries treatment; behavioral management; molar incisor hypomineralization; dental trauma; sedation; oral health-related quality of life

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

Cardiac Anesthesia: Current Research and Future Prospects

edited by