Novel Diagnostic and Therapeutic Perspectives in Systemic Sclerosis
A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Immunology & Rheumatology".
Deadline for manuscript submissions: 15 June 2026 | Viewed by 89
Special Issue Editor
2. Internal Medicine Department, School of Medicine, University of Split, 21000 Split, Croatia
Interests: connective tissue diseases; rheumatoid arthritis; psoriatic disease; cardiorheumatology; interstitial lung disease; pulmonary arterial hypertension; microcirculation in rheumatic diseases
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Early diagnosis and treatment of systemic sclerosis are advancing through a mechanistic understanding of vasculopathy, immune dysregulation, and fibrosis. Diagnostic improvements include VEDOSS criteria, autoantibody biomarkers, advanced imaging, and nailfold capillaroscopy for early detection. Targeted therapies, such as mycophenolate mofetil, nintedanib, tocilizumab, and rituximab, are emerging, with autologous stem cell transplantation being considered for select patients.
Personalized, biomarker-driven therapies targeting immune, vascular, and fibrotic pathways are under development. CD19 CAR-T cell therapy, bsAbs, and novel agents targeting interferon pathways, BAFF, FcRn, and pro-fibrotic signaling represent a shift towards precision medicine and immune reprogramming. These are promising for patients with early diffuse disease or refractory complications.
Early intervention and cross-organ treatment strategies offer potential for disease modification beyond symptom management. The critical goal is validating early biomarkers of disease trajectory and incorporating them into treatment algorithms to enable personalized and preventive strategies. This necessitates adaptive, mechanism-based trial designs to accelerate the implementation of novel therapies.
Dr. Mislav Radić
Guest Editor
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Keywords
- systemic sclerosis
- biomarkers
- diagnosis
- treatment
- diagnostic imaging technique
- early detection
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