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Journal of Clinical Medicine publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Orthodontics: State of the Art and Prospects
edited by Beatriz Tarazona-Álvarez and
submission deadline 5 Jun 2026 | 1 articles | Viewed by 1800 | Submission Open
Keywords: digital orthodontics; clear aligners; 3D printing; accelerated orthodontics; digital treatment plan; nanotechnology
(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)
Latest Research on Male Infertility submission deadline 5 Jun 2026 | 1 articles | Viewed by 950 | Submission Open
Keywords: testis; sperm; seminal plasma; spermatogenesis; fertilization; omics; proteomics; oxidative stress; sperm DNA fragmentation; varicocele; male infertility; testicular cancer; infertility management; ART
(This special issue belongs to the Section Reproductive Medicine & Andrology)
New Insights on Pharmacologic and Non-Pharmacologic Therapy of Advanced Heart Failure
edited by
submission deadline 5 Jun 2026 | Viewed by 68 | Submission Open
Keywords: advanced heart failure (AHF); mechanical circulatory support systems; heart transplantation (HTx); immunosuppression; cardiac allograft rejections
(This special issue belongs to the Section Cardiology)
Sjogren’s Syndrome: Clinical Advances and Insights
edited by David A. Isenberg
submission deadline 7 Jun 2026 | 1 articles | Viewed by 209 | Submission Open
Keywords: xerostomia; xerophthalmia; non-Hodgkins lymphoma; autoimmune rheumatic diseases; Sjogren’ s syndrome
(This special issue belongs to the Section Immunology & Rheumatology)
Clinical Research and Personalized Medicine in Inflammatory Bowel Disease
edited by and Loris Riccardo Lopetuso
submission deadline 10 Jun 2026 | 4 articles | Viewed by 5300 | Submission Open
Keywords: inflammatory bowel disease (IBD); personalized medicine; precision medicine; Crohn’ s disease; ulcerative colitis; targeted therapy; artificial intelligence
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Clinical Perspectives of Vascular and Endovascular Surgeries submission deadline 10 Jun 2026 | 2 articles | Viewed by 2440 | Submission Open
Keywords: vascular surgery; varicose veins; abdominal aortic aneurysms; carotid disease; peripheral arterial disease
(This special issue belongs to the Section Vascular Medicine)
Regional Anesthesia and Pain Management: Mastering Clinical Art for Optimal Patient Satisfaction
edited by
submission deadline 10 Jun 2026 | 2 articles | Viewed by 2136 | Submission Open
Keywords: regional anesthesia; pain management; ultrasound-guided nerve blocks; fascial plane blocks; multimodal analgesia; postoperative analgesia; chronic pain management; opioid-sparing strategies; non-opioid analgesics; patient satisfaction; anesthesia techniques; perioperative care; pain interventions; nerve block techniques; clinical outcomes
(This special issue belongs to the Section Anesthesiology)
Cardiovascular Health: Advances in Prevention, Treatment and Innovative Therapies
edited by
submission deadline 10 Jun 2026 | Viewed by 1296 | Submission Open
Keywords: atherosclerosis; dyslipidemia; cardiac risk factors; premature ASCVD; left atrium function; atrial fibrillation; coronary imaging
(This special issue belongs to the Section Cardiovascular Medicine)
Surgical Management of Maxillofacial Fractures and Reconstruction of Facial Deformities
edited by , and Francesco Arcuri
submission deadline 10 Jun 2026 | 2 articles | Viewed by 933 | Submission Open
Keywords: head and neck reconstruction; facial fractures; minimally invasive treatments; facial reconstruction; bioengineering in head and neck disorders; CAD/CAM in maxillo facial trauma and deformities
(This special issue belongs to the Section Plastic, Reconstructive and Aesthetic Surgery/Aesthetic Medicine)
Diabetes Mellitus and Emerging Health Challenges: A Multidisciplinary Perspective
edited by Katarzyna A. Majewska and
submission deadline 10 Jun 2026 | 2 articles | Viewed by 848 | Submission Open
Keywords: diabetes mellitus; type 1 diabetes; type 2 diabetes; diabetic complications; prediabetes; diabetes treatment; autoimmune diabetes
(This special issue belongs to the Section Endocrinology & Metabolism)
Clinical Outcomes Improvement and Perioperative Management of Surgical Patients: 3rd Edition submission deadline 10 Jun 2026 | 2 articles | Viewed by 410 | Submission Open
Keywords: clinical outcomes; surgery; quality; quality of life; quality improvement; postoperative; morbidity; postoperative care
(This special issue belongs to the Section General Surgery)
Exploring Cardiomyopathy: Comprehensive Guide to Causes, Symptoms and Care
edited by
submission deadline 10 Jun 2026 | Viewed by 309 | Submission Open
Keywords: cardiomyopathy; heart failure; genetics; hypertrophic cardiomyopathy; dilated cardiomyopathy; left ventricular noncompaction; pediatric cardiomyopathies; cardiac imaging
(This special issue belongs to the Section Cardiology)
Clinical and Diagnostic Strategies for Glioma Treatment
edited by Aleksandrs Krigers and Egils Valeinis
submission deadline 10 Jun 2026 | Viewed by 74 | Submission Open
Keywords: glioma; glioblastoma; astrocytoma; oligodendroglioma; IDH; neuro-oncology; neurosurgery; radiotherapy; neuropathology; diagnostics; treatment
(This special issue belongs to the Section Clinical Neurology)
Cardiac Arrest and Postcardiac Arrest Care: State of the Art and Future Directions
edited by and Soheil Saadat
submission deadline 10 Jun 2026 | Viewed by 72 | Submission Open
Keywords: out-of-hospital cardiac arrest; cardiopulmonary resuscitation; postcardiac arrest syndrome; postcardiac arrest care; survival; neurologic outcomes
(This special issue belongs to the Section Emergency Medicine)
New Technologies for Personalized Medicine in Head and Neck Surgery submission deadline 10 Jun 2026 | Viewed by 62 | Submission Open
Keywords: personalized medicine; head and neck surgery; 3D printing; surgical navigation; artificial intelligence; computer-assisted surgery; regenerative medicine; precision oncology; craniofacial reconstruction; biomaterials; virtual surgical planning; genomics and proteomics; tissue engineering; functional rehabilitation
(This special issue belongs to the Section Otolaryngology)
Cardiomyopathy: Diagnosis and Therapeutic Advances
edited by Ilaria Dentamaro and Annagrazia Cecere
submission deadline 10 Jun 2026 | Viewed by 57 | Submission Open
Keywords: cardiomiopathy; cardiac magnetic resonance (CMR); advanced echocardiography; heart failure; hypertrophic cardiomyopathy
(This special issue belongs to the Section Cardiology)
Clinical Advancements in Intraocular Lens Power Calculation Methods
edited by and Thomas Kohnen
submission deadline 12 Jun 2026 | 2 articles | Viewed by 2331 | Submission Open
Keywords: emmetropia; IOL power calculation; effective lens position; refractive lens exchange; IOL; refractive surgery; biometry
(This special issue belongs to the Section Ophthalmology)
Systemic Sclerosis: State of the Art and Future Directions
edited by Antonino Mazzone and
submission deadline 12 Jun 2026 | Viewed by 55 | Submission Open
Keywords: systemic sclerosis; current knowledge; advanced knowledge; vasculopathy; interstitial lung disease; pulmonary arterial hypertension; perspectives; novelties
(This special issue belongs to the Section Dermatology)
Evidence-Based Clinical Management of Orthopaedic Trauma: 25 Years in Retrospect, and a Forecast of 25 Years to Come
edited by Dirk Stengel and
submission deadline 15 Jun 2026 | 5 articles | Viewed by 10753 | Submission Open
Keywords: evidence-based medicine; orthopaedic surgery; clinical trials; systematic reviews; patient outcomes; multiple trauma; artificial intelligence; injuries
(This special issue belongs to the Section Orthopedics)
Coronary Heart Disease: Causes, Diagnosis and Management
edited by
submission deadline 15 Jun 2026 | 3 articles | Viewed by 9964 | Submission Open
Keywords: coronary heart disease; coronary revascularization; coronary artery disease; ischemic heart disease; atherosclerosis
(This special issue belongs to the Section Cardiology)
Aortic Pathologies: Aneurysm, Atherosclerosis and More
edited by Alexander Gombert and Panagiotis Doukas
submission deadline 15 Jun 2026 | 4 articles | Viewed by 8355 | Submission Open
Keywords: aorta; aortic aneurysm; thoracoabdominal aortic aneurysm; fenestrated endovascular aortic repair (FEVAR); branched endovascular aortic repair (BEVAR); spinal cord ischemia; coral reef aorta; surgery; endovascular aortic surgery
(This special issue belongs to the Section Cardiovascular Medicine)
Male Sexual and Reproductive Health: Clinical Aspects, Metabolic Profile, Environmental Factors and Lifestyle: 2nd Edition
edited by
submission deadline 15 Jun 2026 | 3 articles | Viewed by 7641 | Submission Open
Keywords: male sexual dysfunction; reproductive health; erectile dysfunction; premature ejaculation; infertility; epidemiology; causes; diagnosis; treatments; environmental factors; lifestyle
(This special issue belongs to the Section Reproductive Medicine & Andrology)
Advances in the Diagnosis and Treatment of Glaucoma
edited by
submission deadline 15 Jun 2026 | 4 articles | Viewed by 5553 | Submission Open
Keywords: OCT; glaucoma; MIGS; neuroprotection; drug delivery systems; artificial intelligence; pharmacologic agents; per-sonalized medicine
(This special issue belongs to the Section Ophthalmology)
Scoliosis: Advances in Diagnosis and Management
edited by Michal Latalski
submission deadline 15 Jun 2026 | 3 articles | Viewed by 5398 | Submission Open
Keywords: scoliosis; adolescent idiopathic scoliosis; adult scoliosis; congenital scoliosis; neuromuscular scoliosis; diagnosis; imaging; treatment; surgery; bracing; rehabilitation; patient-reported outcomes; quality of life
(This special issue belongs to the Section Orthopedics)
Arthroplasty: Advances in Surgical Techniques and Patient Outcomes—2nd Edition
edited by Senthil Sambandam
submission deadline 15 Jun 2026 | 2 articles | Viewed by 3211 | Submission Open
Keywords: hip arthroplasty; knee arthroplasty; hip fractures; arthroplasty; osteoarthritis; knee arthroscopy; joint replacement
(This special issue belongs to the Section Orthopedics)
Emergency Surgery: Clinical Updates and New Perspectives
edited by
submission deadline 15 Jun 2026 | 1 articles | Viewed by 2076 | Submission Open
Keywords: emergency surgery; trauma surgery; acute abdomen; hernia emergencies; surgical decision making; perioperative care; damage control surgery; emergency management; critical care surgery; multidisciplinary approach
(This special issue belongs to the Section Emergency Medicine)
Blood Cancers: Current Status and Future Challenges
edited by and Massimo Breccia
submission deadline 15 Jun 2026 | 1 articles | Viewed by 1607 | Submission Open
Keywords: acute myeloid leukemia; hematology; leukemia; venetoclax; blood disorders
(This special issue belongs to the Section Hematology)
Gender Differences and Diversity in the Treatment of Gastric Cancer and Other Malignancies
edited by Claus Schildberg and Frank Meyer
submission deadline 15 Jun 2026 | 2 articles | Viewed by 1603 | Submission Open
Keywords: gastric cancer; other cancers; other treatment; gender differences; diversity; new challances
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Thoracic Surgery: Current Practice and Future Directions: 2nd Edition
edited by
submission deadline 15 Jun 2026 | 3 articles | Viewed by 1576 | Submission Open
Keywords: NSCLC; mediastinum; thymoma; esophageal disease; immunotherapy; new technologies; minimally invasive surgery; VATS; RATS
(This special issue belongs to the Section Respiratory Medicine)
Clinical Updates on Valvular Heart Diseases: A New Era in Personalized Treatment
edited by Massimiliano Mariani
submission deadline 15 Jun 2026 | 2 articles | Viewed by 1433 | Submission Open
Keywords: valvular heart disease; structural heart intervention; imaging in valve disease; interventional echocardiography; minimally invasive cardiac surgery; aortic valve intervention; tricuspid valve intervention; valve intervention in GUCH; patient-specific therapy; advanced diagnostic techniques; gutting-edge cardiac imaging; catheter-based interventions; innovative cardiac therapies
(This special issue belongs to the Section Cardiology)
Perioperative Management in Thoracic Surgery: Current Advances and Future Perspectives submission deadline 15 Jun 2026 | 1 articles | Viewed by 998 | Submission Open
Keywords: thoracic surgery; perioperative care; ERAS; minimally invasive surgery; interventional pulmonology; preoperative assessment; postoperative management; surgical outcomes; multidisciplinary approach; technology in surgery
(This special issue belongs to the Section Respiratory Medicine)
Cardiac Arrest: Strategies, Innovations, and Improvements in Outcomes
edited by
submission deadline 15 Jun 2026 | Viewed by 987 | Submission Open
Keywords: cardiac arrest; cardiopulmonary resuscitation; post-cardiac arrest syndrome; neurological outcomes
(This special issue belongs to the Section Cardiology)
New Clinical Advances in Pediatric Asthma
edited by
submission deadline 15 Jun 2026 | 1 articles | Viewed by 921 | Submission Open
Keywords: pediatric asthma; clinical management; treatment advances; diagnostic advances; biologic therapy; inhaled steroids; control of asthma; exacerbation prevention; quality of life
(This special issue belongs to the Section Clinical Pediatrics)
Transjugular Intrahepatic Portosystemic Shunt: Challenges and Perspectives—2nd Edition
edited by , Stefania Gioia and
submission deadline 15 Jun 2026 | 1 articles | Viewed by 657 | Submission Open
Keywords: hepatic encephalopathy; spontaneous portal-systemic shunts; transjugular intrahepatic portosystemic shunt; cirrhosis; portal hypertension; sarcopenia; myosteatosis; gastrointestinal bleeding; ascites; non cirrhotic portal hypertension
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Congenital Heart Diseases: Epidemiology, Treatment and Lifelong Support
edited by Sebastian Freilinger, , and Oliver Dewald
submission deadline 15 Jun 2026 | 1 articles | Viewed by 565 | Submission Open
Keywords: congenital heart disease (CHD); adults with CHD; epidemiology; comorbidities; intervention; surgical treatment; psychological aspects; quality of life (QoL); risk factors; rehabilitation; health promotion; prevention; health literacy; physical activity; lifelong support
(This special issue belongs to the Section Cardiology)
Dental Implantology: Clinical Updates and Perspectives—2nd Edition
edited by
submission deadline 15 Jun 2026 | 1 articles | Viewed by 427 | Submission Open
Keywords: dental implantology; reconstructive surgery; biomaterials; tissue engineering; regenerative medicine; digital dentis-try; periimplantitis; peri-implant soft tissues
(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)
Clinical Advances in Cancer Imaging submission deadline 15 Jun 2026 | Viewed by 229 | Submission Open
Keywords: pelvic oncology; cancer imaging; CT; MRI; tumor staging; treatment response; morphological criteria; gynecologic cancer; bladder cancer; rectal cancer; artificial intelligence; radiomics; texture analysis; image biomarkers; clinical imaging
(This special issue belongs to the Section Oncology)
New Advances of Infectious Disease Epidemiology submission deadline 15 Jun 2026 | Viewed by 103 | Submission Open
Keywords: infectious disease epidemiology; genomic sequencing; computational modeling; collaborative surveillance; digital epidemiology; one health; pandemic intelligence; public health data integration; emerging pathogens; epidemiologic insights
(This special issue belongs to the Section Epidemiology & Public Health)
Traumatic Brain Injury: Clinical Diagnosis and Management
edited by Alessio Caccioppola
submission deadline 15 Jun 2026 | Viewed by 100 | Submission Open
Keywords: glasgow coma scale; intracranial pressure monitoring; traumatic brain injury; diffuse axonal injury; post-traumatic epilepsy; decompressive craniectomy; neuromonitoring
(This special issue belongs to the Section Brain Injury)
Clinical Advancements in Foot and Ankle Surgery: 2nd Edition
edited by
submission deadline 15 Jun 2026 | Viewed by 87 | Submission Open
Keywords: flat foot; hindfoot motion; diabetic foot; hallux valgus; foot infection; foot trauma
(This special issue belongs to the Section Orthopedics)
Current Challenges and Opportunities in Assisted Reproductive Technologies
edited by Andrea Milostić-Srb and
submission deadline 15 Jun 2026 | Viewed by 82 | Submission Open
Keywords: artificial reproductive technologies; ART; mental health effect on ART; IVF; AI in reproductive medicine
(This special issue belongs to the Section Obstetrics & Gynecology)
Aortic Surgery: State of the Art and Future Directions submission deadline 15 Jun 2026 | Viewed by 51 | Submission Open
Keywords: aortic surgery; aortic aneurysm; aortic dissection; aortic arch; biomaterials; endovascular approach; FET; TEVAR
(This special issue belongs to the Section Cardiovascular Medicine)
Clinical Diagnosis and Management of Erectile Dysfunction
edited by Maurizio De Rocco Ponce and
submission deadline 15 Jun 2026 | Viewed by 48 | Submission Open
Keywords: erectile dysfunction; clinical management; cardiovascular disease; penile prosthesis; personalized medicine; hipogonadism
(This special issue belongs to the Section Reproductive Medicine & Andrology)
Novel Diagnostic and Therapeutic Perspectives in Systemic Sclerosis
edited by Mislav Radić
submission deadline 15 Jun 2026 | Viewed by 37 | Submission Open
Keywords: systemic sclerosis; biomarkers; diagnosis; treatment; diagnostic imaging technique; early detection
(This special issue belongs to the Section Immunology & Rheumatology)
Gynecologic Oncology: Current Therapies and New Frontiers
edited by Laura Paleari and Mariangela Rutigliani
submission deadline 19 Jun 2026 | Viewed by 81 | Submission Open
Keywords: ovarian cancers; gynecological cancer; drug delivery; AI; screening; new therapies
(This special issue belongs to the Section Obstetrics & Gynecology)
Gynecologic and Obstetric Pathologies: From Birth to Menopause (Third Edition) submission deadline 20 Jun 2026 | 6 articles | Viewed by 20718 | Submission Open
Keywords: obstetrics; gynecology; pathology; pediatric and adolescent gynecology; menopause; urinary disorders; infertility; gynecologic oncology; maternal– fetal medicine; incontinence; menstruation; reproduction; polycystic ovarian syndrome; endometriosis; dysmenorrhea; assisted reproduction; IVF; laparoscopy; hysteroscopy; gynecologic robotic surgery; high-risk pregnancy
(This special issue belongs to the Section Obstetrics & Gynecology)
Advances in Trauma Care and Emergency Medicine submission deadline 20 Jun 2026 | 2 articles | Viewed by 13394 | Submission Open
Keywords: trauma; trauma care; emergency medicine; pre-hospital; emergency room; intensive care unit
(This special issue belongs to the Section Emergency Medicine)
Clinical Advances in Metabolic Dysfunction-Associated Steatotic Liver Disease
edited by Hirsh D. Trivedi
submission deadline 20 Jun 2026 | 5 articles | Viewed by 9897 | Submission Open
Keywords: metabolic dysfunction-associated steatotic liver disease; MASLD; non-alcoholic fatty liver disease; NAFLD; liver disease; liver fibrosis; metabolic syndrome
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Latest Advances in Orthodontics
edited by
submission deadline 20 Jun 2026 | 3 articles | Viewed by 6941 | Submission Open
Keywords: digital treatment planning; clear aligners; skeletal anchorage; OSAS; artificial intelligence
(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)
Advancements in Gait Rehabilitation: Innovative Approaches and Clinical Insights submission deadline 20 Jun 2026 | 4 articles | Viewed by 5891 | Submission Open
Keywords: sarcopenia; swallowing therapy; physical therapy; early mobilization; early rehabilitation; robot-assisted gait training; neurorehabilitation; wearable sensors
(This special issue belongs to the Section Clinical Rehabilitation)
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